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  1. Article: m

    Gao, Yuan / Yu, Miao / Liu, Zengyuan / Liu, Yi / Kong, Zhijun / Zhu, Chunfu / Qin, Xihu / Li, Yan / Tang, Liming

    Translational oncology

    2024  Volume 41, Page(s) 101858

    Abstract: ALKBH5 plays critical roles in various cellular processes via post-transcriptional regulation of oncogenes or tumor suppressors in an N6-methyladenosine (m6A)-dependent manner. However, its function in intrahepatic cholangiocarcinoma (ICC) remains ... ...

    Abstract ALKBH5 plays critical roles in various cellular processes via post-transcriptional regulation of oncogenes or tumor suppressors in an N6-methyladenosine (m6A)-dependent manner. However, its function in intrahepatic cholangiocarcinoma (ICC) remains unclear. In the present study, bioinformatic analyses of The Cancer Genome Atlas (TCGA) data were performed, and the association of ALKBH5 in predicting overall survival in patients with ICC was investigated. Then, the clinical data of patients from The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University (Changzhou, China) was used to reveal the overall survival of patients with ICC with different ALKBH5 expression levels by Kaplan-Meier survival analysis. Subsequently, in vitro and in vivo studies were conducted to explore and verify the downstream genes regulated by ALKBH5. The results from TCGA data demonstrated that ALKBH5 expression is elevated in ICC and that patients with high ALKBH5 expression exhibited poor survival compared with patients with low expression. In addition, in vitro assays demonstrated that ALKBH5 promoted cell viability and maintained the stemness of ICC cells, leading to ICC progression. The present study also demonstrated that BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B) is the downstream gene regulated by ALKBH5 and targeting BUB1B suppressed cell growth. The in vitro and vivo experiments revealed that ALKBH5 might function through BUB1B to maintain the stemness of ICC and that altering BUB1B may suppress ICC progression.
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2443840-6
    ISSN 1936-5233
    ISSN 1936-5233
    DOI 10.1016/j.tranon.2023.101858
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: m

    Li, Kexin / Shu, Shanrong / Zou, Jiahua / Li, Manmei / Liu, Zhong

    Genes & diseases

    2023  Volume 10, Issue 6, Page(s) 2278–2281

    Language English
    Publishing date 2023-03-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2821806-1
    ISSN 2352-3042 ; 2352-3042
    ISSN (online) 2352-3042
    ISSN 2352-3042
    DOI 10.1016/j.gendis.2023.01.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: M

    Wang, Ruixi / Cheng, Xingyuan / Chi, Dongmei / Liu, Shiliang / Li, Qiaoqiao / Chen, Baoqing / Xi, Mian

    Discover. Oncology

    2023  Volume 14, Issue 1, Page(s) 99

    Abstract: ... has explored methylation modifications in m: Methods: Public gene-expression data and clinical ... were analyzed to identify potential consensus clusters of m: Results: Consensus clustering analysis ... based on m: Conclusions: Transcriptomic prognostic signatures based on m ...

    Abstract Background: Esophageal squamous cell carcinoma (ESCC) is the most common esophageal malignancy, and RNA methylation has been reported to be involved in the tumorigenesis of ESCC. However, no study has explored methylation modifications in m
    Methods: Public gene-expression data and clinical annotation of 254 patients obtained from The Cancer Genome Atlas and the Gene Expression Omnibus databases were analyzed to identify potential consensus clusters of m
    Results: Consensus clustering analysis based on m
    Conclusions: Transcriptomic prognostic signatures based on m
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article
    ISSN 2730-6011
    ISSN (online) 2730-6011
    DOI 10.1007/s12672-023-00710-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: m

    Zhu, Xiaolong / Wu, Xingwei / Yang, Hui / Xu, Qiancheng / Zhang, Mengying / Liu, Xiaocen / Lv, Kun

    Biology direct

    2023  Volume 18, Issue 1, Page(s) 27

    Abstract: ... methyladenine (m: Results: LINC01003 expression was upregulated in glioma cell lines and tissues. Higher ... LINC01003 upregulation is induced by m: Conclusion: This study characterized LINC01003 as a lncRNA ...

