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Article ; Online: No evidence for ac4C within human mRNA upon data reassessment.

Georgeson, Joseph / Schwartz, Schraga

2024 Volume 84, Issue 8, Page(s) 1601–1610.e2

Abstract: Cytidine acetylation (ac4C) of RNA is a post-transcriptional modification catalyzed by Nat10. Recently, an approach termed RedaC:T was employed to map ac4C in human mRNA, relying on detection of C>T mutations in WT but not in Nat10-KO cells. RedaC:T ... ...

Abstract	Cytidine acetylation (ac4C) of RNA is a post-transcriptional modification catalyzed by Nat10. Recently, an approach termed RedaC:T was employed to map ac4C in human mRNA, relying on detection of C>T mutations in WT but not in Nat10-KO cells. RedaC:T suggested widespread ac4C presence. Here, we reanalyze RedaC:T data. We find that mismatch signatures are not reproducible, as C>T mismatches are nearly exclusively present in only one of two biological replicates. Furthermore, all mismatch types-not only C>T-are highly enriched in WT samples, inconsistent with an acetylation signature. We demonstrate that the originally observed enrichment in mutations in one of the WT samples is due to its low complexity, resulting in the technical amplification of all classes of mismatch counts. Removal of duplicate reads abolishes the skewed mismatch patterns. These analyses account for the irreproducible mismatch patterns across samples while failing to find evidence for acetylation of RedaC:T sites.
MeSH term(s)	Humans ; RNA, Messenger/genetics ; RNA ; Acetylation ; Cytidine ; Mutation
Chemical Substances	RNA, Messenger ; RNA (63231-63-0) ; Cytidine (5CSZ8459RP)
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2024.03.017
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Zs.A 5055: Show issues

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Article ; Online: Flexor Retinaculum Release and Posterior Tibial Tendon Mobilization for Lateral Peritalar Dislocation.

Schwartz, Joshua M / Ruland, Jeffrey R / Ramamurti, Pradip / Moran, Thomas E / Park, Joseph S

Foot & ankle orthopaedics

2023 Volume 8, Issue 4, Page(s) 24730114231209768

Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Case Reports
ISSN	2473-0114
ISSN (online)	2473-0114
DOI	10.1177/24730114231209768
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Article ; Online: Comparison of outcomes for routine versus American Heart Association-recommended technique for blood pressure measurement (CORRECT BP): a randomised cohort study.

Alpert, Bruce S / Schwartz, Joseph E / Shapiro, Mira / Wexler, Randell K

EClinicalMedicine

2023 Volume 64, Page(s) 102219

Abstract: Background: Optimal clinical care, diagnosis and treatment requires accurate blood pressure (BP) values. The primary objective was to compare BP readings taken while adhering to American Heart Association (AHA) guidelines to those typical of routine ... ...

