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Article ; Online: Gold(I)-Mediated Cycloisomerization/Cycloaddition Enables Bioinspired Syntheses of Neonectrolides B-E and Analogues.

Purgett, Thomas J / Dyer, Matthew W / Bickel, Bryce / McNeely, James / Porco, John A

Journal of the American Chemical Society

2019 Volume 141, Issue 38, Page(s) 15135–15144

Abstract: Development of a synthetic route to the oxaphenalenone (OP) natural products neonectrolides B-E is ...

Abstract	Development of a synthetic route to the oxaphenalenone (OP) natural products neonectrolides B-E is described. The synthesis relies on gold-catalyzed 6-
MeSH term(s)	Biological Products/chemical synthesis ; Biological Products/chemistry ; Cycloaddition Reaction ; Gold/chemistry ; Molecular Structure ; Quantum Theory ; Stereoisomerism
Chemical Substances	Biological Products ; Gold (7440-57-5)
Language	English
Publishing date	2019-09-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.9b06355
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Article: Gold(I)-Mediated Cycloisomerization/Cycloaddition Enables Bioinspired Syntheses of Neonectrolides B–E and Analogues

Purgett, Thomas J / Dyer, Matthew W / Bickel, Bryce / McNeely, James / Porco, John A

Journal of the American Chemical Society. 2019 Aug. 30, v. 141, no. 38

2019

Abstract: Development of a synthetic route to the oxaphenalenone (OP) natural products neonectrolides B–E is ... the neonectrolides. The tricyclic OP natural product SF226 could be converted to corymbiferan lactone E and a related ... of neonectrolides B–E as well as previously unreported exo-diastereomers. ...

Abstract	Development of a synthetic route to the oxaphenalenone (OP) natural products neonectrolides B–E is described. The synthesis relies on gold-catalyzed 6-endo-dig hydroarylation of an unusual enynol substrate as well as a one-pot Rieche formylation/cyclization/deprotection sequence to efficiently construct the tricyclic oxaphenalenone framework in the form of a masked ortho-quinone methide (o-QM). A tandem cycloisomerization/[4 + 2] cycloaddition strategy was employed to quickly construct molecules resembling the neonectrolides. The tricyclic OP natural product SF226 could be converted to corymbiferan lactone E and a related masked o-QM. Our study culminates with the application of the tandem reaction sequence to syntheses of neonectrolides B–E as well as previously unreported exo-diastereomers.
Keywords	catalytic activity ; cycloaddition reactions ; gold ; lactones
Language	English
Dates of publication	2019-0830
Size	p. 15135-15144.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.9b06355
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Article ; Online: Technologies for interprofessional education: the interprofessional education-distributed "e-Classroom-of-the-Future".

Weinstein, Ronald S / McNeely, Richard A / Holcomb, Michael J / Doppalapudi, Leela / Sotelo, Michael J / Lopez, Ana Maria / Erps, Kristine A / Martin, Christopher J / Krupinski, Elizabeth A / Graham, Anna R / Barker, Gail P

Journal of allied health

2010 Volume 39 Suppl 1, Page(s) 238–245

Abstract: Communications strategies are central to the planning and execution of interprofessional education (IPE) programs. The diversity of telecommunications-based tools and platforms available for IPE is rapidly expanding. Each tool and platform has a ... ...

Abstract	Communications strategies are central to the planning and execution of interprofessional education (IPE) programs. The diversity of telecommunications-based tools and platforms available for IPE is rapidly expanding. Each tool and platform has a potentially important role to play. The selection, testing, and embedding of tools, such as social networking platforms, within education programs can be very challenging. The goal was to create, in Phoenix, a "command-and-control" video conferencing center (the T-Health Amphitheater or Telehealth Amphitheater) in which tele-consultation patients, located physically at one of the affiliated tele-clinics around the state, could be presented electronically to interprofessional teams of faculty members from the University of Arizona Colleges of Medicine, Nursing, Pharmacy, and Public Health, as well as those from the allied health colleges of other universities in Arizona, for interprofessional team training in a virtual classroom setting. The T-Health video conferencing facility was designed and built. Early assessments show that its novel learning environment is student- and faculty-friendly. T-Health Amphitheater's pair of innovative visible social networking platforms (eStacks™ and eSwaps™) may help break down some of the traditional communications barriers encountered in healthcare IPE and medical practices.
MeSH term(s)	Allied Health Personnel/education ; Arizona ; Computer-Assisted Instruction ; Cooperative Behavior ; Education, Professional/methods ; Educational Technology ; Facility Design and Construction ; Humans ; Interdisciplinary Studies ; Interprofessional Relations ; Models, Educational ; Program Development
Language	English
Publishing date	2010
Publishing country	United States
Document type	Journal Article
ZDB-ID	197884-6
ISSN	1945-404X ; 0090-7421
ISSN (online)	1945-404X
ISSN	0090-7421
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Article ; Online: Visual performance and subjective experience 3 months and 12 months after combined implantation of 2 new complementary continuous phase multifocal intraocular lenses.

