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  1. Article ; Online: Maintenance of genome integrity under physical constraints.

    Soutoglou, Evi / Oberdoerffer, Philipp

    Chromosoma

    2024  Volume 133, Issue 1, Page(s) 1–3

    Language English
    Publishing date 2024-02-14
    Publishing country Austria
    Document type Editorial
    ZDB-ID 203083-4
    ISSN 1432-0886 ; 0009-5915
    ISSN (online) 1432-0886
    ISSN 0009-5915
    DOI 10.1007/s00412-024-00816-y
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  2. Article ; Online: Guiding DNA repair at the nuclear periphery.

    Audibert, Sylvain / Soutoglou, Evi

    Nature cell biology

    2023  Volume 25, Issue 7, Page(s) 928–930

    MeSH term(s) Cell Nucleus/genetics ; DNA Repair
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-023-01164-2
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  3. Article: Chromatin and Nuclear Dynamics in the Maintenance of Replication Fork Integrity.

    Wootton, Jack / Soutoglou, Evi

    Frontiers in genetics

    2021  Volume 12, Page(s) 773426

    Abstract: Replication of the eukaryotic genome is a highly regulated process and stringent control is required to maintain genome integrity. In this review, we will discuss the many aspects of the chromatin and nuclear environment that play key roles in the ... ...

    Abstract Replication of the eukaryotic genome is a highly regulated process and stringent control is required to maintain genome integrity. In this review, we will discuss the many aspects of the chromatin and nuclear environment that play key roles in the regulation of both unperturbed and stressed replication. Firstly, the higher order organisation of the genome into A and B compartments, topologically associated domains (TADs) and sub-nuclear compartments has major implications in the control of replication timing. In addition, the local chromatin environment defined by non-canonical histone variants, histone post-translational modifications (PTMs) and enrichment of factors such as heterochromatin protein 1 (HP1) plays multiple roles in normal S phase progression and during the repair of replicative damage. Lastly, we will cover how the spatial organisation of stalled replication forks facilitates the resolution of replication stress.
    Language English
    Publishing date 2021-12-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2021.773426
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  4. Article ; Online: CRISPR/Cas9-Induced Breaks in Heterochromatin, Visualized by Immunofluorescence.

    Mitrentsi, Ioanna / Soutoglou, Evi

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2153, Page(s) 439–445

    Abstract: CRISPR/Cas9 technology can be used to investigate how double-strand breaks (DSBs) occurring in constitutive heterochromatin are getting repaired. This technology can be used to induce specific breaks on mouse pericentromeric heterochromatin, by using a ... ...

    Abstract CRISPR/Cas9 technology can be used to investigate how double-strand breaks (DSBs) occurring in constitutive heterochromatin are getting repaired. This technology can be used to induce specific breaks on mouse pericentromeric heterochromatin, by using a guide RNA specific for the major satellite repeats and co-expressing it with Cas9. Those clean DSBs can be visualized later by confocal microscopy. More specifically, immunofluorescence can be used to visualize the main factors of each DSB repair pathway and quantify their percentage and pattern of recruitment at the heterochromatic region.
    MeSH term(s) Animals ; CRISPR-Cas Systems ; DNA Breaks, Double-Stranded ; DNA Repair ; Fluorescent Antibody Technique ; Heterochromatin/genetics ; Mice ; NIH 3T3 Cells
    Chemical Substances Heterochromatin
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0644-5_30
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  5. Article ; Online: 53BP1-RIF1: sculpting the DNA repair focus in 3D.

    Ghodke, Indrajeet / Soutoglou, Evi

    Nature structural & molecular biology

    2019  Volume 26, Issue 12, Page(s) 1087–1088

    MeSH term(s) Animals ; Chromatin/genetics ; Chromatin/metabolism ; DNA/genetics ; DNA/metabolism ; DNA Damage ; DNA Repair ; Genomic Instability ; Humans ; Telomere-Binding Proteins/metabolism ; Tumor Suppressor p53-Binding Protein 1/metabolism
    Chemical Substances Chromatin ; Rif1 protein, human ; TP53BP1 protein, human ; Telomere-Binding Proteins ; Tumor Suppressor p53-Binding Protein 1 ; DNA (9007-49-2)
    Language English
    Publishing date 2019-12-02
    Publishing country United States
    Document type News
    ZDB-ID 2126708-X
    ISSN 1545-9985 ; 1545-9993
    ISSN (online) 1545-9985
    ISSN 1545-9993
    DOI 10.1038/s41594-019-0348-1
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    Zs.MG 56: Show issues

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  6. Article ; Online: How to maintain the genome in nuclear space.

    Mitrentsi, Ioanna / Yilmaz, Duygu / Soutoglou, Evi

    Current opinion in cell biology

    2020  Volume 64, Page(s) 58–66

    Abstract: Genomic instability can be life-threatening. The fine balance between error-free and mutagenic DNA repair pathways is essential for maintaining genome integrity. Recent advances in DNA double-strand break induction and detection techniques have allowed ... ...

