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  1. Article: Understanding of genetic variables for growth and yield traits of dill (Anethum graveolens L.)

    Sinhasane, Shalaka Ramling / Shinde, Uday S. / Dhumal, Sangram Sahebrao / Aher, Adhir R. / Manjunathagowda, Dalasanuru Chandergowda / Benke, Ashwini Prashant

    Genetic resources and crop evolution. 2022 Oct., v. 69, no. 7

    2022  

    Abstract: Dill (Anethum graveolense L.) is one of the neglected and minor spice crop, with low genetic variability. The genetic improvement of dill is being limited due to lack of genetic resources. Dill is mainly grown for seed as well as foliage leaf, the leaf ... ...

    Abstract Dill (Anethum graveolense L.) is one of the neglected and minor spice crop, with low genetic variability. The genetic improvement of dill is being limited due to lack of genetic resources. Dill is mainly grown for seed as well as foliage leaf, the leaf yields are varied with the genetic background of genotypes. Therefore, the selection of genotypes with high leaf yield is highly desired, along with magnitude of heritability and genetic advance for wider adaptation and cultivation. In this view, the local genotypes were collected and their genetic variables were assessed, and results of analysis of variance revealed the significant differences among the genotypes. High heritability coupled with high genetic advance as per cent over mean was observed for economical trait (85.5 and 34.7% for leaf yield, respectively) indicated that, the traits were highly heritable in nature, hence selection breeding is most effective. The phenotypic coefficient of variation was noted low (3.29–8.66), medium (10.6–18.2) and high (26.9), and genotypic coefficient of variation witnessed low (1.71–8.1), medium (10.3–17.5) and high (24.0) variation among genotypes and lines. The leaf yield was highly significant, positively correlated with growth and other yield traits. The genotypic correlation was greater than the phenotypic correlation among the genotypes. Hence, either simple selection, or mass selection of desirable traits and their associated traits would be effective for improvement of leaf yield of dill genotypes. Furthermore, significantly high leaf yielding genotypes (ACKD-6, ACKD-8, ACKD-11, ACKD-14, ACKD-16, ACKD-23, ACKD-28, ACKD-29 and ACKD-30) can be directly recommended for cultivation.
    Keywords Anethum graveolens ; analysis of variance ; dill ; evolution ; genetic background ; genetic improvement ; genetic variation ; heritability ; leaves ; phenotype ; phenotypic correlation ; spices
    Language English
    Dates of publication 2022-10
    Size p. 2575-2584.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 1134125-7
    ISSN 0925-9864
    ISSN 0925-9864
    DOI 10.1007/s10722-022-01409-3
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Utilization of infrared, Raman spectroscopy for structural analysis of alkali boro-germanate glasses

    Taqiullah, S. M. / Alshahrani, Thamraa / Shariq, Mohammad / Hakami, Jabir / Ahmad, Nafis / Alshehri, A. M. / Chaudhary, Anis Ahmad / Khan, M. Shakir / Shinde, Sangram M. / Slimani, Y. / Ansari, Akhalakur Rahman / Siddiqui, Mohd Asim / Imran, Mohd / Khan, Firoz

    Journal of Taibah University for Science. 2022 Dec. 31, v. 16, no. 1 p.820-827

    2022  

    Abstract: Melt quenching technique was used to prepare (30-x)Li₂O–xNa₂O–40B₂O₃–30GeO₂ glasses (x = 0, 5, 10, 20 & 30 mol %). The room temperature infrared spectra of the powdered glass samples were recorded in the range of 400–2000cm⁻¹. Raman measurements were ... ...

    Abstract Melt quenching technique was used to prepare (30-x)Li₂O–xNa₂O–40B₂O₃–30GeO₂ glasses (x = 0, 5, 10, 20 & 30 mol %). The room temperature infrared spectra of the powdered glass samples were recorded in the range of 400–2000cm⁻¹. Raman measurements were performed in the range of 200–2000cm⁻¹ at room temperature. Raman and Infrared spectroscopy was utilized for structural study of this glass system. Specific modes of vibration and peak position were identified from de-convolution of infrared and Raman spectra using Gaussian fitting. Ge–O–Ge bonds’ symmetrical stretching vibrations related to 3 members GeO₄ rings were allotted to the IR band of 483 cm⁻¹. The strongest Raman band was allotted to symmetrical stretching vibrations of Ge–O in GeO₄ having one non-bridging oxygen with 3 bridging oxygens at 797 cm⁻¹. The observed Raman and IR spectra of various specimens are utilized here to explain the structural characteristics of current glass.
    Keywords Raman spectroscopy ; ambient temperature ; glass ; infrared spectroscopy ; oxygen ; vibration ; Raman and infrared spectroscopy ; Mixed alkali effect ; Borogermanate glass
    Language English
    Dates of publication 2022-1231
    Size p. 820-827.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2834710-9
    ISSN 1658-3655
    ISSN 1658-3655
    DOI 10.1080/16583655.2022.2119770
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  3. Article: Mitra shunt (spleen preserving, side to side lieno-renal shunt) for portal hypertension with hypersplenism in early infancy.