McNeely, Richard N / Stewart, Stephen A / Moore, Jonathan E

Journal of cataract and refractive surgery

2023 Volume 49, Issue 9, Page(s) 921–928

Abstract: Purpose: To assess the 3-month and 12-month postoperative visual performance and subjective quality of vision (QoV) after combined implantation of complementary continuous phase multifocal intraocular lenses (IOLs).: Setting: Private practice, United ...

Abstract	Purpose: To assess the 3-month and 12-month postoperative visual performance and subjective quality of vision (QoV) after combined implantation of complementary continuous phase multifocal intraocular lenses (IOLs). Setting: Private practice, United Kingdom. Design: Case series. Methods: The study enrolled 44 patients undergoing phacoemulsification with implantation of an Artis Symbiose Mid in the dominant eye and an Artis Symbiose Plus in the nondominant eye. Refraction, uncorrected distance visual acuity (UDVA), corrected distance visual acuity, uncorrected intermediate visual acuity (UIVA), uncorrected near visual acuity (UNVA), electronic reading desk, and a QoV questionnaire were evaluated at 3 months and 12 months postoperatively. Results: The mean binocular UDVA was -0.06 ± 0.08 logMAR and -0.07 ± 0.06 logMAR at 3 months and 12 months ( P = .097), respectively. The mean binocular UIVA was 0.03 ± 0.13 logMAR and 0.03 ± 0.10 logMAR ( P = 1.0), respectively. The mean binocular UNVA was 0.07 ± 0.10 logMAR and 0.07 ± 0.08 logMAR ( P = .875), respectively. There was a significant improvement in QoV for both day and night between 3 and 12 months, with a significant reduction in halos at 12 months. Spectacle independence was reported in 93.2% of cases at 12 months. Conclusions: The Artis Symbiose Mid and Plus IOL combined implantation provided an excellent range of uncorrected vision at 3 and 12 months. There was a significant improvement in QoV and less halos at 12 months. This IOL combination provided very high rates of complete spectacle independence.
MeSH term(s)	Humans ; Multifocal Intraocular Lenses ; Lens Implantation, Intraocular ; Patient Satisfaction ; Prosthesis Design ; Lenses, Intraocular ; Refraction, Ocular ; Phacoemulsification ; Vision, Binocular
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	632744-8
ISSN	1873-4502 ; 0886-3350
ISSN (online)	1873-4502
ISSN	0886-3350
DOI	10.1097/j.jcrs.0000000000001236
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Article: Heritability of C-reactive protein and association with apolipoprotein E genotypes in Japanese Americans.

Austin, M A / Zhang, C / Humphries, S E / Chandler, W L / Talmud, P J / Edwards, K L / Leonetti, D L / McNeely, M J / Fujimoto, W Y

Annals of human genetics

2004 Volume 68, Issue Pt 3, Page(s) 179–188

Abstract: Numerous studies have demonstrated that increased C-reactive protein (CRP) levels predict coronary heart disease, stroke, peripheral vascular disease, and diabetes, and are associated with features of the metabolic syndrome. Only three previous studies ... ...

