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Article ; Online: Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription modified Shen-Yan-Fang-Shuai formula in treating diabetic nephropathy.

Yu, Borui / Zhou, Mengqi / Dong, Zhaocheng / Zheng, Huijuan / Zhao, Yuxue / Zhou, Jingwei / Zhang, Chao / Wei, Fudong / Yu, Guoyong / Liu, Wei Jing / Liu, Hongfang / Wang, Yaoxian

Pharmaceutical biology

2023 Volume 61, Issue 1, Page(s) 1222–1233

Abstract: ... Fang-Shuai formula (M-SYFSF) has excellent clinical efficacy in treating diabetic kidney disease ...

Abstract	Context: Diabetic nephropathy (DN) is the main cause of end-stage renal disease. Modified Shen-Yan-Fang-Shuai formula (M-SYFSF) has excellent clinical efficacy in treating diabetic kidney disease. However, the potential mechanism of M-SYFSF remains unknown. Objective: To investigate the mechanism of M-SYFSF against DN by network pharmacological analysis and biological experiments. Materials and methods: Utilizing a web-based pharmacology database, the potential mechanisms of M-SYFSF against DN were identified. Results: Network pharmacological analysis showed that MAPK pathway was the potential pathway. Results showed that compared with the Model group, M-SYFSF significantly reduced 24h urine albumin, UACR, and serum creatinine levels (54.90 ± 26.67 vs. 111.78 ± 4.28, 8.87 ± 1.69 vs. 53.94 ± 16.01, 11.56 ± 1.70 vs. 118.70 ± 49.57, respectively), and improved renal pathological changes. Furthermore, the intervention of M-SYFSF reduced the expression of pro-inflammatory cytokines and inhibited the activation of MAPK pathway in AGEs-treated HK-2 cells. Discussion and conclusion: M-SYFSF is likely to reduce inflammation in DN by inhibiting the MAPK pathway. It provides a theoretical basis for the clinical application of M-SYFSF in the treatment of DN.
MeSH term(s)	Rats ; Male ; Humans ; Animals ; Diabetic Nephropathies/metabolism ; Network Pharmacology ; Rats, Sprague-Dawley ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Glycation End Products, Advanced/metabolism
Chemical Substances	Drugs, Chinese Herbal ; Glycation End Products, Advanced
Language	English
Publishing date	2023-08-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2023.2241521
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Article ; Online: Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription modified Shen-Yan-Fang-Shuai formula in treating diabetic nephropathy

Borui Yu / Mengqi Zhou / Zhaocheng Dong / Huijuan Zheng / Yuxue Zhao / Jingwei Zhou / Chao Zhang / Fudong Wei / Guoyong Yu / Wei Jing Liu / Hongfang Liu / Yaoxian Wang

Pharmaceutical Biology, Vol 61, Iss 1, Pp 1222-

2023 Volume 1233

Abstract: ... Shen-Yan-Fang-Shuai formula (M-SYFSF) has excellent clinical efficacy in treating ...

Abstract	AbstractContext Diabetic nephropathy (DN) is the main cause of end-stage renal disease. Modified Shen-Yan-Fang-Shuai formula (M-SYFSF) has excellent clinical efficacy in treating diabetic kidney disease. However, the potential mechanism of M-SYFSF remains unknown.Objective To investigate the mechanism of M-SYFSF against DN by network pharmacological analysis and biological experiments.Materials and methods Utilizing a web-based pharmacology database, the potential mechanisms of M-SYFSF against DN were identified. In vivo experiments, male SD rats were injected with streptozotocin (50 mg/kg) and got uninephrectomy to construct a model of DN. M-SYFSF (11.34 g/kg/d) was gavaged once per day for 12 weeks after model establishment. In vitro experiments, human proximal tubular cells (HK-2) were performed with advanced glycation end-products (AGEs) (100 μg/mL), then intervened with M-SYFSF freeze-dried powder. Pathological staining, WB, IHC, ELISA were conducted to explore the mechanism of M-SYFSF against DN.Results Network pharmacological analysis showed that MAPK pathway was the potential pathway. Results showed that compared with the Model group, M-SYFSF significantly reduced 24h urine albumin, UACR, and serum creatinine levels (54.90 ± 26.67 vs. 111.78 ± 4.28, 8.87 ± 1.69 vs. 53.94 ± 16.01, 11.56 ± 1.70 vs. 118.70 ± 49.57, respectively), and improved renal pathological changes. Furthermore, the intervention of M-SYFSF reduced the expression of pro-inflammatory cytokines and inhibited the activation of MAPK pathway in AGEs-treated HK-2 cells.Discussion and conclusion M-SYFSF is likely to reduce inflammation in DN by inhibiting the MAPK pathway. It provides a theoretical basis for the clinical application of M-SYFSF in the treatment of DN.
Keywords	Traditional Chinese medicine formula ; protein-protein interaction network ; MAPK signaling pathway ; inflammation ; Therapeutics. Pharmacology ; RM1-950
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sanhuang Shu'ai decoction alleviates DSS-induced ulcerative colitis via regulation of gut microbiota, inflammatory mediators and cytokines.

