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  1. Article ; Online: A Study of the Ping An Health App Based on User Reviews with Sentiment Analysis.

    Fang, Fang / Zhou, Yin / Ying, Shi / Li, Zhijuan

    International journal of environmental research and public health

    2023  Volume 20, Issue 2

    Abstract: By mining the dimensional sentiment and dimension weight of the Ping An Health App reviews ... suggestions for the Ping An Health App operators to improve user satisfaction. Firstly, the topic model is ... of the Ping An Health App in the Apple App Store, users' concerns about Ping An Health App can be summarized ...

    Abstract By mining the dimensional sentiment and dimension weight of the Ping An Health App reviews, this paper explores the changing trend of the influence of dimensions on user satisfaction and provides suggestions for the Ping An Health App operators to improve user satisfaction. Firstly, the topic model is used to identify the topic of user comments, and then the fine-grained sentiment analysis method is used to calculate the sentiment and weight of each dimension. Finally, the changing trend of the weight of each dimension and the changing trend of user satisfaction of each dimension are drawn. Based on the reviews of the Ping An Health App in the Apple App Store, users' concerns about Ping An Health App can be summarized into seven main dimensions: Usage, Bug report, Reliability, Feature information, Services, Other apps, and User Background. The "Feature information" dimension and "Reliability" dimension have a great impact on user satisfaction with the Ping An Health App, while the "Bug report" dimension has the lowest user satisfaction.
    MeSH term(s) Mobile Applications ; Sentiment Analysis ; Personal Satisfaction ; Attitude
    Language English
    Publishing date 2023-01-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20021591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Salt-Stress-Induced Ion Transport Contributes to K+/Na+ Homeostasis in Roots of Ping’ou Hybrid Hazelnut

    Luo, Da / Song, Fenghui / Lu, Mingyan / Shi, Yanjiang / Ma, Qinghua

    Forests. 2023 Aug. 15, v. 14, no. 8

    2023  

    Abstract: ... Soil salinization in Xinjiang of China is very serious. Ping’ou hybrid hazelnut, as an important ecological and ... Understanding the salt-tolerance mechanism of Ping’ou hybrid hazelnut is of great significance for the breeding ... variety of Ping’ou hybrid hazelnut, was selected as test material, and seedlings were treated with 0 ...

