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  1. Article ; Online: Effective Strategies to Promote the Cultivation of Public Legal Consciousness from the Perspective of Social Psychology.

    Yi, Liang / Li, Tianxia

    publication RETRACTED

    Journal of environmental and public health

    2022  Volume 2022, Page(s) 8275938

    Abstract: In order to build a harmonious economic society, show the legal function in the society, enable people to live and work in a better environment, and increase people's practicality in the legal society, it needs to be analyzed from the perspective of ... ...

    Abstract In order to build a harmonious economic society, show the legal function in the society, enable people to live and work in a better environment, and increase people's practicality in the legal society, it needs to be analyzed from the perspective of social psychology. This paper comprehensively analyzes the current public legal knowledge, uses a deep neural network model, and implements the cultivation of public legal awareness. On this basis, it integrates the data and information before and after 2020, uses the method of book case distribution training, constructs a legal framework, relies on the data distribution technology, constructs a web legal awareness training system, and increases the conditions for promoting the cultivation of public legal awareness based on the background operation of the integrated website. It can be seen that in the perspective of social psychology, the importance of the cultivation of public legal awareness can be achieved through new algorithms, so that people can pay attention to the cultivation of legal awareness, which can provide corresponding protection for the operation and maintenance of the legal system.
    MeSH term(s) Consciousness ; Humans ; Psychology, Social
    Language English
    Publishing date 2022-10-03
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2526611-1
    ISSN 1687-9813 ; 1687-9813
    ISSN (online) 1687-9813
    ISSN 1687-9813
    DOI 10.1155/2022/8275938
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: miR-26 inhibits proliferation and promotes apoptosis of multiple myeloma cells by targeting BNIP3.

    Zhou, Meiyu / Deng, Tianxia / Tan, Yonghong / Liu, Li / Wang, Mingxia

    Cellular and molecular biology (Noisy-le-Grand, France)

    2023  Volume 69, Issue 11, Page(s) 260–265

    Abstract: This study was carried out to investigate the molecular mechanism of microRNA-26 (miR-26) targeting BNIP3 to mediate proliferation and apoptosis of multiple myeloma (MM) cells. The expression of miR-26 and BNIP3 in MM and normal tissues was detected by ... ...

    Abstract This study was carried out to investigate the molecular mechanism of microRNA-26 (miR-26) targeting BNIP3 to mediate proliferation and apoptosis of multiple myeloma (MM) cells. The expression of miR-26 and BNIP3 in MM and normal tissues was detected by qRT-PCR and Western blot. According to the average expression of miR-26 and BNIP3, the patients were divided into 12 cases with high miR-26 expression group, 18 cases with low miR-26 expression group, 20 cases with BNIP3 high expression group, and 10 cases with BNIP3 low expression group. The correlation between the expression of miR-26 and BNIP3 and the clinicopathological characteristics of MM patients was compared and analyzed. The effect of up-regulation of miR-26 expression and BNIP3 overexpression on the proliferation of multiple myeloma cells RPMI8226 was examined by MTT assay. Flow cytometry was used to detect the effect of miR-26 expression and BNIP3 overexpression on the apoptosis of RPMI8226 cells. The dual luciferase reporter assay validated the targeted regulation of miR-26 on BNIP3. The expression level of miR-26 in MM tissues was lower than that in normal tissues (P<0.05), and the expression level of BNIP3 in MM tissues was higher than that in normal tissues (P<0.05). miR-26 was closely related to clinical stage, M protein type and light chain type (P<0.05), while BNIP3 was closely related to M protein type and light chain type (P<0.05). After up-regulating miR-26 expression, cell viability was significantly decreased (P<0.05), apoptosis rate was significantly increased (P<0.05) Dual luciferase reporter experiments confirmed that miR-26 could target BNIP3 and negatively regulate the expression of BNIP3 (P<0.05). Overexpression of BNIP3 reversed the effect of up-regulation of miR-26 expression on proliferation and apoptosis of RPMI8226 cells. Up-regulation of miR-26 expression inhibits MM cell proliferation and promotes apoptosis by targeting BNIP3.
    MeSH term(s) Humans ; Apoptosis/genetics ; Cell Proliferation/genetics ; Luciferases ; Membrane Proteins/genetics ; MicroRNAs/genetics ; Multiple Myeloma/genetics ; Proto-Oncogene Proteins/genetics
    Chemical Substances BNIP3 protein, human ; Luciferases (EC 1.13.12.-) ; Membrane Proteins ; MicroRNAs ; Proto-Oncogene Proteins ; MIRN26 microRNA, human
    Language English
    Publishing date 2023-11-15
    Publishing country France
    Document type Journal Article
    ZDB-ID 1161779-2
    ISSN 1165-158X ; 0145-5680
    ISSN (online) 1165-158X
    ISSN 0145-5680
    DOI 10.14715/cmb/2023.69.11.39
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3812: Show issues Location:
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  3. Article ; Online: Author Correction: Redesigning the tomato fruit shape for mechanized production.

