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  1. Book: Chung yao tsʻai tsai pʻei chi shu

    Yang, Chi-hsiang / Chuang, Wen-chʻing

    (hsi hsin, yüeh chien tsʻao, pʻing pei mu, tzʻu wu chia)

    (Nung yeh shih yung chi shu tsʻung shu ;)

    1988  

    Author's details Yang Chi-hsiang, Chuang Wen-chʻing pien
    Series title Nung yeh shih yung chi shu tsʻung shu ;
    Keywords Medicinal plants ; Medicinal plants/Processing
    Language Chinese
    Size 51 p. :, ill. ;, 19 cm.
    Edition Ti 1 pan.
    Publisher Chi-lin kʻo hsüeh chi shu chʻu pan she ; Chi-lin sheng hsin hua shu tien fa hsing
    Publishing place Chʻang-chʻun shih
    Document type Book
    ISBN 7538401431 ; 9787538401431
    Database NAL-Catalogue (AGRICOLA)

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  2. Book: Hsiang-kang Chung tsʻao yao

    Chuang, Chao-hsiang / Li, Ning-han

    Chung Ying tui chao

    1978  

    Author's details Chuang Chao-hsiang, Li Ning-han chu pien
    Keywords Botany, Medical ; Materia medica, Vegetable ; Herbs/Therapeutic use.
    Language Chinese ; English
    Dates of publication 1978-9999
    Size v. <1-2, 4-5 > :, ill. (some col.) ;, 22 cm.
    Publisher Shang wu yin shu kuan
    Publishing place Hsiang-kang
    Document type Book
    Note Title also in English on spine: Chinese medicinal herbs of Hong Kong. ; Includes indexes.
    ISBN 9620730178 ; 9620730658 ; 962073064X ; 9789620730177 ; 9789620730658 ; 9789620730641
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Alternative role of glucagon-like Peptide-1 receptor agonists in neurodegenerative diseases.

    Chen, Shang-Der / Chuang, Yao-Chung / Lin, Tsu-Kung / Yang, Jenq-Lin

    European journal of pharmacology

    2022  Volume 938, Page(s) 175439

    Abstract: Aging is a crucial risk factor for common neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). Limited options are available for the treatment of age-related, multiple pathogenic mechanism-contributed diseases that ... ...

    Abstract Aging is a crucial risk factor for common neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). Limited options are available for the treatment of age-related, multiple pathogenic mechanism-contributed diseases that usually advance to irreversible conditions with severe neurological deficits and result in a heavy socioeconomic burden on patients, families, and society. A therapy that decelerates disease progression and reduces the socioeconomic burden stemming from these diseases is required. Glucagon-like peptide-1 receptor (GLP-1R) is an important class of medication for type 2 diabetes mellitus (T2DM). Through pancreatic effects, GLP-1R agonists can stimulate insulin secretion, increase β-cell proliferation, reduce β-cell apoptosis, and inhibit glucagon secretion in patients with T2DM. Currently, seven clinically approved GLP-1R agonists are used for T2DM: exenatide, liraglutide, lixisenatide, extended-release exenatide, albiglutide, dulaglutide, and semaglutide. Besides the pancreas, GLP-1Rs are also expressed in organs, such as the gastrointestinal tract, heart, lung, kidney, and brain, indicating their potential use in diseases other than T2DM. Emerging evidence reveals that GLP-1R agonists possess pleiotropic effects that enrich neurogenesis, diminish apoptosis, preclude neurons from oxidative stress, and reduce neuroinflammation in various neurological conditions. These favorable effects may also be employed in neurodegenerative diseases. Herein, we reviewed the recent progress, both in preclinical studies and clinical trials, regarding these clinically used GLP-1R agonists in aging-related neurodegenerative diseases, mainly AD and PD. We stress the pleiotropic characteristics of GLP-1R agonists as repurposing drugs to target multiple pathological mechanisms and for use in the future for these devastating neurodegenerative conditions.
    Language English
    Publishing date 2022-12-02
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2022.175439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 522: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Exploring factors associated with interictal heart rate variability in patients with medically controlled focal epilepsy.

