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Article ; Online: CD31 as a probable responding and gate-keeping protein of the blood-brain barrier and the risk of Alzheimer's disease.

Zhang, Zhengrong / Gan, Qini / Han, Jingyan / Tao, Qiushan / Qiu, Wei Qiao / Madri, Joseph A

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

2023 Volume 43, Issue 7, Page(s) 1027–1041

Abstract: Several studies have shown that an abnormal vascular-immunity link could increase Alzheimer's disease (AD) risk; however, the mechanism is unclear. CD31, also named platelet endothelial cell adhesion molecule (PECAM), is a surface membrane protein of ... ...

Abstract	Several studies have shown that an abnormal vascular-immunity link could increase Alzheimer's disease (AD) risk; however, the mechanism is unclear. CD31, also named platelet endothelial cell adhesion molecule (PECAM), is a surface membrane protein of both endothelial and immune cells and plays important roles in the interaction between the vascular and immune systems. In this review, we focus on research regarding CD31 biological actions in the pathological process that may contribute to AD based on the following rationales. First, endothelial, leukocyte and soluble forms of CD31 play multi-roles in regulating transendothelial migration, increasing blood-brain barrier (BBB) permeability and resulting in neuroinflammation. Second, CD31 expressed by endothelial and immune cells dynamically modulates numbers of signaling pathways, including Src family kinases, selected G proteins, and β-catenin which in turn affect cell-matrix and cell-cell attachment, activation, permeability, survival, and ultimately neuronal cell injury. In endothelia and immune cells, these diverse CD31-mediated pathways act as a critical regulator in the immunity-endothelia-brain axis, thereby mediating AD pathogenesis in ApoE4 carriers, which is the major genetic risk factor for AD. This evidence suggests a novel mechanism and potential drug target for CD31 in the background of genetic vulnerabilities and peripheral inflammation for AD development and progression.
MeSH term(s)	Humans ; Alzheimer Disease/metabolism ; Blood-Brain Barrier/metabolism ; Platelet Endothelial Cell Adhesion Molecule-1/genetics ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Signal Transduction ; Transendothelial and Transepithelial Migration
Chemical Substances	Platelet Endothelial Cell Adhesion Molecule-1 ; PECAM1 protein, human
Language	English
Publishing date	2023-04-12
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	604628-9
ISSN	1559-7016 ; 0271-678X
ISSN (online)	1559-7016
ISSN	0271-678X
DOI	10.1177/0271678X231170041
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Does feeding more phases reduce ammonia concentrations from broiler litter?

Brink, Madri / Janssens, Geert P J / Delezie, Evelyne

Animal nutrition (Zhongguo xu mu shou yi xue hui)

2022 Volume 11, Page(s) 152–159

Abstract: We compared a 3- and 5-phase feeding program in terms of ammonia concentrations measured at litter level, litter composition and quality, nitrogen (N) utilization, performance, welfare, and meat deposition in broilers. A total of 744 Ross 308 male ... ...

Abstract	We compared a 3- and 5-phase feeding program in terms of ammonia concentrations measured at litter level, litter composition and quality, nitrogen (N) utilization, performance, welfare, and meat deposition in broilers. A total of 744 Ross 308 male broilers was divided into 2 treatments, each with 6 replicates. The 3-phase diets were formulated to CP and digestible lysine contents of 205 and 11.5 g/kg (0 to 9 d), 195 and 10.8 g/kg (9 to 24 d), and 183.3 and 10.15 g/kg (24 to 39 d), respectively. The 5-phase diets had additional phases from 17 to 24 d and 32 to 39 d with CP and digestible lysine contents of 188 and 10.4 g/kg and 177 and 9.8 g/kg, respectively. Feeding 5 phases reduced the NH
Language	English
Publishing date	2022-08-12
Publishing country	China
Document type	Journal Article
ISSN	2405-6383
ISSN (online)	2405-6383
DOI	10.1016/j.aninu.2022.06.020
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Does feeding more phases reduce ammonia concentrations from broiler litter?