Wu, Zi-Cong / Zhao, Zhen-Ling / Deng, Jian-Ping / Huang, Jing-Tao / Wang, Yi-Fei / Wang, Zhi-Ping

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2020 Volume 125, Page(s) 109934

Abstract: Background: Sanhuangshu'ai decoction (SH), a traditional Chinese medicine (TCM) prescription, has been safely used to treat diarrhea, dysentery and other inflammatory diseases with little side effect and low cost for thousands of years. However, its ... ...

Abstract	Background: Sanhuangshu'ai decoction (SH), a traditional Chinese medicine (TCM) prescription, has been safely used to treat diarrhea, dysentery and other inflammatory diseases with little side effect and low cost for thousands of years. However, its mechanism remains elusive. This study was designed to investigate the anti-ulcerative colitis (UC) activity of SH and mechanism by detecting its anti-inflammatory, anti-oxidative, and intervention effects of intestinal flora with the dextran sodium sulfate (DSS)-induced colitis mice. Methods: The DSS-induced colitis mice was orally administered SH for 1 week with 0.8 or 1.6 g kg Results: Oral administration of SH significantly prevented the development of colitis. It reduced the expression of interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-α in the colon. Moreover, SH administration alleviated the oxidative stress in the colon of DSS-induced colitis mice, evidenced by the decrease of myeloperoxidase (MPO) activity and malondialdehyde (MDA) level, and increase of ROS level. Furthermore, SH can prevent the decrease ofLactobacillus sp. and population abundance of intestinal flora caused by DSS. Conclusion: SH significantly ameliorates the symptoms of DSS-induced colitis mice and the potential mechanism of SH may involve in multiple kinds of metabolic pathway including the regulation of gut microbiota, inflammatory mediators and cytokines.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/administration & dosage ; Antioxidants/pharmacology ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/physiopathology ; Cytokines/metabolism ; Dextran Sulfate ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Gastrointestinal Microbiome/drug effects ; Inflammation Mediators/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Oxidative Stress/drug effects
Chemical Substances	Anti-Inflammatory Agents ; Antioxidants ; Cytokines ; Drugs, Chinese Herbal ; Inflammation Mediators ; sanhuang ; Dextran Sulfate (9042-14-2)
Language	English
Publishing date	2020-02-12
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2020.109934
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Article ; Online: Sanhuang Shu'ai decoction alleviates DSS-induced ulcerative colitis via regulation of gut microbiota, inflammatory mediators and cytokines

Zi-cong Wu / Zhen-ling Zhao / Jian-ping Deng / Jing-tao Huang / Yi-fei Wang / Zhi-ping Wang

Biomedicine & Pharmacotherapy, Vol 125, Iss , Pp 109934- (2020)

2020

Abstract: Background: Sanhuangshu’ai decoction (SH), a traditional Chinese medicine (TCM) prescription, has been safely used to treat diarrhea, dysentery and other inflammatory diseases with little side effect and low cost for thousands of years. However, its ... ...

