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  1. Article ; Online: My 60-Year Love Affair with Natural Products.

    Kingston, David G I

    Journal of natural products

    2021  Volume 84, Issue 3, Page(s) 932–948

    Abstract: The author describes his 60-year career in studying the chemistry of natural products, which includes structural, synthetic, and biosynthetic studies of natural products ranging from insect pigments, antibiotics, and fecal mutagens to taxol and other ... ...

    Abstract The author describes his 60-year career in studying the chemistry of natural products, which includes structural, synthetic, and biosynthetic studies of natural products ranging from insect pigments, antibiotics, and fecal mutagens to taxol and other anticancer natural products as well as antimalarial natural products. One of the compounds discussed, napabucasin, is now an anticancer drug in phase III clinical trials.
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Antimalarials/chemistry ; Antineoplastic Agents/chemistry ; Biological Products/chemistry ; Career Choice ; Drug Discovery ; Paclitaxel/chemistry
    Chemical Substances Anti-Bacterial Agents ; Antimalarials ; Antineoplastic Agents ; Biological Products ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2021-01-12
    Publishing country United States
    Document type Journal Article ; Personal Narrative ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.0c01237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Book: Anticancer agents from natural products

    Cragg, Gordon M. / Kingston, David G. I. / Newman, David J.

    2012  

    Title variant Natural products
    Author's details ed. by Gordon M. Cragg ; David G. I. Kingston ; David J. Newman
    Keywords Antineoplastic Agents ; Pharmacognosy ; Biological Factors ; Antineoplastic agents ; Materia medica, Vegetable
    Subject code 616.994061
    Language English
    Size XV, 751 S., [8] Bl. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher CRC Press
    Publishing place Boca Raton, Fla. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017043583
    ISBN 978-1-4398-1382-9 ; 1-4398-1382-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 4941 order for loan Magazin

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  3. Article: Correction to: Antimalarial Natural Products.

    Kingston, David G I / Cassera, Maria Belen

    Progress in the chemistry of organic natural products

    2022  Volume 117, Page(s) C1

    Language English
    Publishing date 2022-06-06
    Publishing country Austria
    Document type Journal Article ; Comment
    ISSN 2191-7043
    ISSN 2191-7043
    DOI 10.1007/978-3-030-89873-1_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: My 60-Year Love Affair with Natural Products

    Kingston, David G. I

    Journal of natural products. 2021 Jan. 12, v. 84, no. 3

    2021  

    Abstract: The author describes his 60-year career in studying the chemistry of natural products, which includes structural, synthetic, and biosynthetic studies of natural products ranging from insect pigments, antibiotics, and fecal mutagens to taxol and other ... ...

    Abstract The author describes his 60-year career in studying the chemistry of natural products, which includes structural, synthetic, and biosynthetic studies of natural products ranging from insect pigments, antibiotics, and fecal mutagens to taxol and other anticancer natural products as well as antimalarial natural products. One of the compounds discussed, napabucasin, is now an anticancer drug in phase III clinical trials.
    Keywords antimalarials ; antineoplastic agents ; biosynthesis ; chemistry ; insects ; paclitaxel
    Language English
    Dates of publication 2021-0112
    Size p. 932-948.
    Publishing place American Chemical Society and American Society of Pharmacognosy
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.0c01237
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Antimalarial Natural Products.

    Kingston, David G I / Cassera, Maria Belen

    Progress in the chemistry of organic natural products

    2022  Volume 117, Page(s) 1–106

    Abstract: Natural products have made a crucial and unique contribution to human health, and this is especially true in the case of malaria, where the natural products quinine and artemisinin and their derivatives and analogues, have saved millions of lives. The ... ...

    Abstract Natural products have made a crucial and unique contribution to human health, and this is especially true in the case of malaria, where the natural products quinine and artemisinin and their derivatives and analogues, have saved millions of lives. The need for new drugs to treat malaria is still urgent, since the most dangerous malaria parasite, Plasmodium falciparum, has become resistant to quinine and most of its derivatives and is becoming resistant to artemisinin and its derivatives. This volume begins with a short history of malaria and follows this with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment and then describes quinine's biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine's structure. The volume then covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of other natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature's combinatorial library is challenging, it is very likely to yield new antimalarial drugs. The chapter thus ends by identifying over ten natural products with development potential as clinical antimalarial agents.
    MeSH term(s) Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Biological Products/pharmacology ; Humans ; Malaria/drug therapy ; Plasmodium falciparum ; Quinine/pharmacology ; Quinine/therapeutic use
    Chemical Substances Antimalarials ; Biological Products ; Quinine (A7V27PHC7A)
    Language English
    Publishing date 2022-01-01
    Publishing country Austria
    Document type Journal Article
    ISSN 2191-7043
    ISSN 2191-7043
    DOI 10.1007/978-3-030-89873-1_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Structure Reassignment of Cryptorigidifoliols E and K.

    Du, Yongle / Kingston, David G I

    Journal of natural products

    2018  Volume 81, Issue 2, Page(s) 414–417

    Abstract: The structures of the α-pyrones cryptorigidifoliols E (5) and K (11) have been reassigned as 5C and 11C. ...

    Abstract The structures of the α-pyrones cryptorigidifoliols E (5) and K (11) have been reassigned as 5C and 11C.
    MeSH term(s) Magnetic Resonance Spectroscopy/methods ; Pyrones/chemistry
    Chemical Substances Pyrones
    Language English
    Publishing date 2018-01-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.7b00830
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Anti-Proliferative Acyl Phenols and Arylnonanoids from the Fruit Rind of Myristica malabarica Lam.

