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Article ; Online: Een vrouw met gezwollen tandvlees.

Castelijn, D A R / Wondergem, M J / Heijink, D M

2021 Volume 165

Abstract: A 65-year-old female complained of diffuse and rapidly progressive gingival enlargement. Gingival overgrowth can be caused by medication, infections or systemic diseases. In case of generalized, quickly progressive gingival enlargement, acute myeloid ... ...

Title translation	A woman with gingival enlargement.
Abstract	A 65-year-old female complained of diffuse and rapidly progressive gingival enlargement. Gingival overgrowth can be caused by medication, infections or systemic diseases. In case of generalized, quickly progressive gingival enlargement, acute myeloid leukemia should be considered. Blood results showed an acute myelomonocytic leukemia. Treating the leukemia resolved the symptoms.
MeSH term(s)	Aged ; Female ; Gingival Overgrowth/diagnosis ; Gingival Overgrowth/etiology ; Gingival Overgrowth/therapy ; Humans ; Leukemia, Myeloid, Acute/complications ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/therapy ; Leukemia, Myelomonocytic, Acute/complications ; Leukemia, Myelomonocytic, Acute/diagnosis ; Leukemia, Myelomonocytic, Acute/therapy
Language	Dutch
Publishing date	2021-02-03
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Ua VI Zs.18: Show issues

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Article ; Online: Deformability and collision-induced reorientation enhance cell topotaxis in dense microenvironments.

van Steijn, Leonie / Wondergem, Joeri A J / Schakenraad, Koen / Heinrich, Doris / Merks, Roeland M H

Biophysical journal

2023 Volume 122, Issue 13, Page(s) 2791–2807

Abstract: In vivo, cells navigate through complex environments filled with obstacles such as other cells and the extracellular matrix. Recently, the term "topotaxis" has been introduced for navigation along topographic cues such as obstacle density gradients. ... ...

Abstract	In vivo, cells navigate through complex environments filled with obstacles such as other cells and the extracellular matrix. Recently, the term "topotaxis" has been introduced for navigation along topographic cues such as obstacle density gradients. Experimental and mathematical efforts have analyzed topotaxis of single cells in pillared grids with pillar density gradients. A previous model based on active Brownian particles (ABPs) has shown that ABPs perform topotaxis, i.e., drift toward lower pillar densities, due to decreased effective persistence lengths at high pillar densities. The ABP model predicted topotactic drifts of up to 1% of the instantaneous speed, whereas drifts of up to 5% have been observed experimentally. We hypothesized that the discrepancy between the ABP and the experimental observations could be in 1) cell deformability and 2) more complex cell-pillar interactions. Here, we introduce a more detailed model of topotaxis based on the cellular Potts model (CPM). To model persistent cells we use the Act model, which mimics actin-polymerization-driven motility, and a hybrid CPM-ABP model. Model parameters were fitted to simulate the experimentally found motion of Dictyostelium discoideum on a flat surface. For starved D. discoideum, the topotactic drifts predicted by both CPM variants are closer to the experimental results than the previous ABP model due to a larger decrease in persistence length. Furthermore, the Act model outperformed the hybrid model in terms of topotactic efficiency, as it shows a larger reduction in effective persistence time in dense pillar grids. Also pillar adhesion can slow down cells and decrease topotaxis. For slow and less-persistent vegetative D. discoideum cells, both CPMs predicted a similar small topotactic drift. We conclude that deformable cell volume results in higher topotactic drift compared with ABPs, and that feedback of cell-pillar collisions on cell persistence increases drift only in highly persistent cells.
MeSH term(s)	Dictyostelium ; Extracellular Matrix ; Motion
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218078-9
ISSN	1542-0086 ; 0006-3495
ISSN (online)	1542-0086
ISSN	0006-3495
DOI	10.1016/j.bpj.2023.06.001
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Zs.A 235: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 2: Show issues

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Article: Incidental Findings on

Broos, Wouter A M / Knol, Remco J J / Zant, Friso M van der / Schaper, Nicolaas C / Wondergem, Maurits

World journal of nuclear medicine

2022 Volume 21, Issue 3, Page(s) 192–199

Abstract: ... ...

Abstract	Introduction
Language	English
Publishing date	2022-08-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2911903-0
ISSN	1607-3312 ; 1450-1147
ISSN (online)	1607-3312
ISSN	1450-1147
DOI	10.1055/s-0042-1751031
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Zs.A 7137: Show issues

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Article ; Online: Impact of neurite alignment on organelle motion.

