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  1. Article: A tribute to Tony Lowe

    Shahin, Ibrahim O

    International journal of critical accounting : IJCA Vol. 7, No. 5/6 , p. 452-459

    the man who taught me how to think

    2015  Volume 7, Issue 5, Page(s) 452–459

    Author's details Ibrahim O. Shahin (Faculty of Commerce, Helwan University, Helwan, Cairo, Egypt)
    Keywords Tony Lowe ; Sheffield School of 'Accounting' Thought ; interdisciplinary approach to accounting ; Critical Perspectives on Accounting ; management control ; the system's approach ; behavioural research in accounting ; Empirical research in Accounting ; internal auditing ; accounting education
    Language English
    Publisher Inderscience Enterprises
    Publishing place Genève [u.a.]
    Document type Article
    ZDB-ID 2524381-0
    ISSN 1757-9848
    Database ECONomics Information System

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  2. Article ; Online: UGT1A1 Testing in Breast Cancer: should it become routine practice in patients treated with antibody-drug conjugates?

    Ibrahim, Rebecca / Khoury, Rita / Ibrahim, Tony / Le Cesne, Axel / Assi, Tarek

    Critical reviews in oncology/hematology

    2024  Volume 196, Page(s) 104265

    Abstract: The use of genetic testing to personalize therapeutic strategies in cancer is rapidly evolving and thus changing the landscape of treatment of oncologic patients. The UGT1A1 gene is an important component for the metabolism and glucoronidation of certain ...

    Abstract The use of genetic testing to personalize therapeutic strategies in cancer is rapidly evolving and thus changing the landscape of treatment of oncologic patients. The UGT1A1 gene is an important component for the metabolism and glucoronidation of certain drugs, including irinotecan and sacituzumab govitecan (SG); therefore, various UGT1A1 polymorphisms leading to decreased function of the UGT1A1 enzyme may lead to increased risk of treatment-related side effects. Testing for UGT1A1 polymorphism is not routinely adopted in clinical practice; that is due to the lack of concise studies and recommendations concerning the clinical relevance of this test and its impact on the quality of life of cancer patients. The knowledge regarding UGT1A1 polymorphism and its clinical relevance will be reviewed in this article, as well as the published literature on the association between UGT1A1 polymorphism and the toxicity risk of irinotecan as well as sacituzumab govitecan. The current recommendations and guidelines on UGT1A1 testing will be discussed in detail in the hopes of providing guidance to oncologists in their clinical practice.
    MeSH term(s) Humans ; Female ; Irinotecan ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/chemically induced ; Quality of Life ; Camptothecin/adverse effects ; Immunoconjugates/adverse effects ; Genotype ; Glucuronosyltransferase
    Chemical Substances Irinotecan (7673326042) ; UGT1A1 enzyme (EC 2.4.1.-) ; Camptothecin (XT3Z54Z28A) ; Immunoconjugates ; Glucuronosyltransferase (EC 2.4.1.17)
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605680-5
    ISSN 1879-0461 ; 0737-9587 ; 1040-8428
    ISSN (online) 1879-0461
    ISSN 0737-9587 ; 1040-8428
    DOI 10.1016/j.critrevonc.2024.104265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Response to "Response to 'Characteristics of nursing homes associated with COVID-19 outbreaks and mortality among residents in Victoria, Australia'".

    Li, Yingtong / Pham, Tony / Ibrahim, Joseph E

    Australasian journal on ageing

    2022  Volume 41, Issue 2, Page(s) 346–349

    MeSH term(s) Aged ; COVID-19 ; Disease Outbreaks ; Homes for the Aged ; Humans ; Nursing Homes ; Victoria/epidemiology
    Language English
    Publishing date 2022-06-14
    Publishing country Australia
    Document type Letter ; Comment
    ZDB-ID 1457406-8
    ISSN 1741-6612 ; 0726-4240 ; 1440-6381
    ISSN (online) 1741-6612
    ISSN 0726-4240 ; 1440-6381
    DOI 10.1111/ajag.13050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: NALIRIFOX in the upfront setting of metastatic pancreatic cancer: can FOLFIRINOX finally be dethroned?