    Yeh, Wei-Chih / Lin, Hsun-Chang / Chuang, Yao-Chung / Hsu, Chung-Yao

    Seizure

    2021  Volume 92, Page(s) 24–28

    Abstract: Purpose: Heart rate variability (HRV) reflects the balance between the functional outputs of the sympathetic and parasympathetic nervous systems. It is lower in patients with epilepsy than in the healthy controls. However, HRV has been inadequately ... ...

    Abstract Purpose: Heart rate variability (HRV) reflects the balance between the functional outputs of the sympathetic and parasympathetic nervous systems. It is lower in patients with epilepsy than in the healthy controls. However, HRV has been inadequately studied in different patient subgroups with medically controlled epilepsy. Hence, this study aimed to investigate factors associated with interictal HRV in patients with medically controlled epilepsy.
    Methods: This retrospective cohort study included 54 patients (24 males and 30 females) with medically controlled focal epilepsy who only received monotherapy to eliminate the confounding effect of different antiseizure medications (ASMs). Patients with major systemic or psychiatric disorder comorbidities were excluded. For HRV analysis, electroencephalography and 5-minute well-qualified electrocardiogram segment recording were conducted during stage N1 or N2 sleep. In addition, the association between age, gender, seizure onset type, ASMs, and the time domain and frequency-domain HRV measures was analyzed.
    Results: HRV negatively correlated with advanced age. Patients with focal to bilateral tonic-clonic seizure (FBTCS) had a significantly lower HRV than focal impaired awareness seizures (FIAS). HRV was not associated with any gender and ASMs.
    Conclusions: HRV negatively correlated with age, and patients with FBTCS had a decreased HRV. Thus, these patients may have a declining autonomic function. Therefore, different seizure types may carry different risks of autonomic dysfunction in patients with medically controlled focal epilepsy.
    MeSH term(s) Electroencephalography ; Epilepsies, Partial/drug therapy ; Epilepsy ; Female ; Heart Rate ; Humans ; Male ; Retrospective Studies ; Seizures
    Language English
    Publishing date 2021-08-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1137610-7
    ISSN 1532-2688 ; 1059-1311
    ISSN (online) 1532-2688
    ISSN 1059-1311
    DOI 10.1016/j.seizure.2021.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3573: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Quantitative evaluation of the microstructure of rapid eye movement sleep in refractory epilepsy: a preliminary study using electroencephalography and heart rate variability analysis.

    Yeh, Wei-Chih / Lin, Pei-Jung / Chuang, Yao-Chung / Hsu, Chung-Yao

    Sleep medicine

    2021  Volume 85, Page(s) 239–245

    Abstract: Introduction: Patients with epilepsy have a disturbed sleep architecture. Polysomnographic studies have shown that patients with refractory epilepsy have decreased rapid eye movement (REM) sleep and longer REM latency than those with medically ... ...

