LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 200

Search options

  1. Book ; Online ; E-Book: Therapeutic Strategies in Veterinary Oncology

    Khanna, Chand / Amato, Nicole / Cawley, Jacob / Dow, Steven / Fenger, Joelle / Flory, Andi / Gordon, Ira / Harding, Kayla / Kow, Kelvin / London, Cheryl

    2023  

    Abstract: A comprehensive resource for veterinary oncologists and trainees, covering therapeutic strategies used in the treatment of veterinary patients. The book gives readers a better understanding of the key differences between different treatment strategies in ...

    Abstract A comprehensive resource for veterinary oncologists and trainees, covering therapeutic strategies used in the treatment of veterinary patients. The book gives readers a better understanding of the key differences between different treatment strategies in one relatively short reference book.
    Language English
    Size 1 online resource (434 pages)
    Edition 1st ed.
    Publisher CAB International
    Publishing place Oxford
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-78924-582-6 ; 978-1-78924-582-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Retrospective evaluation of the impact of hypoxemia during thoracic surgery in dogs on outcome: a multicenter analysis of 94 cases.

    Duffee, Lauren / Stewart, Samuel / Banerjee, Tanisha / Khanna, Chand

    Veterinary anaesthesia and analgesia

    2023  Volume 50, Issue 4, Page(s) 341–348

    Abstract: Objective: To investigate the statistical association of severe intraoperative hypoxemia in thoracic surgery with mortality, postoperative hospitalization times and cost of care.: Study design: Retrospective study.: Animals: Dogs that underwent ... ...

    Abstract Objective: To investigate the statistical association of severe intraoperative hypoxemia in thoracic surgery with mortality, postoperative hospitalization times and cost of care.
    Study design: Retrospective study.
    Animals: Dogs that underwent thoracic surgery in three veterinary hospitals between October 1, 2018 and October 1, 2020.
    Methods: Anesthesia and hospitalization records from 112 dogs were reviewed and 94 cases met inclusion criteria. Recorded data included signalment, disease etiology, pulmonary or extrapulmonary nature of disease, surgical procedure performed, episodes of severe intraoperative hypoxemia defined as a pulse oximetry reading (SpO
    Results: Group A had a greater risk of mortality (odds ratio 10.6, 95% confidence interval 1.9-106.7; p = 0.002), prolonged hospitalization (median 62 hours versus 46 hours; p = 0.035) and more expensive cost of care (median US$10,287 versus $8506; p = 0.056) than group B. No significant difference was found for the type of surgical procedure or pulmonary versus extrapulmonary nature of disease.
    Conclusions and clinical relevance: Severe intraoperative hypoxemia was statistically associated with an increased risk of mortality and longer postoperative hospitalization times. Although not achieving statistical significance, there was a trend toward increased costs to the client for animals with intraoperative hypoxemia.
    MeSH term(s) Dogs ; Animals ; Retrospective Studies ; Thoracic Surgery ; Hypoxia/etiology ; Hypoxia/veterinary ; Thoracic Surgical Procedures/adverse effects ; Thoracic Surgical Procedures/veterinary ; Oximetry/veterinary
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2020582-X
    ISSN 1467-2995 ; 1467-2987
    ISSN (online) 1467-2995
    ISSN 1467-2987
    DOI 10.1016/j.vaa.2023.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Leveraging Comparative Oncology in the Hopes of Improving Therapies for Breast Cancer.

    Khanna, Chand

    Seminars in oncology

    2017  Volume 44, Issue 4, Page(s) 301

    MeSH term(s) Animals ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/therapy ; Dog Diseases/genetics ; Dog Diseases/therapy ; Dogs ; Drug Evaluation, Preclinical ; Female ; Humans ; Medical Oncology/methods ; Medical Oncology/organization & administration ; Neoplasms/therapy ; Neoplasms/veterinary ; Pets ; Veterinary Medicine/organization & administration
    Language English
    Publishing date 2017-11-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189220-4
    ISSN 1532-8708 ; 0093-7754
    ISSN (online) 1532-8708
    ISSN 0093-7754
    DOI 10.1053/j.seminoncol.2017.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1348: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: An early clinical phenotype of necrotizing meningoencephalitis in the Pug reveals similarities to multiple sclerosis in humans.

    Windsor, Rebecca / Stewart, Samuel / Huentelman, Matt / Keller, Stefan / Khanna, Chand

    American journal of veterinary research

    2023  Volume 85, Issue 1

    Abstract: Necrotizing meningoencephalitis (NME) is a fatal neuroinflammatory disease that previously carried a uniformly grave prognosis. Our recent identification of a novel early form of NME in Pugs suggests that disease onset and progression are likely more ... ...