Mytiliniou, Maria / Wondergem, Joeri A J / Schmidt, Thomas / Heinrich, Doris

Journal of the Royal Society, Interface

2022 Volume 19, Issue 187, Page(s) 20210617

Abstract: Intracellular transport is pivotal for cell growth and survival. Malfunctions in this process have been associated with devastating neurodegenerative diseases, highlighting the need for a deeper understanding of the mechanisms involved. Here, we use an ... ...

Abstract	Intracellular transport is pivotal for cell growth and survival. Malfunctions in this process have been associated with devastating neurodegenerative diseases, highlighting the need for a deeper understanding of the mechanisms involved. Here, we use an experimental methodology that leads neurites of differentiated PC12 cells into either one of two configurations: a one-dimensional configuration, where the neurites align along lines, or a two-dimensional configuration, where the neurites adopt a random orientation and shape on a flat substrate. We subsequently monitored the motion of functional organelles, the lysosomes, inside the neurites. Implementing a time-resolved analysis of the mean-squared displacement, we quantitatively characterized distinct motion modes of the lysosomes. Our results indicate that neurite alignment gives rise to faster diffusive and super-diffusive lysosomal motion than the situation in which the neurites are randomly oriented. After inducing lysosome swelling through an osmotic challenge by sucrose, we confirmed the predicted slowdown in diffusive mobility. Surprisingly, we found that the swelling-induced mobility change affected each of the (sub-/super-)diffusive motion modes differently and depended on the alignment configuration of the neurites. Our findings imply that intracellular transport is significantly and robustly dependent on cell morphology, which might in part be controlled by the extracellular matrix.
MeSH term(s)	Animals ; Biological Transport ; Extracellular Matrix/metabolism ; Lysosomes/metabolism ; Neurites/metabolism ; Organelles/metabolism ; Rats
Language	English
Publishing date	2022-02-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2156283-0
ISSN	1742-5662 ; 1742-5689
ISSN (online)	1742-5662
ISSN	1742-5689
DOI	10.1098/rsif.2021.0617
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Article ; Online: Matched-Pair Comparison of

Wondergem, Maurits / van der Zant, Friso M / Broos, Wouter A M / Knol, Remco J J

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2021 Volume 62, Issue 10, Page(s) 1422–1429

Abstract: Over 20 different prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals for both imaging and therapy have been synthesized. Although variability in biodistribution and affinity for binding to the PSMA receptor is known to exist between ...

Abstract	Over 20 different prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals for both imaging and therapy have been synthesized. Although variability in biodistribution and affinity for binding to the PSMA receptor is known to exist between different PSMA-targeting radiopharmaceuticals, little is known about the clinical implications of this variability. Therefore, this study analyzed differences in interreader agreement and detection rate between 2 regularly used
MeSH term(s)	Aged ; Humans ; Male ; Middle Aged ; Niacinamide/analogs & derivatives ; Oligopeptides ; Positron Emission Tomography Computed Tomography ; Prostatic Neoplasms ; Tissue Distribution
Chemical Substances	Oligopeptides ; PSMA-1007 ; Niacinamide (25X51I8RD4)
Language	English
Publishing date	2021-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.120.258574
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Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 328: Show issues

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Article ; Online: Early response evaluation of PD-1 blockade in NSCLC patients through FDG-PET-CT and T cell profiling of tumor-draining lymph nodes.

Borm, Frank J / Smit, Jasper / Bakker, Joyce / Wondergem, Maurits / Smit, Egbert F / de Langen, Adrianus J / de Gruijl, Tanja D

Oncoimmunology

2023 Volume 12, Issue 1, Page(s) 2204745

Abstract: Better biomarkers for programmed death - (ligand) 1 (PD-(L)1) checkpoint blockade in non-small cell lung cancer (NSCLC) are needed. We explored the predictive value of early response evaluation using Fluor-18-deoxyglucose positron emission tomography and ...

