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  1. Book ; Online ; E-Book: Greenspan's basic & clinical endocrinology

    Gardner, David G. / Gardner, David G / Shoback, Dolores M / Greenspan, Francis S.

    2018  

    Title variant Basic & Clinical Endocrinology
    MeSH term(s) Endocrine Glands/physiology ; Endocrine System Diseases ; Hormones/physiology
    Language English
    Edition 10th edition
    Publisher McGraw Hill Education
    Publishing place New York
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 978-1-259-58928-7 ; 1-259-58928-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Article ; Online: Misidentified Dopamine Agonists Undermine Investigation Into Aripiprazole Link With Impulse Control Disorders.

    Gardner, David M

    Journal of clinical psychopharmacology

    2023  Volume 43, Issue 2, Page(s) 190–191

    MeSH term(s) Humans ; Aripiprazole ; Dopamine Agonists ; Disruptive, Impulse Control, and Conduct Disorders/drug therapy ; Antipsychotic Agents/therapeutic use
    Chemical Substances Aripiprazole (82VFR53I78) ; Dopamine Agonists ; Antipsychotic Agents
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604631-9
    ISSN 1533-712X ; 0271-0749
    ISSN (online) 1533-712X
    ISSN 0271-0749
    DOI 10.1097/JCP.0000000000001674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Gardner and Sutherland's chromosome abnormalities and genetic counseling

    Gardner, R. J. McKinlay / Amor, David J.

    (Oxford monographs on medical genetics ; no. 70)

    2018  

    Title translation Chromosome abnormalities and genetic counseling
    Author's details R. J. McKinlay Gardner(Adjunct Professor, Clinical Genetics Group, University of Otago, Dunedin, NewZealand), David J. Amor (Lorenzo and Pamela Galli Chair, University of Melbourne, Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Roayl Children's Hospital, Melbourne, Australia)
    Series title Oxford monographs on medical genetics ; no. 70
    Collection
    Keywords Chromosome Aberrations ; Genetic Counseling
    Language English
    Size xii, 714 Seiten, Illustrationen
    Edition Fifth edition
    Publisher Oxford University Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT019651582
    ISBN 978-0-19-932900-7 ; 0-19-932900-1
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2018 A 498 available for loan (reading room) Lesesaal EG

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  4. Book: Antipsychotics and their side effects

    Gardner, David M. / Teehan, Michael D.

    2011  

    Author's details David M. Gardner ; Michael D. Teehan
    Language English
    Size XXVII, 199 S. : Ill., 25 cm
    Publisher Cambridge Univ. Press
    Publishing place Cambridge u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016599631
    ISBN 978-0-521-13208-4 ; 0-521-13208-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 5903 order for loan Magazin

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  5. Article ; Online: Prescriber Acceptability of a Direct-to-Patient Intervention for Benzodiazepine Receptor Agonist Deprescribing and Behavioural Management of Insomnia in Older Adults.

    Murphy, Andrea L / Turner, Justin P / Rajda, Malgorzata / Allen, Kathleen G / Gardner, David M

    Canadian journal on aging = La revue canadienne du vieillissement

    2024  , Page(s) 1–9

    Abstract: Behavioural treatments are recommended first-line for insomnia, but long-term benzodiazepine receptor agonist (BZRA) use remains common and engaging patients in a deprescribing consultation is challenging. Few deprescribing interventions directly target ... ...

    Abstract Behavioural treatments are recommended first-line for insomnia, but long-term benzodiazepine receptor agonist (BZRA) use remains common and engaging patients in a deprescribing consultation is challenging. Few deprescribing interventions directly target patients. Prescribers' support of patient-targeted interventions may facilitate their uptake. Recently assessed in the Your Answers When Needing Sleep in New Brunswick (YAWNS NB) study, Sleepwell (mysleepwell.ca) was developed as a direct-to-patient behaviour change intervention promoting BZRA deprescribing and non-pharmacological insomnia management. BZRA prescribers of YAWNS NB participants were invited to complete an online survey assessing the acceptability of Sleepwell as a direct-to-patient intervention. The survey was developed using the seven construct components of the theoretical framework of acceptability (TFA) framework. Respondents (40/250, 17.2%) indicated high acceptability, with positive responses per TFA construct averaging 32.3/40 (80.7%). Perceived as an ethical, credible, and useful tool, Sleepwell also promoted prescriber-patient BZRA deprescribing engagements (11/19, 58%). Prescribers were accepting of Sleepwell and supported its application as a direct-to-patient intervention.
    Language English
    Publishing date 2024-03-08
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 632851-9
    ISSN 1710-1107 ; 0714-9808
    ISSN (online) 1710-1107
    ISSN 0714-9808
    DOI 10.1017/S0714980824000114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Erythropoietin