    Abstract Introduction: Patients with epilepsy have a disturbed sleep architecture. Polysomnographic studies have shown that patients with refractory epilepsy have decreased rapid eye movement (REM) sleep and longer REM latency than those with medically controlled epilepsy. However, little is known about the differences in the REM sleep microstructure between these patient groups.
    Methods: We conducted a retrospective case-control study of 20 patients with refractory epilepsy (refractory group) and 28 patients with medically controlled epilepsy (medically controlled group). All patients completed sleep questionnaires and underwent overnight in-lab polysomnography. Five-minute electroencephalogram recordings at the C3 and C4 electrodes from each REM sleep were selected for spectral analysis, and 5-min electrocardiogram segments recorded during REM sleep were used for heart rate variability analysis. The groups' scores on the sleep questionnaires, polysomnographic sleep parameters, indices of sleep-related breathing disorders, and REM sleep electroencephalogram spectra were compared.
    Results: The refractory group had decreased REM sleep (p < 0.001) and longer REM latency (p = 0.0357) than those of the medically controlled group. Moreover, electroencephalogram spectral analysis revealed that the refractory group had decreased absolute beta power (p = 0.0039) and relative beta power (p = 0.0035) as well as increased relative delta power (p = 0.0015) compared with the medically controlled group.
    Conclusions: Differences in the polysomnographic macrostructure and REM sleep microstructure between the study groups suggest REM sleep dysregulation in patients with refractory epilepsy.
    MeSH term(s) Case-Control Studies ; Drug Resistant Epilepsy ; Electroencephalography ; Heart Rate ; Humans ; Retrospective Studies ; Sleep ; Sleep, REM
    Language English
    Publishing date 2021-07-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2012041-2
    ISSN 1878-5506 ; 1389-9457
    ISSN (online) 1878-5506
    ISSN 1389-9457
    DOI 10.1016/j.sleep.2021.07.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5315: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 635: Show issues

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  6. Article: Correction: Lin et al. Grounding the Body Improves Sleep Quality in Patients with Mild Alzheimer's Disease: A Pilot Study.

    Lin, Chien-Hung / Tseng, Shih-Ting / Chuang, Yao-Chung / Kuo, Chun-En / Chen, Nai-Ching

    Healthcare (Basel, Switzerland)

    2022  Volume 10, Issue 6

    Abstract: The authors would like to make the following corrections to the published paper [ ... ]. ...

    Abstract The authors would like to make the following corrections to the published paper [...].
    Language English
    Publishing date 2022-05-26
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare10060988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Grounding the Body Improves Sleep Quality in Patients with Mild Alzheimer's Disease: A Pilot Study.

    Lin, Chien-Hung / Tseng, Shih-Ting / Chuang, Yao-Chung / Kuo, Chun-En / Chen, Nai-Ching

    Healthcare (Basel, Switzerland)

    2022  Volume 10, Issue 3

    Abstract: Background: Grounding refers to having direct contact with the Earth, such as by walking barefoot or lying on the ground. Research has found that grounding can improve inflammation, free radical damage, blood pressure, sleep quality, pain, stress, mood, ...

    Abstract Background: Grounding refers to having direct contact with the Earth, such as by walking barefoot or lying on the ground. Research has found that grounding can improve inflammation, free radical damage, blood pressure, sleep quality, pain, stress, mood, and wound healing. However, there has been no research on the effect of utilizing grounding for patients with Alzheimer's disease (AD). Thus, in this study, we investigated the effectiveness of grounding as a non-pharmacological therapy for treating sleep disturbances, anxiety, and depression in patients with mild AD.
    Methods: Patients with mild AD were enrolled in the study. The electrochemical analyzer CHI 1205b was employed to check the electrochemical signals at acupoints KI1 and GV16. We used the Pittsburgh Sleep Quality Index (PSQI), Beck Anxiety Inventory (BAI), and Beck Depression Inventory-II (BDI-II) to evaluate sleep quality, anxiety, and depression, respectively, at weeks 0 and 12.
    Results: This 12-week placebo-controlled study enrolled 22 patients, but only 15 patients completed the 12-week intervention and survey. Grounding significantly improved PSQI scores compared to the sham-grounding group (mean ± SD: 0.3 ± 0.7 vs. 3.0 ± 1.9,
    Conclusions: Grounding can improve sleep quality, but it does not significantly improve anxiety and depression among patients with mild AD.
    Language English
    Publishing date 2022-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare10030581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Disrupted Sleep Homeostasis and Altered Expressions of Clock Genes in Rats with Chronic Lead Exposure.

    Hsu, Chung-Yao / Chuang, Yao-Chung / Chang, Fang-Chia / Chuang, Hung-Yi / Chiou, Terry Ting-Yu / Lee, Chien-Te

    Toxics

    2021  Volume 9, Issue 9

    Abstract: Sleep disturbance is one of the neurobehavioral complications of lead neurotoxicity. The present study evaluated the impacts of chronic lead exposure on alteration of the sleep-wake cycle in association with changes of clock gene expression in the ... ...

