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Article ; Online: Incidence and predictors of type 1 diabetes among younger adults aged 20-45 years: The diabetes in young adults (DiYA) study.

Lawrence, Jean M / Slezak, Jeff M / Quesenberry, Charles / Li, Xia / Yu, Liping / Rewers, Marian / Alexander, Janet G / Takhar, Harpreet S / Sridhar, Sneha / Albright, Ann / Rolka, Deborah B / Saydah, Sharon / Imperatore, Giuseppina / Ferrara, Assiamira

Diabetes research and clinical practice

2020 Volume 171, Page(s) 108624

Abstract: Aims: To estimate incidence of type 1 diabetes (T1D) and to develop a T1D prediction model among young adults.: Methods: Adults 20-45 years newly-diagnosed with diabetes in 2017 were identified within Kaiser Permanente's healthcare systems in ... ...

Abstract	Aims: To estimate incidence of type 1 diabetes (T1D) and to develop a T1D prediction model among young adults. Methods: Adults 20-45 years newly-diagnosed with diabetes in 2017 were identified within Kaiser Permanente's healthcare systems in California and invited for diabetes autoantibody (DAA) testing. Multiple imputation was conducted to assign missing DAA status. The primary outcome for incidence rates (IR) and the prediction model was T1D defined by ≥1 positive DAA. Results: Among 2,347,989 persons at risk, 7862 developed diabetes, 2063 had DAA measured, and 166 (8.0%) had ≥1 positive DAA. T1D IR (95% CI) per 100,000 person-years was 15.2 (10.2-20.1) for ages 20-29 and 38.2 (28.6-47.8) for ages 30-44 years. The age-standardized IRs were 32.5 (22.2-42.8) for men and 27.2 (21.0-34.5) for women. The age/sex-standardized IRs were 30.1 (23.5-36.8) overall; 41.4 (25.3-57.5) for Hispanics, 37.0 (11.6-62.4) for Blacks, 21.4 (14.3-28.6) for non-Hispanic Whites, and 19.4 (8.5-30.2) for Asians. Predictors of T1D among cases included female sex, younger age, lower BMI, insulin use and having T1D based on diagnostic codes. Conclusions: T1D may account for up to 8% of incident diabetes cases among young adults. Follow-up is needed to establish the clinical course of patients with one DAA at diagnosis.
MeSH term(s)	Adult ; Autoantibodies/blood ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Young Adult
Chemical Substances	Autoantibodies
Language	English
Publishing date	2020-12-15
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2020.108624
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Article ; Online: MetaQA

Diya Li / Zhe Zhang

PLoS ONE, Vol 18, Iss 11, p e

Enhancing human-centered data search using Generative Pre-trained Transformer (GPT) language model and artificial intelligence.

2023 Volume 0293034

Abstract: Accessing and utilizing geospatial data from various sources is essential for developing scientific research to address complex scientific and societal challenges that require interdisciplinary knowledge. The traditional keyword-based geosearch approach ... ...

Abstract	Accessing and utilizing geospatial data from various sources is essential for developing scientific research to address complex scientific and societal challenges that require interdisciplinary knowledge. The traditional keyword-based geosearch approach is insufficient due to the uncertainty inherent within spatial information and how it is presented in the data-sharing platform. For instance, the Gulf of Mexico Coastal Ocean Observing System (GCOOS) data search platform stores geoinformation and metadata in a complex tabular. Users can search for data by entering keywords or selecting data from a drop-down manual from the user interface. However, the search results provide limited information about the data product, where detailed descriptions, potential use, and relationship with other data products are still missing. Language models (LMs) have demonstrated great potential in tasks like question answering, sentiment analysis, text classification, and machine translation. However, they struggle when dealing with metadata represented in tabular format. To overcome these challenges, we developed Meta Question Answering System (MetaQA), a novel spatial data search model. MetaQA integrates end-to-end AI models with a generative pre-trained transformer (GPT) to enhance geosearch services. Using GCOOS metadata as a case study, we tested the effectiveness of MetaQA. The results revealed that MetaQA outperforms state-of-the-art question-answering models in handling tabular metadata, underlining its potential for user-inspired geosearch services.
Keywords	Medicine ; R ; Science ; Q
Subject code	006
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: AKR1B10 accelerates glycolysis through binding HK2 to promote the malignant progression of oral squamous cell carcinoma.