Brink, Madri / Janssens, Geert P.J. / Delezie, Evelyne

Chinese Association of Animal Science and Veterinary Medicine Animal nutrition. 2022 June 19,

2022

Abstract	We compared a 3- and 5-phase feeding program in terms of ammonia concentrations measured at litter level, litter composition and quality, nitrogen (N) utilization, performance, welfare, and meat deposition in broilers. A total of 744 Ross 308 male broilers was divided into 2 treatments, each with 6 replicates. The 3-phase diets were formulated to CP and digestible lysine contents of 205 and 11.5 g/kg (0 to 9 d), 195 and 10.8 g/kg (9 to 24 d), and 183.3 and 10.15 g/kg (24 to 39 d), respectively. The 5-phase diets had additional phases from 17 to 24 d and 32 to 39 d with CP and digestible lysine contents of 188 and 10.4 g/kg and 177 and 9.8 g/kg, respectively. Feeding 5 phases reduced the NH₃ concentrations at litter level by 37.95% and 20.81% at 23 (P < 0.05) and 37 d of age (P < 0.05), respectively. There was a tendency for a lower litter total ammoniacal nitrogen concentration for the 5-phase treatment than the 3-phase treatment at 24 and 39 d of age (P < 0.1 for both). Total N concentration of the litter also tended to be lower for the 5-phase treatment at 39 d of age (P < 0.1). The lower NH₃ coincided with a lower average litter pH at 24 and 32 d of age (P < 0.05 for both). Birds fed the 5-phase treatments had a lower incidence of foot lesions at 24 d of age (P < 0.001). Performance as well as carcass yield could be maintained, except for FCR, which was reduced for the 5-phase treatment between 17 and 24 d of age and the overall period (P < 0.05 and < 0.001, respectively). The impact of the 5-phase treatment regarding the utilization of N (digestibility, excretion, and retention) was less clear, however the NH₃ volatilized from the litter was significantly reduced. Feeding 5 phases may therefore potentially reduce the NH₃ emitted from broiler houses which has several environmental and health benefits. Although the 5-phase treatment resulted in a significant decrease in feed efficiency, growth performance and meat deposition were maintained.
Keywords	ammonia ; ammonium nitrogen ; carcass yield ; digestibility ; excretion ; feed conversion ; growth performance ; lysine ; males ; meat ; nitrogen ; pH ; poultry manure ; total nitrogen
Language	English
Dates of publication	2022-0619
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	2834745-6
ISSN	2405-6545
ISSN	2405-6545
DOI	10.1016/j.aninu.2022.06.020
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Modeling the neurovascular niche: implications for recovery from CNS injury.

Madri, J A

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society

2009 Volume 60 Suppl 4, Page(s) 95–104

Abstract: While survival from stroke, traumatic brain and spinal cord injuries, neurodegenerative diseases and hypoxia has improved over the past several years, treatments are limited and impacts of these injuries and diseases to patients, families and society can ...

Abstract	While survival from stroke, traumatic brain and spinal cord injuries, neurodegenerative diseases and hypoxia has improved over the past several years, treatments are limited and impacts of these injuries and diseases to patients, families and society can be devastating. Recovery from these injuries is variable and involves in part an orchestrated angiogenesis and neurogenesis in the neurogenic zones (neurovascular niches) of the CNS. In this focused review the roles of HIF-1alpha mediated responses to hypoxia in CNS neurovascular niches is discussed. Using in vivo and in vitro murine models of sublethal hypoxia we mimicked the variable responses observed in the human population and correlated differences in baseline and hypoxia-induced induction of HIF-1alpha and several downstream signaling components including BDNF, VEGF, SDF-1, TrkB, Nrp-1, CXCR4 and NO with differences in survival as well as endothelial cell and neural stem cell survival and proliferation, providing insight into this important and timely problem and suggesting that optimization of expression levels of some or all of these signaling components may have the potential of maximizing recovery following CNS injury.
MeSH term(s)	Animals ; Blood Vessels/innervation ; Blood Vessels/pathology ; Central Nervous System/pathology ; Central Nervous System Diseases/pathology ; Cerebrovascular Circulation/physiology ; Developmental Disabilities/pathology ; Dogs ; Humans ; Infant, Newborn ; Infant, Premature ; Mice ; Rats ; Recovery of Function ; Stem Cells/physiology
Language	English
Publishing date	2009-10
Publishing country	Poland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1125221-2
ISSN	1899-1505 ; 0867-5910 ; 0044-6033
ISSN (online)	1899-1505
ISSN	0867-5910 ; 0044-6033
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.B 1358: Show issues

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Article ; Online: A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells.

