LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 2 of total 2

Search options

  1. Article ; Online: Modeling new therapies for infantile spasms.

    Chudomelova, Lenka / Scantlebury, Morris H / Raffo, Emmanuel / Coppola, Antonietta / Betancourth, David / Galanopoulou, Aristea S

    Epilepsia

    2010  Volume 51 Suppl 3, Page(s) 27–33

    Abstract: Infantile spasms are the classical seizure type of West syndrome. Infantile spasms often herald a dismal prognosis, due to the high probability to evolve into intractable forms of epilepsies with significant cognitive deficits, especially if not ... ...

    Abstract Infantile spasms are the classical seizure type of West syndrome. Infantile spasms often herald a dismal prognosis, due to the high probability to evolve into intractable forms of epilepsies with significant cognitive deficits, especially if not adequately treated. The current therapies-high doses of adrenocorticotropic hormone, steroids, or the gamma-aminobutyric acid (GABA) transaminase inhibitor vigabatrin--are often toxic and may not always be effective. The need to identify new therapies for spasms has led to the generation of a number of rodent models of infantile spasms. These include acute and chronic models of infantile spasms, with cryptogenic or symptomatic origin, many of which are based on specific etiologies. In this review, we summarize the clinical experience with treating infantile spasms and the main features of the new animal models of infantile spasms and discuss their utility in the preclinical development of new therapies for infantile spasms.
    MeSH term(s) Adrenocorticotropic Hormone/therapeutic use ; Animals ; Anticonvulsants/therapeutic use ; Disease Models, Animal ; Humans ; Infant ; Mice ; Rats ; Receptors, GABA/drug effects ; Sirolimus/therapeutic use ; Spasms, Infantile/drug therapy ; Spasms, Infantile/etiology ; Vigabatrin/therapeutic use
    Chemical Substances Anticonvulsants ; Receptors, GABA ; Adrenocorticotropic Hormone (9002-60-2) ; Vigabatrin (GR120KRT6K) ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2010-07-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/j.1528-1167.2010.02605.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 475: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: A model of symptomatic infantile spasms syndrome.

    Scantlebury, Morris H / Galanopoulou, Aristea S / Chudomelova, Lenka / Raffo, Emmanuel / Betancourth, David / Moshé, Solomon L

    Neurobiology of disease

    2009  Volume 37, Issue 3, Page(s) 604–612

    Abstract: Infantile spasms are characterized by age-specific expression of epileptic spasms and hypsarrhythmia and often result in significant cognitive impairment. Other epilepsies or autism often ensue especially in symptomatic IS (SIS). Cortical or subcortical ... ...

    Abstract Infantile spasms are characterized by age-specific expression of epileptic spasms and hypsarrhythmia and often result in significant cognitive impairment. Other epilepsies or autism often ensue especially in symptomatic IS (SIS). Cortical or subcortical damage, including white matter, have been implicated in the pathogenesis of SIS. To generate a model of SIS, we recreated this pathology by injecting rats with lipopolysaccharide and doxorubicin intracerebrally at postnatal day (P) 3 and with p-chlorophenylalanine intraperitoneally at P5. Spasms occurred between P4 and 13 and were associated with ictal EEG correlates, interictal EEG abnormalities and neurodevelopmental decline. After P9 other seizures, deficits in learning and memory, and autistic-like behaviors (indifference to other rats, increased grooming) were observed. Adrenocorticotropic hormone (ACTH) did not affect spasms. Vigabatrin transiently suppressed spasms at P5. This new model of SIS will be useful to study the neurobiology and treatment of SIS, including those that are refractory to ACTH.
    MeSH term(s) Adrenocorticotropic Hormone/pharmacology ; Animals ; Animals, Newborn ; Antibiotics, Antineoplastic/toxicity ; Anticonvulsants/pharmacology ; Autistic Disorder/chemically induced ; Autistic Disorder/pathology ; Autistic Disorder/physiopathology ; Brain/drug effects ; Brain/metabolism ; Brain/physiopathology ; Brain Damage, Chronic/chemically induced ; Brain Damage, Chronic/pathology ; Brain Damage, Chronic/physiopathology ; Cognition Disorders/chemically induced ; Cognition Disorders/pathology ; Cognition Disorders/physiopathology ; Disease Models, Animal ; Doxorubicin/toxicity ; Drug Resistance/physiology ; Electroencephalography/drug effects ; Evoked Potentials/drug effects ; Evoked Potentials/physiology ; Fenclonine/toxicity ; Humans ; Infant, Newborn ; Inflammation Mediators/toxicity ; Lipopolysaccharides/toxicity ; Male ; Neurodegenerative Diseases/chemically induced ; Neurodegenerative Diseases/pathology ; Neurodegenerative Diseases/physiopathology ; Rats ; Serotonin Antagonists/toxicity ; Spasms, Infantile/chemically induced ; Spasms, Infantile/complications ; Spasms, Infantile/physiopathology ; Vigabatrin/pharmacology
    Chemical Substances Antibiotics, Antineoplastic ; Anticonvulsants ; Inflammation Mediators ; Lipopolysaccharides ; Serotonin Antagonists ; Doxorubicin (80168379AG) ; Adrenocorticotropic Hormone (9002-60-2) ; Vigabatrin (GR120KRT6K) ; Fenclonine (R5J7E3L9SP)
    Language English
    Publishing date 2009-11-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2009.11.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4444: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top