Cai, Ye / Li, Huiling / Xie, Diya / Zhu, Yanan

Discover oncology

2024 Volume 15, Issue 1, Page(s) 132

Abstract: Background: Oral squamous cell carcinoma (OSCC) remains a rampant oral cavity neoplasm with high degree of aggressiveness. Aldo-keto reductase 1B10 (AKR1B10) that is an oxidoreductase dependent on nicotinamide adenine dinucleotide phosphate (NADPH) has ... ...

Abstract	Background: Oral squamous cell carcinoma (OSCC) remains a rampant oral cavity neoplasm with high degree of aggressiveness. Aldo-keto reductase 1B10 (AKR1B10) that is an oxidoreductase dependent on nicotinamide adenine dinucleotide phosphate (NADPH) has been introduced to possess prognostic potential in OSCC. The present work was focused on specifying the involvement of AKR1B10 in the process of OSCC and its latent functional mechanism. Methods: AKR1B10 expression in OSCC tissues and cells were detected by RT-qPCR and Western blot analysis. CCK-8 method, EdU staining, wound healing and transwell assays respectively assayed cell viability, proliferation, migration and invasion. Immunofluorescence staining and Western blot evaluated epithelial mesenchymal transition (EMT). Adenosine triphosphate (ATP) contents, glucose consumption and extracellular acidification rate (ECAR) were measured by relevant commercially available kits and Seahorse XF96 Glycolysis Analyzer, severally. The expressions of proteins associated with metastasis and glycolysis were examined with Western blot. Co-IP assay confirmed the binding between AKR1B10 and hexokinase 2 (HK2). Results: It was observed that AKR1B10 expression was increased in OSCC tissues and cells. After AKR1B10 was knocked down, the proliferation, migration, invasion and EMT of OSCC cells were all hampered. Additionally, AKR1B10 silencing suppressed glycolysis and bound to HK2 in OSCC cells. Up-regulation of HK2 partially abolished the hampered glycolysis, proliferation, migration, invasion and EMT of AKR1B10-silenced OSCC cells. Conclusion: To sum up, AKR1B10 could bind to HK2 to accelerate glycolysis, thereby facilitating the proliferation, migration, invasion and EMT of OSCC cells.
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article
ISSN	2730-6011
ISSN (online)	2730-6011
DOI	10.1007/s12672-024-00996-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: NHANES-based analysis of the correlation between leisure-time physical activity, serum cotinine levels and periodontitis risk.

Fu, Hua / Zhang, Diya / Li, Yining

BMC oral health

2024 Volume 24, Issue 1, Page(s) 466

Abstract: Objective: To investigate the association of leisure-time physical activity and serum cotinine levels with the risk of periodontitis in the general population and to further analyze the interaction between leisure-time physical activity and serum ... ...