Boisvert, Erin M / Means, Robert E / Michaud, Michael / Thomson, Jason J / Madri, Joseph A / Katz, Samuel G

Journal of visualized experiments : JoVE

2020 , Issue 157

Abstract: Human brain organoids differentiated from embryonic stem cells offer the unique opportunity to study complicated interactions of multiple cell types in a three-dimensional system. Here we present a relatively straightforward and inexpensive method that ... ...

Abstract	Human brain organoids differentiated from embryonic stem cells offer the unique opportunity to study complicated interactions of multiple cell types in a three-dimensional system. Here we present a relatively straightforward and inexpensive method that yields brain organoids. In this protocol human pluripotent stem cells are broken into small clusters instead of single cells and grown in basic media without a heterologous basement membrane matrix or exogenous growth factors, allowing the intrinsic developmental cues to shape the organoid's growth. This simple system produces a diversity of brain cell types including glial and microglial cells, stem cells, and neurons of the forebrain, midbrain, and hindbrain. Organoids generated from this protocol also display hallmarks of appropriate temporal and spatial organization demonstrated by brightfield images, histology, immunofluorescence and real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). Because these organoids contain cell types from various parts of the brain, they can be utilized for studying a multitude of diseases. For example, in a recent paper we demonstrated the use of organoids generated from this protocol for studying the effects of hypoxia on the human brain. This approach can be used to investigate an array of otherwise difficult to study conditions such as neurodevelopmental handicaps, genetic disorders, and neurologic diseases.
MeSH term(s)	Brain/cytology ; Brain/metabolism ; Cell Differentiation ; Human Embryonic Stem Cells/cytology ; Humans ; Mesencephalon ; Neurons/cytology ; Organoids/metabolism ; Pluripotent Stem Cells/cytology ; Tissue Culture Techniques
Language	English
Publishing date	2020-03-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/60379
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reduction of dietary crude protein and feed form: Impact on broiler litter quality, ammonia concentrations, excreta composition, performance, welfare, and meat quality.

Brink, Madri / Janssens, Geert P J / Demeyer, Peter / Bağci, Özer / Delezie, Evelyne

Animal nutrition (Zhongguo xu mu shou yi xue hui)

2022 Volume 9, Page(s) 291–303

Abstract: Nitrogen (N) excreted by poultry is converted to ammonia ( ... ...

Abstract	Nitrogen (N) excreted by poultry is converted to ammonia (NH
Language	English
Publishing date	2022-03-15
Publishing country	China
Document type	Journal Article
ISSN	2405-6383
ISSN (online)	2405-6383
DOI	10.1016/j.aninu.2021.12.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Reduction of dietary crude protein and feed form: Impact on broiler litter quality, ammonia concentrations, excreta composition, performance, welfare, and meat quality

Brink, Madri / Janssens, Geert P.J. / Demeyer, Peter / Bagci, Özer / Delezie, Evelyne

Chinese Association of Animal Science and Veterinary Medicine Animal nutrition. 2021 Dec. 09,

2021

Abstract: Nitrogen (N) excreted by poultry is converted to ammonia (NH₃), presenting an environmental risk and a health risk to the farmer and animals. A study was performed to investigate the effect of reduced CP and feed form on broiler performance and welfare, ... ...

