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  1. Article ; Online: Gastrointestinal Side Effects of Post-Transplant Therapy.

    Lucan, Valerian Ciprian / Berardinelli, Luisa

    Journal of gastrointestinal and liver diseases : JGLD

    2016  Volume 25, Issue 3, Page(s) 367–373

    Abstract: Modern immunosuppressive therapy has produced a real revolution in renal and organ transplantation but it comes with the price of multiple side effects. There are many gastrointestinal (GI) complications that are the consequence of transplant ... ...

    Abstract Modern immunosuppressive therapy has produced a real revolution in renal and organ transplantation but it comes with the price of multiple side effects. There are many gastrointestinal (GI) complications that are the consequence of transplant immunosuppressant medication. In fact, for any immunosuppressant therapy, certain standardized precepts and attitudes that aim to reduce the incidence and the impact of the medication side effects must be applied. Many patients undergo renal transplantation and the physicians have to be aware of the advantages and the risks associated. This article reviews the main GI complications that may arise as a consequence of immunosuppressive therapy after solid organ transplantation, focusing on renal and renal/pancreas transplantation, as well as the ways in which the incidence of these complications can be reduced. Management of the post-transplant therapy is mandatory in order to increase not only the grafts' and the patients' survival, but also their quality of life by the occurrence of fewer complications.
    MeSH term(s) Gastrointestinal Diseases/chemically induced ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Diseases/immunology ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Graft Survival/drug effects ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation/adverse effects ; Opportunistic Infections/chemically induced ; Opportunistic Infections/diagnosis ; Opportunistic Infections/immunology ; Pancreas Transplantation/adverse effects ; Prognosis ; Risk Factors ; Treatment Outcome
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2016-09
    Publishing country Romania
    Document type Journal Article ; Review
    ZDB-ID 2427021-0
    ISSN 1842-1121 ; 1841-8724
    ISSN (online) 1842-1121
    ISSN 1841-8724
    DOI 10.15403/jgld.2014.1121.253.ptt
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3825: Show issues Location:
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  2. Article ; Online: Re: Mark W. Ball, Nathaniel Readal, Phillip M. Pierorazio, Mohamad E. Allaf. Splitting One Kidney into Two: Robotic Partial Kidney Transplant in a Porcine Model. Eur Urol 2016;69:968-9.

    Lucan, Valerian Ciprian / Butticè, Salvatore / Pappalardo, Rosa / Magno, Carlo

    European urology

    2016  Volume 70, Issue 3, Page(s) e81

    Language English
    Publishing date 2016-09
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2016.03.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Renal Tumor Cryoablation Planning. The Efficiency of Simulation on Reconstructed 3D CT Scan

    Ciprian Valerian LUCAN

    Applied Medical Informatics, Vol 27, Iss 4, Pp 1-

    2010  Volume 6

    Abstract: Introduction & Objective: Nephron-sparing surgical techniques risks are related to tumor relationships with adjacent anatomic structures. Complexity of the renal anatomy drives the interest to develop tools for 3D reconstruction and surgery simulation. ... ...

    Abstract Introduction & Objective: Nephron-sparing surgical techniques risks are related to tumor relationships with adjacent anatomic structures. Complexity of the renal anatomy drives the interest to develop tools for 3D reconstruction and surgery simulation. The aim of the article was to assess the simulation on reconstructed 3D CT scan used for planning the cryoablation. Material & Method: A prospective randomized study was performed between Jan. 2007 and July 2009 on 27 patients who underwent retroperitoneoscopic T1a renal tumors cryoablation (RC). All patients were assessed preoperatively by CT scan, also used for 3D volume rendering. In the Gr.A, the patients underwent surgery planning by simulation on 3D CT scan. In the Gr.B., patients underwent standard RC. The two groups were compared in terms of surgical time, bleeding, postoperative drainage, analgesics requirement, hospital stay, time to socio-professional reintegration. Results: Fourteen patients underwent preoperative cryoablation planning (Gr.A) and 13 patients underwent standard CR (Gr.B). All parameters analyzed were shorter in the Gr.A. On multivariate logistic regression, only shortens of the surgical time (138.79±5.51 min. in Gr.A. vs. 140.92±5.54 min in Gr.B.) and bleeding (164.29±60.22 mL in Gr.A. vs. 215.38±100.80 mL in Gr.B.) achieved statistical significance (p<0.05). The number of cryoneedles assessed by simulation had a 92.52% accuracy when compared with those effectively used. Conclusions: Simulation of the cryoablation using reconstructed 3D CT scan improves the surgical results. The application used for simulation was able to accurately assess the number of cryoneedles required for tumor ablation, their direction and approach.
    Keywords Cryosurgery ; Renal tumor ; Nephron-sparing surgery ; Computer applications to medicine. Medical informatics ; R858-859.7
    Subject code 616
    Language English
    Publishing date 2010-12-01T00:00:00Z
    Publisher Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Does Vaginal Wall Surgical Trauma During Hybrid Transvaginal NOTES Nephrectomy Have Traumatic Effects On Sexual Functions? A Prospective Study.