    Abstract Necrotizing meningoencephalitis (NME) is a fatal neuroinflammatory disease that previously carried a uniformly grave prognosis. Our recent identification of a novel early form of NME in Pugs suggests that disease onset and progression are likely more insidious than previously recognized and provides new hope that early therapeutic intervention may halt disease progression and ultimately prevent or cure NME. This novel perspective also sheds new light on the clinical similarities to multiple sclerosis (MS) in humans and provides a rationale for cross-species translation. The history of recent scientific discoveries in NME and new parallels between MS and NME will be reviewed.
    MeSH term(s) Humans ; Dogs ; Animals ; Multiple Sclerosis/diagnosis ; Multiple Sclerosis/veterinary ; Meningoencephalitis/diagnosis ; Meningoencephalitis/veterinary ; Meningoencephalitis/genetics ; Phenotype ; Dog Diseases/genetics
    Language English
    Publishing date 2023-11-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390796-x
    ISSN 1943-5681 ; 0002-9645
    ISSN (online) 1943-5681
    ISSN 0002-9645
    DOI 10.2460/ajvr.23.07.0164
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 422: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Towards the Delivery of Precision Veterinary Cancer Medicine.

    Katogiritis, Anna / Khanna, Chand

    The Veterinary clinics of North America. Small animal practice

    2019  Volume 49, Issue 5, Page(s) 809–818

    Abstract: We introduce a next phase in the evolution of medicine affecting human and veterinary patients. This evolution, genomic cancer medicine (Pmed), involves expansion of genomic and molecular biology into clinical medicine. The implementation of these new ... ...

    Abstract We introduce a next phase in the evolution of medicine affecting human and veterinary patients. This evolution, genomic cancer medicine (Pmed), involves expansion of genomic and molecular biology into clinical medicine. The implementation of these new technologies has already begun and is a commercial reality. We introduce the underpinnings for this evolution, and focus on application in complex disease states. Pet owners have begun requesting Pmed technologies. To meet this demand, it is important to be aware of the opportunities and obstacles associated with available Pmed offerings as well as the current state of the field.
    MeSH term(s) Animals ; Cat Diseases/genetics ; Cat Diseases/therapy ; Cats ; Dog Diseases/genetics ; Dog Diseases/therapy ; Dogs ; Genetic Predisposition to Disease ; Genomics/methods ; Hemangiosarcoma/genetics ; Hemangiosarcoma/therapy ; Hemangiosarcoma/veterinary ; Humans ; Neoplasms/genetics ; Neoplasms/therapy ; Neoplasms/veterinary ; Precision Medicine/methods ; Precision Medicine/veterinary ; Sequence Analysis ; Veterinary Medicine/methods
    Language English
    Publishing date 2019-06-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 757662-6
    ISSN 1878-1306 ; 0195-5616
    ISSN (online) 1878-1306
    ISSN 0195-5616
    DOI 10.1016/j.cvsm.2019.04.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Se 252: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6.

    Yu, Yanlin / Dai, Meng / Huang, Liping / Chen, Weiping / Yu, Ellen / Mendoza, Arnulfo / Michael, Helen / Khanna, Chand / Bosenberg, Marcus / McMahon, Martin / Merlino, Glenn

    iScience

    2023  Volume 26, Issue 2, Page(s) 106070

    Abstract: ... ...

    Abstract PTEN
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.106070
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article: Pharmacokinetic Exposures Associated With Oral Administration of Sorafenib in Dogs With Spontaneous Tumors.

    Cawley, Jacob R / Stewart, Samuel D / Mochel, Jonathan Paul / Veluvolu, Sridhar / Khanna, Chand / Fenger, Joelle M

    Frontiers in veterinary science

    2022  Volume 9, Page(s) 888483

    Abstract: Sorafenib is a multi-kinase small molecule inhibitor that targets serine/threonine and tyrosine kinases including the RAF kinase family, VEGFR-2, and PDGFR. The aim of this study was to evaluate the systemic pharmacokinetics of a previously defined ... ...

