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  1. Article ; Online: Age-associated inflammation and implications for skeletal muscle responses to exercise.

    Kunz, Hawley E / Lanza, Ian R

    Experimental gerontology

    2023  Volume 177, Page(s) 112177

    Abstract: Aging is associated with profound alterations in skeletal muscle, including loss of muscle mass and function, local inflammation, altered mitochondrial physiology, and attenuated anabolic responses to exercise termed anabolic resistance. "Inflammaging," ... ...

    Abstract Aging is associated with profound alterations in skeletal muscle, including loss of muscle mass and function, local inflammation, altered mitochondrial physiology, and attenuated anabolic responses to exercise termed anabolic resistance. "Inflammaging," the chronic, low-grade inflammation associated with aging, may contribute to many of the age-related derangements in skeletal muscle, including its ability to respond to exercise and nutritional stimuli. Inflammation and exercise are closely intertwined in numerous ways. A single bout of muscle-damaging exercise stimulates an acute inflammatory response in the skeletal muscle that is essential for muscle repair and regeneration; however, the chronic systemic and local inflammation associated with aging may impair acute inflammatory and anabolic responses to exercise. In contrast, exercise training is anti-inflammatory, targeting many of the potential root causes of inflammaging. In this review, we discuss the interplay between inflammation and exercise in aging and highlight potential therapeutic targets for improving adaptive responses to exercise in older adults.
    MeSH term(s) Humans ; Aged ; Muscle, Skeletal/physiology ; Exercise/physiology ; Aging/physiology ; Inflammation ; Anti-Inflammatory Agents
    Chemical Substances Anti-Inflammatory Agents
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 390992-x
    ISSN 1873-6815 ; 0531-5565
    ISSN (online) 1873-6815
    ISSN 0531-5565
    DOI 10.1016/j.exger.2023.112177
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  2. Article ; Online: A Fresh Look at Fuel Selection in Working Muscle.

    Kunz, Hawley E / Lanza, Ian R

    Metabolic syndrome and related disorders

    2022  Volume 21, Issue 1, Page(s) 1–2

    MeSH term(s) Humans ; Muscle, Skeletal/physiology
    Language English
    Publishing date 2022-11-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 2151220-6
    ISSN 1557-8518 ; 1540-4196
    ISSN (online) 1557-8518
    ISSN 1540-4196
    DOI 10.1089/met.2022.0087
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  3. Article ; Online: Metabolomic response to acute resistance exercise in healthy older adults by 1H-NMR.

    Moosavi, Darya / Vuckovic, Ivan / Kunz, Hawley E / Lanza, Ian R

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0301037

    Abstract: Background: The favorable health-promoting adaptations to exercise result from cumulative responses to individual bouts of physical activity. Older adults often exhibit anabolic resistance; a phenomenon whereby the anabolic responses to exercise and ... ...

    Abstract Background: The favorable health-promoting adaptations to exercise result from cumulative responses to individual bouts of physical activity. Older adults often exhibit anabolic resistance; a phenomenon whereby the anabolic responses to exercise and nutrition are attenuated in skeletal muscle. The mechanisms contributing to age-related anabolic resistance are emerging, but our understanding of how chronological age influences responsiveness to exercise is incomplete. The objective was to determine the effects of healthy aging on peripheral blood metabolomic response to a single bout of resistance exercise and whether any metabolites in circulation are predictive of anabolic response in skeletal muscle.
    Methods: Thirty young (20-35 years) and 49 older (65-85 years) men and women were studied in a cross-sectional manner. Participants completed a single bout of resistance exercise consisting of eight sets of 10 repetitions of unilateral knee extension at 70% of one-repetition maximum. Blood samples were collected before exercise, immediately post exercise, and 30-, 90-, and 180-minutes into recovery. Proton nuclear magnetic resonance spectroscopy was used to profile circulating metabolites at all timepoints. Serial muscle biopsies were collected for measuring muscle protein synthesis rates.
    Results: Our analysis revealed that one bout of resistance exercise elicits significant changes in 26 of 33 measured plasma metabolites, reflecting alterations in several biological processes. Furthermore, 12 metabolites demonstrated significant interactions between exercise and age, including organic acids, amino acids, ketones, and keto-acids, which exhibited distinct responses to exercise in young and older adults. Pre-exercise histidine and sarcosine were negatively associated with muscle protein synthesis, as was the pre/post-exercise fold change in plasma histidine.
    Conclusions: This study demonstrates that while many exercise-responsive metabolites change similarly in young and older adults, several demonstrate age-dependent changes even in the absence of evidence of sarcopenia or frailty.
    Trial registration: Clinical trial registry: ClinicalTrials.gov NCT03350906.
    MeSH term(s) Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Cross-Sectional Studies ; Histidine/metabolism ; Muscle Proteins/metabolism ; Muscle, Skeletal/physiology ; Proton Magnetic Resonance Spectroscopy ; Resistance Training ; Young Adult ; Adult
    Chemical Substances Histidine (4QD397987E) ; Muscle Proteins
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0301037
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  4. Article ; Online: Age-associated inflammation and implications for skeletal muscle responses to exercise

    Hawley E. Kunz / Ian R. Lanza

    Experimental Gerontology, Vol 177, Iss , Pp 112177- (2023)

    2023  

    Abstract: Aging is associated with profound alterations in skeletal muscle, including loss of muscle mass and function, local inflammation, altered mitochondrial physiology, and attenuated anabolic responses to exercise termed anabolic resistance. “Inflammaging,” ... ...

