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Article: [Besprechung von:] Dunnett, Peter J. S.: The decline of the British motor industry. London 1980

Armstrong, Alan / Dunnett, Peter J. S

The economic journal : the journal of the Royal Economic Society Vol. 90 , p. 921-922

1980 Volume 90, Page(s) 921–922

Author's details	Alan Armstrong
Language	Undetermined
Publisher	Wiley-Blackwell
Publishing place	Oxford [u.a.]
Document type	Article
ZDB-ID	3025-9 ; 1473822-3
ISSN	1468-0297 ; 0013-0133
ISSN (online)	1468-0297
ISSN	0013-0133
Database	ECONomics Information System

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Article ; Online: Under-Diagnosis of Dementia with Lewy Bodies in Individuals Racialized as Black: Hypotheses Regarding Potential Contributors.

Armstrong, Melissa J / Barnes, Lisa L

Journal of Alzheimer's disease : JAD

2024 Volume 97, Issue 4, Page(s) 1571–1580

Abstract: ... with race in order to hypothesize why DLB may be under-diagnosed in Black adults in the U.S. In terms ...

Abstract	Dementia with Lewy bodies (DLB) is one of the most common degenerative dementias after Alzheimer's disease (AD) dementia. DLB is under-diagnosed across populations but may be particularly missed in older Black adults. The object of this review was to examine key features of DLB and potential associations with race in order to hypothesize why DLB may be under-diagnosed in Black adults in the U.S. In terms of dementia, symptoms associated with high rates of co-pathology (e.g., AD, vascular disease) in older Black adults may obscure the clinical picture that might suggest Lewy body pathology. Research also suggests that clinicians may be predisposed to give AD dementia diagnoses to Black adults, potentially missing contributions of Lewy body pathology. Hallucinations in Black adults may be misattributed to AD or primary psychiatric disease rather than Lewy body pathology. Research on the prevalence of REM sleep behavior in diverse populations is lacking, but REM sleep behavior disorder could be under-diagnosed in Black adults due to sleep patterns or reporting by caregivers who are not bed partners. Recognition of parkinsonism could be reduced in Black adults due to clinician biases, cultural effects on self-report, and potentially underlying differences in the frequency of parkinsonism. These considerations are superimposed on structural and systemic contributions to health (e.g., socioeconomic status, education, structural racism) and individual-level social exposures (e.g., social interactions, discrimination). Improving DLB recognition in Black adults will require research to investigate reasons for diagnostic disparities and education to increase identification of core symptoms in this population.
MeSH term(s)	Humans ; Aged ; Lewy Body Disease/pathology ; Lewy Bodies/pathology ; Alzheimer Disease/psychology ; Parkinsonian Disorders/diagnosis ; REM Sleep Behavior Disorder/complications
Language	English
Publishing date	2024-01-26
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-231177
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Book: Parkinson's disease

Hawley, Jason S. / Armstrong, Melissa J. / Weiner, William J.

improving patient care

(Oxford American neurology library)

2014

Author's details	ed. by Jason S. Hawley ; Melissa J. Armstrong ; William J. Weiner
Series title	Oxford American neurology library
Keywords	Parkinson Disease ; Patient Care Planning
Language	English
Size	XI, 107 S. : Ill.
Publisher	Oxford Univ. Press
Publishing place	New York u.a.
Publishing country	United States
Document type	Book
Note	Includes bibliographical references and index
HBZ-ID	HT018192995
ISBN	978-0-19-999787-9 ; 0-19-999787-X
Database	Catalogue ZB MED Medicine, Health

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2014 A 977	available for loan (reading room)	Lesesaal EG

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Article ; Online: How to address the inverse care law and increase GP recruitment in areas of socioeconomic deprivation: a qualitative study of GP trainees' views and experiences in the UK.

Armstrong, Matthew J / Wildman, Josephine M / Sowden, Sarah

BJGP open

2024

Abstract: Background: The Deep End network in the North East and North Cumbria (NENC) was set up to tackle health inequalities in general practice. One aim is to address the inverse care law and improve recruitment of GPs, which is known to be especially ... ...