    Abstract Background: Long non-coding RNAs (lncRNAs) play important roles in the progression of glioma. Here, we examined the potential functions of a lncRNA, LINC01003, in glioma and characterized the underlying molecular mechanisms.
    Methods: The GEIPA2 and Chinese Glioma Genome Atlas (CCGA) databases were employed to analyze gene expression and the overall survival curve in patients with glioma. The functions of LINC01003 in glioma growth and migration were assessed by loss-of-function experiments in vitro and in vivo. RNA sequencing was used to determine the signaling pathways effected by LINC01003. Bioinformatics analysis and RNA immunoprecipitation (RIP) assays were used to explore the mechanism underlying the N6-methyladenine (m
    Results: LINC01003 expression was upregulated in glioma cell lines and tissues. Higher LINC01003 expression predicted shorter overall survival time in glioma patients. Functionally, LINC01003 knockdown inhibited the cell cycle and cell proliferation and migration in glioma cells. Mechanistically, RNA sequencing revealed that LINC01003 mediated the focal adhesion signaling pathway. Furthermore, LINC01003 upregulation is induced by m
    Conclusion: This study characterized LINC01003 as a lncRNA that contributes to tumorigenesis in glioma and demonstrated that the LINC01003-CAV1-FAK axis serves as a potential therapeutic target for glioma.
    MeSH term(s) Humans ; Up-Regulation ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Signal Transduction/genetics ; Glioma/genetics ; Glioma/metabolism ; Cell Movement/genetics ; Cell Proliferation/genetics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; MicroRNAs/genetics ; Methyltransferases/genetics ; Methyltransferases/metabolism
    Chemical Substances RNA, Long Noncoding ; MicroRNAs ; METTL3 protein, human (EC 2.1.1.62) ; Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2023-06-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2221028-3
    ISSN 1745-6150 ; 1745-6150
    ISSN (online) 1745-6150
    ISSN 1745-6150
    DOI 10.1186/s13062-023-00386-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: m

    Shan, Ting / Liu, Feiyan / Wen, Miaomiao / Chen, Zonggui / Li, Shaopeng / Wang, Yafen / Cheng, Hong / Zhou, Yu

    Molecular cell

    2023  Volume 83, Issue 24, Page(s) 4494–4508.e6

    Abstract: ... but the mechanism for this regulation has largely remained elusive. Here, we report that m ...

    Abstract In the cytoplasm, mRNAs are dynamically partitioned into translating and non-translating pools, but the mechanism for this regulation has largely remained elusive. Here, we report that m
    MeSH term(s) Humans ; Chromatography, Liquid ; HeLa Cells ; Polyribosomes/genetics ; Processing Bodies ; Proteomics ; RNA, Messenger/genetics ; Tandem Mass Spectrometry ; Adenine/analogs & derivatives ; Adenine/metabolism ; RNA-Binding Proteins/metabolism ; Protein Biosynthesis
    Chemical Substances RNA, Messenger ; 6-methyladenine (W7IBY2BGAX) ; Adenine (JAC85A2161) ; IGF2BP3 protein, human ; RNA-Binding Proteins
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2023.10.040
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5055: Show issues Location:
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  6. Article ; Online: m

    Cao, Xiaoxue / Geng, Qishun / Fan, Danping / Wang, Qiong / Wang, Xing / Zhang, Mengxiao / Zhao, Lu / Jiao, Yi / Deng, Tingting / Liu, Honglin / Zhou, Jing / Jia, Liqun / Xiao, Cheng

    Molecular cancer

    2023  Volume 22, Issue 1, Page(s) 42

    Abstract: N6-methyladenosine (m ...

    Abstract N6-methyladenosine (m
    MeSH term(s) Humans ; Methylation ; Immune Evasion ; Tumor Microenvironment ; Adenosine ; Carcinogenesis
    Chemical Substances Adenosine (K72T3FS567)
    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2091373-4
    ISSN 1476-4598 ; 1476-4598
    ISSN (online) 1476-4598
    ISSN 1476-4598
    DOI 10.1186/s12943-022-01704-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: m

    Wu, Zeming / Lu, Mingming / Liu, Di / Shi, Yue / Ren, Jie / Wang, Si / Jing, Ying / Zhang, Sheng / Zhao, Qian / Li, Hongyu / Yu, Zihui / Liu, Zunpeng / Bi, Shijia / Wei, Tuo / Yang, Yun-Gui / Xiao, Jingfa / Belmonte, Juan Carlos Izpisua / Qu, Jing / Zhang, Weiqi /
    Ci, Weimin / Liu, Guang-Hui

    Nature aging

    2023  Volume 3, Issue 6, Page(s) 705–721

    Abstract: ... How ... ...