Abstract	Background: Sanhuangshu’ai decoction (SH), a traditional Chinese medicine (TCM) prescription, has been safely used to treat diarrhea, dysentery and other inflammatory diseases with little side effect and low cost for thousands of years. However, its mechanism remains elusive. This study was designed to investigate the anti-ulcerative colitis (UC) activity of SH and mechanism by detecting its anti-inflammatory, anti-oxidative, and intervention effects of intestinal flora with the dextran sodium sulfate (DSS)-induced colitis mice. Methods: The DSS-induced colitis mice was orally administered SH for 1 week with 0.8 or 1.6 g kg−1 d-1 dosage. A clinical disease activity score was evaluated daily. The colonic tissues of the mice were collected and prepared to detect its anti-inflammatory, anti-oxidative, intervention effects of intestinal flora and hydrogen peroxide(H2O2) in vivo, cytotoxicity and ROS influencing effects in vitro. Histological colitis severity and expression of cytokines were also determined. Results: Oral administration of SH significantly prevented the development of colitis. It reduced the expression of interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-α in the colon. Moreover, SH administration alleviated the oxidative stress in the colon of DSS-induced colitis mice, evidenced by the decrease of myeloperoxidase (MPO) activity and malondialdehyde (MDA) level, and increase of ROS level. Furthermore, SH can prevent the decrease ofLactobacillus sp. and population abundance of intestinal flora caused by DSS. Conclusion: SH significantly ameliorates the symptoms of DSS-induced colitis mice and the potential mechanism of SH may involve in multiple kinds of metabolic pathway including the regulation of gut microbiota, inflammatory mediators and cytokines.
Keywords	Sanhuangshu'ai decoction ; Traditional Chinese medicine ; Ulcerative colitis ; Inflammation ; Intestinal flora ; Therapeutics. Pharmacology ; RM1-950
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sanhuang Shu'ai decoction alleviates DSS-induced ulcerative colitis via regulation of gut microbiota, inflammatory mediators and cytokines

Zi-cong Wu / Zhen-ling Zhao / Jian-ping Deng / Jing-tao Huang / Yi-fei Wang / Zhi-ping Wang

Biomedicine & Pharmacotherapy, Vol 125, Iss , Pp 109934- (2020)

2020

Abstract	Background: Sanhuangshu’ai decoction (SH), a traditional Chinese medicine (TCM) prescription, has been safely used to treat diarrhea, dysentery and other inflammatory diseases with little side effect and low cost for thousands of years. However, its mechanism remains elusive. This study was designed to investigate the anti-ulcerative colitis (UC) activity of SH and mechanism by detecting its anti-inflammatory, anti-oxidative, and intervention effects of intestinal flora with the dextran sodium sulfate (DSS)-induced colitis mice. Methods: The DSS-induced colitis mice was orally administered SH for 1 week with 0.8 or 1.6 g kg−1 d-1 dosage. A clinical disease activity score was evaluated daily. The colonic tissues of the mice were collected and prepared to detect its anti-inflammatory, anti-oxidative, intervention effects of intestinal flora and hydrogen peroxide(H2O2) in vivo, cytotoxicity and ROS influencing effects in vitro. Histological colitis severity and expression of cytokines were also determined. Results: Oral administration of SH significantly prevented the development of colitis. It reduced the expression of interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-α in the colon. Moreover, SH administration alleviated the oxidative stress in the colon of DSS-induced colitis mice, evidenced by the decrease of myeloperoxidase (MPO) activity and malondialdehyde (MDA) level, and increase of ROS level. Furthermore, SH can prevent the decrease ofLactobacillus sp. and population abundance of intestinal flora caused by DSS. Conclusion: SH significantly ameliorates the symptoms of DSS-induced colitis mice and the potential mechanism of SH may involve in multiple kinds of metabolic pathway including the regulation of gut microbiota, inflammatory mediators and cytokines.
Keywords	Sanhuangshu'ai decoction ; Traditional Chinese medicine ; Ulcerative colitis ; Inflammation ; Intestinal flora ; Therapeutics. Pharmacology ; RM1-950
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chemical composition differentiation of Shen-Shuai-Ning granule between combined decoction and separated decoction using HPLC-DAD-ESI-QTOF-MS.