    Shinde, Sangram / Gopalan, Sarath / Kandpal, Deepak K / Chowdhary, Sujit K

    Journal of Indian Association of Pediatric Surgeons

    2014  Volume 19, Issue 2, Page(s) 96–99

    Abstract: Extrahepatic portal vein obstruction (EHPVO) is the commonest cause of portal hypertension presenting with gastrointestinal bleeding and splenomegaly. Medical management of this condition may provide relief, but involves repeated hospital visits and ... ...

    Abstract Extrahepatic portal vein obstruction (EHPVO) is the commonest cause of portal hypertension presenting with gastrointestinal bleeding and splenomegaly. Medical management of this condition may provide relief, but involves repeated hospital visits and endoscopic procedures. Surgery is an effective curative solution by lowering portal venous pressure with effective shunting of venous blood from splanchnic to systemic circulation. Shunt surgery for such a small baby has not been previously reported and splenectomy has its own problems. Similarly, banding or sclerotherapy in such babies is not without risk. Among the various shunt options, Mitra shunt (spleen preserving, side-to-side lienorenal shunt), developed and standardized in our own country, stands out as the most optimum surgical treatment for EHPVO in early infancy. We report a 4-month-old baby, youngest recipient of Mitra shunt reported in literature with successful outcome.
    Language English
    Publishing date 2014-02-28
    Publishing country India
    Document type Case Reports
    ZDB-ID 2164528-0
    ISSN 1998-3891 ; 0971-9261
    ISSN (online) 1998-3891
    ISSN 0971-9261
    DOI 10.4103/0971-9261.129604
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  4. Article ; Online: Mitra shunt (spleen preserving, side to side lieno-renal shunt) for portal hypertension with hypersplenism in early infancy

    Sangram Shinde / Sarath Gopalan / Deepak K Kandpal / Sujit K Chowdhary

    Journal of Indian Association of Pediatric Surgeons, Vol 19, Iss 2, Pp 96-

    2014  Volume 99

    Abstract: Extrahepatic portal vein obstruction (EHPVO) is the commonest cause of portal hypertension presenting with gastrointestinal bleeding and splenomegaly. Medical management of this condition may provide relief, but involves repeated hospital visits and ... ...

    Abstract Extrahepatic portal vein obstruction (EHPVO) is the commonest cause of portal hypertension presenting with gastrointestinal bleeding and splenomegaly. Medical management of this condition may provide relief, but involves repeated hospital visits and endoscopic procedures. Surgery is an effective curative solution by lowering portal venous pressure with effective shunting of venous blood from splanchnic to systemic circulation. Shunt surgery for such a small baby has not been previously reported and splenectomy has its own problems. Similarly, banding or sclerotherapy in such babies is not without risk. Among the various shunt options, Mitra shunt (spleen preserving, side-to-side lienorenal shunt), developed and standardized in our own country, stands out as the most optimum surgical treatment for EHPVO in early infancy. We report a 4-month-old baby, youngest recipient of Mitra shunt reported in literature with successful outcome.
    Keywords Extrahepatic portal venous obstruction ; Mitra shunt ; side to side lieno-renal shunt ; Medicine ; R ; Pediatrics ; RJ1-570 ; Surgery ; RD1-811
    Publishing date 2014-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Discovery and Development of N-[4-(1-Cyclobutylpiperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide Dihydrochloride (SUVN-G3031): A Novel, Potent, Selective, and Orally Active Histamine H

    Nirogi, Ramakrishna / Shinde, Anil / Mohammed, Abdul Rasheed / Badange, Rajesh Kumar / Reballi, Veena / Bandyala, Thrinath Reddy / Saraf, Sangram Keshari / Bojja, Kumar / Manchineella, Sravanthi / Achanta, Pramod Kumar / Kandukuri, Kiran Kumar / Subramanian, Ramkumar / Benade, Vijay / Palacharla, Raghava Choudary / Jayarajan, Pradeep / Pandey, Santoshkumar / Jasti, Venkat

    Journal of medicinal chemistry

    2019  Volume 62, Issue 3, Page(s) 1203–1217

    Abstract: A series of chemical optimizations guided by in vitro affinity at a histamine ... ...