    Abstract Aging is associated with profound alterations in skeletal muscle, including loss of muscle mass and function, local inflammation, altered mitochondrial physiology, and attenuated anabolic responses to exercise termed anabolic resistance. “Inflammaging,” the chronic, low-grade inflammation associated with aging, may contribute to many of the age-related derangements in skeletal muscle, including its ability to respond to exercise and nutritional stimuli. Inflammation and exercise are closely intertwined in numerous ways. A single bout of muscle-damaging exercise stimulates an acute inflammatory response in the skeletal muscle that is essential for muscle repair and regeneration; however, the chronic systemic and local inflammation associated with aging may impair acute inflammatory and anabolic responses to exercise. In contrast, exercise training is anti-inflammatory, targeting many of the potential root causes of inflammaging. In this review, we discuss the interplay between inflammation and exercise in aging and highlight potential therapeutic targets for improving adaptive responses to exercise in older adults.
    Keywords Aging ; Exercise ; Inflammation ; Skeletal muscle ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 796
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Enhancing the Metabolic Benefits of Bariatric Surgery: Tipping the Scales With Exercise.

    Lanza, Ian R

    Diabetes

    2015  Volume 64, Issue 11, Page(s) 3656–3658

    MeSH term(s) Exercise/physiology ; Female ; Gastric Bypass ; Humans ; Insulin Resistance/physiology ; Lipid Metabolism/physiology ; Male ; Mitochondria, Muscle/metabolism ; Obesity/surgery ; Weight Loss/physiology
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/dbi15-0018
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  6. Article ; Online: Mitochondrial ADP Sensitivity and Transport: New Insights Into Diet-Induced Mitochondrial Impairments.

    Hart, Corey R / Lanza, Ian R

    Diabetes

    2018  Volume 67, Issue 11, Page(s) 2152–2153

    MeSH term(s) Adenosine Diphosphate ; Diet, High-Fat ; Mitochondria ; Mitochondria, Muscle
    Chemical Substances Adenosine Diphosphate (61D2G4IYVH)
    Language English
    Publishing date 2018-10-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/dbi18-0030
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  7. Article ; Online: A Randomized Trial of ω-3 Fatty Acid Supplementation and Circulating Lipoprotein Subclasses in Healthy Older Adults.

    Moosavi, Darya / Vuckovic, Ivan / Kunz, Hawley E / Lanza, Ian R

    The Journal of nutrition

    2022  Volume 152, Issue 7, Page(s) 1675–1689

    Abstract: Background: Omega-3 (n-3) PUFAs are recognized for triglyceride-lowering effects in people with dyslipidemia, but it remains unclear if n-3-PUFA intake influences lipoprotein profiles in older adults without hypertriglyceridemia.: Objectives: The ... ...

    Abstract Background: Omega-3 (n-3) PUFAs are recognized for triglyceride-lowering effects in people with dyslipidemia, but it remains unclear if n-3-PUFA intake influences lipoprotein profiles in older adults without hypertriglyceridemia.
    Objectives: The objective was to determine the effect of n-3-PUFA supplementation on plasma lipoprotein subfractions in healthy older men and women in the absence of cardiovascular disease (CVD) or hypertriglyceridemia. This was a secondary analysis and considered exploratory.
    Methods: Thirty young (20-35 y old) and 54 older (65-85 y old) men and women were enrolled in the study. Fasting plasma samples were collected. After baseline sample collection, 44 older adults were randomly assigned to receive either n-3-PUFA ethyl esters (3.9 g/d) or placebo (corn oil) for 6 mo. Pre- and postintervention plasma samples were used for quantitative lipoprotein subclass analysis using high-resolution proton NMR spectroscopy.
    Results: The number of large, least-dense LDL particles decreased 17%-18% with n-3 PUFAs compared with placebo (<1% change; P < 0.01). The number of small, dense LDL particles increased 26%-44% with n-3 PUFAs compared with placebo (∼11% decrease; P < 0.01). The cholesterol content of large HDL particles increased by 32% with n-3 PUFAs and by 2% in placebo (P < 0.01). The cholesterol content of small HDL particles decreased by 23% with n-3 PUFAs and by 2% in placebo (P < 0.01).
    Conclusions: Despite increasing abundance of small, dense LDL particles that are associated with CVD risk, n-3 PUFAs reduced total triglycerides, maintained HDL, reduced systolic blood pressure, and shifted the HDL particle distribution toward a favorable cardioprotective profile in healthy older adults without dyslipidemia. This study suggests potential benefits of n-3-PUFA supplementation to lipoprotein profiles in healthy older adults without dyslipidemia, which should be considered when weighing the potential health benefits against the cost and ecological impact of widespread use of n-3-PUFA supplements.This trial was registered at clinicaltrials.gov as NCT03350906.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Cardiovascular Diseases/prevention & control ; Cholesterol ; Dietary Supplements ; Fatty Acids, Omega-3/administration & dosage ; Female ; Humans ; Hypertriglyceridemia ; Lipoproteins/blood ; Male ; Triglycerides ; Young Adult
    Chemical Substances Fatty Acids, Omega-3 ; Lipoproteins ; Triglycerides ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2022-04-07
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.1093/jn/nxac084
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  8. Article: Metabolic Flux Analysis: Moving beyond Static Metabolomics.