    Abstract Soil salinity is a worldwide problem that adversely affects plant growth and development. Soil salinization in Xinjiang of China is very serious. Ping’ou hybrid hazelnut, as an important ecological and economic tree species, as well as a salt-tolerant plant, has been grown in Xinjiang for over 20 years. Understanding the salt-tolerance mechanism of Ping’ou hybrid hazelnut is of great significance for the breeding of salt-tolerant varieties and the rational utilization of salinized land. In this study, ‘Liaozhen 7’, a fine variety of Ping’ou hybrid hazelnut, was selected as test material, and seedlings were treated with 0 (control), 50, 100 and 200 mM NaCl. Subsequently, the pattern of NaCl-induced fluxes of Na⁺, K⁺ and H⁺ in the root meristematic zone and their response to ion transport inhibitors were studied using non-invasive micro-test technology (NMT). Different concentrations of NaCl stress significantly increased the Na⁺ concentration in roots, while K⁺ concentration decreased first and then increased with the increase of NaCl concentration. Meanwhile, NaCl stress induced a significant decline in K⁺/Na⁺ ratio. Control and 200 mM NaCl-induced Na⁺ and K⁺ fluxes in roots exhibited an outward efflux, whereas an inward flux was observed for H⁺. Under 200 mM NaCl stress, the average rates of net Na⁺ and K⁺ efflux, as well as H⁺ influx in roots were significantly increased, which were 11.6, 6.7 and 2.3 times higher than that of control, respectively. Furthermore, pharmacological experiments showed that 200 mM NaCl-induced Na⁺ efflux; H⁺ influx was significantly suppressed by amiloride, an inhibitor of plasma membrane (PM) Na⁺/H⁺ antiporter, and sodium vanadate, an inhibitor of PM H⁺-ATPase. Net Na⁺ efflux and H⁺ influx induced by NaCl decreased by 89.9% and 135.0%, respectively. The NaCl-induced Na⁺ efflux was mediated by a Na⁺/H⁺ antiporter using energy provided by PM H⁺-ATPase. The NaCl-induced K⁺ efflux was significantly restricted by tetraethylamine chloride, a K⁺ channel inhibitor, and promoted by sodium vanadate, which decreased by 111.2% and increased by 80.8%, respectively, indicating that K⁺ efflux was regulated by depolarization-activated outward-rectifying K⁺ channels and non-selective cation channels (NSCCs). In conclusion, NMT data revealed that NaCl stress up regulated the root Na⁺/H⁺ antiporter and H⁺ pump (an activity of PM Na⁺/H⁺ antiport system) of ‘Liaozhen 7’, which compelled the Na⁺/H⁺ exchange across the PM and restricted K⁺ loss via depolarization-activated K⁺ channels and NSCCs simultaneously, thereby maintaining the K⁺/Na⁺ homeostasis and higher salt tolerance.
    Keywords antiporters ; cations ; chlorides ; energy ; growth and development ; hazelnuts ; homeostasis ; hybrids ; meristems ; plant growth ; plasma membrane ; salt stress ; salt tolerance ; sodium ; soil salinity ; soil salinization ; trees ; China
    Language English
    Dates of publication 2023-0815
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2527081-3
    ISSN 1999-4907
    ISSN 1999-4907
    DOI 10.3390/f14081651
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Erratum: SHENGBO ZHOU (), LI HE (), SIYU MA (), SHUJUN XU (), QIANG ZHAI (), PING GUAN (), HUI WANG ()amp; JINGSONG SHI () (2022)Taxonomic status of Rana nigromaculata mongolia and the validity of Pelophylax tenggerensis (Anura, Ranidae) Zootaxa 5165 (4): 486500.

    Zhou, Shengbo / He, L I / Ma, Siyu / Xu, Shujun / Zhai, Qiang / Guan, Ping / Wang, Hui / Shi, Jingsong

    Zootaxa

    2022  Volume 5174, Issue 5, Page(s) 600

    Language English
    Publishing date 2022-08-12
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.5174.5.8
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  4. Article ; Online: Ping Feng Qingfei mixture treats airway hyperresponsiveness: a network pharmacology and molecular docking study.

    Wang, Min / Peng, Min / Shi, Hongshuo / Dong, Chengda / Cui, Lujie / Chang, Hui / Kan, Zunqi / Zhen, Kun / Si, Guomin / Li, Hui

    Annals of palliative medicine

    2021  Volume 10, Issue 4, Page(s) 4747–4759

    Abstract: ... AHR). Ping Feng Qingfei Mixture (PFQF) is effective in treating AHR caused by PM2.5. As there is ...

    Abstract Background: As air pollution has increased in severity over recent years, fine particulate matter (PM) (<25 µm; PM2.5) has led to a greater incidence of disease, including airway hyperresponsiveness (AHR). Ping Feng Qingfei Mixture (PFQF) is effective in treating AHR caused by PM2.5. As there is a lack of knowledge regarding the mechanisms of PFQF in the treatment of AHR, we conducted a network pharmacology study to clarify this issue.
    Methods: We obtained the composition of PFQF from the traditional Chinese medicine (TCM) systems pharmacology database and its potential targets. The potential targets of AHR were obtained from the Online Mendelian Inheritance in Man and Gene Cards databases. Then psychophysiological interaction, KEGG pathway, and Gene Ontology biological process analyses were carried out for targeting PFQF in treating AHR. We further constructed a related network diagram and verified the experimental results in molecular docking.
    Results: We identified a total of 4 core active compounds, and through KEGG analysis obtained multiple signaling pathways, including T helper17 (Th17) cell differentiation and interleukin-17 (IL-17) signaling pathway. Our molecular docking also verified that PFQF could effectively regulate the imbalance of Th17-T regulatory (Treg) cells.
    Conclusions: PFQF can effectively treat the AHR caused by PM2.5 through Th17-Treg immune balance. The combination of molecular docking and network pharmacology provides a way to elucidate the complex mechanism of action of this Chinese herbal medicine.
    MeSH term(s) Cell Differentiation ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Medicine, Chinese Traditional ; Molecular Docking Simulation ; Signal Transduction
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2021-05-09
    Publishing country China
    Document type Journal Article
    ZDB-ID 2828544-X
    ISSN 2224-5839 ; 2224-5839
    ISSN (online) 2224-5839
    ISSN 2224-5839
    DOI 10.21037/apm-21-802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A closer look at ping-pong gaze: an observational study and literature review.