    Abstract Genomic instability can be life-threatening. The fine balance between error-free and mutagenic DNA repair pathways is essential for maintaining genome integrity. Recent advances in DNA double-strand break induction and detection techniques have allowed the investigation of DNA damage and repair in the context of the highly complex nuclear structure. These studies have revealed that the 3D genome folding, nuclear compartmentalization and cytoskeletal components control the spatial distribution of DNA lesions within the nuclear space and dictate their mode of repair.
    MeSH term(s) Animals ; Cell Nucleus/genetics ; DNA Damage ; DNA Repair/genetics ; Genome ; Genomic Instability ; Humans ; Transcription, Genetic
    Language English
    Publishing date 2020-03-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2020.02.014
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    Zs.A 2963: Show issues Location:
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  7. Article: Genome Editing Fidelity in the Context of DNA Sequence and Chromatin Structure.

    Chechik, Lyuba / Martin, Ophelie / Soutoglou, Evi

    Frontiers in cell and developmental biology

    2020  Volume 8, Page(s) 319

    Abstract: Genome editing by Clustered Regularly Inter Spaced Palindromic Repeat (CRISPR) associated (Cas) systems has revolutionized medical research and holds enormous promise for correcting genetic diseases. Understanding how these Cas nucleases work and induce ... ...

    Abstract Genome editing by Clustered Regularly Inter Spaced Palindromic Repeat (CRISPR) associated (Cas) systems has revolutionized medical research and holds enormous promise for correcting genetic diseases. Understanding how these Cas nucleases work and induce mutations, as well as identifying factors that affect their efficiency and fidelity is key to developing this technology for therapeutic uses. Here, we discuss recent studies that reveal how DNA sequence and chromatin structure influences the different steps of genome editing. These studies also demonstrate that a deep understanding of the balance between error prone and error free DNA repair pathways is crucial for making genome editing a safe clinical tool, which does not induce further mutations to the genome.
    Language English
    Publishing date 2020-05-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2020.00319
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  8. Article ; Online: Genome Editing Fidelity in the Context of DNA Sequence and Chromatin Structure

    Lyuba Chechik / Ophelie Martin / Evi Soutoglou

    Frontiers in Cell and Developmental Biology, Vol

    2020  Volume 8

    Abstract: Genome editing by Clustered Regularly Inter Spaced Palindromic Repeat (CRISPR) associated (Cas) systems has revolutionized medical research and holds enormous promise for correcting genetic diseases. Understanding how these Cas nucleases work and induce ... ...

    Abstract Genome editing by Clustered Regularly Inter Spaced Palindromic Repeat (CRISPR) associated (Cas) systems has revolutionized medical research and holds enormous promise for correcting genetic diseases. Understanding how these Cas nucleases work and induce mutations, as well as identifying factors that affect their efficiency and fidelity is key to developing this technology for therapeutic uses. Here, we discuss recent studies that reveal how DNA sequence and chromatin structure influences the different steps of genome editing. These studies also demonstrate that a deep understanding of the balance between error prone and error free DNA repair pathways is crucial for making genome editing a safe clinical tool, which does not induce further mutations to the genome.
    Keywords chromatin ; dna editing crispr ; knock in ; DNA repair ; nucleus ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Finding DNA Ends within a Haystack of Chromatin.

    Banerjee, Ujjwal / Soutoglou, Evi

    Molecular cell

    2016  Volume 63, Issue 5, Page(s) 726–728

    Abstract: Identifying DNA fragile sites is crucial to reveal hotspots of genomic rearrangements, yet their precise mapping has been a challenge. A new study in this issue of Molecular Cell (Canela et al., 2016) introduces a highly sensitive and accurate method to ... ...

    Abstract Identifying DNA fragile sites is crucial to reveal hotspots of genomic rearrangements, yet their precise mapping has been a challenge. A new study in this issue of Molecular Cell (Canela et al., 2016) introduces a highly sensitive and accurate method to detect DNA breaks in vivo that can be adapted to various experimental and clinical settings.
    MeSH term(s) Chromatin ; Chromosome Fragile Sites ; DNA ; Genome ; Genomics ; Humans
    Chemical Substances Chromatin ; DNA (9007-49-2)
    Language English
    Publishing date 2016-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2016.08.012
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  10. Article ; Online: Nuclear compartmentalization of DNA repair.

    Kalousi, Alkmini / Soutoglou, Evi

    Current opinion in genetics & development

    2016  Volume 37, Page(s) 148–157

    Abstract: The continuous threats on genome integrity by endogenous and exogenous sources have rendered cells competent to overcome these challenges by activating DNA repair pathways. A complex network of proteins and their modifications participate in orchestrated ...

    Abstract The continuous threats on genome integrity by endogenous and exogenous sources have rendered cells competent to overcome these challenges by activating DNA repair pathways. A complex network of proteins and their modifications participate in orchestrated signaling cascades, which are induced in response to DNA damage and may determine the choice of repair pathway. In this review, we summarize recent findings in the field of DNA Double Strand Break repair with regard to the positioning of the break in the highly compartmentalized nucleus. We aim to highlight the importance of chromatin state along with the nuclear position of the DNA lesions on the choice of DNA repair pathway and maintenance of genome integrity.
    MeSH term(s) Cell Compartmentation/genetics ; Cell Nucleus/genetics ; Chromatin/genetics ; DNA Breaks, Double-Stranded ; DNA Damage/genetics ; DNA Repair/genetics ; Humans ; Recombination, Genetic
    Chemical Substances Chromatin
    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077312-5
    ISSN 1879-0380 ; 0959-437X
    ISSN (online) 1879-0380
    ISSN 0959-437X
    DOI 10.1016/j.gde.2016.05.013
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