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Article ; Online: Editorial: Amino Acid Transport and Metabolism During Homeostasis and Inflammation.

Cibrian, Danay / Baixauli, Francesc / Palacin, Manuel

2022 Volume 12, Page(s) 833258

MeSH term(s)	Amino Acid Transport Systems/genetics ; Amino Acid Transport Systems/metabolism ; Amino Acids/metabolism ; Animals ; Biological Transport ; Biomarkers ; Disease Susceptibility ; Energy Metabolism ; Homeostasis ; Humans ; Inflammation/etiology ; Inflammation/metabolism
Chemical Substances	Amino Acid Transport Systems ; Amino Acids ; Biomarkers
Language	English
Publishing date	2022-01-17
Publishing country	Switzerland
Document type	Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.833258
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Article ; Online: Combined supplementation with hesperidin, phytosterols and curcumin decreases adiposity and improves metabolic health in ovariectomized rats.

Baudin, Julio / Hernandez-Baixauli, Julia / Quesada-Vázquez, Sergio / Mulero, Francisca / Puiggròs, Francesc / Arola, Lluís / Caimari, Antoni

Food & function

2024

Abstract: In recent years many women have looked for alternative therapies to address menopause. Hesperidin, phytosterols and curcumin are bioactive compounds that can ameliorate some cardiovascular risk factors associated with menopause, although there are no ... ...

Abstract	In recent years many women have looked for alternative therapies to address menopause. Hesperidin, phytosterols and curcumin are bioactive compounds that can ameliorate some cardiovascular risk factors associated with menopause, although there are no data concerning the effects of their combined supplementation. We used ovariectomized (OVX) rats, a postmenopausal model with oestrogen deficiency, to evaluate whether supplementation with a multi-ingredient (MI) including hesperidin, phytosterols and curcumin for 57 days would display beneficial effects against fat mass accretion and metabolic disturbances associated with menopause. Twenty OVX rats were orally supplemented with either MI (OVX-MI) or vehicle (OVX). Furthermore, 10 OVX rats orally received the vehicle along with subcutaneous injections of 17β-oestradiol biweekly (OVX-E2), whereas 10 rats were sham operated and received oral and injected vehicles (control group; SH). MI supplementation partly counteracted the fat mass accretion observed in OVX animals, which was evidenced by decreased total fat mass, adiposity index, the weight of retroperitoneal, inguinal and mesenteric white adipose tissue (MWAT) depots and MWAT adipocyte hypertrophy. These effects were accompanied by a significant decrease in the circulating levels of leptin and the mRNA levels of the fatty acid uptake-related genes
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d3fo05122f
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Article ; Online: Potassium shapes antitumor immunity.

Baixauli, Francesc / Villa, Matteo / Pearce, Erika L

Science (New York, N.Y.)

2019 Volume 363, Issue 6434, Page(s) 1395–1396

MeSH term(s)	Histone Deacetylase Inhibitors ; Humans ; Immunity ; Neoplasms ; Potassium ; T-Lymphocytes
Chemical Substances	Histone Deacetylase Inhibitors ; Potassium (RWP5GA015D)
Language	English
Publishing date	2019-03-28
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.aaw8800
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Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Mediterranean natural extracts improved cognitive behavior in zebrafish and healthy rats and ameliorated lps-induced cognitive impairment in a sex dependent manner.

Pusceddu, Matteo M / Hernandez-Baixauli, Julia / Puiggrós, Francesc / Arola, Lluis / Caimari, Antoni / Del Bas, Josep M / Baselga, Laura

Behavioral and brain functions : BBF

2022 Volume 18, Issue 1, Page(s) 5

Abstract: Background: Several findings suggest neuroinflammation as a contributing factor for the onset of psychiatric disorders such as Alzheimer's disease, depression, and anxiety. There is increasing evidence pointing out that the Mediterranean diet influences ...