Abstract	Nitrogen (N) excreted by poultry is converted to ammonia (NH₃), presenting an environmental risk and a health risk to the farmer and animals. A study was performed to investigate the effect of reduced CP and feed form on broiler performance and welfare, meat and litter quality, N utilization, and NH₃ concentrations at litter level. A total of 2,232 Ross 308 male broilers was divided into 6 treatments and 6 replicates, which was fed diets in both pellet and mash forms with different CP levels of 205.0 g/kg (H, high), 187.5 g/kg (M, intermediate) and 175.0 g/kg (L, low) in the grower phase and 195.0 g/kg (H), 180.0 g/kg (M) and 165.6 g/kg (L) in the finisher phase. Individual amino acids (AA) were supplemented to maintain digestible AA-to-digestible lysine ratios. Decreasing dietary CP content to 187.5 g/kg in the grower phase and 180.0 g/kg in the finisher phase reduced NH₃ concentrations at litter level (P < 0.001), but a further reduction in dietary CP had no additional effect. Mash treatments had better litter qualities and lower incidences of foot and hock lesions than pellet treatments at d 38 (P < 0.001). In addition, treatments with reduced CP had lower incidence of foot lesions at d 38 (P < 0.001). Broilers fed pelleted diets had higher ADFI, ADG, and final BW, improved feed conversion ratio (FCR), and heavier carcasses (P < 0.001) than those fed mash diets over a production period of 39 d. Performance could not be maintained when birds were fed L CP pelleted diets. This study demonstrated that, with the supplementation of AA to meet requirements, the concentration of dietary CP can be reduced to 187.5 and 180.0 g/kg in the grower and finisher phases respectively, without impairing broiler performance, meat yield and quality. Mash diets were favorable when considering the overall litter quality and welfare of the birds. However, they could not maintain the same broiler performance and slaughter yield as pelleted diets. Results from the present study may assist the poultry sector towards a socially acceptable low-emission farming system.
Keywords	ammonia ; crude protein ; excreta ; farmers ; feed conversion ; hock ; lysine ; males ; mash ; meat ; meat quality ; nitrogen ; poultry manure ; risk ; slaughter
Language	English
Dates of publication	2021-1209
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	2834745-6
ISSN	2405-6545
ISSN	2405-6545
DOI	10.1016/j.aninu.2021.12.009
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Somatic PRKAR1A mutation in sporadic atrial myxoma with cerebral parenchymal metastases: a case report.

Roque, Ashley / Kimbrough, Tara / Traner, Christopher / Baehring, Joachim M / Huttner, Anita / Adams, Jennifer / Canosa, Sandra / Sklar, Jeffrey / Madri, Joseph A

Journal of medical case reports

2019 Volume 13, Issue 1, Page(s) 389

Abstract: Background: Atrial myxomas are generally considered benign neoplasms. The majority of tumors are sporadic and less than 10% are associated with an autosomal dominant condition known as the Carney complex, which is most often caused by germline mutation ... ...

Abstract	Background: Atrial myxomas are generally considered benign neoplasms. The majority of tumors are sporadic and less than 10% are associated with an autosomal dominant condition known as the Carney complex, which is most often caused by germline mutation in the gene PRKAR1A. Whether this gene plays a role in the development of sporadic myxomas has been an area of debate, although recent studies have suggested that some fraction of sporadic tumors also carry mutations in PRKARIA. Extra-cardiac complications of atrial myxoma include dissemination of tumor to the brain; however, the dissemination of viable invasive tumor cells is exceedingly rare. Case presentation: We present here a 48-year-old white woman who developed multiple intracranial hemorrhagic lesions secondary to tumor embolism that progressed to 'false' aneurysm formation and invasion through the vascular wall into brain parenchyma 7 months after resection of an atrial myxoma. Whole exome sequencing of her tumor revealed multiple mutations in PRKAR1A not found in her germline deoxyribonucleic acid (DNA), suggesting that the myxoma in this patient was sporadic. Conclusions: Our patient illustrates that mutations in PRKAR1A may be found in sporadic lesions. Whether the presence of this mutation affects the clinical behavior of sporadic tumors and increases risk for metastasis is not clear. Regardless, the protein kinase A pathway which is regulated by PRKAR1A represents a possible target for treatment in patients with metastatic cardiac myxomas harboring mutations in the PRKARIA gene.
MeSH term(s)	Brain Neoplasms/physiopathology ; Brain Neoplasms/secondary ; Brain Neoplasms/therapy ; Carney Complex/diagnosis ; Carney Complex/genetics ; Chemoradiotherapy ; Cyclic AMP-Dependent Protein Kinase RIalpha Subunit/genetics ; Dopamine Agents/therapeutic use ; Female ; Gene Expression Regulation, Neoplastic ; Genes, Tumor Suppressor ; Germ-Line Mutation ; Heart Neoplasms/diagnosis ; Heart Neoplasms/physiopathology ; Heart Neoplasms/therapy ; Humans ; Intracranial Hemorrhages ; Memantine/therapeutic use ; Middle Aged ; Myxoma/diagnosis ; Myxoma/physiopathology ; Myxoma/therapy ; Treatment Outcome ; Whole Exome Sequencing
Chemical Substances	Cyclic AMP-Dependent Protein Kinase RIalpha Subunit ; Dopamine Agents ; PRKAR1A protein, human ; Memantine (W8O17SJF3T)
Language	English
Publishing date	2019-12-25
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-019-2317-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A static self-directed method for generating brain organoids from human embryonic stem cells

