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  1. Book: Bioinformatics for omics data

    Mayer, Bernd

    methods and protocols

    (Methods in molecular biology ; 719 ; Springer protocols)

    2011  

    Author's details ed. by Bernd Mayer
    Series title Methods in molecular biology ; 719
    Springer protocols
    Collection
    Language English
    Size XII, 584 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT016663981
    ISBN 978-1-61779-026-3 ; 1-61779-026-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 1180 order for loan Magazin

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  2. Article ; Online: Acrolein exposure from electronic cigarettes.

    Mayer, Bernd

    European heart journal

    2020  Volume 41, Issue 15, Page(s) 1523

    MeSH term(s) Acrolein/adverse effects ; Brain ; E-Cigarette Vapor ; Electronic Nicotine Delivery Systems ; Humans ; NADPH Oxidases ; Oxidative Stress
    Chemical Substances E-Cigarette Vapor ; Acrolein (7864XYD3JJ) ; NADPH Oxidases (EC 1.6.3.-)
    Language English
    Publishing date 2020-03-24
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 640: Show issues

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  3. Article: Heat Accumulation-Induced Surface Structures at High Degrees of Laser Pulse Overlap on Ti6Al4V Surfaces by Femtosecond Laser Texturing.

    Babadjanov, Farkhod / Specht, Uwe / Lukasczyk, Thomas / Mayer, Bernd

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 6

    Abstract: In this work, femtosecond laser pulses at high repetition rates were used to fabricate unique microstructures on the surface of Ti6Al4V. We investigated the influence of pulse overlap and laser repetition rates on structure formation. Laser texturing ... ...

    Abstract In this work, femtosecond laser pulses at high repetition rates were used to fabricate unique microstructures on the surface of Ti6Al4V. We investigated the influence of pulse overlap and laser repetition rates on structure formation. Laser texturing with a high degree of overlap resulted in melting of the material, leading to the formation of specific microstructures that can be used as cavities for drug delivery. The reason for melt formation is attributed to local heat accumulation at high repetition rates. Such structures can be fabricated on materials with low thermal conductivity, which prevent heat dissipation into the bulk of the material. The heat accumulation effect has also been demonstrated on steel, which also has low thermal conductivity.
    Language English
    Publishing date 2023-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16062498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Influence of Contour Scan Variation on Surface, Bulk and Mechanical Properties of LPBF-Processed AlSi7Mg0.6.

    Buchenau, Theresa / Amkreutz, Marc / Bruening, Hauke / Mayer, Bernd

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 8

    Abstract: Metal additive manufacturing technologies have great potential for future use in load-bearing aerospace applications, requiring a deeper understanding of mechanical performance and influencing factors. The objective of this study was to investigate the ... ...

    Abstract Metal additive manufacturing technologies have great potential for future use in load-bearing aerospace applications, requiring a deeper understanding of mechanical performance and influencing factors. The objective of this study was to investigate the influence of contour scan variation on surface quality, tensile and fatigue strength for laser powder bed fusion samples made of AlSi7Mg0.6 material and to create high-quality as-built surfaces. The samples were produced with identical bulk and different contour scan parameters to accommodate the investigation of the impact of as-built surface texture on mechanical properties. The bulk quality was evaluated by density measurements according to Archimedes' principle and tensile testing. The surfaces were investigated using the optical fringe projection method, and surface quality was assessed by the areal surface texture parameters Sa (arithmetic mean height) and Sk (core height, derived from material ratio curve). Fatigue life was tested at different load levels, and the endurance limit was estimated based on a logarithmic-linear relation between number of cycles and stress. All samples were found to have a relative density of more than 99%. Surface conditions distinctive in Sa and Sk were successfully created. The resulting mean values of the ultimate tensile strength σult are between 375 and 405 MPa for 7 different surface conditions. It was confirmed that the influence of contour scan variation on bulk quality is insignificant for the assessed samples. Regarding fatigue, one as-built condition was found to perform as well as surface post-processed parts and better than the as-cast material (compared to literature values). The fatigue strength at the endurance limit for 106 cycles is between 45 and 84 MPa for the three considered surface conditions.
    Language English
    Publishing date 2023-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16083169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Using systems biology to evaluate targets and mechanism of action of drugs for diabetes comorbidities.

    Mayer, Bernd

    Diabetologia

    2016  Volume 59, Issue 12, Page(s) 2503–2506

    Abstract: Medications approved for diabetes-associated renal and cardiovascular morbidities and candidate drugs currently in development are subject to substantial variability in drug response. Heterogeneity on a molecular phenotype level is not apparent at ... ...