Abstract	Background: Several findings suggest neuroinflammation as a contributing factor for the onset of psychiatric disorders such as Alzheimer's disease, depression, and anxiety. There is increasing evidence pointing out that the Mediterranean diet influences brain and behavior. Mediterranean herbs and spices have been shown to be within those components of the Mediterranean diet involved in cognitive enhancement. Thus, we investigated the influence of Mediterranean natural extracts (MNE), Rosemary extract (RE) and Glycyrrhiza glabra root extract (GGRE), on cognitive behavior. Results: Adult zebrafish were exposed to RE or GGRE (100 and 250 mg/L) treatments. Both MNE improved memory retention during the T-maze test, although no improvements were observed during the novel object preference. Similarly, chronic administration of RE (150 mg/Kg) and GGRE (150 mg/Kg) improved, respectively, spatial and retention memory, as assessed by the Morris Water Maze (MWM), and the Elevated Plus Maze (EPM) in healthy male rats. However, no improvements were observed during the novel object recognition. Finally, male, and female rats were chronically treated with lipopolysaccharide [(LPS) 300 ug/kg] and orally administered with RE. Interestingly, RE reversed LPS-induced cognitive deficit during the MWM and EPM in female rats. Conclusions: We found that MNE improved cognition in both zebrafish and rats. Moreover, MNE rescued LPS-induced cognitive impairment in a gender-specific manner. Therefore, our study supports the view that zebrafish represent a valuable preclinical model for drug discovery in neuroscience. These findings contribute to an exciting and growing body of research suggesting that MNE may play an important role in the prevention of cognitive impairment.
MeSH term(s)	Animals ; Cognition ; Cognitive Dysfunction/chemically induced ; Cognitive Dysfunction/drug therapy ; Disease Models, Animal ; Female ; Hippocampus ; Lipopolysaccharides/adverse effects ; Male ; Maze Learning ; Memory Disorders/drug therapy ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Rats ; Zebrafish
Chemical Substances	Lipopolysaccharides ; Plant Extracts
Language	English
Publishing date	2022-02-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2185773-8
ISSN	1744-9081 ; 1744-9081
ISSN (online)	1744-9081
ISSN	1744-9081
DOI	10.1186/s12993-022-00190-8
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Article: Interorganelle Communication between Mitochondria and the Endolysosomal System.

Soto-Heredero, Gonzalo / Baixauli, Francesc / Mittelbrunn, María

Frontiers in cell and developmental biology

2017 Volume 5, Page(s) 95

Abstract: The function of mitochondria and lysosomes has classically been studied separately. However, evidence has now emerged of intense crosstalk between these two organelles, such that the activity or stress status of one organelle may affect the other. Direct ...

Abstract	The function of mitochondria and lysosomes has classically been studied separately. However, evidence has now emerged of intense crosstalk between these two organelles, such that the activity or stress status of one organelle may affect the other. Direct physical contacts between mitochondria and the endolysosomal compartment have been reported as a rapid means of interorganelle communication, mediating lipid or other metabolite exchange. Moreover, mitochondrial derived vesicles can traffic obsolete mitochondrial proteins into the endolysosomal system for their degradation or secretion to the extracellular milieu as exosomes, representing an additional mitochondrial quality control mechanism that connects mitochondria and lysosomes independently of autophagosome formation. Here, we present what is currently known about the functional and physical communication between mitochondria and lysosomes or lysosome-related organelles, and their role in sustaining cellular homeostasis.
Language	English
Publishing date	2017-11-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2017.00095
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Article: Mitochondria Know No Boundaries: Mechanisms and Functions of Intercellular Mitochondrial Transfer.

Torralba, Daniel / Baixauli, Francesc / Sánchez-Madrid, Francisco

Frontiers in cell and developmental biology

2016 Volume 4, Page(s) 107

Abstract: Mitochondria regulate multiple cell processes, including calcium signaling, apoptosis and cell metabolism. Mitochondria contain their own circular genome encoding selected subunits of the oxidative phosphorylation complexes. Recent findings reveal that, ... ...

Abstract	Mitochondria regulate multiple cell processes, including calcium signaling, apoptosis and cell metabolism. Mitochondria contain their own circular genome encoding selected subunits of the oxidative phosphorylation complexes. Recent findings reveal that, in addition to being maternally inherited, mitochondria can traverse cell boundaries and thus be horizontally transferred between cells. Although, the physiological relevance of this phenomenon is still under debate, mitochondria uptake rescues mitochondrial respiration defects in recipient cells and regulates signaling, proliferation or chemotherapy resistance
Language	English
Publishing date	2016-09-28
Publishing country	Switzerland
Document type	Review ; Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2016.00107
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Article ; Online: Interorganelle Communication between Mitochondria and the Endolysosomal System

Gonzalo Soto-Heredero / Francesc Baixauli / María Mittelbrunn

Frontiers in Cell and Developmental Biology, Vol

2017 Volume 5

Abstract	The function of mitochondria and lysosomes has classically been studied separately. However, evidence has now emerged of intense crosstalk between these two organelles, such that the activity or stress status of one organelle may affect the other. Direct physical contacts between mitochondria and the endolysosomal compartment have been reported as a rapid means of interorganelle communication, mediating lipid or other metabolite exchange. Moreover, mitochondrial derived vesicles can traffic obsolete mitochondrial proteins into the endolysosomal system for their degradation or secretion to the extracellular milieu as exosomes, representing an additional mitochondrial quality control mechanism that connects mitochondria and lysosomes independently of autophagosome formation. Here, we present what is currently known about the functional and physical communication between mitochondria and lysosomes or lysosome-related organelles, and their role in sustaining cellular homeostasis.
Keywords	lysosome ; exosomes ; autophagy ; quality control ; proteostasis ; aging ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2017-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prostaglandin E

