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  1. Article: From pixel to image analysis.

    van der Stelt, P F

    Dento maxillo facial radiology

    2020  Volume 50, Issue 2, Page(s) 20200305

    Abstract: Over the past 50 years, computer technology has evolved enormously. This has made it possible to carry out radiography in a completely new way, allowing to process X-ray images in an advanced manner and to extract the information from the image data. ... ...

    Abstract Over the past 50 years, computer technology has evolved enormously. This has made it possible to carry out radiography in a completely new way, allowing to process X-ray images in an advanced manner and to extract the information from the image data. This article gives an overview of some of the most important developments in dental radiology. These include capturing the images, analysing and interpreting the image information and using the images for 3D reconstruction.
    MeSH term(s) Humans ; Image Processing, Computer-Assisted ; Radiographic Image Enhancement ; Radiography ; Radiography, Dental, Digital
    Language English
    Publishing date 2020-11-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 221323-0
    ISSN 1476-542X ; 0250-832X ; 0349-490X
    ISSN (online) 1476-542X
    ISSN 0250-832X ; 0349-490X
    DOI 10.1259/dmfr.20200305
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  2. Article ; Online: Fluorescence-Based NAPE-PLD Activity Assay.

    Mock, Elliot D / Driever, Wouter P F / van der Stelt, Mario

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2576, Page(s) 233–240

    Abstract: N-Acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is regarded as the principal enzyme that generates N-acylethanolamines (NAEs), a family of signaling lipids that includes the endocannabinoid anandamide. To investigate the biological function and ...

    Abstract N-Acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is regarded as the principal enzyme that generates N-acylethanolamines (NAEs), a family of signaling lipids that includes the endocannabinoid anandamide. To investigate the biological function and biosynthesis of NAEs, we sought to develop potent NAPE-PLD inhibitors. To this aim, we utilized a high-throughput screening-compatible NAPE-PLD activity assay, which uses the fluorescence-quenched substrate PED6. This assay conveniently uses membrane fractions of NAPE-PLD overexpressing HEK293T cell lysates, thus avoiding the need for protein purification. Here, we give a detailed description of the NAPE-PLD PED6 fluorescence activity assay, which has increased throughput compared to previous radioactivity- or mass-spectrometry-based assays.
    MeSH term(s) Humans ; Endocannabinoids ; Fluorescence ; HEK293 Cells ; Phospholipase D/metabolism
    Chemical Substances Endocannabinoids ; Phospholipase D (EC 3.1.4.4)
    Language English
    Publishing date 2022-09-22
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2728-0_19
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  3. Article: Lusten en lasten.

    van der Stelt, P F

    Nederlands tijdschrift voor tandheelkunde

    2016  Volume 123, Issue 4, Page(s) 171

    MeSH term(s) Diagnosis, Differential ; Humans ; Netherlands ; Radiography, Dental/trends
    Language Dutch
    Publishing date 2016-04
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 603498-6
    ISSN 0028-2200
    ISSN 0028-2200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Röntgendiagnostiek in de tandheelkunde.

    van der Stelt, P F

    Nederlands tijdschrift voor tandheelkunde

    2015  Volume 122, Issue 5, Page(s) 239

    Title translation X-ray diagnostics in dentistry.
    MeSH term(s) Diagnosis, Differential ; Humans ; Radiography, Dental/adverse effects ; Radiography, Dental/methods ; Radiography, Dental/utilization
    Language Dutch
    Publishing date 2015-05
    Publishing country Netherlands
    Document type Editorial ; English Abstract
    ZDB-ID 603498-6
    ISSN 0028-2200
    ISSN 0028-2200
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  5. Article: Panoramische röntgenopnamen in de tandheelkundige diagnostiek.

    van der Stelt, P F

    Nederlands tijdschrift voor tandheelkunde

    2016  Volume 123, Issue 4, Page(s) 181–187

    Abstract: Panoramic radiographs are frequently used in dental practice in addition to bitewing radiographs and periapical radiographs. The way a panoramic photograph is created is different from that of a projection image, such as bitewing and periapical ... ...

    Title translation Panoramic radiographs in dental diagnostics.
    Abstract Panoramic radiographs are frequently used in dental practice in addition to bitewing radiographs and periapical radiographs. The way a panoramic photograph is created is different from that of a projection image, such as bitewing and periapical radiographs. As a result, the sharpness of detail is much less, and overlap of structures occurs in different areas of the image. Consequently the diagnostic utility is limited to the recognition of anomalies for which small details play a lesser role. The advantage of a panoramic radiograph is that structures over a large area are shown in their relative location. Because of the lower resolution and the higher dose of radiation to the patient compared with a series of intraoral images, the panoramic radiograph is not indicated during a periodic check-up. If clinical inspection indicates a need for it and as a supplement to an intraoral radiograph, a panoramic radiograph can, however, be appropriate in cases of abnormalities that extend over a larger area, such as tumours and developmental disorders.
    MeSH term(s) Humans ; Radiation Dosage ; Radiography, Dental/standards ; Radiography, Panoramic/methods ; Radiography, Panoramic/standards ; Sensitivity and Specificity ; Tooth Diseases/diagnostic imaging
    Language Dutch
    Publishing date 2016-04
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 603498-6
    ISSN 0028-2200
    ISSN 0028-2200
    DOI 10.5177/ntvt.2016.04.15208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Conebeamcomputertomografie: is meer ook beter?