Abstract	Objective: To investigate the association of leisure-time physical activity and serum cotinine levels with the risk of periodontitis in the general population and to further analyze the interaction between leisure-time physical activity and serum cotinine levels on the risk of periodontitis. Methods: This was a cross-sectional study, extracting data from 9605 (56.19%) participants in the National Health and Nutrition Examination Survey (NHANES) database from 2009 to 2014, and analyzing the relationship and interaction effects of serum cotinine level, leisure time physical activity, and risk of periodontitis by weighted univariate logistic modeling; Effect sizes were determined using ratio of ratios (OR), 95% confidence intervals (95% CI). Results: 5,397 (56.19%) of 9,605 participants had periodontitis; an increased risk of periodontitis was found in those in the leisure time physical activity intensity < 750 MET × min/week group (OR = 1.44, 95% CI: 1.17-1.78). Serum cotinine levels ≥ 0.05 ng/ml were associated with an increased risk of periodontitis (OR = 1.99, 95% CI: 1.69-2.33). The group with low leisure physical activity and serum cotinine levels ≥ 0.05 ng/ml had an increased risk of periodontitis compared to the group with high leisure physical activity and serum cotinine levels < 0.05 ng/ml (OR = 2.48, 95% CI: 1.88-3.27). Interaction metrics RERI = 0.90 (95% CI: 0.44-1.36) and API = 0.36 (95% CI: 0.18-0.55); CI for SI = 2.55 (95% CI: 1.03-6.28). for API 0.36. Conclusion: Leisure time physical activity intensity interacted with smoking exposure on periodontitis risk and may provide the general population with the opportunity to Increasing leisure-time physical activity and smoking cessation may provide recommendations for the general population.
MeSH term(s)	Humans ; Cotinine/analysis ; Smoking/adverse effects ; Tobacco Smoke Pollution/adverse effects ; Nutrition Surveys ; Cross-Sectional Studies ; Periodontitis/epidemiology ; Exercise ; Leisure Activities
Chemical Substances	Cotinine (K5161X06LL) ; Tobacco Smoke Pollution
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-024-04141-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: MetaQA: Enhancing human-centered data search using Generative Pre-trained Transformer (GPT) language model and artificial intelligence.

Li, Diya / Zhang, Zhe

PloS one

2023 Volume 18, Issue 11, Page(s) e0293034

Abstract	Accessing and utilizing geospatial data from various sources is essential for developing scientific research to address complex scientific and societal challenges that require interdisciplinary knowledge. The traditional keyword-based geosearch approach is insufficient due to the uncertainty inherent within spatial information and how it is presented in the data-sharing platform. For instance, the Gulf of Mexico Coastal Ocean Observing System (GCOOS) data search platform stores geoinformation and metadata in a complex tabular. Users can search for data by entering keywords or selecting data from a drop-down manual from the user interface. However, the search results provide limited information about the data product, where detailed descriptions, potential use, and relationship with other data products are still missing. Language models (LMs) have demonstrated great potential in tasks like question answering, sentiment analysis, text classification, and machine translation. However, they struggle when dealing with metadata represented in tabular format. To overcome these challenges, we developed Meta Question Answering System (MetaQA), a novel spatial data search model. MetaQA integrates end-to-end AI models with a generative pre-trained transformer (GPT) to enhance geosearch services. Using GCOOS metadata as a case study, we tested the effectiveness of MetaQA. The results revealed that MetaQA outperforms state-of-the-art question-answering models in handling tabular metadata, underlining its potential for user-inspired geosearch services.
MeSH term(s)	Humans ; Artificial Intelligence ; Sentiment Analysis ; Electric Power Supplies ; Gulf of Mexico ; Language
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0293034
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nonlinear relationship between oxidative balance score and hyperuricemia: analyses of NHANES 2007-2018.

Liu, Fengmin / You, Fangqin / Yang, Lihang / Du, Xiaojuan / Li, Cheng / Chen, Geng / Xie, Diya

Nutrition journal

2024 Volume 23, Issue 1, Page(s) 48

Abstract: Background: Limited data regarding the correlation between oxidative balance score (OBS) and hyperuricemia highlights the necessity for thorough investigations. This study aims to examine the link between OBS, which incorporates dietary and lifestyle ... ...