    Abstract Sleep disturbance is one of the neurobehavioral complications of lead neurotoxicity. The present study evaluated the impacts of chronic lead exposure on alteration of the sleep-wake cycle in association with changes of clock gene expression in the hypothalamus. Sprague-Dawley rats with chronic lead exposure consumed drinking water that contained 250 ppm of lead acetate for five weeks. Electroencephalography and electromyography were recorded for scoring the architecture of the sleep-wake cycle in animals. At six Zeitgeber time (ZT) points (ZT2, ZT6, ZT10, ZT14, ZT18, and ZT22), three clock genes, including
    Language English
    Publishing date 2021-09-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics9090217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Correction

    Chien-Hung Lin / Shih-Ting Tseng / Yao-Chung Chuang / Chun-En Kuo / Nai-Ching Chen

    Healthcare, Vol 10, Iss 988, p

    Lin et al. Grounding the Body Improves Sleep Quality in Patients with Mild Alzheimer’s Disease: A Pilot Study. Healthcare 2022, 10 , 581

    2022  Volume 988

    Abstract: The authors would like to make the following corrections to the published paper [.] ...

    Abstract The authors would like to make the following corrections to the published paper [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Interaction of Smoking and Lead Exposure among Carriers of Genetic Variants Associated with a Higher Level of Oxidative Stress Indicators.

    Ho, Kuo-Jung / Chen, Tzu-Hua / Yang, Chen-Cheng / Chuang, Yao-Chung / Chuang, Hung-Yi

    International journal of environmental research and public health

    2021  Volume 18, Issue 16

    Abstract: Smoking and lead (Pb) exposure increased oxidative stress in human body, and people with some gene variants may be susceptible to Pb and smoking via oxidative stress. The aim of this study is to evaluate oxidative stress by measuring thiobarbituric acid ... ...

    Abstract Smoking and lead (Pb) exposure increased oxidative stress in human body, and people with some gene variants may be susceptible to Pb and smoking via oxidative stress. The aim of this study is to evaluate oxidative stress by measuring thiobarbituric acid reactive substances (TBARS) and the relationship of lipid peroxidation markers in Pb workers with different gene polymorphisms (rs4673 and rs1050450) in both smokers and nonsmokers. Blood samples were collected from 267 Pb workers who received their annual health examination in the Kaohsiung Medical University Hospital. Glutathione peroxidase 1 (GPx-1) rs1050450 and cytochrome B-245 Alpha Chain (CYBA) rs4673 single-nucleotide polymorphisms (SNP) were analyzed by specific primer-probes using Real-Time PCR methods. The interaction between blood Pb and smoking increased serum levels of TBARS and the ratio of oxidative low-density lipoprotein and low-density lipoprotein (oxLDL/LDL). Analysis of workers with rs1050450 SNPs showed higher blood Pb levels in the workers with CC genotype than those with CT genotype. Smokers had significantly higher blood Pb, alanine transaminase (ALT), TBARS, and OxLDL levels than nonsmokers. TBARS increased 0.009 nmol/mL when blood Pb increased one µg/dL in smokers compared to nonsmokers. The ratio of OxLDL/LDL increased 0.223 when blood Pb increased one µg/dL in smokers compared to nonsmokers. TBARS levels and the ratio of OxLDL/LDL were positively correlated and interacted between blood Pb and smoking after the adjustment of confounders, suggesting that smoking cessation is an important issue in the Pb-exposed working environment.
    MeSH term(s) Humans ; Lead/adverse effects ; Lipid Peroxidation ; Oxidative Stress/genetics ; Smoking/adverse effects ; Thiobarbituric Acid Reactive Substances
    Chemical Substances Thiobarbituric Acid Reactive Substances ; Lead (2P299V784P)
    Language English
    Publishing date 2021-08-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph18168325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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