Abstract	Background: The Deep End network in the North East and North Cumbria (NENC) was set up to tackle health inequalities in general practice. One aim is to address the inverse care law and improve recruitment of GPs, which is known to be especially challenging in areas of socioeconomic deprivation. Aim: To explore GP trainees' experiences and perceptions of working in Deep End or Deprived Area Practices (DE/DAPs) to identify how GP recruitment can be improved. Design & setting: Qualitative study recruiting 13 doctors training to be GPs from the Northumbria training programme. Method: Audio-recorded, online, semi-structured interviews and discussion groups were undertaken, transcribed verbatim, and analysed with a grounded theory approach, using a process of thematic analysis. Results: Overall, seven interviews and two discussion groups (13 participants in total) were conducted. Three themes were identified. The first theme was working in areas of socioeconomic deprivation is challenging but has many advantages. The challenges of working in DE/DAPs were not deterring factors for GP trainees wanting to work in areas of socioeconomic deprivation. The second theme was trainees are willing to work in areas of socioeconomic deprivation but clinical experience is important. Training in DE/DAPs gives trainees the confidence to work in areas of deprivation. Familiarity with a practice also makes them more likely to stay post-training. The third theme was financial incentives are not an important attracting factor but support and development opportunities are. Non-pecuniary measures, such as clinical support and protected time for continuing professional development (CPD), were found to be important. Conclusion: To improve recruitment to DE/DAPs, investments should be made to increase the opportunities to train in these environments. This can be achieved by supporting more DE/DAPs to become training practices, and providing clinical support and protected time for CPD.
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article
ISSN	2398-3795
ISSN (online)	2398-3795
DOI	10.3399/BJGPO.2023.0201
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Article ; Online: Quality and Safety Education for Nurses Teamwork and Collaboration Competency: Empowering Nurses.

Armstrong, Gail

Journal of continuing education in nursing

2019 Volume 50, Issue 6, Page(s) 252–255

Abstract: Improving the safety of health care continues to be a high priority for U.S. health care systems ... health care teamwork. [J Contin Educ Nurs. 2019;50(6):252-255.]. ...

Abstract	Improving the safety of health care continues to be a high priority for U.S. health care systems. One of the core competencies identified to improve health care safety focuses on improving teamwork. This article focuses on tools nurses can employ to improve health care team communication, thereby enhancing health care teamwork. [J Contin Educ Nurs. 2019;50(6):252-255.].
MeSH term(s)	Adult ; Attitude of Health Personnel ; Communication ; Cooperative Behavior ; Curriculum ; Female ; Health Personnel/education ; Health Personnel/psychology ; Humans ; Interprofessional Relations ; Male ; Middle Aged ; Nursing, Team/organization & administration ; Patient Care Team/organization & administration ; Power, Psychological
Language	English
Publishing date	2019-05-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	410520-5
ISSN	1938-2472 ; 0022-0124
ISSN (online)	1938-2472
ISSN	0022-0124
DOI	10.3928/00220124-20190516-04
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Article ; Online: Intravascular Lithotripsy for Optimal Angioplasty of Infrapopliteal Calcified Lesions.

Giannopoulos, Stefanos / Armstrong, Ehrin J

The Journal of invasive cardiology

2022 Volume 34, Issue 2, Page(s) E132–E141

Abstract: Background: Infrapopliteal arterial disease results from 2 major etiologies: medial calcification and intimal atheromatous plaque. Lesion calcification constitutes one of the most widely encountered risk factors for percutaneous transluminal angioplasty ...

Abstract	Background: Infrapopliteal arterial disease results from 2 major etiologies: medial calcification and intimal atheromatous plaque. Lesion calcification constitutes one of the most widely encountered risk factors for percutaneous transluminal angioplasty failure. Intravascular lithotripsy (IVL) creates selective fracturing of calcium deposits in the arterial wall, increasing the compliance of the target artery and facilitating angioplasty. Results regarding IVL utilization at femoropopliteal and infrapopliteal lesions have been very promising in terms of safety and efficacy. This review presents currently available data on IVL outcomes for infrapopliteal lesions and provides technical information for optimal use of IVL in these challenging lesions.
MeSH term(s)	Angioplasty ; Femoral Artery ; Humans ; Lithotripsy/methods ; Treatment Outcome ; Vascular Calcification/diagnosis ; Vascular Calcification/therapy
Language	English
Publishing date	2022-02-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1154372-3
ISSN	1557-2501 ; 1042-3931
ISSN (online)	1557-2501
ISSN	1042-3931
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Article ; Online: Families Benefit After Utilization of a Clinic-Based Food Pantry Irrespective of Food Insecurity Experiences in a Pediatric Obesity Treatment Program.