Abstract	Better biomarkers for programmed death - (ligand) 1 (PD-(L)1) checkpoint blockade in non-small cell lung cancer (NSCLC) are needed. We explored the predictive value of early response evaluation using Fluor-18-deoxyglucose positron emission tomography and pre- and on-treatment flowcytometric T-cell profiling in peripheral blood and tumor-draining lymph nodes (TDLN). The on-treatment evaluation was performed 7-14 days after the start of PD-1 blockade in NSCLC patients. These data were related to (pathological) tumor response, progression-free survival, and overall survival (OS). We found that increases in total lesion glycolysis (TLG) had a strong reverse correlation with OS (
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/drug therapy ; Positron Emission Tomography Computed Tomography ; Fluorodeoxyglucose F18 ; Programmed Cell Death 1 Receptor ; CD8-Positive T-Lymphocytes/metabolism ; Positron-Emission Tomography ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2023-04-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2645309-5
ISSN	2162-402X ; 2162-402X
ISSN (online)	2162-402X
ISSN	2162-402X
DOI	10.1080/2162402X.2023.2204745
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Book ; Online: Deformability and collision-induced reorientation enhance cell topotaxis in dense microenvironments

van Steijn, Leonie / Wondergem, Joeri A. J. / Schakenraad, Koen / Heinrich, Doris / Merks, Roeland M. H.

2023

Abstract: In vivo, cells navigate through complex environments filled with obstacles. Recently, the term 'topotaxis' has been introduced for navigation along topographic cues such as obstacle density gradients. Experimental and mathematical efforts have analyzed ... ...

Abstract	In vivo, cells navigate through complex environments filled with obstacles. Recently, the term 'topotaxis' has been introduced for navigation along topographic cues such as obstacle density gradients. Experimental and mathematical efforts have analyzed topotaxis of single cells in pillared grids with pillar density gradients. A previous model based on active Brownian particles has shown that ABPs perform topotaxis, i.e., drift towards lower pillar densities, due to decreased effective persistence lengths at high pillars densities. The ABP model predicted topotactic drifts of up to 1% of the instantaneous speed, whereas drifts of up to 5% have been observed experimentally. We hypothesized that the discrepancy between the ABP and the experimental observations could be in 1) cell deformability, and 2) more complex cell-pillar interactions. Here, we introduce a more detailed model of topotaxis, based on the Cellular Potts model. To model persistent cells we use the Act model, which mimicks actin-polymerization driven motility, and a hybrid CPM-ABP model. Model parameters were fitted to simulate the experimentally found motion of D. discoideum on a flat surface. For starved D. discoideum, both CPM variants predict topotactic drifts closer to the experimental results than the previous ABP model, due to a larger decrease in persistence length. Furthermore, the Act model outperformed the hybrid model in terms of topotactic efficiency, as it shows a larger reduction in effective persistence time in dense pillar grids. Also pillar adhesion can slow down cells and decrease topotaxis. For slow and less persistent vegetative D. discoideum cells, both CPMs predicted a similar small topotactic drift. We conclude that deformable cell volume results in higher topotactic drift compared to ABPs, and that feedback of cell-pillar collisions on cell persistence increases drift only in highly persistent cells.
Keywords	Physics - Biological Physics ; Quantitative Biology - Cell Behavior
Subject code	612
Publishing date	2023-06-15
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Deformability and collision-induced reorientation enhance cell topotaxis in dense microenvironments

Steijn, Leonie Van / Wondergem, Joeri A.J. / Schakenraad, Koen / Heinrich, Doris / Merks, Roeland M.H.

2023

Abstract: 2791 ... 2807 ... In vivo, cells navigate through complex environments filled with obstacles such as other cells and the extracellular matrix. Recently, the term “topotaxis” has been introduced for navigation along topographic cues such as obstacle density ... ...