Abstract	Background: Optimal clinical care, diagnosis and treatment requires accurate blood pressure (BP) values. The primary objective was to compare BP readings taken while adhering to American Heart Association (AHA) guidelines to those typical of routine clinical care. Specifically studied: the combined effect of feet flat on the floor, back supported, and arm supported with cuff at heart level, while adhering to other guideline recommendations. Methods: In this prospective, randomised, three-group cohort study, a modified cross-over design was applied in a primary care outpatient office setting in Columbus (OH, USA). Eligible participants were adults (aged ≥18 years) with an arm circumference of ≥18 cm and ≤42 cm who did not have a renal dialysis shunt or a previous or current diagnosis of atrial fibrillation. 150 recruited volunteers meeting the inclusion criteria were randomly randomised into the three groups. Group methodologies were BP readings taken on a fixed-height exam table followed by readings taken in an exam chair with adjustable positioning options (Group A), readings taken in the reverse order, chair then table (Group B), and both sets of readings in the exam chair (Group C). A rest period occurred before each set of readings. Group C was included for the purpose of obtaining an independent estimate of the order effect. The order in which the two types of readings (table vs chair) were taken was randomised. The primary outcome was the difference between the mean of three BP readings taken on the table and the mean of three readings taken in the chair. Findings: Between September and October, 2022, 150 participants were enrolled in the study; all 150 of whom completed testing: 48 in Group A, 49 in Group B, 53 in Group C. The mean systolic/diastolic BP (SBP/DBP) of readings taken on the table (Group A first readings, Group B second readings) were 7.0/4.5 mmHg higher than those taken in the chair (Group A second readings, Group B first readings); both statistically significant, p < 0.0001. These findings show that AHA-recommended positioning-feet flat on the floor, back supported, arm supported with the BP cuff at heart level-results in substantially lower BP values than improper positioning. The mean SBP/DBP of the first set of readings taken on the chair were 1.6/0.6 mmHg higher than for the second set of readings (Group C, included to estimate order effect). Interpretation: The observed benefit of proper positioning is sufficient to change the BP classification of several million patients from having hypertension to not having hypertension and therefore avoiding medication and/or intense follow-up. Funding: Midmark Corporation, Versailles, Ohio, USA.
Language	English
Publishing date	2023-09-14
Publishing country	England
Document type	Journal Article
ISSN	2589-5370
ISSN (online)	2589-5370
DOI	10.1016/j.eclinm.2023.102219
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Article ; Online: Outcomes of SADI and OAGB Compared to RYGB from the Metabolic and Bariatric Surgery Quality Improvement Program: The North American Experience.

Chao, Grace F / Canner, Joseph / Hamid, Safraz / Ying, Lee D / Ghiassi, Saber / Schwartz, Jennifer S / Gibbs, Karen E

Obesity surgery

2024 Volume 34, Issue 2, Page(s) 337–346

Abstract: Background: Rapid adoption of sleeve gastrectomy (SG) in the last decade aptly reflects the desire of patients and surgeons for alternatives to RYGB and DS. While SG provides good outcomes, other options that address specific patient needs are warranted. ...

Abstract	Background: Rapid adoption of sleeve gastrectomy (SG) in the last decade aptly reflects the desire of patients and surgeons for alternatives to RYGB and DS. While SG provides good outcomes, other options that address specific patient needs are warranted. Recently approved by ASMBS, SADI, and OAGB have garnered increasing interest due to their single anastomosis technique. Methods: Using the Metabolic and Bariatric Surgery Quality Improvement Program database, we examined laparoscopic and robotic cases from 2018 to 2021 to understand the percentage of primary bariatric surgery cases that are SADI and OAGB. We used coarsened exact matching to match patients who underwent SADI or OAGB to patients who underwent Roux-en-Y gastric bypass (RYGB). We examined outcomes of matched patients using logistic regression. Results: Of the 667,979 patients that underwent bariatric-metabolic surgery, 1326 (0.2%) underwent SADI, and 2541 (0.4%) underwent OAGB. SADI was not identified in the database until 2020. In 2020, there were 487 SADI procedures compared to 839 in 2021. From 2018 to 2021, OAGBs went from 149 to 940. Compared with RYGB, SADI was associated with higher rates of anastomotic or staple line leak (OR 2.21 (95% CI 1.08-4.53)) and sepsis (OR 3.62 (95% CI 1.62-8.12)). Compared with RYGB, OAGB was associated with lower rates of gastrointestinal bleeding (OR 0.29 (95% CI 0.12-0.71)) and bowel obstruction (OR 0.10 (95% CI 0.02-0.39)). Of note, there were no differences between these procedures and RYGB for 30-day mortality. Conclusion: More SADIs and OAGBs are being performed. However, there were higher complication rates associated with the SADI procedure. Further studies will be needed to better understand the key drivers for these outcomes.
MeSH term(s)	Humans ; Gastric Bypass/methods ; Obesity, Morbid/surgery ; Quality Improvement ; Bariatric Surgery ; Gastrectomy/methods ; North America/epidemiology ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-023-07019-x
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Zs.A 3381: Show issues

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Article ; Online: Correction: Neural correlates of automatic emotion regulation and their association with suicidal ideation in adolescents during the first 90-days of residential care.

