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  1. Book ; Online: Entering the RNA Wonderland: Opportunities and Challenges for RNA Therapeutics in the Cardiovascular System

    Zampetaki, Anna / Maegdefessel, Lars

    2020  

    Keywords Science: general issues ; Physiology ; Noncoding RNA ; Circulating RNA ; Intercellular communication ; Epitranscriptomics ; RNA therapeutics
    Size 1 electronic resource (98 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230163
    ISBN 9782889638826 ; 2889638820
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Targeting non-coding RNAs for novel treatment strategies in vascular diseases.

    Winter, Hanna / Maegdefessel, Lars

    European heart journal

    2023  Volume 44, Issue 25, Page(s) 2267–2269

    MeSH term(s) Humans ; Vascular Diseases/genetics ; Vascular Diseases/therapy ; RNA, Long Noncoding ; MicroRNAs
    Chemical Substances RNA, Long Noncoding ; MicroRNAs
    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 640: Show issues

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  3. Book ; Online ; Thesis: The involvement of non-coding RNAs in smooth muscle cell dynamics in atherosclerosis and abdominal aortic aneurysm

    Winter, Hanna Lydia Verfasser] / [Mägdefessel, Lars [Akademischer Betreuer] / Sluimer, Judith Gutachter] / Kapurniotu, Aphrodite [Gutachter] / [Mägdefessel, Lars [Gutachter]

    2024  

    Author's details Hanna Lydia Winter ; Gutachter: Judith Sluimer, Aphrodite Kapurniotu, Lars Mägdefessel ; Betreuer: Lars Mägdefessel
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  4. Article ; Online: Noncoding RNAs in the Vasculature: Basic Mechanisms and Therapeutic Perspectives.

    Maegdefessel, Lars / Boon, Reinier A / Dimmeler, Stefanie

    Arteriosclerosis, thrombosis, and vascular biology

    2023  Volume 44, Issue 1, Page(s) 3–6

    MeSH term(s) RNA, Untranslated/genetics ; MicroRNAs/genetics ; RNA, Long Noncoding ; Epigenesis, Genetic
    Chemical Substances RNA, Untranslated ; MicroRNAs ; RNA, Long Noncoding
    Language English
    Publishing date 2023-12-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.123.319564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1705: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Book ; Online ; Thesis: Apoptosis inducing factor 1 and its role during plaque stabilization in carotid artery disease and ischemic stroke

    Bischoff, Lukas Verfasser] / [Mägdefessel, Lars [Akademischer Betreuer] / Thorsten, Keßler Gutachter] / [Mägdefessel, Lars [Gutachter]

    2023  

    Author's details Lukas Bischoff ; Gutachter: Keßler Thorsten, Lars Mägdefessel ; Betreuer: Lars Mägdefessel
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  6. Book ; Online ; Thesis: Vascular smooth muscle cell differentiation in patient-derived cells from stable versus ruptured plaques in carotid artery disease

    Groß, Narcisse Sara Verfasser] / [Mägdefessel, Lars [Akademischer Betreuer] / D'Alessandria, Calogero Gutachter] / [Mägdefessel, Lars [Gutachter]

    2023  

    Author's details Narcisse Sara Groß ; Gutachter: Calogero D'Alessandria, Lars Mägdefessel ; Betreuer: Lars Mägdefessel
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

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  7. Book ; Online ; Thesis: Aorta-on-a-chip: a novel tool to gain molecular insight into vascular diseases

    Hummel, Nora Margaux Verfasser] / [Mägdefessel, Lars [Akademischer Betreuer] / Böhm, Johannes Gutachter] / [Mägdefessel, Lars [Gutachter]

    2023  

    Author's details Nora Margaux Hummel ; Gutachter: Johannes Böhm, Lars Mägdefessel ; Betreuer: Lars Mägdefessel
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: Editorial: Entering the RNA Wonderland: Opportunities and Challenges for RNA Therapeutics in the Cardiovascular System.