Suarez, Lilianna / Armstrong, Sarah / Fleming, Rachel / Howard, Janna / Cholera, Rushina

American journal of health promotion : AJHP

2024 , Page(s) 8901171241229828

Abstract: Purpose: To evaluate the congruence between food insecurity screening outcome and clinic-based food pantry utilization and to examine caregiver reported comfort, motivation, and benefits of utilization.: Design: Mixed-methods study.: Setting: ... ...

Abstract	Purpose: To evaluate the congruence between food insecurity screening outcome and clinic-based food pantry utilization and to examine caregiver reported comfort, motivation, and benefits of utilization. Design: Mixed-methods study. Setting: Academic pediatric obesity treatment clinic. Subjects: Convenience sample of caregivers. Intervention: Clinic-based food pantry offered irrespective of food insecurity screening outcome. Measures: Food insecurity screening (Hunger Vital Sign) and severity, self-rated caregiver health, willingness to disclose food insecurity and receive food, and food-related stress. Analysis: Chi-square and t-tests were utilized to examine associations and descriptive analysis explored benefits. Rapid qualitative analysis was utilized to identify themes. Results: Caregivers of 120 children were included (child mean age 11.8; 56.7% female, 67.6% Non-Hispanic Black), with 47 of 59 eligible completing follow-up surveys and 14 completing in-depth interviews. Approximately half (N = 30/59, 50.8%) of families utilizing the food pantry screened negative for food insecurity. Families utilizing the food pantry were more likely to report severe food insecurity (N = 23/59; 38.9%) compared to those declining (N = 3/61; 4.9%, Conclusions: Families who screened both positive and negative for food insecurity utilized and benefited from a clinic-based food pantry. Clinics should consider strategies offering food resources to all families irrespective of screening outcome.
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	645160-3
ISSN	2168-6602 ; 0890-1171
ISSN (online)	2168-6602
ISSN	0890-1171
DOI	10.1177/08901171241229828
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Article ; Online: Predicting pressure injury risk in hospitalised patients using machine learning with electronic health records: a US multilevel cohort study.

Padula, William V / Armstrong, David G / Pronovost, Peter J / Saria, Suchi

BMJ open

2024 Volume 14, Issue 4, Page(s) e082540

Abstract: Objective: To predict the risk of hospital-acquired pressure injury using machine learning compared with standard care.: Design: We obtained electronic health records (EHRs) to structure a multilevel cohort of hospitalised patients at risk for ... ...

Abstract	Objective: To predict the risk of hospital-acquired pressure injury using machine learning compared with standard care. Design: We obtained electronic health records (EHRs) to structure a multilevel cohort of hospitalised patients at risk for pressure injury and then calibrate a machine learning model to predict future pressure injury risk. Optimisation methods combined with multilevel logistic regression were used to develop a predictive algorithm of patient-specific shifts in risk over time. Machine learning methods were tested, including random forests, to identify predictive features for the algorithm. We reported the results of the regression approach as well as the area under the receiver operating characteristics (ROC) curve for predictive models. Setting: Hospitalised inpatients. Participants: EHRs of 35 001 hospitalisations over 5 years across 2 academic hospitals. Main outcome measure: Longitudinal shifts in pressure injury risk. Results: The predictive algorithm with features generated by machine learning achieved significantly improved prediction of pressure injury risk (p<0.001) with an area under the ROC curve of 0.72; whereas standard care only achieved an area under the ROC curve of 0.52. At a specificity of 0.50, the predictive algorithm achieved a sensitivity of 0.75. Conclusions: These data could help hospitals conserve resources within a critical period of patient vulnerability of hospital-acquired pressure injury which is not reimbursed by US Medicare; thus, conserving between 30 000 and 90 000 labour-hours per year in an average 500-bed hospital. Hospitals can use this predictive algorithm to initiate a quality improvement programme for pressure injury prevention and further customise the algorithm to patient-specific variation by facility.
MeSH term(s)	Humans ; Aged ; United States/epidemiology ; Cohort Studies ; Pressure Ulcer/epidemiology ; Pressure Ulcer/prevention & control ; Electronic Health Records ; Medicare ; Machine Learning ; Retrospective Studies ; ROC Curve
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-082540
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Transient anticonvulsant effects of time-restricted feeding in the 6-Hz mouse model.