    van der Stelt, P F

    Nederlands tijdschrift voor tandheelkunde

    2016  Volume 123, Issue 4, Page(s) 189–198

    Abstract: Cone beam computed tomography (CBCT) is a radiographic technique that has now been available in dentistry for about 20 years. The ability to display three-dimensional structures is of importance for many defects in the maxillofacial area. A disadvantage, ...

    Title translation Cone beam computed tomography: is more also better?.
    Abstract Cone beam computed tomography (CBCT) is a radiographic technique that has now been available in dentistry for about 20 years. The ability to display three-dimensional structures is of importance for many defects in the maxillofacial area. A disadvantage, however, is that the dose of a CBCT-study is higher than the dose of more conventional imaging techniques. This should be taken into account when prescribing a CBCT-examination. Because a CBCT-image usually displays a larger area than that of conventional radiography, there is the possibility that abnormalities may be shown that are outside the direct field of experience of the dentist. For all these reasons, the user of a CBCT-device needs to have additional knowledge.
    MeSH term(s) Cone-Beam Computed Tomography/instrumentation ; Cone-Beam Computed Tomography/methods ; Cone-Beam Computed Tomography/standards ; Diagnosis, Differential ; Humans ; Imaging, Three-Dimensional ; Radiation Dosage ; Radiographic Image Enhancement/methods ; Radiography, Dental/methods ; Radiography, Dental/standards
    Language Dutch
    Publishing date 2016-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 603498-6
    ISSN 0028-2200
    ISSN 0028-2200
    DOI 10.5177/ntvt.2016.04.15221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Disruption of tonic endocannabinoid signalling triggers cellular, behavioural and neuroendocrine responses consistent with a stress response.

    Petrie, Gavin N / Balsevich, Georgia / Füzesi, Tamás / Aukema, Robert J / Driever, Wouter P F / van der Stelt, Mario / Bains, Jaideep S / Hill, Matthew N

    British journal of pharmacology

    2023  Volume 180, Issue 24, Page(s) 3146–3159

    Abstract: Background and purpose: Endocannabinoid (eCB) signalling gates many aspects of the stress response, including the hypothalamic-pituitary-adrenal (HPA) axis. The HPA axis is controlled by corticotropin releasing hormone (CRH) producing neurons in the ... ...

    Abstract Background and purpose: Endocannabinoid (eCB) signalling gates many aspects of the stress response, including the hypothalamic-pituitary-adrenal (HPA) axis. The HPA axis is controlled by corticotropin releasing hormone (CRH) producing neurons in the paraventricular nucleus of the hypothalamus (PVN). Disruption of eCB signalling increases drive to the HPA axis, but the mechanisms subserving this process are poorly understood.
    Experimental approach: Using an array of cellular, endocrine and behavioural readouts associated with activation of CRH neurons in the PVN, we evaluated the contributions of tonic eCB signalling to the generation of a stress response.
    Key results: The CB1 receptor antagonist/inverse agonist AM251, neutral antagonist NESS243 and NAPE PLD inhibitor LEI401 all uniformly increased Fos in the PVN, unmasked stress-linked behaviours, such as grooming, and increased circulating CORT, recapitulating the effects of stress. Similar effects were also seen after direct administration of AM251 into the PVN, while optogenetic inhibition of PVN CRH neurons ameliorated stress-like behavioural changes produced by disruption of eCB signalling.
    Conclusions and implications: These data indicate that under resting conditions, constitutive eCB signalling restricts activation of the HPA axis through local regulation of CRH neurons in the PVN.
    MeSH term(s) Animals ; Hypothalamo-Hypophyseal System/metabolism ; Endocannabinoids/pharmacology ; Drug Inverse Agonism ; Pituitary-Adrenal System/metabolism ; Hypothalamus/metabolism ; Corticotropin-Releasing Hormone/metabolism ; Paraventricular Hypothalamic Nucleus ; Corticosterone/pharmacology
    Chemical Substances Endocannabinoids ; Corticotropin-Releasing Hormone (9015-71-8) ; Corticosterone (W980KJ009P)
    Language English
    Publishing date 2023-08-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.16198
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  8. Article: Tandheelkundige radiologie: wet- en regelgeving.

    van der Stelt, P F

    Nederlands tijdschrift voor tandheelkunde

    2015  Volume 122, Issue 5, Page(s) 253–258

    Abstract: Since the discovery of X-rays, medical imaging has been one of its most important applications. In the course of years, understanding of the potentially harmful effects of radiation on tissue has substantially increased as a result of experience and ... ...