    Abstract Sorafenib is a multi-kinase small molecule inhibitor that targets serine/threonine and tyrosine kinases including the RAF kinase family, VEGFR-2, and PDGFR. The aim of this study was to evaluate the systemic pharmacokinetics of a previously defined tolerable oral dose of sorafenib in tumor-bearing dogs. Six client-owned dogs with a cytologic or histologic diagnosis of cancer were enrolled in this open-label, tolerability study. Dogs were administered sorafenib at an intended dose of 3 mg/kg and serum samples were obtained for analysis of sorafenib serum concentrations at 0, 1, 2, 6, 12, 24, 48, 72, 96, and 168 h post-drug administration. Median time to peak serum sorafenib concentration occurred at 4 h (range 2-12 h) resulting in an average serum concentration of 54.9 ± 33.5 ng/mL (118.2 ± 72.1 nM). Mean sorafenib levels declined by over 70% relative to peak serum concentrations by 24 h in all dogs, suggesting the value of at least twice daily administration. Doses of 3 mg/kg were well-tolerated and no patients in the study experienced adverse events that were attributable to sorafenib. Future trials in dogs with cancer are recommended at this dosing schedule to assess the effect of sorafenib administration on anti-tumor efficacy signals and relevant pharmacodynamic target modulation
    Language English
    Publishing date 2022-05-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2022.888483
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Prevalence and clinical features of thoracolumbar intervertebral disc-associated epidural hemorrhage in dogs.

    Bridges, Jenni / Windsor, Rebecca / Stewart, Samuel D / Fuerher-Senecal, Lori / Khanna, Chand

    Journal of veterinary internal medicine

    2022  Volume 36, Issue 4, Page(s) 1365–1372

    Abstract: Background: Intervertebral disc-associated epidural hemorrhage (EH) in dogs is a poorly understood neurological condition.: Objective: To compare the clinical presentation, magnetic resonance imaging (MRI) changes, and clinical outcome of dogs with ... ...

    Abstract Background: Intervertebral disc-associated epidural hemorrhage (EH) in dogs is a poorly understood neurological condition.
    Objective: To compare the clinical presentation, magnetic resonance imaging (MRI) changes, and clinical outcome of dogs with acute thoracolumbar intervertebral disc herniation (TL-IVDH) with and without EH.
    Animals: One hundred sixty client-owned dogs that underwent MRI and hemilaminectomy for acute TL-IVDH at a private practice in Colorado, including 63 dogs with EH and 97 dogs without EH.
    Methods: Retrospective review of medical record data from 160 dogs presenting sequentially to a single practice with acute TL-IVDH that underwent MRI and hemilaminectomy surgery.
    Results: Sixty-three of 160 (39%) dogs had confirmed EH. French Bulldogs were significantly overrepresented (23/63; odds ratio [OR]: 4.1; 95% confidence interval [CI]: 1.8-9.0; P < .001) of the EH cases. Dogs with EH were more likely to present with clinical signs less than 48 hours than were dogs without EH (24-48 vs 48-72 hours; OR: 2.4; 95% CI: 1.2-4.6; P = .02) and were more likely to be nonambulatory on presentation (OR: 2.1; 95% CI: 1.0-4.1; P = .04). Dogs with EH were more likely to have <50% cross-sectional spinal cord compression than dogs without EH (OR: 2.3 vs. 0.4; 95% CI: 1.2-4.4 and 0.2-0.9, respectively), longer longitudinal spinal cord compression (3 spaces vs 1 space, P < .001), and greater intrinsic spinal cord change (grade 3/severe vs grade 1/mild; P < .001) based on MRI. The location of the intervertebral disc herniation in French Bulldogs with EH was more likely to be thoracolumbar (OR: 10.8; 95% CI: 2.1-55.7; P = .03).
    Conclusions and clinical importance: French Bulldogs have a high prevalence of intervertebral disc-associated EH. Dogs with EH have a shorter clinical course and are more likely to be nonambulatory on initial presentation.
    MeSH term(s) Animals ; Cross-Sectional Studies ; Dog Diseases/diagnostic imaging ; Dog Diseases/epidemiology ; Dog Diseases/surgery ; Dogs ; Hemorrhage/veterinary ; Intervertebral Disc ; Intervertebral Disc Displacement/diagnostic imaging ; Intervertebral Disc Displacement/surgery ; Intervertebral Disc Displacement/veterinary ; Prevalence ; Retrospective Studies ; Spinal Cord Compression/diagnostic imaging ; Spinal Cord Compression/surgery ; Spinal Cord Compression/veterinary
    Language English
    Publishing date 2022-05-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 92798-3
    ISSN 1939-1676 ; 0891-6640
    ISSN (online) 1939-1676
    ISSN 0891-6640
    DOI 10.1111/jvim.16442
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4095: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Prospective observational study of dogs with splenic mass rupture suggests potentially lower risk of malignancy and more favourable perioperative outcomes.

    Stewart, Samuel D / Ehrhart, E J / Davies, Rebecca / Khanna, Chand

    Veterinary and comparative oncology

    2020  Volume 18, Issue 4, Page(s) 811–817

    Abstract: Haemoperitoneum secondary to ruptured splenic tumours can be either benign or malignant in origin. The majority of previous studies of canine haemoperitoneum have been retrospective, which are associated with well-recognized biases, such as the potential ...