Villa, Matteo / Sanin, David E / Apostolova, Petya / Corrado, Mauro / Kabat, Agnieszka M / Cristinzio, Carmine / Regina, Annamaria / Carrizo, Gustavo E / Rana, Nisha / Stanczak, Michal A / Baixauli, Francesc / Grzes, Katarzyna M / Cupovic, Jovana / Solagna, Francesca / Hackl, Alexandra / Globig, Anna-Maria / Hässler, Fabian / Puleston, Daniel J / Kelly, Beth /

Cabezas-Wallscheid, Nina / Hasselblatt, Peter / Bengsch, Bertram / Zeiser, Robert / Sagar / Buescher, Joerg M / Pearce, Edward J / Pearce, Erika L

Nature communications

2024 Volume 15, Issue 1, Page(s) 451

Abstract: Immune cells must adapt to different environments during the course of an immune response. Here we study the adaptation of ... ...

Abstract	Immune cells must adapt to different environments during the course of an immune response. Here we study the adaptation of CD8
MeSH term(s)	Humans ; Animals ; Mice ; CD8-Positive T-Lymphocytes ; Autophagy ; Dinoprostone ; Genes, Mitochondrial ; Glutathione
Chemical Substances	Dinoprostone (K7Q1JQR04M) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-44689-2
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Article ; Online: Mitochondria know no boundaries

Daniel Torralba / Francesc Baixauli / Francisco Sanchez-Madrid

Frontiers in Cell and Developmental Biology, Vol

mechanisms and functions of intercellular mitochondrial transfer

2016 Volume 4

Abstract	Mitochondria regulate multiple cell processes, including calcium signaling, apoptosis and cell metabolism. Mitochondria contain their own circular genome encoding selected subunits of the oxidative phosphorylation complexes. Recent findings reveal that, in addition to being maternally inherited, mitochondria can traverse cell boundaries and thus be horizontally transferred between cells. Although the physiological relevance of this phenomenon is still under debate, mitochondria uptake rescues mitochondrial respiration defects in recipient cells and regulates signaling, proliferation or chemotherapy resistance in vitro and in vivo. In this review, we outline the pathophysiological consequences of horizontal mitochondrial transfer and offer a perspective on the cellular and molecular mechanisms mediating their intercellular transmission, including tunneling nanotubes, extracellular vesicles, cellular fusion and GAP junctions. The physiological relevance of mitochondrial transfer and the potential therapeutic application of this exchange for treating mitochondrial-related diseases are discussed.
Keywords	Communication ; Exosomes ; Inflammation ; Mitochondrial Diseases ; DAMPs ; extracellular vesicles ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2016-09-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Exosomes and autophagy: coordinated mechanisms for the maintenance of cellular fitness.

Baixauli, Francesc / López-Otín, Carlos / Mittelbrunn, Maria

Frontiers in immunology

2014 Volume 5, Page(s) 403

Abstract: Conditions resulting from loss of cellular homeostasis, including oxidative stress, inflammation, protein aggregation, endoplasmic reticulum stress, metabolic stress, and perturbation of mitochondrial function, are common to many pathological disorders ... ...

Abstract	Conditions resulting from loss of cellular homeostasis, including oxidative stress, inflammation, protein aggregation, endoplasmic reticulum stress, metabolic stress, and perturbation of mitochondrial function, are common to many pathological disorders and contribute to aging. Cells face these stress situations by engaging quality control mechanisms aimed to restore cellular homeostasis and preserve cell viability. Among them, the autophagy-lysosomal pathway mediates the specific degradation of damaged proteins and organelles, and its proper function is related to cellular protection and increased life span in many model organisms. Besides autophagy, increasing evidence underscores a role for exosomes in the selective secretion of harmful/damaged proteins and RNAs and thus in the maintenance of cellular fitness. In this perspective article, we discuss the emerging function of exosomes as a means of alleviating intracellular stress conditions, and how secretion of harmful or unwanted material in exosomes, in coordination with the autophagy-lysosomal pathway, is essential to preserve intracellular protein and RNA homeostasis. Finally, we provide an overview about the consequences of the spreading of the exosome content in physiological and pathological situations, and suggest putative therapeutic strategies for these exosome-mediated alterations.
Language	English
Publishing date	2014-08-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2014.00403
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