    Zhu, Qiang / Deng, Lei / Chen, Jie / Rodríguez, Gustavo R / Sun, Chuanlong / Chang, Zeqian / Yang, Tianxia / Zhai, Huawei / Jiang, Hongling / Topcu, Yasin / Francis, David / Hutton, Samuel / Sun, Liang / Li, Chang-Bao / van der Knaap, Esther / Li, Chuanyou

    Nature plants

    2024  Volume 10, Issue 1, Page(s) 195

    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Published Erratum
    ISSN 2055-0278
    ISSN (online) 2055-0278
    DOI 10.1038/s41477-024-01620-3
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  4. Article ; Online: P53-induced GAP-43 Upregulation in Primary Cortical Neurons of Rats.

    Li, Tianxia / Jia, Yuexin / Fu, Junxian / Fu, Zhuo / Qiao, Zhidong / Liu, Xiaoyang / Lv, Ting / Tang, Rong / Yang, Guanglu

    Protein and peptide letters

    2024  

    Abstract: Objective: In this study, we employed an in-vitro culturing technique to investigate the impact of p53 on the modulation of growth-associated protein-43 (GAP-43) within the primary cortical neurons of rat specimens.: Methods: 1) Within the first 24 ... ...

    Abstract Objective: In this study, we employed an in-vitro culturing technique to investigate the impact of p53 on the modulation of growth-associated protein-43 (GAP-43) within the primary cortical neurons of rat specimens.
    Methods: 1) Within the first 24 hours after birth, the bilateral cortex was extracted from newborn Wistar rats and primary cortical neurons were cultured and identified. 2) The changes in the mRNA and protein expressions of GAP-43 induced by p53 in rat primary cortical neurons cultured in- -vitro were identified utilizing real-time polymerase chain reaction and western blot techniques.
    Results: 1) Lentiviral transfection of p53 within primary cortical neurons of rats elicited elevated levels of both mRNA and protein expressions of GAP-43, consequently culminating in a noteworthy augmentation of p53 expression. 2) The introduction of a p53 inhibitor in rat primary cortical neurons resulted in a reduction in both mRNA and protein expressions of GAP-43.
    Conclusion: Within primary rat cortical neurons, p53 has the potential to prompt an augmentation in both the transcriptional and protein expression levels of the GAP-43 protein.
    Language English
    Publishing date 2024-01-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1280776-x
    ISSN 1875-5305 ; 0929-8665
    ISSN (online) 1875-5305
    ISSN 0929-8665
    DOI 10.2174/0109298665263864231221071712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4452: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Inflammatory Cytokines in Cancer

    Tianxia Lan / Li Chen / Xiawei Wei

    Cells, Vol 10, Iss 100, p

    Comprehensive Understanding and Clinical Progress in Gene Therapy

    2021  Volume 100

    Abstract: The relationship between chronic inflammation and neoplastic diseases is not fully understood. The inflammatory microenvironment of a tumor is an intricate network that consists of numerous types of cells, cytokines, enzymes and signaling pathways. ... ...