    Title translation Oral and maxillofacial radiology: laws and regulations.
    Abstract Since the discovery of X-rays, medical imaging has been one of its most important applications. In the course of years, understanding of the potentially harmful effects of radiation on tissue has substantially increased as a result of experience and scientific studies. This has led to the International Commission on Radiological Protection (ICRP), the organisation that is now regarded as the most authoritative in the field of information on radiation and radiation protection. In most countries the law governing radiation is based on the 3 principles of the ICRP: justification, ALARA and dosage limits. For the Dutch situation, these are the Nuclear Energy Act (Kernenergiewet) and the Radiation Protection Decree (Besluit stralingsbescherming). The Practice Guidelines on Radiology are available for the practical implementation of the regulations. By working according to the Practice Guidelines, the dentist satisfies the legal regulations, but, more importantly, he can apply X-ray diagnostics in a manner that is safe for him, the dental team, the patients and all other visitors of the practice.
    MeSH term(s) Dose-Response Relationship, Radiation ; Guidelines as Topic ; Humans ; International Cooperation ; Patient Safety ; Radiation Injuries/prevention & control ; Radiation Protection/legislation & jurisprudence ; Radiography, Dental/adverse effects
    Language Dutch
    Publishing date 2015-05
    Publishing country Netherlands
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 603498-6
    ISSN 0028-2200
    ISSN 0028-2200
    DOI 10.5177/ntvt.2015.05.14252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Airway Phenotypes and Nocturnal Wearing of Dentures in Elders with Sleep Apnea.

    Chen, H / Emami, E / Kauffmann, C / Rompré, P / Almeida, F / Schmittbuhl, M / van der Stelt, P / Ge, S / Lavigne, G / Huynh, N

    Journal of dental research

    2022  Volume 102, Issue 3, Page(s) 263–269

    Abstract: The objective of this study was to examine to what extent the anatomic characteristics of the upper airway can influence the effect of nocturnal wearing of dentures on the sleep of edentulous elders with untreated sleep apnea. This study used the data ... ...

    Abstract The objective of this study was to examine to what extent the anatomic characteristics of the upper airway can influence the effect of nocturnal wearing of dentures on the sleep of edentulous elders with untreated sleep apnea. This study used the data from a randomized crossover clinical trial and an exploratory approach to address its objectives. Cone beam computed tomography scans of 65 edentulous individuals (female,
    MeSH term(s) Male ; Female ; Humans ; Sleep Apnea, Obstructive ; Respiratory System ; Sleep ; Mouth, Edentulous/complications ; Oxygen ; Dentures
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80207-4
    ISSN 1544-0591 ; 0022-0345
    ISSN (online) 1544-0591
    ISSN 0022-0345
    DOI 10.1177/00220345221133278
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  10. Article ; Online: A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence.

    Jiang, Ming / Huizenga, Mirjam C W / Wirt, Jonah L / Paloczi, Janos / Amedi, Avand / van den Berg, Richard J B H N / Benz, Joerg / Collin, Ludovic / Deng, Hui / Di, Xinyu / Driever, Wouter F / Florea, Bogdan I / Grether, Uwe / Janssen, Antonius P A / Hankemeier, Thomas / Heitman, Laura H / Lam, Tsang-Wai / Mohr, Florian / Pavlovic, Anto /
    Ruf, Iris / van den Hurk, Helma / Stevens, Anna F / van der Vliet, Daan / van der Wel, Tom / Wittwer, Matthias B / van Boeckel, Constant A A / Pacher, Pal / Hohmann, Andrea G / van der Stelt, Mario

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 8039

    Abstract: Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG) and eicosanoid signalling. MAGL inhibition provides therapeutic opportunities but clinical potential is limited by central nervous system (CNS)-mediated side effects. ... ...

    Abstract Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG) and eicosanoid signalling. MAGL inhibition provides therapeutic opportunities but clinical potential is limited by central nervous system (CNS)-mediated side effects. Here, we report the discovery of LEI-515, a peripherally restricted, reversible MAGL inhibitor, using high throughput screening and a medicinal chemistry programme. LEI-515 increased 2-AG levels in peripheral organs, but not mouse brain. LEI-515 attenuated liver necrosis, oxidative stress and inflammation in a CCl
    MeSH term(s) Animals ; Mice ; Monoacylglycerol Lipases ; Monoglycerides ; Rimonabant ; Endocannabinoids ; Analgesics/pharmacology ; Receptor, Cannabinoid, CB1 ; Mice, Inbred C57BL
    Chemical Substances Monoacylglycerol Lipases (EC 3.1.1.23) ; Monoglycerides ; Rimonabant (RML78EN3XE) ; Endocannabinoids ; Analgesics ; Receptor, Cannabinoid, CB1
    Language English
    Publishing date 2023-12-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-43606-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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