    Yang, Shi-Lin / Han, Xiang / Guo, Chun-Ni / Zhu, Xiao-Ying / Dong, Qiang / Wang, Yan

    Journal of neurology

    2018  Volume 265, Issue 12, Page(s) 2825–2833

    Abstract: Background: Little is known about ping-pong gaze (PPG) outside of individual case reports ...

    Abstract Background: Little is known about ping-pong gaze (PPG) outside of individual case reports. We aimed to describe PPG through an observational study and literature review.
    Methods: Consecutive patients with PPG at Shanghai General Hospital (SGH) from February 2016 to March 2018 were enrolled. A literature review through March 2018 was conducted.
    Results: Of the 14 patients with PPG in SGH, the median age was 60 years and 12 were males. The median Glasgow coma scale score was 7.5. The cycle of the PPG ranged from 1.5 to 6.5 s. The leading three etiologies were acute ischemic stroke in five patients, post-seizure state in three patients, and hypoxic-ischemic encephalopathy in two patients. A total of 88.9% (8/9) of the patients with consistent whole-field PPG had similar bilateral hemispheric damage, whereas 80.0% (4/5) of the patients with PPG in the hemifield had unilateral or extremely asymmetric bilateral hemispheric damage. The hemifiled side was the same side as the sole/dominant hemispheric lesion. The final clinical outcomes were neurologic remission for seven patients, vegetative state for one patient, and death for six patients.
    Conclusions: PPG is a sign with localizing value that suggests hemispheric damage and asymmetric PPG might help to predict lateralization of the lesions. Acute ischemic stroke is the most common cause of PPG. Etiology and initial outcome are likely important prognostic factors of PPG.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Brain/diagnostic imaging ; Eye Movement Measurements ; Female ; Humans ; Male ; Middle Aged ; Nystagmus, Pathologic/diagnostic imaging ; Nystagmus, Pathologic/etiology ; Nystagmus, Pathologic/physiopathology ; Review Literature as Topic
    Language English
    Publishing date 2018-09-25
    Publishing country Germany
    Document type Journal Article ; Observational Study
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-018-9062-x
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  6. Article ; Online: Ping-pong gaze and ocular nodding in bacterial meningitis.

    Wang, Yan / Huang, Yong-Heng / Yang, Shi-Lin

    Neurology

    2017  Volume 89, Issue 19, Page(s) 2021

    MeSH term(s) Adult ; Humans ; Male ; Meningitis, Bacterial/complications ; Meningitis, Bacterial/physiopathology ; Ocular Motility Disorders/complications ; Ocular Motility Disorders/physiopathology
    Language English
    Publishing date 2017-11-06
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000004633
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  7. Article ; Online: Effect of Xiao-Ai-Ping injection on paclitaxel pharmacokinetics in rats by LC-MS/MS method.

    Shi, Mei-Zhi / Xing, Ting-Yu / Chen, Jun-Jun / Jiang, Bo / Xiao, Xiao / Yang, Jiao / Zhu, Jiang / Guo, Cheng / Hu, Jiu-Dong / Han, Yong-Long

    Journal of pharmaceutical and biomedical analysis

    2019  Volume 174, Page(s) 728–733

    Abstract: Xiao-Ai-Ping injection (XAP) has been shown to be clinically effective in treatment of gastric ...