    Abstract The relationship between chronic inflammation and neoplastic diseases is not fully understood. The inflammatory microenvironment of a tumor is an intricate network that consists of numerous types of cells, cytokines, enzymes and signaling pathways. Recent evidence shows that the crucial components of cancer-related inflammation are involved in a coordinated system to influence the development of cancer, which may shed light on the development of potential anticancer therapies. Since the last century, considerable effort has been devoted to developing gene therapies for life-threatening diseases. When it comes to modulating the inflammatory microenvironment for cancer therapy, inflammatory cytokines are the most efficient targets. In this manuscript, we provide a comprehensive review of the relationship between inflammation and cancer development, especially focusing on inflammatory cytokines. We also summarize the clinical trials for gene therapy targeting inflammatory cytokines for cancer treatment. Future perspectives concerned with new gene-editing technology and novel gene delivery systems are finally provided.
    Keywords gene therapy ; cancer therapy ; inflammation ; tumor microenvironment ; cytokine ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Tomato CYP94C1 inactivates bioactive JA-Ile to attenuate jasmonate-mediated defense during fruit ripening.

    Yang, Tianxia / Deng, Lei / Wang, Qinyang / Sun, Chuanlong / Ali, Muhammad / Wu, Fangming / Zhai, Huawei / Xu, Qian / Xin, Peiyong / Cheng, Shujing / Chu, Jinfang / Huang, Tingting / Li, Chang-Bao / Li, Chuanyou

    Molecular plant

    2024  Volume 17, Issue 4, Page(s) 509–512

    Abstract: As the master regulators of the ET signaling pathway, EIL transcription factors directly activate the expression of CYP94C1 to inactivate bioactive JA-Ile, thereby attenuating JA-mediated defense during fruit ripening. Knockout of CYP94C1 improves tomato ...

    Abstract As the master regulators of the ET signaling pathway, EIL transcription factors directly activate the expression of CYP94C1 to inactivate bioactive JA-Ile, thereby attenuating JA-mediated defense during fruit ripening. Knockout of CYP94C1 improves tomato fruit resistance to necrotrophs without compromising fruit quality.
    MeSH term(s) Solanum lycopersicum/genetics ; Fruit/genetics ; Fruit/metabolism ; Oxylipins/metabolism ; Cyclopentanes/metabolism ; Gene Expression Regulation, Plant ; Isoleucine/analogs & derivatives
    Chemical Substances jasmonic acid (6RI5N05OWW) ; jasmonoyl-isoleucine ; Oxylipins ; Cyclopentanes ; Isoleucine (04Y7590D77)
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2393618-6
    ISSN 1752-9867 ; 1674-2052
    ISSN (online) 1752-9867
    ISSN 1674-2052
    DOI 10.1016/j.molp.2024.02.004
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  7. Book ; Online: Graph Neural Network-based Power Flow Model

    Tuo, Mingjian / Li, Xingpeng / Zhao, Tianxia

    2023  

    Abstract: Power flow analysis plays a crucial role in examining the electricity flow within a power system network. By performing power flow calculations, the system's steady-state variables, including voltage magnitude, phase angle at each bus, active/reactive ... ...

    Abstract Power flow analysis plays a crucial role in examining the electricity flow within a power system network. By performing power flow calculations, the system's steady-state variables, including voltage magnitude, phase angle at each bus, active/reactive power flow across branches, can be determined. While the widely used DC power flow model offers speed and robustness, it may yield inaccurate line flow results for certain transmission lines. This issue becomes more critical when dealing with renewable energy sources such as wind farms, which are often located far from the main grid. Obtaining precise line flow results for these critical lines is vital for next operations. To address these challenges, data-driven approaches leverage historical grid profiles. In this paper, a graph neural network (GNN) model is trained using historical power system data to predict power flow outcomes. The GNN model enables rapid estimation of line flows. A comprehensive performance analysis is conducted, comparing the proposed GNN-based power flow model with the traditional DC power flow model, as well as deep neural network (DNN) and convolutional neural network (CNN). The results on test systems demonstrate that the proposed GNN-based power flow model provides more accurate solutions with high efficiency comparing to benchmark models.

