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  1. Article ; Online: Molecular Phylogenetic and Comparative Genomic Analysis of

    Liu, Zuoheng / Lu, Yingling / Tang, Dexiang / Zhu, Juye / Luo, Lijun / Chen, Yue / Yu, Hong

    Journal of fungi (Basel, Switzerland)

    2024  Volume 10, Issue 4

    Abstract: ... ...

    Abstract Several
    Language English
    Publishing date 2024-04-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof10040297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Probing Oxidation Mechanisms in Plasmonic Catalysis: Unraveling the Role of Reactive Oxygen Species.

    Wei, Yunjia / Fan, Xingce / Chen, Dexiang / Zhu, Xiangnan / Yao, Lei / Zhao, Xing / Tang, Xiao / Wang, Jiawei / Zhang, Yuanjian / Qiu, Teng / Hao, Qi

    Nano letters

    2024  Volume 24, Issue 6, Page(s) 2110–2117

    Abstract: Plasmon-induced oxidation has conventionally been attributed to the transfer of plasmonic hot holes. However, this theoretical framework encounters challenges in elucidating the latest experimental findings, such as enhanced catalytic efficiency under ... ...

    Abstract Plasmon-induced oxidation has conventionally been attributed to the transfer of plasmonic hot holes. However, this theoretical framework encounters challenges in elucidating the latest experimental findings, such as enhanced catalytic efficiency under uncoupled irradiation conditions and superior oxidizability of silver nanoparticles. Herein, we employ liquid surface-enhanced Raman spectroscopy (SERS) as a real-time and
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c04979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: C5b-9 promotes ferritinophagy leading to ferroptosis in renal tubular epithelial cells of trichloroethylene-sensitized mice.

    Liu, Zhibing / Zhou, Sifan / Wang, Feng / Xie, Haibo / Zhang, Jiaxiang / Wu, Changhao / Xu, Dexiang / Zhu, Qixing

    The Science of the total environment

    2024  Volume 923, Page(s) 171378

    Abstract: Trichloroethylene (TCE) is a common environmental contaminant that can cause a severe allergic reaction called TCE hypersensitivity syndrome, which often implicates the patient's kidneys. Our previous study revealed that C5b-9-induced tubular ferroptosis ...

    Abstract Trichloroethylene (TCE) is a common environmental contaminant that can cause a severe allergic reaction called TCE hypersensitivity syndrome, which often implicates the patient's kidneys. Our previous study revealed that C5b-9-induced tubular ferroptosis is involved in TCE-caused kidney damage. However, the study did not explain how tubule-specific C5b-9 causes free iron overload, a key event in ferroptosis. Here, we aimed to explore the role of NCOA4-mediated ferritinophagy in C5b-9-induced iron overload and ferroptosis in TCE-sensitized mice. Our results showed that TCE sensitization does not affect iron import or export, but does affect iron storage, causing ferritin degradation and free iron overload. In addition, mitochondrial ROS was upregulated, and these changes were blocked by C5b-9 inhibition. Interestingly, TCE-induced ferritin degradation and ferroptosis were significantly antagonized by the application of the mitochondrial ROS inhibitor, Mito-TEMPO. Moreover, all of these modes of action were further verified in C5b-9-attack signalling HK-2 cells. Further investigation demonstrated that C5b-9-upregulated mitochondrial ROS induced a marked increase in nuclear receptor coactivator 4 (NCOA4), a master regulator of ferritinophagy. In addition, the application of NCOA4 small interfering RNA not only significantly reversed ferritinophagy caused by C5b-9 but also reduced C5b-9-induced ferroptosis in HK-2 cells. Taken together, these results suggest that tubule-specific C5b-9 deposition activates NCOA4 through the upregulation of mitochondrial ROS, causing ferritin degradation and elevated free iron, which ultimately leads to tubular epithelial cell ferroptosis and kidney injury in TCE-sensitized mice.
    MeSH term(s) Animals ; Mice ; Humans ; Trichloroethylene/toxicity ; Complement Membrane Attack Complex/metabolism ; Reactive Oxygen Species/metabolism ; Ferroptosis ; Iron/toxicity ; Iron/metabolism ; Ferritins/metabolism ; Epithelial Cells ; Iron Overload
    Chemical Substances Trichloroethylene (290YE8AR51) ; Complement Membrane Attack Complex ; Reactive Oxygen Species ; Iron (E1UOL152H7) ; Ferritins (9007-73-2)
    Language English
    Publishing date 2024-03-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171378
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  4. Article ; Online: Wide field electromagnetic method calculation in arbitrary orientation and its effectiveness analysis