Dobbertin, Matthew / Blair, Karina S / Aloi, Joseph / Bajaj, Sahil / Bashford-Largo, Johannah / Mathur, Avantika / Zhang, Ru / Carollo, Erin / Schwartz, Amanda / Elowsky, Jaimie / Ringle, J L / Tyler, Patrick / Blair, R James

Translational psychiatry

2024 Volume 14, Issue 1, Page(s) 100

Language	English
Publishing date	2024-02-19
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2609311-X
ISSN	2158-3188 ; 2158-3188
ISSN (online)	2158-3188
ISSN	2158-3188
DOI	10.1038/s41398-024-02817-y
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Article ; Online: The Perceived Stress Scale as a Measure of Stress: Decomposing Score Variance in Longitudinal Behavioral Medicine Studies.

Harris, Kristie M / Gaffey, Allison E / Schwartz, Joseph E / Krantz, David S / Burg, Matthew M

Annals of behavioral medicine : a publication of the Society of Behavioral Medicine

2023 Volume 57, Issue 10, Page(s) 846–854

Abstract: Background: The Perceived Stress Scale (PSS) is a widely used measure designed to assess perceptions of recent stress. However, it is unclear to what extent the construct assessed by the PSS represents factors that are stable versus variable within ... ...

Abstract	Background: The Perceived Stress Scale (PSS) is a widely used measure designed to assess perceptions of recent stress. However, it is unclear to what extent the construct assessed by the PSS represents factors that are stable versus variable within individuals, and how these components might vary over time. Purpose: Determine the degree to which variability in repeated PSS assessments is attributable to between-person versus within-person variance in two different studies and populations. Methods: Secondary analyses utilized data from two studies with up to 13 PSS assessments: An observational study of 127 patients with heart failure followed over 39 months (Study 1), and an experimental study of 73 younger, healthy adults followed over 12 months (Study 2). Multilevel linear mixed modeling was used to estimate sources of variance in the PSS total and subscale scores across assessments. Results: Between-person variance accounted for a large proportion of the total variance in PSS total scores in Study 1 (42.3%) and Study 2 (51.1%); within-person variance comprised the remainder. Between-person variance was higher for shorter assessment periods (e.g., 1 week), and was comparable when examining only the first 12 months of assessments in each study (52.9% vs. 51.1%). Conclusions: Within two samples differing in age and health status, between-person variance accounted for approximately half of the total variation in PSS scores over time. While within-person variance was observed, the construct assessed by the PSS may substantially reflect a more stable characteristic of how an individual perceives stressful life circumstances than previously appreciated.
MeSH term(s)	Adult ; Humans ; Psychometrics ; Behavioral Medicine ; Stress, Psychological/diagnosis ; Reproducibility of Results ; Longitudinal Studies ; Surveys and Questionnaires
Language	English
Publishing date	2023-04-21
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	632630-4
ISSN	1532-4796 ; 0883-6612
ISSN (online)	1532-4796
ISSN	0883-6612
DOI	10.1093/abm/kaad015
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Zs.B 2815: Show issues

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Article ; Online: Four-color fiber-coupled mid-infrared laser-absorption sensor for temperature, CO, CO

Stiborek, Joshua W / Schwartz, Charles J / Kempema, Nathan J / Szente, Joseph J / Loos, Michael J / Goldenstein, Christopher S

Applied optics

2023 Volume 62, Issue 32, Page(s) 8517–8528

Abstract: A mid-infrared (MIR) laser absorption spectroscopy (LAS) sensor was developed for temperature, CO, NO, ... ...

Abstract	A mid-infrared (MIR) laser absorption spectroscopy (LAS) sensor was developed for temperature, CO, NO, and
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.504122
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Article: Experimental confirmation of long hyperbolic polariton lifetimes in monoisotopic (

Pavlidis, Georges / Schwartz, Jeffrey J / Matson, Joseph / Folland, Thomas / Liu, Song / Edgar, James H / Caldwell, Josh D / Centrone, Andrea

APL materials

2023 Volume 9, Issue 9

Abstract: ... resonance (PTIR) and scattering-type scanning near-field optical microscopy (s-SNOM), are used to map ...