Abstract	Background: Limited data regarding the correlation between oxidative balance score (OBS) and hyperuricemia highlights the necessity for thorough investigations. This study aims to examine the link between OBS, which incorporates dietary and lifestyle factors, and the occurrence of hyperuricemia. Methods: We conducted a cross-sectional study involving 13,636 participants from the 2007-2018 National Health and Nutrition Examination Survey (NHANES). The oxidative balance score (OBS) was determined based on four lifestyle factors and sixteen dietary nutrients. We assessed the levels of serum uric acid (SUA) and the occurrence of hyperuricemia as outcomes. Weighted logistic regression and linear models were used for statistical analysis, using Restricted Cubic Splines (RCS) to examine potential nonlinear associations. Subgroup analysis and sensitivity assessments were performed to identify any variations and ensure the robustness of the findings. Results: Higher OBS was consistently correlated with decreased SUA levels and a reduced prevalence of hyperuricemia. RCS highlighted a significant negative nonlinear association, particularly in females. Subgroup analysis revealed gender-based differences and interactive correlation, providing additional insights regarding OBS and hyperuricemia relationship. Conclusion: This study underscores a robust negative correlation between OBS and SUA levels as well as the incidence of hyperuricemia, emphasizing the importance of dietary and lifestyle factors. Incorporating RCS, subgroup analysis, and sensitivity assessments enhances the depth of our findings, providing valuable insights for further research.
MeSH term(s)	Humans ; Hyperuricemia/blood ; Hyperuricemia/epidemiology ; Female ; Male ; Cross-Sectional Studies ; Nutrition Surveys/methods ; Nutrition Surveys/statistics & numerical data ; Middle Aged ; Adult ; Uric Acid/blood ; Life Style ; Diet/methods ; Diet/statistics & numerical data ; Oxidative Stress ; Prevalence ; Aged
Chemical Substances	Uric Acid (268B43MJ25)
Language	English
Publishing date	2024-05-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2091602-4
ISSN	1475-2891 ; 1475-2891
ISSN (online)	1475-2891
ISSN	1475-2891
DOI	10.1186/s12937-024-00953-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Profiles and predictors of mental health of university students in Hong Kong under the COVID-19 pandemic.

Shek, Daniel T L / Chai, Wenyu / Li, Xiang / Dou, Diya

Frontiers in psychology

2023 Volume 14, Page(s) 1211229

Abstract: This study investigated the mental health problems of university students in Hong Kong and related sociodemographic and psychosocial predictors under the pandemic. A total of 978 undergraduate students (mean age = 20.69 ± 1.61) completed an online ... ...

Abstract	This study investigated the mental health problems of university students in Hong Kong and related sociodemographic and psychosocial predictors under the pandemic. A total of 978 undergraduate students (mean age = 20.69 ± 1.61) completed an online questionnaire measuring sociodemographic factors, psychological morbidity, positive well-being, COVID-19 related stress and self-efficacy, and positive psychosocial attributes. Psychosocial risk factors included psychological morbidity, COVID-19 related stress, and difficulties encountered under the pandemic, whereas protective factors comprised pandemic related self-efficacy, positive psychological attributes, positive environmental factors, need satisfaction and positive perception toward service. Results showed that psychological morbidity in the participants was widespread, and it was related to sociodemographic factors, particularly family financial difficulties. While pandemic related stress positively predicted psychological morbidity and negatively predicted well-being indicators, COVID-19 self-efficacy showed an opposite effect. Besides, positive psychological attributes (resilience, emotional competence, and positive beliefs related to adversity) and environmental factors (healthy family functioning, peer support, and supportive community atmosphere) negatively predicted psychological morbidity and positively predicted well-being. Furthermore, need satisfaction and positive perception toward service were negatively associated with psychological morbidity and positively associated with well-being, while perceived difficulties showed an opposite effect.
Language	English
Publishing date	2023-07-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1211229
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Psychometric properties of the Chinese Family Assessment Instrument: evidence from mainland China.

Shek, Daniel T L / Leung, Kim Hung / Li, Xiang / Dou, Diya

Frontiers in psychology

2023 Volume 14, Page(s) 1290224

Abstract: Regarding the assessment of family functioning in Chinese people, there are several research gaps. First, although there are some instruments in the field, there are very few validated instruments. Second, while some translated measures have been ... ...