Abstract	Numerous studies have demonstrated that increased C-reactive protein (CRP) levels predict coronary heart disease, stroke, peripheral vascular disease, and diabetes, and are associated with features of the metabolic syndrome. Only three previous studies have investigated the heritability of CRP levels, primarily in samples of Caucasian families. The purpose of the present study was to estimate the magnitude of genetic influences on CRP levels, and to examine potential associations between variation in the APOE gene and CRP levels, using a sample of 562 individual Japanese Americans from 68 extended kindreds. In general, correlation coefficients between first-degree relatives for CRP were approximately 0.2, and spouse correlations did not differ from zero, consistent with genetic influences. Heritability estimates were approximately 0.3 (p < 0.01), even with adjustment for factors known to influence CRP levels. A significant relationship was seen between unadjusted CRP levels and APOE genotypes (p = 0.02), with the highest mean CRP level among epsilon2 carriers (1.20 mg/L), and nearly the same mean levels among epsilon3/epsilon3 subjects and epsilon4 carriers (0.72 and 0.74 mg/L, respectively). However, this relationship was diminished with adjustment for covariates (p = 0.07). These results demonstrate the presence of both genetic and environmental effects on CRP levels among Asian Americans, and additional studies are needed to determine if the APOE gene contributes to these genetic influences.
MeSH term(s)	Adult ; Aged ; Apolipoproteins E/genetics ; Asian Americans/genetics ; C-Reactive Protein/genetics ; C-Reactive Protein/metabolism ; Female ; Gene Frequency ; Genetics, Population ; Genotype ; Humans ; Male ; Middle Aged ; Pedigree
Chemical Substances	Apolipoproteins E ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2004-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	333-5
ISSN	1469-1809 ; 0003-4800
ISSN (online)	1469-1809
ISSN	0003-4800
DOI	10.1046/j.1529-8817.2004.00078.x
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Article: Effects of vitamin E preparations on plasma tocopherol levels.

OVERMAN, R S / McNEELY, J M / TODD, M E / WRIGHT, I S

The Journal of clinical nutrition

2003 Volume 2, Issue 3, Page(s) 168–178

MeSH term(s)	Blood ; Humans ; Vitamin E/blood
Chemical Substances	Vitamin E (1406-18-4)
Language	English
Publishing date	2003-10-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	280047-0
ISSN	0095-9871
ISSN	0095-9871
DOI	10.1093/ajcn/2.3.168
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Article ; Online: Editorial: Aerospace health and safety: today and the future, volume I.

Scheibler, Christopher / Crane-Godreau, Mardi A / McNeely, Eileen

Frontiers in public health

2023 Volume 11, Page(s) 1264524

MeSH term(s)	Travel ; Occupational Exposure
Language	English
Publishing date	2023-09-25
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1264524
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Article ; Online: Patient-Reported Decisional Regret After Operative Otolaryngology Procedures: A Scoping Review.

Liu, Alice Q / McNeely, Brendan D / Prisman, Eitan / Hu, Amanda

The Laryngoscope

2023

Abstract: Objective: To review the published literature on decisional regret in adult patients undergoing operative otolaryngology procedures. The primary outcome was decisional regret scale (DRS) scores. DRS scores of 0 indicate no regret, 1-25 mild regret, and > ...

Abstract	Objective: To review the published literature on decisional regret in adult patients undergoing operative otolaryngology procedures. The primary outcome was decisional regret scale (DRS) scores. DRS scores of 0 indicate no regret, 1-25 mild regret, and >25 moderate to strong/severe regret. Data sources: A comprehensive librarian-designed strategy was used to search MEDLINE, Embase, and CINAHL from inception to September 2023. Review methods: Inclusion criteria consisted of English-language studies of adult patients who underwent operative otolaryngology treatments and reported DRS scores. Data was extracted by two independent reviewers. Preferred Reporting Items for Systematic Reviews and Meta-analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines were followed. Oxford Centre's Levels of Evidence were used for quality assessment. Results: In total, 6306 studies were screened by two independent reviewers; 13 studies were included after full-text analysis. Subspecialties comprised: Head and neck (10), endocrine (1), general (1), and rhinology (1). The DRS results of the included studies spanned a mean range of 10.1-23.9 or a median range of 0-20.0. There was a trend toward more decisional regret after large head and neck procedures or when patients underwent multiple treatment modalities. Depression, anxiety, and patient-reported quality of life measures were all correlated with decisional regret. Oxford Centre's Levels of Evidence ranged from 2 to 4. Conclusion: This is the first comprehensive review of decisional regret in otolaryngology. The majority of patients had no or mild (DRS <25) decisional regret after otolaryngology treatments. Future research on pre-operative counseling and shared decision-making to further minimize patient decisional regret is warranted. Level of evidence: N/A Laryngoscope, 2023.
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.31176
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Article ; Online: Participants' Evaluation and Outcomes following Integration of Self-Management Support into Outpatient Schizophrenia Case Management.