    Hongjun Tian / Jianke Qiang / Kun Li / Zhangkun Tan / Ying Zhang / Dexiang Zhu

    Frontiers in Earth Science, Vol

    2023  Volume 11

    Abstract: The wide field electromagnetic method E_Ex observation method requires the horizontal electrical field source (AB) to be parallel to the measure station (MN), but the complex terrain conditions make it difficult to meet the AB parallel MN in field ... ...

    Abstract The wide field electromagnetic method E_Ex observation method requires the horizontal electrical field source (AB) to be parallel to the measure station (MN), but the complex terrain conditions make it difficult to meet the AB parallel MN in field construction, and there is always an azimuthal difference α between them, which will bring a large calculation error and cause distortion of the interpretation parameters if the calculation method E_Ex continues to be used. In order to tackle this problem, we analyse and study the E_Ex method and derive the new calculation method of E_EMN for the wide field electromagnetic method along the MN (E_EMN). The method is based on the intrinsic relationship between the electric field components Ex, Ey and the azimuthal difference α and derives the expression for the electric field E_EMN along the MN direction, and then uses the E_EMN to calculate the wide field apparent resistivity. In this paper, we design a three-layer geoelectric model and calculate the azimuthal angle difference α = 0° and α = 15°wide field apparent resistivity parameters, respectively. The results show that the relative error between the calculated apparent resistivity and the theoretical value is less than 1%, which verifies the correctness and validity of the method. To further verify the accuracy of the method, experimental work on azimuthal difference α was carried out next to a known well in Sichuan. The results show that: firstly, when α is 1°, 3°, 5°, 10°, and 15°, respectively, the relative error of each frequency point increases with α increasing. Secondly, when α is 1°, 3°, 5°, 10°, and 15°, respectively, the relative error of each frequency point is less than 10% when the EMN method is used to calculate the wide field apparent resistivity value; thirdly, taking α = 15° as an example, single-station inversions are performed with Ex and EMN apparent resistivity parameters, in which the Ex inversion results are more different from the trend of the logging curve, while the EMN inversion results ...
    Keywords electromagnetic prospecting ; controlled source electromagnetic ; wide field electromagnetic method ; azimuth angle correction ; accuracy and validity ; Science ; Q
    Subject code 600
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Erratum: Zinc-α2-glycoprotein 1 promotes EMT in colorectal cancer by filamin A mediated focal adhesion pathway: Erratum.

    Ji, Meiling / Li, Wenxiang / He, Guodong / Zhu, Dexiang / Lv, Shixu / Tang, Wentao / Jian, Mi / Zheng, Peng / Yang, Liangliang / Qi, Zhipeng / Mao, Yihao / Ren, Li / Zhong, Yunshi / Tu, Yongjiu / Wei, Ye / Xu, Jianmin

    Journal of Cancer

    2023  Volume 14, Issue 12, Page(s) 2359–2360

    Abstract: This corrects the article DOI: 10.7150/jca.35380.]. ...

    Abstract [This corrects the article DOI: 10.7150/jca.35380.].
    Language English
    Publishing date 2023-07-26
    Publishing country Australia
    Document type Published Erratum
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.87171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Highly Sensitive Immunosensing of Carcinoembryonic Antigen Based on Gold Nanoparticles Dotted PB@PANI Core-Shell Nanocubes as a Signal Probe.

    Feng, Dexiang / Chen, Lingzhi / Zhang, Ke / Zhu, Shuangshuang / Ying, Meichen / Jiang, Peng / Fu, Menglan / Wei, Yan / Li, Lihua

    Journal of analytical methods in chemistry

    2023  Volume 2023, Page(s) 7009624

    Abstract: Herein, a method was developed for the sensitive monitoring of carcinoembryonic antigen (CEA) by gold nanoparticles dotted prussian blue@polyaniline core-shell nanocubes (Au NPs/PB@PANI). First, a facile low-temperature method was used to prepare the ... ...