    Sener, Tarik Emre / Sahin, Bahadir / Fichera, Michele / Panella, Marco Marzio / Tanidir, Yiloren / Lucan, Ciprian Valerian / Netsch, Christopher / Lunelli, Luca

    Journal of investigative surgery : the official journal of the Academy of Surgical Research

    2020  Volume 34, Issue 8, Page(s) 914–921

    Abstract: Background: Surgical trauma due to vaginal wall incision to extract the specimen during transvaginal hybrid Natural-Orifices-Transluminal-Endoscopic-Surgery (NOTES) nephrectomy can result in sexual dysfunction and have traumatic psychological impacts. ... ...

    Abstract Background: Surgical trauma due to vaginal wall incision to extract the specimen during transvaginal hybrid Natural-Orifices-Transluminal-Endoscopic-Surgery (NOTES) nephrectomy can result in sexual dysfunction and have traumatic psychological impacts. We evaluated the alteration of sexual functions in the postoperative period.
    Methods: Patients who underwent a transvaginal NOTES nephrectomy were prospectively enrolled. Patients and their partners were evaluated with the Golombok-Rust Inventory of Sexual Satisfaction (GRISS) questionnaire pre- and post-operatively. Surgical characteristics were recorded.
    Results: Fifty-three patients (mean age: 52.72 ± 2.39 years; mean tumor size 4.77 ± 2.55 cm) were included. The total GRISS scores of all patients were similar in pre- and post-operative periods. Although females reported no change in the GRISS score, 60.4% of partners showed a drop in the total score. Non-communication and avoidance subdomains showed significant changes for females; males showed a significant change in avoidance, non-sensuality and dissatisfaction subdomains. Subgroup analyses showed that neither tumor stage nor nulliparous status did not affect total score changes for both genders. The trocar number and perioperative complication rates had no significant effects on total score changes.
    Conclusion: Sexual function can be affected after transvaginal NOTES nephrectomy and care should include a stringent approach to addressing sexual dysfunction. We support the transvaginal NOTES nephrectomy technique if adequate secondary measures to protect sexual function are taken.
    MeSH term(s) Female ; Humans ; Male ; Middle Aged ; Natural Orifice Endoscopic Surgery/adverse effects ; Nephrectomy/adverse effects ; Prospective Studies ; Surgical Instruments ; Vagina/surgery
    Language English
    Publishing date 2020-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639444-9
    ISSN 1521-0553 ; 0894-1939
    ISSN (online) 1521-0553
    ISSN 0894-1939
    DOI 10.1080/08941939.2019.1710627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2364: Show issues Location:
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  5. Article: Modern lymphatic dissection techniques for preventing post renal transplant lymphocele.

    Lucan, Ciprian Valerian / Jurchis, Ionut / Suciu, Mihai / Selicean, Sonia Emilia / Buttice, Salvatore

    Clujul medical (1957)

    2017  Volume 90, Issue 4, Page(s) 416–419

    Abstract: Background and aims: Development of a lymphocele is a well-known complication following kidney transplant. Among causative factors, recipient iliac lymphatics dissection plays an important role. Electrothermal bipolar sealing devices (LigaSure: ... ...

    Abstract Background and aims: Development of a lymphocele is a well-known complication following kidney transplant. Among causative factors, recipient iliac lymphatics dissection plays an important role. Electrothermal bipolar sealing devices (LigaSure
    Methods: 48 patients admitted for renal transplant were included in the study. They were randomly assigned to either conventional ligation or LigaSure
    Results: One patient in the LigaSure
    Conclusion: Electrothermal bipolar sealing devices exhibit safety and efficiency when used in renal transplant lymphatic dissection. In the present study, this technique proved to be superior to conventional ligation in terms of post-operative lymphatic complications.
    Language English
    Publishing date 2017-10-20
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 419197-3
    ISSN 2066-8872 ; 1222-2119 ; 1224-550X
    ISSN (online) 2066-8872
    ISSN 1222-2119 ; 1224-550X
    DOI 10.15386/cjmed-716
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    Zs.B 2836: Show issues Location:
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  6. Article: Cryotherapy for low risk prostate cancer, oncological and functional medium term outcomes: A three center prospective study.

    Lucan, Valerian Ciprian / Lugnani, Franco / Butticè, Salvatore / Sener, Emre / Netsch, Christopher / Talso, Michele / Cantiello, Francesco / Pappalardo, Rosa / Magno, Carlo

    Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

    2017  Volume 89, Issue 2, Page(s) 97–101

    Abstract: Objectives: Analyze the oncologic and functional outcomes in patients affected by low risk prostate cancer underwent prostate cryotherapy. Materiasl and methods: It's a prospective tricentric study of 434 patients treated with prostate cryoablation for ... ...