Abstract	Regarding the assessment of family functioning in Chinese people, there are several research gaps. First, although there are some instruments in the field, there are very few validated instruments. Second, while some translated measures have been developed, there are very few assessment tools based on indigenous Chinese concepts. Third, compared to Hong Kong, research on family assessment is relatively inactive in mainland China. Fourth, there are very few family assessment tools to assess perceived family functioning in older children and early adolescents. Fifth, few studies used large samples to validate family assessment tools. Sixth, researchers seldom utilized longitudinal data to examine the psychometric properties of family assessment tools. Finally, few studies have examined factorial validity across samples and time to demonstrate the stability of Chinese family assessment measures. In Hong Kong, based on focus group data (i.e., indigenous concepts of family functioning) and an integration with the family science literature, we have developed the Chinese Family Assessment Instrument (C-FAI) to assess perceived family functioning according to the perception of adolescents. Results showed that the C-FAI possessed good reliability and validity. Specifically, five dimensions of the measure (mutuality, communication, conflict, parental concern and parental control) were supported via exploratory factor analysis and confirmatory factor analysis. Convergent validity and reliability of the C-FAI were illustrated. To understand the psychometric properties of the C-FAI in mainland China, we collected three waves of data from students in the period of preadolescence and early adolescence in mainland China (
Language	English
Publishing date	2023-12-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1290224
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Article: Family functioning and resilience in children in mainland China: life satisfaction as a mediator.

Dou, Diya / Shek, Daniel T L / Tan, Lindan / Zhao, Li

Frontiers in psychology

2023 Volume 14, Page(s) 1175934

Abstract: Introduction: Grounded in the perspective of "Positive Youth Development" (PYD), resilience is an important developmental asset shaping human development. Although many studies have examined the impact of resilience on child developmental outcomes, ... ...

Abstract	Introduction: Grounded in the perspective of "Positive Youth Development" (PYD), resilience is an important developmental asset shaping human development. Although many studies have examined the impact of resilience on child developmental outcomes, relatively few studies have focused on the predictors of resilience, in particular familial antecedents of resilience in Chinese children and adolescents. In addition, the degree to which life satisfaction contributes to the mechanism by which family functioning impacts the development of children's resilience over time needs to be clarified. Besides, there is a scarcity of studies that incorporate family functioning, resilience as well as life satisfaction in a single comprehensive investigation to analyze the mediating impact of life satisfaction on the linkage between family functioning and resilience under COVID-19. Methods: The study investigated the predictive role of family functioning on resilience as well as the mediating effect of life satisfaction within the context of COVID-19, using data gathered in two waves before the onset of the pandemic and after the resumption of school during the pandemic, with 6 months apart. We employed the 33-item "Chinese Family Assessment Instrument" to evaluate family functioning, the 7-item "Chinese Resilience Scale" to assess resilience, and the "Satisfaction with Life Scale" with 5 items to measure life satisfaction. Results: As per the responses of 4,783 students in Grades 4 through 7 recruited in Sichuan, China, family functioning significantly predicted resilience concurrently and longitudinally. After controlling for resilience scores in Wave 1, results demonstrated that family functioning examined in Wave 1 predicted an increase in resilience reported in Wave 2. In addition, family functioning significantly predicted life satisfaction, which also significantly predicted resilience. Multiple regression using PROCESS analyses indicated that life satisfaction mediated the predictive relationship between family functioning and child resilience. Discussion: The findings spotlight the significant involvement of family functioning as well as life satisfaction in shaping children's resilience in the Chinese context. The study also supports the hypothesis that perceived satisfaction with life serves as a mediator between family functioning and child resilience, suggesting interventions and support should concentrate on the family level for enhancing resilience in children.
Language	English
Publishing date	2023-05-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1175934
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Psychosocial correlates of mental health of university students in Hong Kong under COVID-19.

Shek, Daniel T L / Chai, Wenyu / Dou, Diya / Li, Xiang / Chan, Cathy H M

Frontiers in psychology

2023 Volume 14, Page(s) 1294026

Abstract: Although the COVID-19 pandemic has caused many problems for university students, there are several research gaps in the study of psychological well-being of Hong Kong university students. First, few studies have examined different ecological correlates ... ...

Abstract	Although the COVID-19 pandemic has caused many problems for university students, there are several research gaps in the study of psychological well-being of Hong Kong university students. First, few studies have examined different ecological correlates of mental health in a single study. Second, few studies have used both psychological morbidity and positive well-being as indicators of mental health. Third, we know little about the relationships between university students' perceived need satisfaction, difficulties, service utilization, and their mental health. Hence, we conducted a study (
Language	English
Publishing date	2023-11-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1294026
Database	MEDical Literature Analysis and Retrieval System OnLINE

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