    O'Flaherty, Róisín / Amez Martín, Manuela / Gardner, Richard A / Jennings, Patrick M / Rudd, Pauline M / Spencer, Daniel I R / Falck, David

    Biomolecules

    2024  Volume 14, Issue 1

    Abstract: Recombinant human erythropoietin (EPO) is a biopharmaceutical frequently used in the treatment of anemia. It is a heavily glycosylated protein with a diverse and complex glycome. ... ...

    Abstract Recombinant human erythropoietin (EPO) is a biopharmaceutical frequently used in the treatment of anemia. It is a heavily glycosylated protein with a diverse and complex glycome. EPO
    MeSH term(s) Humans ; Glycosylation ; Erythropoietin ; Protein Processing, Post-Translational ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Acetylation
    Chemical Substances Erythropoietin (11096-26-7)
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14010125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The immense value of qualitative research to pharmacy.

    Gardner, David M

    Canadian pharmacists journal : CPJ = Revue des pharmaciens du Canada : RPC

    2016  Volume 149, Issue 4, Page(s) 195

    Language English
    Publishing date 2016-07-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2200008-2
    ISSN 1913-701X ; 1715-1635
    ISSN (online) 1913-701X
    ISSN 1715-1635
    DOI 10.1177/1715163516651881
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  8. Article ; Online: Differences/Disorders of Sex Development: Medical Conditions at the Intersection of Sex and Gender.

    Sandberg, David E / Gardner, Melissa

    Annual review of clinical psychology

    2022  Volume 18, Page(s) 201–231

    Abstract: Defined as congenital conditions in which development of chromosomal, gonadal, or anatomic sex is atypical, differences or disorders of sex development (DSDs) comprise many discrete diagnoses ranging from those associated with few phenotypic differences ... ...

    Abstract Defined as congenital conditions in which development of chromosomal, gonadal, or anatomic sex is atypical, differences or disorders of sex development (DSDs) comprise many discrete diagnoses ranging from those associated with few phenotypic differences between affected and unaffected individuals to those where questions arise regarding gender of rearing, gonadal tumor risk, genital surgery, and fertility. Controversies exist in numerous areas including how DSDs are conceptualized, how to refer to the set of conditions and those affected by them, and aspects of clinical management that extend from social media to legislative bodies, courts of law, medicine, clinical practice, and scholarly research in psychology and sociology. In addition to these aspects, this review covers biological and social influences on psychosocial development and adjustment, the psychosocial and psychosexual adaptation of people born with DSDs, and roles for clinical psychologists in the clinical management of DSDs.
    MeSH term(s) Disorders of Sex Development/diagnosis ; Disorders of Sex Development/psychology ; Disorders of Sex Development/therapy ; Female ; Gender Identity ; Humans ; Male ; Sexual Development
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2194815-X
    ISSN 1548-5951 ; 1548-5943
    ISSN (online) 1548-5951
    ISSN 1548-5943
    DOI 10.1146/annurev-clinpsy-081219-101412
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  9. Article ; Online: Evaluation of an artificial intelligence-facilitated sperm detection tool in azoospermic samples for use in ICSI.

    Goss, Dale M / Vasilescu, Steven A / Vasilescu, Phillip A / Cooke, Simon / Kim, Shannon Hk / Sacks, Gavin P / Gardner, David K / Warkiani, Majid E

    Reproductive biomedicine online

    2024  Volume 49, Issue 1, Page(s) 103910

    Abstract: Research question: Can artificial intelligence (AI) improve the efficiency and efficacy of sperm searches in azoospermic samples?: Design: This two-phase proof-of-concept study began with a training phase using eight azoospermic patients (>10,000 ... ...