Armstrong, Oliver J / Neal, Elliott S / Vidovic, Diana / Xu, Weizhi / Borges, Karin

Epilepsy & behavior : E&B

2024 Volume 151, Page(s) 109618

Abstract: Introduction: Intermittent fasting enhances neural bioenergetics, is neuroprotective, and elicits antioxidant effects in various animal models. There are conflicting findings on seizure protection, where intermittent fasting regimens often cause severe ... ...

Abstract	Introduction: Intermittent fasting enhances neural bioenergetics, is neuroprotective, and elicits antioxidant effects in various animal models. There are conflicting findings on seizure protection, where intermittent fasting regimens often cause severe weight loss resembling starvation which is unsustainable long-term. Therefore, we tested whether a less intensive intermittent fasting regimen such as time-restricted feeding (TRF) may confer seizure protection. Methods: Male CD1 mice were assigned to either ad libitum-fed control, continuous 8 h TRF, or 8 h TRF with weekend ad libitum food access (2:5 TRF) for one month. Body weight, food intake, and blood glucose levels were measured. Seizure thresholds were determined at various time points using 6-Hz and maximal electroshock seizure threshold (MEST) tests. Protein levels and mRNA expression of genes, enzyme activity related to glucose metabolism, as well as mitochondrial dynamics were assessed in the cortex and hippocampus. Markers of antioxidant defence were evaluated in the plasma, cortex, and liver. Results: Body weight gain was similar in the ad libitum-fed and TRF mouse groups. In both TRF regimens, blood glucose levels did not change between the fed and fasted state and were higher during fasting than in the ad libitum-fed groups. Mice in the TRF group had increased seizure thresholds in the 6-Hz test on day 15 and on day 19 in a second cohort of 2:5 TRF mice, but similar seizure thresholds at other time points compared to ad libitum-fed mice. Continuous TRF did not alter MEST seizure thresholds on day 28. Mice in the TRF group showed increased maximal activity of pyruvate dehydrogenase in the cortex, which was accompanied by increased protein levels of mitochondrial pyruvate carrier 1 in the cortex and hippocampus. There were no other major changes in protein or mRNA levels associated with energy metabolism and mitochondrial dynamics in the brain, nor markers of antioxidant defence in the brain, liver, or plasma. Conclusions: Both continuous and 2:5 TRF regimens transiently increased seizure thresholds in the 6-Hz model at around 2 weeks, which coincided with stability of blood glucose levels during the fed and fasted periods. Our findings suggest that the lack of prolonged anticonvulsant effects in the acute electrical seizure models employed may be attributed to only modest metabolic and antioxidant adaptations found in the brain and liver. Our findings underscore the potential therapeutic value of TRF in managing seizure-related conditions.
MeSH term(s)	Humans ; Male ; Animals ; Mice ; Anticonvulsants/therapeutic use ; Intermittent Fasting ; Blood Glucose ; Antioxidants ; Body Weight ; Disease Models, Animal ; Seizures/drug therapy ; RNA, Messenger
Chemical Substances	Anticonvulsants ; Blood Glucose ; Antioxidants ; RNA, Messenger
Language	English
Publishing date	2024-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010587-3
ISSN	1525-5069 ; 1525-5050
ISSN (online)	1525-5069
ISSN	1525-5050
DOI	10.1016/j.yebeh.2023.109618
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Article ; Online: Response to bipolar androgen therapy and PD-1 inhibition in a patient with metastatic castration-resistant prostate cancer and a germline

Berger, Benjamin T / Labriola, Matthew K / Antonarakis, Emmanuel S / Armstrong, Andrew J

BMJ case reports

2023 Volume 16, Issue 1

Abstract: We present the case of a patient with ... ...

Abstract	We present the case of a patient with germline
MeSH term(s)	Male ; Humans ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/genetics ; Prostatic Neoplasms, Castration-Resistant/pathology ; Androgens/therapeutic use ; Programmed Cell Death 1 Receptor ; Prostate-Specific Antigen ; Germ-Line Mutation ; Androgen Antagonists/therapeutic use ; Germ Cells/pathology ; Checkpoint Kinase 2/genetics
Chemical Substances	Androgens ; Programmed Cell Death 1 Receptor ; Prostate-Specific Antigen (EC 3.4.21.77) ; Androgen Antagonists ; CHEK2 protein, human (EC 2.7.11.1) ; Checkpoint Kinase 2 (EC 2.7.1.11)
Language	English
Publishing date	2023-01-18
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2022-251320
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