    Abstract Herein, a method was developed for the sensitive monitoring of carcinoembryonic antigen (CEA) by gold nanoparticles dotted prussian blue@polyaniline core-shell nanocubes (Au NPs/PB@PANI). First, a facile low-temperature method was used to prepare the uniform PB@PANI core-shell nanocubes with the assistance of PVP, where PB acted as the electron transfer mediator to provide electrochemical signals, and the PANI with excellent conductivity and desirable chemical stability not only played the role of a protective layer to prevent etching of PB in basic media but also effectively improved electron transfer. Importantly, to further enhance the electrical conductivity and biocompatibility of PB@PANI and to further enhance the electrochemical signal and capture a large amount of Ab
    Language English
    Publishing date 2023-04-07
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2654178-6
    ISSN 2090-8873 ; 2090-8865
    ISSN (online) 2090-8873
    ISSN 2090-8865
    DOI 10.1155/2023/7009624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: TFCP2 Overcomes Senescence by Cooperating With SREBP2 to Activate Cholesterol Synthesis in Pancreatic Cancer.

    Zhang, Dexiang / Lu, Pinxiang / Zhu, Kaihua / Wu, Haixia / Dai, Yuedi

    Frontiers in oncology

    2021  Volume 11, Page(s) 724437

    Abstract: KRAS mutation is very common in pancreatic cancer. How pancreatic cancer cells overcome oncogene-induced senescence is not fully understood. Our previous studies showed that up-regulation of TFCP2 (transcription factor CP2) in pancreatic cancer promoted ... ...

    Abstract KRAS mutation is very common in pancreatic cancer. How pancreatic cancer cells overcome oncogene-induced senescence is not fully understood. Our previous studies showed that up-regulation of TFCP2 (transcription factor CP2) in pancreatic cancer promoted the growth and metastasis of pancreatic cancer cells. However, whether TFCP2 plays an important role in pancreatic cancer cell senescence is not clear. In this study, we found upregulation of TFCP2 expression in pancreatic cancer was associated with KRAS mutation. Overexpression of TFCP2 inhibited cell senescence. Knockdown of TFCP2 promoted cell senescence. Mechanistically, the interaction between TFCP2 and SREBP2 (sterol regulatory element binding transcription factor 2) synergistically activated the expression of HMGCR, a rate-limiting enzyme in cholesterol synthesis, and statins could reverse the inhibitory effect of TFCP2 on senescence. In conclusion, our study reveals a new mechanism underlying the TFCP2 regulation of pancreatic cancer cell senescence, providing a new target for the treatment of pancreatic cancer.
    Language English
    Publishing date 2021-11-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.724437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Carbene Footprinting Directs Design of Genetically Encoded Proximity-Reactive Protein Binders.

    Ye, Hui / Zhu, Yinxue / Kong, Ying / Wen, Hongtao / Lu, Wenjie / Wang, Dexiang / Tang, Shuo / Zhan, Mengru / Lu, Gaoyuan / Shao, Chang / Wang, Nanxi / Hao, Haiping

    Analytical chemistry

    2024  

    Abstract: Genetically encoding proximal-reactive unnatural amino acids (PrUaas), such as fluorosulfate-l-tyrosine (FSY), into natural proteins of interest (POI) confer the POI with the ability to covalently bind to its interacting proteins (IPs). The PrUaa- ... ...

    Abstract Genetically encoding proximal-reactive unnatural amino acids (PrUaas), such as fluorosulfate-l-tyrosine (FSY), into natural proteins of interest (POI) confer the POI with the ability to covalently bind to its interacting proteins (IPs). The PrUaa-incorporated POIs hold promise for blocking undesirable POI-IP interactions. Selecting appropriate PrUaa anchor sites is crucial, but it remains challenging with the current methodology, which heavily relies on crystallography to identify the proximal residues between the POIs and the IPs for the PrUaa anchorage. To address the challenge, here, we propose a footprinting-directed genetically encoded covalent binder (footprinting-GECB) approach. This approach employs carbene footprinting, a structural mass spectrometry (MS) technique that quantifies the extent of labeling of the POI following the addition of its IP, and thus identifies the responsive residues. By genetically encoding PrUaa into these responsive sites, POI variants with covalent bonding ability to its IP can be produced without the need for crystallography. Using the POI-IP model, KRAS/RAF1, we showed that engineering FSY at the footprint-assigned KRAS residue resulted in a KRAS variant that can bind irreversibly to RAF1. Additionally, we inserted FSY at the responsive residue in RAF1 upon footprinting the oncogenic KRAS
    Language English
    Publishing date 2024-04-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.4c00424
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  9. Article ; Online: Highly Sensitive Immunosensing of Carcinoembryonic Antigen Based on Gold Nanoparticles Dotted PB@PANI Core-Shell Nanocubes as a Signal Probe