    Abstract Xiao-Ai-Ping injection (XAP) has been shown to be clinically effective in treatment of gastric carcinoma, liver cancer and lung cancer, when it was combined with anticancer drug paclitaxel (PTX). To analyze the effect of XAP on the pharmacokinetics of PTX, a liquid chromatography-tandem mass spectroscopy (LCMS/MS) assay method was developed and validated to quantify PTX simultaneously and its main metabolite 3'-p-hydroxypaclitaxel (C3'-OHP) in rat plasma. PTX and C3'-OHP were quantified using positive MRM mode. The analysis method was validated for specificity, recovery, carry-over, accuracy, precision, sample stability and dilution integrity under various storage conditions. The pharmacokinetic parameters were determined in rats after tail intravenous administration of 6 mg/mL PTX in the absence (control group) or presence of intraperitoneal administration of 10 mL/kg、20 mL/kg XAP (study groups). Compared to control group, the area under the plasma concentration-time curve (AUC) of PTX and C3'-OHP in study groups increased significantly following consecutive administration with XAP for 10 days. In conclusion, pretreatment with XAP enhanced the exposure of PTX and C3'-OHP. There would be herb-drug interaction happening between XAP and PTX in rats.
    MeSH term(s) Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/blood ; Antineoplastic Agents, Phytogenic/pharmacokinetics ; Calibration ; Chromatography, Liquid ; Drugs, Chinese Herbal/administration & dosage ; Female ; Herb-Drug Interactions ; Linear Models ; Paclitaxel/administration & dosage ; Paclitaxel/blood ; Paclitaxel/pharmacokinetics ; Quality Control ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Sensitivity and Specificity ; Tandem Mass Spectrometry
    Chemical Substances Antineoplastic Agents, Phytogenic ; Drugs, Chinese Herbal ; Marsdeniae tenacissimae extract ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2019-07-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2019.07.003
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  8. Article ; Online: Xiao-Ai-Ping Injection Enhances Effect of Paclitaxel to Suppress Breast Cancer Proliferation and Metastasis via Activating Transcription Factor 3.

    Chen, Junjun / Zhang, Xiangqi / Xiao, Xiao / Ding, Yawei / Zhang, Wei / Shi, Meizhi / Yang, Jiao / Liu, Ying / Han, Yonglong

    Integrative cancer therapies

    2020  Volume 19, Page(s) 1534735420906463

    Abstract: ... effects in the progress of treating breast cancer. Xiao-Ai-Ping (XAP) injection, composed of a traditional ...

    Abstract Chemotherapy is an effective treatment for invasive breast cancer. Paradoxically, many recently published findings showed that the first-line chemotherapeutic agent paclitaxel (PTX) showed pro-metastatic effects in the progress of treating breast cancer. Xiao-Ai-Ping (XAP) injection, composed of a traditional herbal medicine,
    MeSH term(s) Activating Transcription Factor 3/metabolism ; Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Breast Neoplasms ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drugs, Chinese Herbal/pharmacology ; Female ; Humans ; Mice ; Neoplasm Invasiveness/prevention & control ; Paclitaxel/pharmacology ; Xenograft Model Antitumor Assays
    Chemical Substances Activating Transcription Factor 3 ; Antineoplastic Agents ; Antineoplastic Agents, Phytogenic ; Drugs, Chinese Herbal ; Marsdeniae tenacissimae extract ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2020-04-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2182320-0
    ISSN 1552-695X ; 1534-7354
    ISSN (online) 1552-695X
    ISSN 1534-7354
    DOI 10.1177/1534735420906463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Hu shi dian ping hong lou meng

    Hu, Shi

    (Hong lou da jia cong shu ; 红楼大家丛书)

    2004  

    Author's details Hu shi
    Series title Hong lou da jia cong shu
    红楼大家丛书
    Language Chinese
    Edition Di 1 ban
    Publisher Tuan jie chu ban she
    Publishing place Bei jing
    Document type Book
    ISBN 7801308425 ; 9787801308429
    Database Former special subject collection: coastal and deep sea fishing

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  10. Article ; Online: Preventive effects of a fractioned polysaccharide from a traditional Chinese herbal medical formula (Yu Ping Feng San) on carbon tetrachloride-induced hepatic fibrosis.