    Zampetaki, Anna / Maegdefessel, Lars

    Frontiers in physiology

    2020  Volume 11, Page(s) 60

    Language English
    Publishing date 2020-02-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2020.00060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Endothelial microRNAs and long noncoding RNAs in cardiovascular ageing.

    Bink, Diewertje I / Pauli, Jessica / Maegdefessel, Lars / Boon, Reinier A

    Atherosclerosis

    2023  Volume 374, Page(s) 99–106

    Abstract: Atherosclerosis and numerous other cardiovascular diseases develop in an age-dependent manner. The endothelial cells that line the vessel walls play an important role in the development of atherosclerosis. Non-coding RNA like microRNAs and long non- ... ...

    Abstract Atherosclerosis and numerous other cardiovascular diseases develop in an age-dependent manner. The endothelial cells that line the vessel walls play an important role in the development of atherosclerosis. Non-coding RNA like microRNAs and long non-coding RNAs are known to play an important role in endothelial function and are implicated in the disease progression. Here, we summarize several microRNAs and long non-coding RNAs that are known to have an altered expression with endothelial aging and discuss their role in endothelial cell function and senescence. These processes contribute to aging-induced atherosclerosis development and by targeting the non-coding RNAs controlling endothelial cell function and senescence, atherosclerosis can potentially be attenuated.
    MeSH term(s) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Endothelial Cells/metabolism ; Aging/genetics ; Atherosclerosis/metabolism
    Chemical Substances MicroRNAs ; RNA, Long Noncoding
    Language English
    Publishing date 2023-04-05
    Publishing country Ireland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2023.03.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 226: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Long non-coding RNAs at the crossroad of vascular smooth muscle cell phenotypic modulation in atherosclerosis and neointimal formation.

    Fasolo, Francesca / Paloschi, Valentina / Maegdefessel, Lars

    Atherosclerosis

    2022  Volume 374, Page(s) 34–43

    Abstract: Despite extraordinary advances in the comprehension of the pathophysiology of atherosclerosis and the employment of very effective treatments, cardiovascular diseases are still a major cause of mortality and represent a large share of health expenditure ... ...

    Abstract Despite extraordinary advances in the comprehension of the pathophysiology of atherosclerosis and the employment of very effective treatments, cardiovascular diseases are still a major cause of mortality and represent a large share of health expenditure worldwide. Atherosclerosis is a disease affecting the medium and large arteries, which consists of a progressive accumulation of fatty substances, cellular waste products and fibrous elements, which culminates in the buildup of a plaque obstructing the blood flow. Endothelial dysfunction represents an early pathological event, favoring immune cells recruitment and triggering local inflammation. The release of inflammatory cytokines and other signaling molecules stimulates phenotypic modifications in the underlying vascular smooth muscle cells, which, in physiological conditions, are responsible for the maintenance of vessels architecture while regulating vascular tone. Vascular smooth muscle cells are highly plastic and may respond to disease stimuli by de-differentiating and losing their contractility, while increasing their synthetic, proliferative, and migratory capacity. This phenotypic switching is considered a pathological hallmark of atherogenesis and is ruled by the activation of selective gene programs. The advent of genomics and the improvement of sequencing technologies deepened our knowledge of the complex gene expression regulatory networks mediated by non-coding RNAs, and favored the rise of innovative therapeutic approaches targeting the non-coding transcriptome. In the context of atherosclerosis, long non-coding RNAs have received increasing attention as potential translational targets, due to their contribution to the molecular dynamics modulating the expression of vascular smooth muscle cells contractile/synthetic gene programs. In this review, we will focus on the most well-characterized long non-coding RNAs contributing to atherosclerosis by controlling expression of the contractile apparatus and genes activated in perturbed vascular smooth muscle cells.
    MeSH term(s) Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Muscle, Smooth, Vascular/pathology ; Atherosclerosis/pathology ; Plaque, Atherosclerotic/metabolism ; Arteries/metabolism ; Myocytes, Smooth Muscle/pathology ; Cell Proliferation ; Phenotype
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2022-12-06
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2022.11.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 226: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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