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  1. Article ; Online: How universal does universal test and treat have to be?

    Baggaley, Rebecca F / Hollingsworth, T Déirdre

    The lancet. HIV

    2020  Volume 7, Issue 5, Page(s) e306–e308

    MeSH term(s) Eswatini ; HIV Infections ; HIV Seropositivity ; HIV-1 ; Humans ; Incidence
    Language English
    Publishing date 2020-02-13
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(20)30031-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Deter or dispose? A critique of the relocation of asylum applicants to Rwanda and its public health implications.

    Chaloner, Jonathan / Baggaley, Rebecca F / Ryan, Bernard / Nellums, Laura B / Pareek, Manish

    The Lancet regional health. Europe

    2022  Volume 18, Page(s) 100442

    Language English
    Publishing date 2022-06-22
    Publishing country England
    Document type Journal Article
    ISSN 2666-7762
    ISSN (online) 2666-7762
    DOI 10.1016/j.lanepe.2022.100442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Health economic analyses of latent tuberculosis infection screening and preventive treatment among people living with HIV in lower tuberculosis incidence settings: a systematic review.

    Baggaley, Rebecca F / Vegvari, Carolin / Dimala, Christian A / Lipman, Marc / Miller, Robert F / Brown, James / Degtyareva, Svetlana / White, Helena A / Hollingsworth, T Déirdre / Pareek, Manish

    Wellcome open research

    2023  Volume 6, Page(s) 51

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-01-05
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2398-502X
    ISSN 2398-502X
    DOI 10.12688/wellcomeopenres.16604.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Sustainable Surveillance of Neglected Tropical Diseases for the Post-Elimination Era.

    Hatherell, Hollie-Ann / Simpson, Hope / Baggaley, Rebecca F / Hollingsworth, T Déirdre / Pullan, Rachel L

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 72, Issue Suppl 3, Page(s) S210–S216

    Abstract: The World Health Organization's (WHO's) 2030 road map for neglected tropical diseases (NTDs) emphasizes the importance of strengthened, institutionalized "post-elimination" surveillance. The required shift from disease-siloed, campaign-based programming ... ...

    Abstract The World Health Organization's (WHO's) 2030 road map for neglected tropical diseases (NTDs) emphasizes the importance of strengthened, institutionalized "post-elimination" surveillance. The required shift from disease-siloed, campaign-based programming to routine, integrated surveillance and response activities presents epidemiological, logistical, and financial challenges, yet practical guidance on implementation is lacking. Nationally representative survey programs, such as demographic and health surveys (DHS), may offer a platform for the integration of NTD surveillance within national health systems and health information systems. Here, we describe characteristics of DHS and other surveys conducted within the WHO Africa region in terms of frequency, target populations, and sample types and discuss applicability for post-validation and post-elimination surveillance. Maximizing utility depends not only on the availability of improved diagnostics but also on better understanding of the spatial and temporal dynamics of transmission at low prevalence. To this end, we outline priorities for obtaining additional data to better characterize optimal post-elimination surveillance platforms.
    MeSH term(s) Africa ; Global Health ; Humans ; Neglected Diseases ; Tropical Medicine
    Language English
    Publishing date 2021-04-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab211
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  5. Article ; Online: Are clinical outcomes from COVID-19 improving in ethnic minority groups?

    Pan, Daniel / Sze, Shirley / Irizar, Patricia / George, Nisha / Chaka, Aasiya / Lal, Zainab / Martin, Christopher A / Nazareth, Joshua / Baggaley, Rebecca F / Gray, Laura J / Katikireddi, S Vittal / Nellums, Laura B / Khunti, Kamlesh / Pareek, Manish

    EClinicalMedicine

    2023  Volume 61, Page(s) 102091

    Language English
    Publishing date 2023-07-11
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2023.102091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Disproportionate infection, hospitalisation and death from COVID-19 in ethnic minority groups and Indigenous Peoples: an application of the Priority Public Health Conditions analytical framework.

    Irizar, Patricia / Pan, Daniel / Taylor, Harry / Martin, Christopher A / Katikireddi, Srinivasa Vittal / Kannangarage, Niluka Wijekoon / Gomez, Susana / La Parra Casado, Daniel / Srinivas, Prashanth Nuggehalli / Diderichsen, Finn / Baggaley, Rebecca F / Nellums, Laura B / Koller, Theadora Swift / Pareek, Manish

    EClinicalMedicine

    2024  Volume 68, Page(s) 102360

    Abstract: The COVID-19 pandemic has resulted in disproportionate consequences for ethnic minority groups and Indigenous Peoples. We present an application of the Priority Public Health Conditions (PPHC) framework from the World Health Organisation (WHO), to ... ...