    Abstract Objectives: Analyze the oncologic and functional outcomes in patients affected by low risk prostate cancer underwent prostate cryotherapy. Materiasl and methods: It's a prospective tricentric study of 434 patients treated with prostate cryoablation for low risk prostate cancer. By low risk we refer to the D'Amico's risk classification. Two cycles of freezing/thawing are run for each patient following the technique described by Onik.
    Results: For the 434 patients, the median age was 66 years with a standard deviation of ± 6.68, the average PSA was 6.17 ng/d/L, the median 5.55 with a standard deviation of ± 2.13, the mean prostate volume was 35.59 cc, the median 34.00 cc, with a standard deviation of ± 7.89. Biochemical failure occurred in 67 patients (15.4%). Pre-operative erectile function in men was distributed as follows: severe in 95 patients (19.2%), moderate in 95 (19.2%), medium-moderate in 180 (36.4%), mild in 92 (18.6%), with no dysfunction in 32 (6.5%) patients. Post-operative erectile function, measured 1 month after cryotherapy, was distributed as follows: severe in 321 (65%) patients, moderate in 69 (14%), medium-moderate in 79 (16%), mild in 23 (4.7%), and no dysfunction in only 2 patients (0.4%). Post-operative erectile function after 3 months was distributed as follows: severe in 233 (47.2%) patients, moderate in 66 (13.4%), medium-moderate in 122 (24.7%), mild in 65 (13.2%), and no dysfunction in 8 patients (1.6%). Urinary incontinence was present in 21 patients (4.8%) after 3 months while it dropped to 13 patients (2.9%) after 6 months.
    Conclusions: Cryotherapy in the treatment of prostate cancer remains a viable alternative. The availability of new cryoprobes and the use of new diagnostic means such as fusion magnetic resonance will make this more precise and more effective method.
    Language English
    Publishing date 2017-06-30
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1153526-x
    ISSN 2282-4197 ; 1124-3562 ; 1120-8538
    ISSN (online) 2282-4197
    ISSN 1124-3562 ; 1120-8538
    DOI 10.4081/aiua.2017.2.97
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  7. Article ; Online: Hybrid Transvaginal NOTES Nephrectomy: Postoperative Sexual Outcomes. A Three-center Matched Study.

    Butticè, Salvatore / Sener, Tarik Emre / Lucan, Valerian Ciprian / Lunelli, Luca / Laganà, Antonio Simone / Vitale, Salvatore Giovanni / Netsch, Christopher / Tanidir, Yiloren / Pappalardo, Rosa / Magno, Carlo

    Urology

    2017  Volume 99, Page(s) 131–135

    Abstract: Objective: To evaluate our experience in patients undergoing hybrid transvaginal natural orifices transluminal endoscopic surgery (NOTES) nephrectomy and evaluate the sexual functions in the postoperative period.: Materials and methods: Prospective ... ...

    Abstract Objective: To evaluate our experience in patients undergoing hybrid transvaginal natural orifices transluminal endoscopic surgery (NOTES) nephrectomy and evaluate the sexual functions in the postoperative period.
    Materials and methods: Prospective data of 71 patients with renal tumors who underwent hybrid NOTES radical nephrectomy in three different centers were collected from March 2010 to October 2015. Patient and surgical characteristics were recorded. Sexual function was evaluated using the Female Sexual Function Index questionnaire the day prior to the operation and 3 months after.
    Results: The mean age, tumor size, and operation duration were 66.16 ± 11.21, 8.51 ± 3.31 cm, and 119.94 ± 21.38 minutes, respectively. Five patients were immediately reoperated due to bleeding from uterine veins. The complication risk increases significantly with increasing tumor size. Among the whole cohort, even the Female Sexual Function Index score differences are small; there is a statistically significant decrease in the postoperative period in all domains except sexual satisfaction. In fact, the patients reported unaltered sexual function after surgery and satisfaction with the result when asked directly. In subgroup analyses, in nulliparous patients (n = 60), arousal, sexual desire, orgasm, and satisfaction domains have no significant differences in pre- and postoperative periods.
    Conclusions: Hybrid NOTES nephrectomy is a feasible, safe operation that can be performed for large renal tumors. Due to incisions in the vaginal wall for specimen retrieval, sexual function can be altered in the postoperative period. So patient selection, preoperative evaluation, and close follow-up are mandatory. With this in mind, we strongly support the use of hybrid transvaginal NOTES nephrectomy for large renal tumors especially in nulliparous patients.
    Language English
    Publishing date 2017-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2016.09.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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