    Comment: arXiv admin note: text overlap with arXiv:2112.08418
    Keywords Electrical Engineering and Systems Science - Systems and Control ; Computer Science - Machine Learning
    Subject code 621
    Publishing date 2023-07-05
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Comprehensive analysis of RNA m6A methylation in pressure overload-induced cardiac hypertrophy.

    Li, Weidong / Xing, Chenxv / Bao, Limeng / Han, Shengna / Luo, Tianxia / Wang, Zhiju / Fan, Hongkun

    BMC genomics

    2022  Volume 23, Issue 1, Page(s) 576

    Abstract: Aim: To analyze and compare the mRNA N: Materials and methods: Colorimetric quantification was used to probe the changes in m: Results: Compared with the control group, the TAC group exhibited higher m: Conclusion: Our findings provide novel ... ...

    Abstract Aim: To analyze and compare the mRNA N
    Materials and methods: Colorimetric quantification was used to probe the changes in m
    Results: Compared with the control group, the TAC group exhibited higher m
    Conclusion: Our findings provide novel information regarding m
    MeSH term(s) Adenosine/metabolism ; Animals ; Cardiomegaly/genetics ; Methylation ; Mice ; RNA, Messenger/genetics ; Transcriptome
    Chemical Substances RNA, Messenger ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2022-08-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041499-7
    ISSN 1471-2164 ; 1471-2164
    ISSN (online) 1471-2164
    ISSN 1471-2164
    DOI 10.1186/s12864-022-08833-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy.

    Lan, Tianxia / Chen, Li / Wei, Xiawei

    Cells

    2021  Volume 10, Issue 1

    Abstract: The relationship between chronic inflammation and neoplastic diseases is not fully understood. The inflammatory microenvironment of a tumor is an intricate network that consists of numerous types of cells, cytokines, enzymes and signaling pathways. ... ...

    Abstract The relationship between chronic inflammation and neoplastic diseases is not fully understood. The inflammatory microenvironment of a tumor is an intricate network that consists of numerous types of cells, cytokines, enzymes and signaling pathways. Recent evidence shows that the crucial components of cancer-related inflammation are involved in a coordinated system to influence the development of cancer, which may shed light on the development of potential anticancer therapies. Since the last century, considerable effort has been devoted to developing gene therapies for life-threatening diseases. When it comes to modulating the inflammatory microenvironment for cancer therapy, inflammatory cytokines are the most efficient targets. In this manuscript, we provide a comprehensive review of the relationship between inflammation and cancer development, especially focusing on inflammatory cytokines. We also summarize the clinical trials for gene therapy targeting inflammatory cytokines for cancer treatment. Future perspectives concerned with new gene-editing technology and novel gene delivery systems are finally provided.
    MeSH term(s) Clinical Trials as Topic ; Cytokines/metabolism ; Genetic Therapy ; Humans ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Neoplasms/genetics ; Neoplasms/therapy
    Chemical Substances Cytokines ; Inflammation Mediators
    Language English
    Publishing date 2021-01-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10010100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Effect of Different Phosphates on Pyrolysis Temperature-Dependent Carbon Sequestration and Phosphorus Release Performance in Biochar.

    Bai, Tianxia / Ma, Wenge / Li, Wenhui / Jiang, Jinling / Chen, Jiamin / Cao, Rui / Yang, Wenjie / Dong, Dan / Liu, Tingwu / Xu, Yonggang

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 9

    Abstract: Carbon sequestration is the primary function of biochar. Hence, it is necessary to design biochar with high carbon (C) retention and low C loss. In this study, three P compounds, including ... ...

    Abstract Carbon sequestration is the primary function of biochar. Hence, it is necessary to design biochar with high carbon (C) retention and low C loss. In this study, three P compounds, including KH
    MeSH term(s) Phosphates ; Temperature ; Phosphorus ; Carbon Sequestration ; Pyrolysis ; Hydrogen Peroxide ; Charcoal ; Carbon
    Chemical Substances biochar ; Phosphates ; Phosphorus (27YLU75U4W) ; Hydrogen Peroxide (BBX060AN9V) ; Charcoal (16291-96-6) ; Carbon (7440-44-0)
    Language English
    Publishing date 2023-05-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28093950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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