    Abstract A series of chemical optimizations guided by in vitro affinity at a histamine H
    MeSH term(s) Administration, Oral ; Animals ; Caco-2 Cells ; Dogs ; Drug Development ; Drug Discovery ; Drug Inverse Agonism ; Histamine Agonists/administration & dosage ; Histamine Agonists/chemistry ; Histamine Agonists/pharmacology ; Humans ; Male ; Morpholines/administration & dosage ; Morpholines/chemistry ; Morpholines/pharmacokinetics ; Morpholines/pharmacology ; Piperidines/administration & dosage ; Piperidines/chemistry ; Piperidines/pharmacology ; Rats ; Rats, Wistar ; Receptors, Histamine H3/drug effects ; Structure-Activity Relationship ; Wakefulness/drug effects
    Chemical Substances Histamine Agonists ; Morpholines ; Piperidines ; Receptors, Histamine H3 ; samelisant (65V47O9NOP)
    Language English
    Publishing date 2019-01-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.8b01280
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    Zs.B 151: Show issues Location:
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  6. Article ; Online: Benzamide derivatives and their constrained analogs as histamine H3 receptor antagonists.

    Nirogi, Ramakrishna / Shinde, Anil / Tiriveedhi, Vinaykumar / Kota, Laxman / Saraf, Sangram Keshari / Badange, Rajesh Kumar / Mohammed, Abdul Rasheed / Subramanian, Ramkumar / Muddana, Nageshwararao / Bhyrapuneni, Gopinadh / Abraham, Renny

    European journal of medicinal chemistry

    2016  Volume 108, Page(s) 655–662

    Abstract: A series of 4-(1-substituted piperidin-4-yloxy) benzamides and 6-(1-substituted piperidin-4-yloxy)-3,4-dihydro-2H-isoquinolin-1-one derivatives have been synthesized and tested for their binding affinity towards H3 receptor. Most of these synthesized ... ...

    Abstract A series of 4-(1-substituted piperidin-4-yloxy) benzamides and 6-(1-substituted piperidin-4-yloxy)-3,4-dihydro-2H-isoquinolin-1-one derivatives have been synthesized and tested for their binding affinity towards H3 receptor. Most of these synthesized compounds have displayed potent binding affinity for H3 receptor when tested in in vitro binding assay. Preliminary SAR studies, functional activity, pharmacokinetic profile and efficacy profile constitute the subject matter of this communication.
    MeSH term(s) Administration, Oral ; Animals ; Benzamides/administration & dosage ; Benzamides/chemistry ; Benzamides/pharmacology ; Dose-Response Relationship, Drug ; Histamine H3 Antagonists/administration & dosage ; Histamine H3 Antagonists/chemistry ; Histamine H3 Antagonists/pharmacology ; Humans ; Male ; Molecular Structure ; Rats ; Rats, Wistar ; Receptors, Histamine H3/metabolism ; Structure-Activity Relationship
    Chemical Substances Benzamides ; Histamine H3 Antagonists ; Receptors, Histamine H3
    Language English
    Publishing date 2016-01-27
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2015.12.005
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    Zs.B 784: Show issues Location:
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  7. Article ; Online: Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT

    Nirogi, Ramakrishna / Shinde, Anil / Kambhampati, Rama Sastry / Mohammed, Abdul Rasheed / Saraf, Sangram Keshari / Badange, Rajesh Kumar / Bandyala, Thrinath Reddy / Bhatta, Venugopalarao / Bojja, Kumar / Reballi, Veena / Subramanian, Ramkumar / Benade, Vijay / Palacharla, Raghava Choudary / Bhyrapuneni, Gopinadh / Jayarajan, Pradeep / Goyal, Vinod / Jasti, Venkat

    Journal of medicinal chemistry

    2017  Volume 60, Issue 5, Page(s) 1843–1859

    Abstract: Optimization of a novel series of 3-(piperazinylmethyl) indole derivatives as 5-hydroxytryptamine-6 receptor (5- ... ...

    Abstract Optimization of a novel series of 3-(piperazinylmethyl) indole derivatives as 5-hydroxytryptamine-6 receptor (5-HT
    MeSH term(s) Administration, Oral ; Alzheimer Disease/drug therapy ; Animals ; Drug Discovery ; Humans ; Indoles/administration & dosage ; Indoles/chemistry ; Indoles/pharmacokinetics ; Indoles/pharmacology ; Male ; Piperazines/administration & dosage ; Piperazines/chemistry ; Piperazines/pharmacokinetics ; Piperazines/pharmacology ; Rats ; Rats, Wistar ; Receptors, Serotonin/drug effects ; Serotonin Antagonists/pharmacokinetics ; Serotonin Antagonists/pharmacology ; Serotonin Antagonists/therapeutic use
    Chemical Substances Indoles ; Piperazines ; Receptors, Serotonin ; Serotonin Antagonists ; serotonin 6 receptor ; 1-((2-bromophenyl)sulfonyl)-5-methoxy-3-((4-methyl-1-piperazinyl)methyl)-1H-indole dimesylate monohydrate (8XZ281AO3G)
    Language English
    Publishing date 2017-02-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.6b01662
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