    Khoury, Rita / Ibrahim, Rebecca / Ibrahim, Tony / Cesne, Axel Le / Assi, Tarek

    Future oncology (London, England)

    2023  Volume 19, Issue 9, Page(s) 617–620

    MeSH term(s) Humans ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/pathology ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Irinotecan/therapeutic use ; Fluorouracil/therapeutic use ; Leucovorin/therapeutic use
    Chemical Substances folfirinox ; Irinotecan (7673326042) ; Fluorouracil (U3P01618RT) ; Leucovorin (Q573I9DVLP)
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Editorial
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2023-0088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6478: Show issues Location:
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  5. Article ; Online: KRAS

    Ibrahim, Rebecca / Khoury, Rita / Ibrahim, Tony / Assi, Tarek / Cesne, Axel Le

    Future oncology (London, England)

    2023  Volume 19, Issue 7, Page(s) 485–488

    MeSH term(s) Humans ; Proto-Oncogene Proteins p21(ras)/genetics ; Lung Neoplasms ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Mutation ; Pancreatic Neoplasms
    Chemical Substances Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; KRAS protein, human
    Language English
    Publishing date 2023-03-22
    Publishing country England
    Document type Editorial
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2023-0067
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  6. Article ; Online: The

    Ibrahim, Rebecca / Chahine, Claude / Felefly, Tony / Khalife, Nadine / Saleh, Khalil

    Future oncology (London, England)

    2023  Volume 19, Issue 4, Page(s) 273–275

    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/surgery ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/surgery ; Lung Neoplasms/drug therapy ; Antineoplastic Agents/therapeutic use ; Anaplastic Lymphoma Kinase ; Protein Kinase Inhibitors/therapeutic use ; Aminopyridines/therapeutic use ; Lactams, Macrocyclic/therapeutic use ; Receptor Protein-Tyrosine Kinases
    Chemical Substances Antineoplastic Agents ; Anaplastic Lymphoma Kinase (EC 2.7.10.1) ; Protein Kinase Inhibitors ; Aminopyridines ; Lactams, Macrocyclic ; LTK protein, human (EC 2.7.10.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
    Language English
    Publishing date 2023-03-21
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2022-1232
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  7. Article ; Online: A Comprehensive Review on the Role of Lurbinectedin in Soft Tissue Sarcomas.

    Khoury, Rita / Assi, Tarek / Ibrahim, Rebecca / Ibrahim, Tony / Verret, Benjamin / Henon, Clemence / Bahleda, Ratislav / Le Cesne, Axel

    Current treatment options in oncology

    2024  Volume 25, Issue 2, Page(s) 176–190

    Abstract: Opinion statement: Soft tissue sarcoma (STS), a substantial group of aggressive and rare tumors with tissue heterogeneity, is infrequently represented in clinical trials with an urgent necessity for newer treatment options. Lurbinectedin, an analog of ... ...

    Abstract Opinion statement: Soft tissue sarcoma (STS), a substantial group of aggressive and rare tumors with tissue heterogeneity, is infrequently represented in clinical trials with an urgent necessity for newer treatment options. Lurbinectedin, an analog of trabectedin, is currently approved, in various countries, as a single agent, for the treatment of patients with relapsed small cell lung cancer (SCLC). However, preclinical and phase I and phase II trials have demonstrated the efficacy of lurbinectedin in different tumor types, including STS. The better understanding of the pathophysiology and evolution of STS as well as the mechanism of action of lurbinectedin in addition to the available data regarding the activity of this drug in this subset of patients will pave the way to newer therapeutic options and strategies.
    MeSH term(s) Humans ; Tetrahydroisoquinolines/therapeutic use ; Tetrahydroisoquinolines/pharmacology ; Antineoplastic Agents, Alkylating/therapeutic use ; Antineoplastic Agents, Alkylating/pharmacology ; Dioxoles/therapeutic use ; Dioxoles/pharmacology ; Neoplasm Recurrence, Local/drug therapy ; Sarcoma/drug therapy ; Sarcoma/pathology ; Soft Tissue Neoplasms/drug therapy ; Carbolines ; Heterocyclic Compounds, 4 or More Rings
    Chemical Substances PM 01183 ; Tetrahydroisoquinolines ; Antineoplastic Agents, Alkylating ; Dioxoles ; Carbolines ; Heterocyclic Compounds, 4 or More Rings
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057351-0
    ISSN 1534-6277 ; 1527-2729
    ISSN (online) 1534-6277
    ISSN 1527-2729
    DOI 10.1007/s11864-024-01178-4
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    Zs.A 5523: Show issues Location:
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  8. Article: Overview of the role of liquid biopsy in cancer management.