    Abstract Research question: Can artificial intelligence (AI) improve the efficiency and efficacy of sperm searches in azoospermic samples?
    Design: This two-phase proof-of-concept study began with a training phase using eight azoospermic patients (>10,000 sperm images) to provide a variety of surgically collected samples for sperm morphology and debris variation to train a convolutional neural network to identify spermatozoa. Second, side-by-side testing was undertaken on two cohorts of non-obstructive azoospermia patient samples: an embryologist versus the AI identifying all the spermatozoa in the still images (cohort 1, n = 4), and a side-by-side test with a simulated clinical deployment of the AI model with an intracytoplasmic sperm injection microscope and the embryologist performing a search with and without the aid of the AI (cohort 2, n = 4).
    Results: In cohort 1, the AI model showed an improvement in the time taken to identify all the spermatozoa per field of view (0.02 ± 0.30  ×  10
    Conclusions: AI-powered image analysis has the potential for seamless integration into laboratory workflows, to reduce the time to identify and isolate spermatozoa from surgical sperm samples from hours to minutes, thus increasing success rates from these treatments.
    Language English
    Publishing date 2024-02-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2113823-0
    ISSN 1472-6491 ; 1472-6483
    ISSN (online) 1472-6491
    ISSN 1472-6483
    DOI 10.1016/j.rbmo.2024.103910
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  10. Article ; Online: Periodontal disease in patients with WHIM syndrome.

    Brenchley, Laurie / McDermott, David H / Gardner, Pamela J / Silva, Lakmali M / Gao, Ji-Liang / Cho, Elena / Velez, Daniel / Moutsopoulos, Niki M / Murphy, Philip M / Fraser, David

    Journal of clinical periodontology

    2024  Volume 51, Issue 4, Page(s) 464–473

    Abstract: Aim: WHIM (warts, hypogammaglobulinaemia, infections and myelokathexis) syndrome is a rare combined primary immunodeficiency disease caused by gain-of-function (GOF) mutations in the chemokine receptor CXCR4 and includes severe neutropenia as a common ... ...

    Abstract Aim: WHIM (warts, hypogammaglobulinaemia, infections and myelokathexis) syndrome is a rare combined primary immunodeficiency disease caused by gain-of-function (GOF) mutations in the chemokine receptor CXCR4 and includes severe neutropenia as a common feature. Neutropenia is a known risk factor for periodontitis; however, a detailed periodontal evaluation of a WHIM syndrome cohort is lacking. This study aimed to establish the evidence base for the periodontal status of patients with WHIM syndrome.
    Materials and methods: Twenty-two adult WHIM syndrome patients and 22 age- and gender-matched healthy volunteers (HVs) were evaluated through a comprehensive medical and periodontal examination. A mouse model of WHIM syndrome was assessed for susceptibility to naturally progressing or inducible periodontitis.
    Results: Fourteen patients with WHIM syndrome (63.6%) and one HV (4.5%) were diagnosed with Stage III/IV periodontitis. No WHIM patient presented with the early onset, dramatic clinical phenotypes typically associated with genetic forms of neutropenia. Age, but not the specific CXCR4 mutation or absolute neutrophil count, was associated with periodontitis severity in the WHIM cohort. Mice with a Cxcr4 GOF mutation did not exhibit increased alveolar bone loss in spontaneous or ligature-induced periodontitis.
    Conclusions: Overall, WHIM syndrome patients presented with an increased severity of periodontitis despite past and ongoing neutrophil mobilization treatments. GOF mutations in CXCR4 may be a risk factor for periodontitis in humans.
    MeSH term(s) Adult ; Humans ; Animals ; Mice ; Immunologic Deficiency Syndromes/complications ; Immunologic Deficiency Syndromes/genetics ; Immunologic Deficiency Syndromes/diagnosis ; Primary Immunodeficiency Diseases/complications ; Primary Immunodeficiency Diseases/genetics ; Warts/genetics ; Warts/therapy ; Neutropenia/complications ; Neutropenia/genetics ; Periodontal Diseases/complications ; Periodontal Diseases/genetics ; Periodontitis/complications ; Periodontitis/genetics
    Language English
    Publishing date 2024-01-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 188647-2
    ISSN 1600-051X ; 0303-6979
    ISSN (online) 1600-051X
    ISSN 0303-6979
    DOI 10.1111/jcpe.13940
    Database MEDical Literature Analysis and Retrieval System OnLINE

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