    Abstract How N
    MeSH term(s) Animals ; Humans ; Primates/genetics ; Liver ; Aging/genetics ; Homeostasis/genetics ; Methyltransferases/genetics
    Chemical Substances METTL3 protein, human (EC 2.1.1.62) ; Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Journal Article
    ISSN 2662-8465
    ISSN (online) 2662-8465
    DOI 10.1038/s43587-023-00393-2
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  8. Article ; Online: m

    Yang, Xia / Bai, Qiaorui / Chen, Weizhong / Liang, Jiaer / Wang, Fang / Gu, Weiqi / Liu, Lei / Li, Quanfeng / Chen, Zishuo / Zhou, Anni / Long, Jianting / Tian, Han / Wu, Jueheng / Ding, Xiaofan / Zhou, Ningning / Li, Mengfeng / Yang, Yi / Cai, Junchao

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 10, Issue 20, Page(s) e2206744

    Abstract: The importance of mRNA N6-methyladenosine (m ...

    Abstract The importance of mRNA N6-methyladenosine (m
    MeSH term(s) Humans ; Adenocarcinoma ; Adenocarcinoma of Lung ; Adenosine ; Cell Cycle Proteins ; Lung Neoplasms/genetics ; RNA, Messenger
    Chemical Substances Adenosine (K72T3FS567) ; Cell Cycle Proteins ; MCM5 protein, human ; RNA, Messenger ; IGF2BP3 protein, human
    Language English
    Publishing date 2023-05-12
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202206744
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  9. Article ; Online: m

    Sun, Yuxiang / Dai, Hui / Dai, Xiaoxia / Yin, Jiekai / Cui, Yuxiang / Liu, Xiaochuan / Gonzalez, Gwendolyn / Yuan, Jun / Tang, Feng / Wang, Nan / Perlegos, Alexandra E / Bonini, Nancy M / Yang, X William / Gu, Weifeng / Wang, Yinsheng

    Nature

    2023  Volume 623, Issue 7987, Page(s) 580–587

    Abstract: Microsatellite repeat expansions within genes contribute to a number of neurological ... ...

    Abstract Microsatellite repeat expansions within genes contribute to a number of neurological diseases
    MeSH term(s) Animals ; Humans ; Adenosine/analogs & derivatives ; Adenosine/metabolism ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; DNA-Binding Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; RNA/chemistry ; RNA/genetics ; RNA/metabolism ; Trinucleotide Repeat Expansion/genetics ; Cytoplasm/metabolism ; Disease Models, Animal
    Chemical Substances Adenosine (K72T3FS567) ; ALKBH3 protein, human (EC 1.14.11.-) ; DNA-Binding Proteins ; RNA (63231-63-0) ; TBPH protein, Drosophila ; N-methyladenosine (CLE6G00625) ; TRMT61A protein, human (EC 2.1.1.220)
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06701-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
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    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  10. Article ; Online: M

    He, Mingyu / Wang, Yang / Xie, Jiajie / Pu, Jiaying / Shen, Zhihua / Wang, Ao / Li, Tao / Wang, Tong / Li, Guanghui / Liu, Ying / Mei, Zhongting / Ren, Zijing / Wang, Wenbo / Liu, Xiaoyan / Hong, Jinhuan / Liu, Qian / Lei, Hong / He, Xiaoqi / Du, Weijie /
    Yuan, Ye / Yang, Lei

    Oncogene

    2023  Volume 43, Issue 5, Page(s) 341–353

    Abstract: Doxorubicin and platinum are widely used in the frontline treatment of osteosarcoma, but resistance to chemotherapy limits its curative effect. Here, we have identified that METTL1 mediated ... ...

    Abstract Doxorubicin and platinum are widely used in the frontline treatment of osteosarcoma, but resistance to chemotherapy limits its curative effect. Here, we have identified that METTL1 mediated N
    MeSH term(s) Humans ; Ferroptosis/genetics ; MicroRNAs/metabolism ; Osteosarcoma/drug therapy ; Osteosarcoma/genetics ; Bone Neoplasms/drug therapy ; Bone Neoplasms/genetics ; RNA, Messenger ; Ferritins ; Oxidoreductases/metabolism
    Chemical Substances MicroRNAs ; RNA, Messenger ; FTH1 protein, human (EC 1.-) ; Ferritins (9007-73-2) ; Oxidoreductases (EC 1.-) ; MIRN98 microRNA, human
    Language English
    Publishing date 2023-12-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-023-02882-5
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    Zs.A 2218: Show issues Location:
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