    Bauri, Ajoy Kumar / Du, Yongle / Brodie, Peggy Jane / Foro, Sabine / Kingston, David G I

    Chemistry & biodiversity

    2022  Volume 19, Issue 12, Page(s) e202200343

    Abstract: Phytochemical investigation of the methanol extract of the fruit rind of Myristica malabarica led to the isolation of eight known compounds that were identified as malabaricones A-D, promalabaricones B and C, 1-(2,6-dihydroxyphenyl)tetradecan-1-one, and ... ...

    Abstract Phytochemical investigation of the methanol extract of the fruit rind of Myristica malabarica led to the isolation of eight known compounds that were identified as malabaricones A-D, promalabaricones B and C, 1-(2,6-dihydroxyphenyl)tetradecan-1-one, and ericanone by comparison with literature spectroscopic data. The structures of malabaricones A-D, promalabaricone B, and 1-(2,6-dihydroxyphenyl)tetradecan-1-one were confirmed by X-ray crystallography. In vitro assay of the isolated phenols indicated that they exhibited moderate anti-proliferative activity against the A2780 human ovarian cancer cell. Compounds (1, 3, 5, 6 and 7) had the most potent activities, whereas the anti-proliferative activities of compounds 2 and 4 were less potent.
    MeSH term(s) Female ; Humans ; Cell Line, Tumor ; Fruit ; Myristica/chemistry ; Ovarian Neoplasms ; Phenols/pharmacology ; Plant Extracts/pharmacology ; Plant Extracts/chemistry
    Chemical Substances Phenols ; Plant Extracts ; ericanone ; promalabaricone B
    Language English
    Publishing date 2022-11-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202200343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Special Issue in Honor of Dr. Barbara N. Timmermann.

    Cardellina, John H / Cragg, Gordon M / Kingston, David G I / Newman, David J

    Journal of natural products

    2019  Volume 82, Issue 3, Page(s) 425–426

    MeSH term(s) Argentina ; Arizona ; Biological Products ; History, 20th Century ; History, 21st Century ; Phytochemicals
    Chemical Substances Biological Products ; Phytochemicals
    Language English
    Publishing date 2019-03-20
    Publishing country United States
    Document type Biography ; Festschrift ; Historical Article ; Portrait
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.9b00008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Plantar Kinetics During Wheeled Knee Walker Use Compared to Different Assistive Walking Devices in Persons With Type 2 Diabetes Mellitus.

    Gwaltney, Holton C / Harrington, Joseph W / Anguiano-Hernandez, Jose G / Kingston, David C

    Foot & ankle orthopaedics

    2024  Volume 9, Issue 1, Page(s) 24730114241235911

    Abstract: Background: Diabetic patients with foot ulcers are commonly prescribed assistive walking devices to unload the affected foot and promote tissue healing. However, the effect on shear loads to the contralateral foot is unknown. This study investigated the ...

    Abstract Background: Diabetic patients with foot ulcers are commonly prescribed assistive walking devices to unload the affected foot and promote tissue healing. However, the effect on shear loads to the contralateral foot is unknown. This study investigated the effect of a wheeled knee walker (WKW), compared to common devices, on compressive and shear plantar forces carried by the propulsive foot during walking in patients with type 2 diabetes mellitus. A secondary objective investigated plantar forces' correlations with body weight unloaded (BWU).
    Methods: Participants walked a maximum of 200 m per condition during normal walking or when using crutches, a standard walker, and a WKW in randomized order. Plantar forces were measured with force plates, and wireless force-sensitive pads measured BWU through the hands. The WKW was instrumented to measure BWU onto the seat and handlebars. Three-dimensional motion capture confirmed gait events.
    Results: The WKW produced the lowest vertical, braking, propulsive, and medial shear forces but the highest lateral shear force among all conditions. Using crutches or a walker had negligible medial and lateral shear (mean = -6.69 N and -7.80 N), with normal walking producing the highest medial shear. There was a poor relationship between BWU and assistive walking devices and shear force values.
    Conclusion: A WKW could be the preferred assistive device for unloading a diabetic foot ulcer. The magnitude of lateral force would need further investigation to determine ulceration risk, given patient susceptibility and neuropathy.
    Clinical relevance: Understanding shear forces on the propulsive foot is important for minimizing contralateral limb tissue damage risk while treating an ulcer. Different assistive walking devices change walking patterns and affect shear forces on the plantar surface of the foot. Although the WKW minimizes several loading metrics, a clinical trial investigating assistive walking device compliance and wound healing in diabetic foot ulcer patients across devices is needed.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ISSN 2473-0114
    ISSN (online) 2473-0114
    DOI 10.1177/24730114241235911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Exposing the tumor microenvironment: how gold nanoparticles enhance and refine drug delivery.

    Tamarkin, Lawrence / I Kingston, David G

    Therapeutic delivery

    2017  Volume 8, Issue 6, Page(s) 363–366

    MeSH term(s) Animals ; Cell Line, Tumor ; Drug Delivery Systems/methods ; Gold/administration & dosage ; Gold/metabolism ; Humans ; Metal Nanoparticles/administration & dosage ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/physiology
    Chemical Substances Gold (7440-57-5)
    Language English
    Publishing date 2017-05-20
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2041-6008
    ISSN (online) 2041-6008
    DOI 10.4155/tde-2016-0095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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