    Dexiang Feng / Lingzhi Chen / Ke Zhang / Shuangshuang Zhu / Meichen Ying / Peng Jiang / Menglan Fu / Yan Wei / Lihua Li

    Journal of Analytical Methods in Chemistry, Vol

    2023  Volume 2023

    Abstract: Herein, a method was developed for the sensitive monitoring of carcinoembryonic antigen (CEA) by gold nanoparticles dotted prussian blue@polyaniline core-shell nanocubes (Au NPs/PB@PANI). First, a facile low-temperature method was used to prepare the ... ...

    Abstract Herein, a method was developed for the sensitive monitoring of carcinoembryonic antigen (CEA) by gold nanoparticles dotted prussian blue@polyaniline core-shell nanocubes (Au NPs/PB@PANI). First, a facile low-temperature method was used to prepare the uniform PB@PANI core-shell nanocubes with the assistance of PVP, where PB acted as the electron transfer mediator to provide electrochemical signals, and the PANI with excellent conductivity and desirable chemical stability not only played the role of a protective layer to prevent etching of PB in basic media but also effectively improved electron transfer. Importantly, to further enhance the electrical conductivity and biocompatibility of PB@PANI and to further enhance the electrochemical signal and capture a large amount of Ab2, Au NPs were doped on the surface of PB@PANI to form Au NPs/PB@PANI nanocomposites. Subsequently, benefiting from the advantages of core-shell structure nanoprobes and gold-platinum bimetallic nanoflower (AuPt NF), a sandwich-type electrochemical immunosensor for CEA detection was constructed, which provided a wide linear detection range from 1.0 pg·mL−1 to 100.0 ng·mL−1 and a low detection limit of 0.35 pg·mL−1 via DPV (at 3σ). Moreover, it displayed a satisfactory result when the core-shell structure nanoprobe-based immunosensor was applied to determine CEA in real human serum samples.
    Keywords Analytical chemistry ; QD71-142
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Metal-organic framework-based self-healing hydrogel fiber random lasers.

    Zhu, Dexiang / Wang, Zhouyuanhang / Xie, Jun / Qu, Guangyin / Yu, Qi / Kuai, Yan / Yu, Benli / Zheng, Jianzhong / Hu, Zhijia / Li, Siqi

    Nanoscale

    2023  Volume 15, Issue 25, Page(s) 10685–10692

    Abstract: Metal-organic frameworks (MOFs), which have well-defined nanoporous skeletons and whose natural structure can work as optical resonant cavities, are emerging as ideal platforms for constructing micro/nanolasers. However, lasing generated from the light ... ...

    Abstract Metal-organic frameworks (MOFs), which have well-defined nanoporous skeletons and whose natural structure can work as optical resonant cavities, are emerging as ideal platforms for constructing micro/nanolasers. However, lasing generated from the light oscillating inside a defined MOFs' cavity usually suffers the drawback of the lasing performance being difficult to maintain once the cavity is destroyed. In this work, we report a MOF-based self-healing hydrogel fiber random laser (MOF-SHFRL) that can withstand extreme damage. The optical feedback of MOF-SHFRLs does not depend on the light reflection inside the MOF cavity but comes from the multiple scattering effects from the MOF nanoparticles (NPs). The hydrogel fiber's one-dimensional waveguide structure also permits confined directional lasing transmission. Based on such an ingenious design, a robust random lasing is achieved without worrying about the destruction of the MOF NPs. More interestingly, the MOF-SHFRL demonstrates excellent self-healing ability without any external stimulation: it can fully recover its initial morphology and lasing performance even when totally broken (
    MeSH term(s) Hydrogels ; Metal-Organic Frameworks ; Lasers ; Optical Devices ; Environmental Monitoring
    Chemical Substances Hydrogels ; Metal-Organic Frameworks
    Language English
    Publishing date 2023-06-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr00675a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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