    Abstract The COVID-19 pandemic has resulted in disproportionate consequences for ethnic minority groups and Indigenous Peoples. We present an application of the Priority Public Health Conditions (PPHC) framework from the World Health Organisation (WHO), to explicitly address COVID-19 and other respiratory viruses of pandemic potential. This application is supported by evidence that ethnic minority groups were more likely to be infected, implying differential exposure (PPHC level two), be more vulnerable to severe disease once infected (PPHC level three) and have poorer health outcomes following infection (PPHC level four). These inequities are driven by various interconnected dimensions of racism, that compounds with socioeconomic context and position (PPHC level one). We show that, for respiratory viruses, it is important to stratify levels of the PPHC framework by infection status and by societal, community, and individual factors to develop optimal interventions to reduce inequity from COVID-19 and future infectious diseases outbreaks.
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2023.102360
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  7. Article: Survey on the perceptions of UK gastroenterologists and endoscopists to artificial intelligence.

    Kader, Rawen / Baggaley, Rebecca F / Hussein, Mohamed / Ahmad, Omer F / Patel, Nisha / Corbett, Gareth / Dolwani, Sunil / Stoyanov, Danail / Lovat, Laurence B

    Frontline gastroenterology

    2022  Volume 13, Issue 5, Page(s) 423–429

    Abstract: Background and aims: With the potential integration of artificial intelligence (AI) into clinical practice, it is essential to understand end users' perception of this novel technology. The aim of this study, which was endorsed by the British Society of ...

    Abstract Background and aims: With the potential integration of artificial intelligence (AI) into clinical practice, it is essential to understand end users' perception of this novel technology. The aim of this study, which was endorsed by the British Society of Gastroenterology (BSG), was to evaluate the UK gastroenterology and endoscopy communities' views on AI.
    Methods: An online survey was developed and disseminated to gastroenterologists and endoscopists across the UK.
    Results: One hundred four participants completed the survey. Quality improvement in endoscopy (97%) and better endoscopic diagnosis (92%) were perceived as the most beneficial applications of AI to clinical practice. The most significant challenges were accountability for incorrect diagnoses (85%) and potential bias of algorithms (82%). A lack of guidelines (92%) was identified as the greatest barrier to adopting AI in routine clinical practice. Participants identified real-time endoscopic image diagnosis (95%) as a research priority for AI, while the most perceived significant barriers to AI research were funding (82%) and the availability of annotated data (76%). Participants consider the priorities for the BSG AI Task Force to be identifying research priorities (96%), guidelines for adopting AI devices in clinical practice (93%) and supporting the delivery of multicentre clinical trials (91%).
    Conclusion: This survey has identified views from the UK gastroenterology and endoscopy community regarding AI in clinical practice and research, and identified priorities for the newly formed BSG AI Task Force.
    Language English
    Publishing date 2022-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2521857-8
    ISSN 2041-4137
    ISSN 2041-4137
    DOI 10.1136/flgastro-2021-101994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Awareness of HIV, hepatitis B, hepatitis C, tuberculosis and COVID-19 in migrant students in the UK: a pilot survey from an Institute of Higher Education.

    Bird, Paul W / Holmes, Christopher W / Pan, Daniel / Martin, Christopher A / Pareek, Manish / Gogoi, Mayuri / Sandhu, Rominder / Sargeant, Pamela / McMurray, Claire L / Baggaley, Rebecca F / Nellums, Laura B

    The Journal of infection

    2023  Volume 86, Issue 4, Page(s) e94–e96

    MeSH term(s) Humans ; Transients and Migrants ; COVID-19 ; Hepatitis B ; Hepatitis C ; Tuberculosis/epidemiology ; Hepacivirus ; HIV Infections/epidemiology ; Students ; United Kingdom/epidemiology ; Surveys and Questionnaires
    Language English
    Publishing date 2023-02-14
    Publishing country England
    Document type Letter
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2023.02.017
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  9. Article ; Online: Prevention and treatment of infectious diseases in migrants in Europe in the era of universal health coverage.