    Abstract Haemoperitoneum secondary to ruptured splenic tumours can be either benign or malignant in origin. The majority of previous studies of canine haemoperitoneum have been retrospective, which are associated with well-recognized biases, such as the potential to underappreciate the diversity of outcomes in a complex presentation such as haemoperitoneum. This study seeks to prospectively define perioperative morbidity and mortality of haemoperitoneum in dogs secondary to ruptured splenic masses. Forty dogs with haemoperitoneum secondary to a ruptured splenic mass met the inclusion criteria. As expected, the cohort predominately consisted of older large breed dogs. All dogs underwent preoperative staging and had a splenectomy performed. Histopathologic analysis was performed on the splenic mass, as well as any possible metastatic lesions that were noted intra-operatively. Perioperative care outside of splenectomy was delivered in specialty practices using current conventional approaches to care (eg, transfusions and anti-arrhythmic medications). Fifteen dogs (37.5%) had benign splenic tumours and were cured with surgery alone, whereas 62.5% had malignant disease (most often haemangiosarcoma [HSA]). Surgical outcomes were highly favourable in the vast majority of dogs. Indeed, 38 dogs (95%) survived and were discharged after a median hospitalization of 39.5 hours. Independent predictors of longer hospitalization times included receiving a transfusion and the development of an arrhythmia. Although small, this cohort defines distinctive and optimistic perspectives for dogs with haemoperitoneum from splenic tumour rupture. These favourable outcomes from this prospective study are sufficient to ask if larger prospective studies should be conducted to better inform owners during this challenging cancer emergency presentation.
    MeSH term(s) Animals ; Dog Diseases/epidemiology ; Dog Diseases/pathology ; Dog Diseases/surgery ; Dogs ; Female ; Hemangiosarcoma/epidemiology ; Hemangiosarcoma/pathology ; Hemangiosarcoma/surgery ; Hemangiosarcoma/veterinary ; Hospitals, Animal ; Liver/pathology ; Male ; Prospective Studies ; Splenectomy/veterinary ; Splenic Neoplasms/epidemiology ; Splenic Neoplasms/pathology ; Splenic Neoplasms/surgery ; Splenic Neoplasms/veterinary ; Splenic Rupture/epidemiology ; Splenic Rupture/pathology ; Splenic Rupture/surgery ; Splenic Rupture/veterinary ; Treatment Outcome ; United States/epidemiology
    Language English
    Publishing date 2020-06-15
    Publishing country England
    Document type Journal Article ; Observational Study, Veterinary
    ZDB-ID 2129634-0
    ISSN 1476-5829 ; 1476-5810
    ISSN (online) 1476-5829
    ISSN 1476-5810
    DOI 10.1111/vco.12621
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Assessing a Novel 3D Assay System for Drug Screening against OS Metastasis.

    Koons, Natalie / Amato, Nicole / Sauer, Scott / Warshawsky, David / Barkan, Dalit / Khanna, Chand

    Pharmaceuticals (Basel, Switzerland)

    2021  Volume 14, Issue 10

    Abstract: Osteosarcoma (OS) is an aggressive mesenchymal cell tumor that carries a poor long-term prognosis. Despite definitive surgery for the primary tumor and adjuvant chemotherapy, pulmonary metastasis is common and is the primary cause of morbidity. To ... ...

    Abstract Osteosarcoma (OS) is an aggressive mesenchymal cell tumor that carries a poor long-term prognosis. Despite definitive surgery for the primary tumor and adjuvant chemotherapy, pulmonary metastasis is common and is the primary cause of morbidity. To improve outcomes for patients, we have developed and optimized a phenotypic screen for drugs that may target OS disseminated tumor cells (DTCs) and inhibit their metastatic outbreak rather than merely screening for cytotoxic activity against proliferating cells, as is commonly conducted in conventional drug discovery approaches. We report on the validation of a previously described 3D reconstituted basement membrane extract (3D BME) model system for tumor dormancy and metastatic outgrowth adapted to clonal pairs of high and low metastatic OS cells. A post-hoc validation of the assay was possible by comparing the activity of a drug in our assay with early evidence of activity in human OS clinical trials (regorafenib and saracatinib). In this validation, we found concordance between our assay and human clinical trial experience We then explored an approved veterinary small molecule inhibitor of Janus kinase-1 (oclacitinib) as a potential drug candidate to take advantage of the high prevalence of OS in pet dogs and its translational value to humans. Despite the biological rationale, we found no evidence to support the use of oclacitinib as an antimetastatic agent in OS. The findings support our 3D BME assay as a highly efficient method to examine drugs for activity in targeting OS DTCs.
    Language English
    Publishing date 2021-09-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph14100971
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top