McNeely, Heather E / Letts, Lori / Martin, Mary-Lou / Strong, Susan

International journal of environmental research and public health

2023 Volume 20, Issue 4

Abstract: 1) Background: Self-management is advocated as a feasible, effective intervention to support individuals to actively manage the impact of illness and live healthier lives. We sought to evaluate a piloted self-management model, SET for Health, tailored ... ...

Abstract	(1) Background: Self-management is advocated as a feasible, effective intervention to support individuals to actively manage the impact of illness and live healthier lives. We sought to evaluate a piloted self-management model, SET for Health, tailored for individuals living with schizophrenia embedded within ambulatory case management. (2) Methods: A mixed-methods design engaged 40 adults living with schizophrenia in the SET for Health protocol. Functional and symptomatic outcomes were measured by self-report and clinician ratings at baseline and completion of self-management plans, on average one year later. Semi-structured qualitative client interviews invited evaluations of personal experiences with the intervention. (3) Results: Significant improvements were found concerning client illness severity, social and occupational functioning, illness management and functional recovery with reductions in emergency visits and days in hospital. Clients endorsed the value of the intervention. Baseline clinical characteristics did not predict who benefited. Participation contributed to motivational gains and quality of life. (4) Conclusions: Results confirmed self-management support embedded within traditional case management improved clients' clinical and functional status, and contributed to quality of life. Clients engaged in their recovery and actively used self-management strategies. Self-management can be successfully adopted by clients with schizophrenia regardless of age, gender, education, illness severity or duration.
MeSH term(s)	Adult ; Humans ; Schizophrenia ; Case Management ; Quality of Life ; Self-Management ; Outpatients
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20043035
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Article ; Online: Figure it out on your own: a mixed-method study on pelvic health survivorship care after gynecologic cancer treatments.

Bernard, Stéphanie / Wiebe, Ericka / Waters, Alexandra / Selmani, Sabrina / Turner, Jill / Dufour, Sinéad / Tandon, Puneeta / Pepin, Donna / McNeely, Margaret L

Journal of cancer survivorship : research and practice

2024

Abstract: Purpose: Pelvic health issues after treatment for gynecological cancer are common. Due to challenges in accessing physiotherapy services, exploring virtual pelvic healthcare is essential. This study aims to understand needs, preferences, barriers, and ... ...

Abstract	Purpose: Pelvic health issues after treatment for gynecological cancer are common. Due to challenges in accessing physiotherapy services, exploring virtual pelvic healthcare is essential. This study aims to understand needs, preferences, barriers, and facilitators for a virtual pelvic healthcare program for gynecological cancer survivors. Methods: A multi-center, sequential mixed-methods study was conducted. An anonymous online survey (N=50) gathered quantitative data on pelvic health knowledge, opportunities, and motivation. Focus groups (N=14) explored patient experiences and consensus on pelvic health interventions and virtual delivery. Quantitative data used descriptive statistics, and focus group analyses employed inductive thematic analysis. Findings were mapped to the capability, opportunity, and motivation (COM-B) behavior change model. Results: Participants reported lacking knowledge about pelvic health interventions and capability related to the use of vaginal dilators and continence care. Barriers to opportunity included lack of healthcare provider-initiated pelvic health discussions, limited time in clinic with healthcare providers, finding reliable information, and cost of physical therapy pelvic health services. Virtual delivery was seen favorably and may help to address motivational barriers related to embarrassment and frustration with care. Conclusion: Awareness of pelvic healthcare is lacking among people treated for gynecological cancer. Virtual delivery of pelvic health interventions is perceived as a solution to enhance access while minimizing travel, cost, embarrassment, and exposure risks. Implications for cancer survivors: A better understanding of the pelvic health needs of individuals following gynecological cancer treatments enables the development of tailored virtual pelvic health rehabilitation interventions which may improve access to pelvic health survivorship care.
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388888-X
ISSN	1932-2267 ; 1932-2259
ISSN (online)	1932-2267
ISSN	1932-2259
DOI	10.1007/s11764-024-01565-8
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