    Baggaley, Rebecca F / Zenner, Dominik / Bird, Paul / Hargreaves, Sally / Griffiths, Chris / Noori, Teymur / Friedland, Jon S / Nellums, Laura B / Pareek, Manish

    The Lancet. Public health

    2022  Volume 7, Issue 10, Page(s) e876–e884

    Abstract: Some subpopulations of migrants to Europe are generally healthier than the population of the country of settlement, but are at increased risk of key infectious diseases, including tuberculosis, HIV, and viral hepatitis, as well as under- immunisation. ... ...

    Abstract Some subpopulations of migrants to Europe are generally healthier than the population of the country of settlement, but are at increased risk of key infectious diseases, including tuberculosis, HIV, and viral hepatitis, as well as under- immunisation. Infection screening programmes across Europe work in disease silos with a focus on individual diseases at the time of arrival. We argue that European health-care practitioners and policy makers would benefit from developing a framework of universal health care for migrants, which proactively offers early testing and vaccinations by delivering multi-disease testing and catch-up vaccination programmes integrated within existing health systems. Such interventions should be codeveloped with migrant populations to overcome barriers faced in accessing services. Aligning policies with the European Centre for Disease Prevention and Control guidance for health care for migrants, community-based preventive health-care programmes should be delivered as part of universal health care. However, effective implementation needs appropriate funding, and to be underpinned by high-quality evidence.
    MeSH term(s) Communicable Diseases/epidemiology ; Communicable Diseases/therapy ; Europe/epidemiology ; Humans ; Transients and Migrants ; Tuberculosis/diagnosis ; Tuberculosis/prevention & control ; Universal Health Insurance
    Language English
    Publishing date 2022-08-26
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2468-2667
    ISSN (online) 2468-2667
    DOI 10.1016/S2468-2667(22)00174-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The impact, effectiveness and outcomes of targeted screening thresholds for programmatic latent tuberculosis infection testing in HIV.

    White, Helena A / Baggaley, Rebecca F / Okhai, Hajra / Patel, Hemu / Stephenson, Iain / Bodimeade, Chris / Wiselka, Martin J / Pareek, Manish

    AIDS (London, England)

    2022  Volume 36, Issue 14, Page(s) 2035–2044

    Abstract: Background: Screening and treatment for latent tuberculosis infection (LTBI) are key for TB control. In the UK, the National Institute for Health and Care Excellence (NICE) and the British HIV Association (BHIVA) give conflicting guidance on which ... ...

    Abstract Background: Screening and treatment for latent tuberculosis infection (LTBI) are key for TB control. In the UK, the National Institute for Health and Care Excellence (NICE) and the British HIV Association (BHIVA) give conflicting guidance on which groups of people with HIV (PWH) should be screened, and previous national analysis demonstrated heterogeneity in how guidance is applied. There is an urgent need for a firmer clinical effectiveness evidence base on which to build screening policy.
    Methods: We conducted a systematic, programmatic LTBI-screening intervention for all PWH receiving care in Leicester, UK. We compared yields (percentage IGRA positive) and number of tests required when applying the NICE and BHIVA testing strategies, as well as strategies targeting screening by TB incidence in patients' countries of birth.
    Results: Of 1053 PWH tested, 118 were IGRA-positive (11.2%). Positivity was associated with higher TB incidence in country-of-birth [adjusted odds ratio, 50-149 cases compared with <50 cases/100 000: 11.6; 95% confidence interval (CI) 4.79-28.10)]. There was high testing uptake (1053/1069, 98.5%). Appropriate chemoprophylaxis was commenced in 100 of 117 (85.5%) patients diagnosed with LTBI, of whom 96 of 100 (96.0%) completed treatment. Delivering targeted testing to PWH from countries with TB incidence greater than 150 per 100 000 population or any sub-Saharan African country, would have correctly identified 89.8% of all LTBI cases while cutting tests required by 46.1% compared with NICE guidance, performing as well as BHIVA 2018 guidance.
    Conclusion: Targeting screening to higher risk PWH increases yield and reduces the number requiring testing. Our proposed 'PWH-LTBI streamlined guidance' offers a simplified approach, with the potential to improve national LTBI-screening implementation.
    MeSH term(s) Humans ; Latent Tuberculosis/diagnosis ; Latent Tuberculosis/epidemiology ; HIV Infections/complications ; Mass Screening ; Communicable Disease Control ; Incidence
    Language English
    Publishing date 2022-08-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000003364
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