    Wang, Jia-Jia / Li, Jun / Shi, Lei / Lv, Xiong-Wen / Cheng, Wen-Ming / Chen, Ying-Ying

    The Journal of pharmacy and pharmacology

    2010  Volume 62, Issue 7, Page(s) 935–942

    Abstract: Objectives: The study was to investigate the prevention effects and possible mechanism of Yu Ping ...

    Abstract Objectives: The study was to investigate the prevention effects and possible mechanism of Yu Ping Feng San fractioned polysaccharide (YPF-P) on CCl(4)-induced liver fibrosis in rats.
    Methods: YPF-P was prepared from root of Astragalus membranaceus, rhizome of Atractylodes macrocephaia and root of Raidix saposhnikoviae, and compared with polysaccharide from root of Astragalus membranaceus (AP). Hepatic fibrosis was induced by subcutaneous injection with carbon tetrachloride twice weekly for 12 weeks in Sprague-Dawley rats. YPF-P, AP and colchicine were administered intragastrically daily to carbon tetrachloride-treated rats. Histopathological changes of the liver and hepatic stellate cells were evaluated by Masson staining and transmission electron microscopy, respectively. Markers of fibrosis were determined by radioimmunoassay, biochemistry assay and ELISA. The mRNA expressions of tissue inhibitor of metalloproteinase-1 (TIMP-1), matrix metalloproteinase-13 (MMP-13), procollagen I and collagen III were detected by RT-PCR.
    Key findings: YPF-P dose-dependently alleviated the degree of liver fibrosis and inhibited hepatic stellate cell transformation into myofibroblast-like cells, markedly reduced the elevated levels of hyaluronic acid, laminin, type IV collagen, type III procollagen, hydroxyproline and transforming growth factor beta-1, suppressed procollagen I, collagen III and TIMP-1 expression, and improved the TIMP-1/MMP-13 ratio. MMP-13 expression was only promoted moderately by YPF-P. Compared with AP, YPF-P showed more potency on most markers except laminin, type IV collagen and MMP-13 mRNA.
    Conclusions: YPF-P prevented the progress of rat liver fibrosis induced by carbon tetrachloride and had a more potent preventative effect. The preventative effect may be associated with the ability of YPF-P to inhibit the synthesis of matrix collagen and balance the TIMP/MMP system.
    MeSH term(s) Animals ; Apiaceae ; Astragalus membranaceus ; Atractylodes ; Carbon Tetrachloride Poisoning/drug therapy ; Carbon Tetrachloride Poisoning/metabolism ; Carbon Tetrachloride Poisoning/pathology ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Chemical and Drug Induced Liver Injury/prevention & control ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Fibrillar Collagens/genetics ; Fibrillar Collagens/metabolism ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Hyaluronic Acid/metabolism ; Hydroxyproline/metabolism ; Laminin/metabolism ; Liver Cirrhosis, Experimental/metabolism ; Liver Cirrhosis, Experimental/pathology ; Liver Cirrhosis, Experimental/prevention & control ; Magnoliopsida ; Male ; Matrix Metalloproteinases/genetics ; Matrix Metalloproteinases/metabolism ; Phytotherapy ; Plant Roots ; Polysaccharides/pharmacology ; Polysaccharides/therapeutic use ; Protective Agents/pharmacology ; Protective Agents/therapeutic use ; RNA, Messenger/metabolism ; Rats ; Rhizome ; Transforming Growth Factor beta1/metabolism
    Chemical Substances Drugs, Chinese Herbal ; Fibrillar Collagens ; Laminin ; Polysaccharides ; Protective Agents ; RNA, Messenger ; Transforming Growth Factor beta1 ; yu ping feng san ; Hyaluronic Acid (9004-61-9) ; Matrix Metalloproteinases (EC 3.4.24.-) ; Hydroxyproline (RMB44WO89X)
    Language English
    Publishing date 2010-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3107-0
    ISSN 2042-7158 ; 0022-3573 ; 0373-1022
    ISSN (online) 2042-7158
    ISSN 0022-3573 ; 0373-1022
    DOI 10.1211/jpp.62.07.0016
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