    Abstract Medications approved for diabetes-associated renal and cardiovascular morbidities and candidate drugs currently in development are subject to substantial variability in drug response. Heterogeneity on a molecular phenotype level is not apparent at clinical presentation, which means that inter-individual differences in drug effect at the molecular level are masked. These findings identify the need for optimising patient phenotyping via use of molecular biomarkers for a personalised therapy approach. Molecular diversity may, on the one hand, result from the effect of genetic polymorphisms on drug transport, metabolism and effective target modulation. Equally relevant, differences may be due to molecular pathologies. The presence of distinct molecular phenotypes is suggested by classifiers aimed at modelling progressive disease. Such functions for prognosis incorporate a complex set of clinical variables or a multitude of molecular markers reflecting a diverse set of molecular disease mechanisms. This information on disease pathology and the mechanism of action of the drug needs to be systematically integrated with data on molecular biomarkers to develop an experimental tool for personalising medicine. The large amount of molecular data available for characterising diabetes-associated morbidities allows for elucidation of molecular process model representations of disease pathologies. Selecting biomarker candidates on such grounds and, in turn identifying their association with progressive disease allows for the identification of molecular processes associated with disease progression. The molecular effect of a drug can also be modelled at a molecular process level, and the integration of disease pathology and drug effect molecular models reveals candidate biomarkers for assessing drug response. Such tools serve as enrichment strategies aimed at adding precision to drug development and use.
    MeSH term(s) Animals ; Comorbidity ; Diabetes Mellitus/metabolism ; Diabetic Nephropathies/metabolism ; Humans ; Pharmacogenetics ; Systems Biology/methods
    Language English
    Publishing date 2016-12
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1694-9
    ISSN 1432-0428 ; 0012-186X
    ISSN (online) 1432-0428
    ISSN 0012-186X
    DOI 10.1007/s00125-016-4032-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 279: Show issues Location:
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  6. Article ; Online: Synchrotron infrared nanospectroscopy in fourth-generation storage rings.

    Santos, Thiago M / Lordano, Sérgio / Mayer, Rafael A / Volpe, Lucas / Rodrigues, Gustavo M / Meyer, Bernd / Westfahl, Harry / Freitas, Raul O

    Journal of synchrotron radiation

    2024  

    Abstract: Fourth-generation synchrotron storage rings represent a significant milestone in synchrotron technology, offering outstandingly bright and tightly focused X-ray beams for a wide range of scientific applications. However, due to their inherently tight ... ...

    Abstract Fourth-generation synchrotron storage rings represent a significant milestone in synchrotron technology, offering outstandingly bright and tightly focused X-ray beams for a wide range of scientific applications. However, due to their inherently tight magnetic lattices, these storage rings have posed critical challenges for accessing lower-energy radiation, such as infrared (IR) and THz. Here the first-ever IR beamline to be installed and to operate at a fourth-generation synchrotron storage ring is introduced. This work encompasses several notable advancements, including a thorough examination of the new IR source at Sirius, a detailed description of the radiation extraction scheme, and the successful validation of our optical concept through both measurements and simulations. This optimal optical setup has enabled us to achieve an exceptionally wide frequency range for our nanospectroscopy experiments. Through the utilization of synchrotron IR nanospectroscopy on biological and hard matter samples, the practicality and effectiveness of this beamline has been successfully demonstrated. The advantages of fourth-generation synchrotron IR sources, which can now operate with unparalleled stability as a result of the stringent requirements for producing low-emittance X-rays, are emphasized.
    Language English
    Publishing date 2024-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2021413-3
    ISSN 1600-5775 ; 0909-0495
    ISSN (online) 1600-5775
    ISSN 0909-0495
    DOI 10.1107/S1600577524002364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Nitric oxide

    Balligand, Jean-Luc / Mayer, Bernd

    (Handbook of experimental pharmacology ; 143)

    2000  

    Author's details contrib. J.-L. Balligand ... Ed. B. Mayer
    Series title Handbook of experimental pharmacology ; 143
    Collection
    Keywords Stickstoffmonoxid ; Physiologie ; Pathophysiologie
    Subject Pathologische Physiologie ; Physiologische Pathologie ; Physiopathologie ; Humanphysiologie ; Mensch ; Körperfunktion
    Language English
    Size XXIX, 667 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT012018999
    ISBN 3-540-66122-0 ; 978-3-540-66122-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2000 A 3188 order for loan Magazin
    2004 A 6661 order for loan Magazin

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  8. Article ; Online: Nonlinear interaction of Rayleigh waves in isotropic materials: Numerical and experimental investigation.