Abstract	2791 2807 In vivo, cells navigate through complex environments filled with obstacles such as other cells and the extracellular matrix. Recently, the term “topotaxis” has been introduced for navigation along topographic cues such as obstacle density gradients. Experimental and mathematical efforts have analyzed topotaxis of single cells in pillared grids with pillar density gradients. A previous model based on active Brownian particles (ABPs) has shown that ABPs perform topotaxis, i.e., drift toward lower pillar densities, due to decreased effective persistence lengths at high pillar densities. The ABP model predicted topotactic drifts of up to 1% of the instantaneous speed, whereas drifts of up to 5% have been observed experimentally. We hypothesized that the discrepancy between the ABP and the experimental observations could be in 1) cell deformability and 2) more complex cell-pillar interactions. Here, we introduce a more detailed model of topotaxis based on the cellular Potts model (CPM). To model persistent cells we use the Act model, which mimics actin-polymerization-driven motility, and a hybrid CPM-ABP model. Model parameters were fitted to simulate the experimentally found motion of Dictyostelium discoideum on a flat surface. For starved D. discoideum, the topotactic drifts predicted by both CPM variants are closer to the experimental results than the previous ABP model due to a larger decrease in persistence length. Furthermore, the Act model outperformed the hybrid model in terms of topotactic efficiency, as it shows a larger reduction in effective persistence time in dense pillar grids. Also pillar adhesion can slow down cells and decrease topotaxis. For slow and less-persistent vegetative D. discoideum cells, both CPMs predicted a similar small topotactic drift. We conclude that deformable cell volume results in higher topotactic drift compared with ABPs, and that feedback of cell-pillar collisions on cell persistence increases drift only in highly persistent cells. 122 13
Keywords	microenvironments ; DDC::500 Naturwissenschaften und Mathematik::570 Biowissenschaften ; Biologie::570 Biowissenschaften ; Biologie ; Biologie::572 Biochemie
Subject code	612
Language	English
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Systematic Review on the Diagnostic Value of Fibroblast Activation Protein Inhibitor PET/CT in Genitourinary Cancers.

Hagens, Marinus J / van Leeuwen, Pim J / Wondergem, Maurits / Boellaard, Thierry N / Sanguedolce, Francesco / Oprea-Lager, Daniela E / Bex, Axel / Vis, André N / van der Poel, Henk G / Mertens, Laura S

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2024

Abstract: In contemporary oncologic diagnostics, molecular imaging modalities are pivotal for precise local and metastatic staging. Recent studies identified fibroblast activation protein as a promising target for molecular imaging across various malignancies. ... ...

Abstract	In contemporary oncologic diagnostics, molecular imaging modalities are pivotal for precise local and metastatic staging. Recent studies identified fibroblast activation protein as a promising target for molecular imaging across various malignancies. Therefore, we aimed to systematically evaluate the current literature on the utility of fibroblast activation protein inhibitor (FAPI) PET/CT for staging patients with genitourinary malignancies.
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.123.267260
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Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 328: Show issues

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Article ; Online: Characterizing the Bone Marrow Environment in Advanced-Stage Myelofibrosis during Ruxolitinib Treatment Using PET/CT and MRI: A Pilot Study.

Slot, Stefanie / Lavini, Cristina / Zwezerijnen, Gerben J C / Boden, Bouke J H / Marcus, J Tim / Huisman, Marc C / Yaqub, Maqsood / Barbé, Ellis / Wondergem, Mariëlle J / Zijlstra, Josée M / Zweegman, Sonja / Raijmakers, Pieter G

Tomography (Ann Arbor, Mich.)

2023 Volume 9, Issue 2, Page(s) 459–474

Abstract: Current diagnostic criteria for myelofibrosis are largely based on bone marrow (BM) biopsy results. However, these have several limitations, including sampling errors. Explorative studies have indicated that imaging might form an alternative for the ... ...

Abstract	Current diagnostic criteria for myelofibrosis are largely based on bone marrow (BM) biopsy results. However, these have several limitations, including sampling errors. Explorative studies have indicated that imaging might form an alternative for the evaluation of disease activity, but the heterogeneity in BM abnormalities complicates the choice for the optimal technique. In our prospective diagnostic pilot study, we aimed to visualize all BM abnormalities in myelofibrosis before and during ruxolitinib treatment using both PET/CT and MRI. A random sample of patients was scheduled for examinations at baseline and after 6 and 18 months of treatment, including clinical and laboratory examinations, BM biopsies, MRI (T1-weighted, Dixon, dynamic contrast-enhanced (DCE)) and PET/CT ([
MeSH term(s)	Humans ; Positron Emission Tomography Computed Tomography/methods ; Bone Marrow/diagnostic imaging ; Bone Marrow/pathology ; Pilot Projects ; Primary Myelofibrosis/diagnostic imaging ; Primary Myelofibrosis/drug therapy ; Primary Myelofibrosis/pathology ; Prospective Studies ; Fluorodeoxyglucose F18 ; Magnetic Resonance Imaging/methods
Chemical Substances	ruxolitinib (82S8X8XX8H) ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2023-02-21
Publishing country	Switzerland
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2379-139X
ISSN (online)	2379-139X
DOI	10.3390/tomography9020038
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