    Assi, Tarek / Khoury, Rita / Ibrahim, Rebecca / Baz, Maria / Ibrahim, Tony / LE Cesne, Axel

    Translational oncology

    2023  Volume 34, Page(s) 101702

    Abstract: With the emergence of novel targeted therapeutic options in early-stage and advanced-stage malignancies, researchers have shifted their focus on developing personalized treatment plans through molecular profiling. Circulating tumor DNA (ctDNA) is a cell- ... ...

    Abstract With the emergence of novel targeted therapeutic options in early-stage and advanced-stage malignancies, researchers have shifted their focus on developing personalized treatment plans through molecular profiling. Circulating tumor DNA (ctDNA) is a cell-free DNA (ctDNA) fragment, originating from tumor cells, and circulating in the bloodstream as well as biological fluids. Over the past decade, many techniques were developed for liquid biopsies through next-generation sequencing. This alternative non-invasive biopsy offers several advantages in various types of tumors over traditional tissue biopsy. The process of liquid biopsy is considered minimally invasive and therefore easily repeatable when needed, providing a more dynamic analysis of the tumor cells. Moreover, it has an advantage in patients with tumors that are not candidates for tissue sampling. Besides, it offers a deeper understanding of tumor burden as well as treatment response, thereby enhancing the detection of minimal residual disease and therapeutic guidance for personalized medicine. Despite its many advantages, ctDNA and liquid biopsy do have some limitations. This paper discusses the basis of ctDNA and the current data available on the subject, as well as its clinical utility. We also reflect on the limitations of using ctDNA in addition to its future perspectives in clinical oncology and precision medicine.
    Language English
    Publishing date 2023-05-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2443840-6
    ISSN 1936-5233
    ISSN 1936-5233
    DOI 10.1016/j.tranon.2023.101702
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  9. Article: Role of microRNAs in the predisposition to gastrointestinal malignancies.

    Baz, Maria / Ibrahim, Tony

    World journal of clinical cases

    2020  Volume 8, Issue 9, Page(s) 1580–1585

    Abstract: MicroRNAs (miRNAs) are highly deregulated in cancer and play a role in the initiation of tumorigenesis. Recently, miRNAs have attracted attention in gastrointestinal (GI) cancers. Single nucleotide polymorphisms (SNPs) could affect the genes involved in ... ...

    Abstract MicroRNAs (miRNAs) are highly deregulated in cancer and play a role in the initiation of tumorigenesis. Recently, miRNAs have attracted attention in gastrointestinal (GI) cancers. Single nucleotide polymorphisms (SNPs) could affect the genes involved in each step of miRNA biosynthesis. Several meta-analyses of case-control studies have assessed the association between miRNA "pathway" gene-SNPs (including biosynthesis regulators and binding sites) and susceptibility to GI cancers. We present in this mini-review the current knowledge on the association between miRNAs "pathway" genes and GI cancer predisposition. The interaction between miRNA/regulators/binding site-SNPs and environmental as well as genomic factors is an interesting field that should be exploited in future studies.
    Language English
    Publishing date 2020-03-12
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v8.i9.1580
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  10. Article ; Online: Mobile phones: A forgotten source of SARS-CoV-2 transmission.

    Ibrahim, Tony / Chamseddine, Ali N / Baz, Maria

    American journal of infection control

    2020  Volume 48, Issue 8, Page(s) 971–972

    MeSH term(s) Betacoronavirus/pathogenicity ; COVID-19 ; Cell Phone ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Humans ; Pandemics ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Letter
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2020.05.019
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