    Gartsev, Sergey / Zuo, Peng / Rjelka, Marek / Mayer, Andreas / Köhler, Bernd

    Ultrasonics

    2022  Volume 122, Page(s) 106664

    Abstract: Surface treatment intensity monitoring is still an open and challenging nondestructive testing problem. For the estimation of residual stress with ultrasonic measurements, local linear and nonlinear elastic constants are needed as input. In this paper, ... ...

    Abstract Surface treatment intensity monitoring is still an open and challenging nondestructive testing problem. For the estimation of residual stress with ultrasonic measurements, local linear and nonlinear elastic constants are needed as input. In this paper, nonlinear elastic-wave interactions (also called wave mixing or scattering) - namely, the generation of secondary ultrasonic waves in a nonlinear medium - are considered as a prospective means for near-surface nonlinear elastic parameter evaluation. The allowed interactions between bulk and surface waves, as well as the dependence of the scattering efficiency on the frequency and angle between source waves, were investigated through an analytical model, then compared with FEM simulations and experimental results. Finally, possible future steps for the development of the applied methods for the determination of near-surface higher-order elastic constants are discussed. In addition, several problem-relevant data processing procedures are presented.
    Language English
    Publishing date 2022-02-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 200839-7
    ISSN 1874-9968 ; 0041-624X
    ISSN (online) 1874-9968
    ISSN 0041-624X
    DOI 10.1016/j.ultras.2021.106664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1133: Show issues Location:
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  9. Article ; Online: Varied effects of tobacco smoke and e-cigarette vapor suggest that nicotine does not affect endothelium-dependent relaxation and nitric oxide signaling.

    Wölkart, Gerald / Kollau, Alexander / Russwurm, Michael / Koesling, Doris / Schrammel, Astrid / Mayer, Bernd

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 15833

    Abstract: Chronic smoking causes dysfunction of vascular endothelial cells, evident as a reduction of flow-mediated dilation in smokers, but the role of nicotine is still controversial. Given the increasing use of e-cigarettes and other nicotine products, it ... ...

    Abstract Chronic smoking causes dysfunction of vascular endothelial cells, evident as a reduction of flow-mediated dilation in smokers, but the role of nicotine is still controversial. Given the increasing use of e-cigarettes and other nicotine products, it appears essential to clarify this issue. We studied extracts from cigarette smoke (CSE) and vapor from e-cigarettes (EVE) and heated tobacco (HTE) for their effects on vascular relaxation, endothelial nitric oxide signaling, and the activity of soluble guanylyl cyclase. The average nicotine concentrations of CSE, EVE, and HTE were 164, 800, and 85 µM, respectively. At a dilution of 1:3, CSE almost entirely inhibited the relaxation of rat aortas and porcine coronary arteries to acetylcholine and bradykinin, respectively, while undiluted EVE, with a 15-fold higher nicotine concentration, had no significant effect. With about 50% inhibition at 1:2 dilution, the effect of HTE was between CSE and EVE. Neither extract affected endothelium-independent relaxation to an NO donor. At the dilutions tested, CSE was not toxic to cultured endothelial cells but, in contrast to EVE, impaired NO signaling and inhibited NO stimulation of soluble guanylyl cyclase. Our results demonstrate that nicotine does not mediate the impaired endothelium-dependent vascular relaxation caused by smoking.
    MeSH term(s) Rats ; Animals ; Swine ; Nicotine/pharmacology ; Endothelial Cells ; Electronic Nicotine Delivery Systems ; E-Cigarette Vapor ; Nitric Oxide ; Tobacco Smoke Pollution ; Soluble Guanylyl Cyclase ; Endothelium
    Chemical Substances Nicotine (6M3C89ZY6R) ; E-Cigarette Vapor ; Nitric Oxide (31C4KY9ESH) ; Tobacco Smoke Pollution ; Soluble Guanylyl Cyclase (EC 4.6.1.2)
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-42750-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Rose Bernd. Und Pippa tanzt!. Die Ratten. Winterballade. Dorothea Angermann. Vor Sonnenuntergang. Die Finsternisse

    Hauptmann, Gerhart / Mayer, Hans

    (Gerhart Hauptmann ; : Ausgewählte Werke ; in acht Bänden / herausgegeben von Hans Mayer] ; 3)

    1962  

    Author's details Gerhart Hauptmann
    Series title Gerhart Hauptmann
    : Ausgewählte Werke
    in acht Bänden / herausgegeben von Hans Mayer] ; 3
    Language German
    Size 607 Seiten
    Publisher Aufbau-Verlag
    Publishing place Berlin
    Document type Book
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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