    Radenkovic, Silvia / Vuckovic, Ivan / Lanza, Ian R

    Trends in biochemical sciences

    2020  Volume 45, Issue 6, Page(s) 545–546

    MeSH term(s) Magnetic Resonance Spectroscopy/methods ; Mass Spectrometry/methods ; Metabolic Networks and Pathways ; Metabolomics
    Language English
    Publishing date 2020-03-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2020.02.011
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  9. Article ; Online: Human myofiber-enriched aging-induced lncRNA FRAIL1 promotes loss of skeletal muscle function.

    Miller, Matthew J / Gries, Kevin J / Marcotte, George R / Ryan, Zachary / Strub, Matthew D / Kunz, Hawley E / Arendt, Bonnie K / Dasari, Surendra / Ebert, Scott M / Adams, Christopher M / Lanza, Ian R

    Aging cell

    2024  Volume 23, Issue 4, Page(s) e14097

    Abstract: The loss of skeletal muscle mass during aging is a significant health concern linked to adverse outcomes in older individuals. Understanding the molecular basis of age-related muscle loss is crucial for developing strategies to combat this debilitating ... ...

    Abstract The loss of skeletal muscle mass during aging is a significant health concern linked to adverse outcomes in older individuals. Understanding the molecular basis of age-related muscle loss is crucial for developing strategies to combat this debilitating condition. Long noncoding RNAs (lncRNAs) are a largely uncharacterized class of biomolecules that have been implicated in cellular homeostasis and dysfunction across a many tissues and cell types. To identify lncRNAs that might contribute to skeletal muscle aging, we screened for lncRNAs whose expression was altered in vastus lateralis muscle from older compared to young adults. We identified FRAIL1 as an aging-induced lncRNA with high abundance in human skeletal muscle. In healthy young and older adults, skeletal muscle FRAIL1 was increased with age in conjunction with lower muscle function. Forced expression of FRAIL1 in mouse tibialis anterior muscle elicits a dose-dependent reduction in skeletal muscle fiber size that is independent of changes in muscle fiber type. Furthermore, this reduction in muscle size is dependent on an intact region of FRAIL1 that is highly conserved across non-human primates. Unbiased transcriptional and proteomic profiling of the effects of FRAIL1 expression in mouse skeletal muscle revealed widespread changes in mRNA and protein abundance that recapitulate age-related changes in pathways and processes that are known to be altered in aging skeletal muscle. Taken together, these findings shed light on the intricate molecular mechanisms underlying skeletal muscle aging and implicate FRAIL1 in age-related skeletal muscle phenotypes.
    MeSH term(s) Humans ; Animals ; Mice ; Aged ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Proteomics ; Muscle, Skeletal/metabolism ; Muscle Fibers, Skeletal/metabolism ; Aging/metabolism
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.14097
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  10. Article ; Online: Preserved skeletal muscle oxidative capacity in older adults despite decreased cardiorespiratory fitness with ageing.

    Zhang, Xiaoyan / Kunz, Hawley E / Gries, Kevin / Hart, Corey R / Polley, Eric C / Lanza, Ian R

    The Journal of physiology

    2021  Volume 599, Issue 14, Page(s) 3581–3592

    Abstract: Key points: Healthy older adults exhibit lower cardiorespiratory fitness ( : Abstract: Declining fitness ( ...

    Abstract Key points: Healthy older adults exhibit lower cardiorespiratory fitness (
    Abstract: Declining fitness (
    MeSH term(s) Aged ; Aging ; Cardiorespiratory Fitness ; Exercise ; Female ; Humans ; Male ; Muscle, Skeletal/metabolism ; Oxidative Stress ; Oxygen Consumption ; Physical Fitness ; Young Adult
    Language English
    Publishing date 2021-06-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP281691
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