Abstract	Hyperbolic phonon polaritons (HPhPs) enable strong confinements, low losses, and intrinsic beam steering capabilities determined by the refractive index anisotropy-providing opportunities from hyperlensing to flat optics and other applications. Here, two scanning-probe techniques, photothermal induced resonance (PTIR) and scattering-type scanning near-field optical microscopy (s-SNOM), are used to map infrared
Language	English
Publishing date	2023-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2722985-3
ISSN	2166-532X
ISSN	2166-532X
DOI	10.1063/5.0061941
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Article ; Online: Future of covid-19 vaccine pricing: lessons from influenza.

Ramachandran, Reshma / Dhodapkar, Meera / Ross, Joseph S / Schwartz, Jason L

BMJ (Clinical research ed.)

2021 Volume 373, Page(s) n1467

MeSH term(s)	COVID-19/economics ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/economics ; Forecasting ; Global Health ; Humans ; Influenza Vaccines/economics ; Influenza, Human/economics ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Pandemics ; Pneumonia, Viral/economics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; SARS-CoV-2
Chemical Substances	COVID-19 Vaccines ; Influenza Vaccines
Language	English
Publishing date	2021-06-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.n1467
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Article ; Online: The Fate of the Inconclusive Periprosthetic Joint Infection Workup and Reliability of Data Points.

Antonios, Joseph K / Lim, Elisabeth S / Chang, Yu-Hui H / Bingham, Joshua S / Clarke, Henry D / Spangehl, Mark J / Schwartz, Adam J

Orthopedics

2023 Volume 46, Issue 5, Page(s) e291–e297

Abstract: In 2018, periprosthetic joint infection (PJI) criteria were revised to include a new category labeled "inconclusive." The purpose of this study was to characterize and describe the fate of the inconclusive PJI workup and to analyze preoperative factors ... ...

Abstract	In 2018, periprosthetic joint infection (PJI) criteria were revised to include a new category labeled "inconclusive." The purpose of this study was to characterize and describe the fate of the inconclusive PJI workup and to analyze preoperative factors associated with outcomes. We reviewed all PJI workups at our institution during a 3-year period (426 patients). Patients were labeled "infected," "not infected," or "inconclusive" according to 2018 PJI preoperative criteria. In addition to standard diagnostic variables, the presence or absence of clinical elements that increase the pretest probability of infection were collected. Patients with any missing preoperative diagnostic test results and those with clinical follow-up less than 30 days were excluded. Logistic regression was used to identify the factors associated with infection. Two hundred ninety-six workups remained after exclusion criteria were applied, consisting of 66 (22.2%) with a preoperative score of 6 or greater defined as infected, 52 (17.6%) inconclusive (score 2-5), and 178 (60.1%) not infected (score 0-1). Postoperative re-scoring of the inconclusive group based on intraoperative findings as per the 2018 criteria identified 6 of 52 (11.5%) as infected, 12 (23.1%) inconclusive, and 34 (65.4%) not infected. Among those preoperatively scored as inconclusive, variables statistically correlated with the presence of infection included history of PJI, factors that increase skin barrier penetration (eg, psoriasis and venous stasis), and presence of comorbidities predisposing to infection. For patients labeled inconclusive, clinical elements of the pretest probability for infection (eg, history of prior PJI) were as reliable as any diagnostic test, including alpha-defensin, in the diagnosis of PJI. [
MeSH term(s)	Humans ; Sensitivity and Specificity ; Prosthesis-Related Infections/diagnosis ; Prosthesis-Related Infections/surgery ; Reproducibility of Results ; Arthritis, Infectious/diagnosis ; Probability ; Synovial Fluid ; Retrospective Studies ; Arthroplasty, Replacement, Hip
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	424447-3
ISSN	1938-2367 ; 0147-7447
ISSN (online)	1938-2367
ISSN	0147-7447
DOI	10.3928/01477447-20230310-08
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Zs.A 1487: Show issues

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