Boisvert, Erin M / Means, Robert E / Michaud, Michael / Thomson, Jason J / Madri, Joseph A / Katz, Samuel G

Journal of visualized experiments. 2020 Mar. 04, , no. 157

2020

Abstract	Human brain organoids differentiated from embryonic stem cells offer the unique opportunity to study complicated interactions of multiple cell types in a three-dimensional system. Here we present a relatively straightforward and inexpensive method that yields brain organoids. In this protocol human pluripotent stem cells are broken into small clusters instead of single cells and grown in basic media without a heterologous basement membrane matrix or exogenous growth factors, allowing the intrinsic developmental cues to shape the organoid's growth. This simple system produces a diversity of brain cell types including glial and microglial cells, stem cells, and neurons of the forebrain, midbrain, and hindbrain. Organoids generated from this protocol also display hallmarks of appropriate temporal and spatial organization demonstrated by brightfield images, histology, immunofluorescence and real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). Because these organoids contain cell types from various parts of the brain, they can be utilized for studying a multitude of diseases. For example, in a recent paper we demonstrated the use of organoids generated from this protocol for studying the effects of hypoxia on the human brain. This approach can be used to investigate an array of otherwise difficult to study conditions such as neurodevelopmental handicaps, genetic disorders, and neurologic diseases.
Keywords	basement membrane ; brain ; embryonic stem cells ; fluorescent antibody technique ; genetic disorders ; growth factors ; histology ; humans ; hypoxia ; neuroglia ; neurons ; organoids ; quantitative polymerase chain reaction ; reverse transcriptase polymerase chain reaction
Language	English
Dates of publication	2020-0304
Size	p. e60379.
Publishing place	Journal of Visualized Experiments
Document type	Article
ZDB-ID	2259946-0
ISSN	1940-087X
ISSN	1940-087X
DOI	10.3791/60379
Database	NAL-Catalogue (AGRICOLA)

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Article: Extracellular matrix modulation of vascular cell behaviour.

Madri, J A

Transplant immunology

1997 Volume 5, Issue 3, Page(s) 179–183

MeSH term(s)	Animals ; Blood Vessels/cytology ; Blood Vessels/metabolism ; Blood Vessels/ultrastructure ; Cell Communication/physiology ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/ultrastructure ; Extracellular Matrix/physiology ; Humans ; Platelet Endothelial Cell Adhesion Molecule-1/biosynthesis ; Receptors, Platelet-Derived Growth Factor/biosynthesis ; Receptors, Transforming Growth Factor beta/biosynthesis
Chemical Substances	Platelet Endothelial Cell Adhesion Molecule-1 ; Receptors, Transforming Growth Factor beta ; Receptors, Platelet-Derived Growth Factor (EC 2.7.10.1)
Language	English
Publishing date	1997-09
Publishing country	Netherlands
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	1160846-8
ISSN	1878-5492 ; 0966-3274
ISSN (online)	1878-5492
ISSN	0966-3274
DOI	10.1016/s0966-3274(97)80035-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3784: Show issues

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