Liu, Jianli / Zhang, Yu / Hao, Yimeng / Zhao, Ying / Li, Yanjiao / Qin, Rulan / Lv, Chongning / Lu, Jincai

Biomedical chromatography : BMC

2017 Volume 31, Issue 9

Abstract: Shen-Shuai-Ning (SSN) granule, a traditional Chinese medicine formula, is widely used in clinical ...

Abstract	Shen-Shuai-Ning (SSN) granule, a traditional Chinese medicine formula, is widely used in clinical practice for treating chronic renal failure. However, its detailed chemical profile is unknown. Here, HPLC-ESI-QTOF-MS was employed for the systematic chemical analysis of SSN. A total of 52 compounds were identified and the characteristic ions of the compounds were described. Furthermore, chemical consistency between the combined decoction and the separated decoction of SSN was evaluated using HPLC-DAD. A chemical comparison between two preparations of SSN granule (combined decoction and separated decoction of Coptides Rhizoma) indicated a significant difference in the content of many compounds, including salvianolic acid A, salvianolic acid B, berberine, palmatine and epiberberine. As a result, separated decoction of Coptides Rhizoma would lead to a significantly decrease in depsides in Salviae Miltiorrhizae Radix et Rhizoma and an increase in alkaloids in Coptidis Rhizoma.
MeSH term(s)	Benzofurans ; Berberine Alkaloids ; Caffeic Acids ; Chromatography, High Pressure Liquid/methods ; Drug Compounding ; Drugs, Chinese Herbal/analysis ; Drugs, Chinese Herbal/chemistry ; Flavones ; Lactates ; Saponins ; Spectrometry, Mass, Electrospray Ionization/methods
Chemical Substances	Benzofurans ; Berberine Alkaloids ; Caffeic Acids ; Drugs, Chinese Herbal ; Flavones ; Lactates ; Saponins ; Shenshuaining ; salvianolic acid A (51622542XO) ; salvianolic acid B (C1GQ844199)
Language	English
Publishing date	2017-09
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.3949
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Article ; Online: Traditional Chinese Medicine Formula Kang Shuai Lao Pian Improves Obesity, Gut Dysbiosis, and Fecal Metabolic Disorders in High-Fat Diet-Fed Mice

Shuqing Gong / Tingting Ye / Meixia Wang / Mengying Wang / Yufei Li / Lina Ma / Yulian Yang / Yi Wang / Xiaoping Zhao / Li Liu / Min Yang / Huan Chen / Jing Qian

Frontiers in Pharmacology, Vol

2020 Volume 11

Abstract: ... defined. In current study, we applied a traditional herbal formula Kang Shuai Lao Pian (KSLP) to HFD-fed ...

Abstract	High-fat diet (HFD)-induced obesity is a risk factor for many metabolic disorders including cardiovascular diseases, diabetes, and fatty liver disease. Although there are accumulating evidences supporting the assumption that regulating gut microbiota as well as its metabolic status is able to mitigate obesity, the inner relationship between the obesity-related gut microbiota and the relevant metabolites are not well defined. In current study, we applied a traditional herbal formula Kang Shuai Lao Pian (KSLP) to HFD-fed mice and evaluated its effect against obesity. Emphases were addressed on identifying profiles of gut microbiota and fecal metabolites with the aid of 16S rRNA gene sequencing and non-target fecal metabolomics techniques. We showed that KSLP could improve HFD-induced obesity, glucose tolerance disorder, as well as gut dysbiosis. In the gut, KSLP corrected the increased abundance of Firmicutes and Proteobacteria, increased ratio of Firmicutes/Bacteroidetes, and decreased abundance of Bacteroidetes caused by HFD. KSLP also reversed HFD-induced significant changes in the abundance of certain genus including Intestinimonas, Oscillibacter, Christensenellaceae_R-7_group, Ruminococcaceae_UCG-010, and Aliihoeflea. Pearson correlation analysis indicated that except for Ruminococcaceae_UCG-010, other four genera had positive correlations with obesity. In addition, 22 key fecal metabolites responding to KSLP treatment were identified. Pearson correlation analysis showed that those metabolites are intimately related to KSLP effective genera of Intestinimonas, Oscillibacter, and Christensenellaceae_R-7_group. Our results indicate that KSLP is a promising traditional Chinese medicine (TCM) applicable for individuals with HFD habit. Intestinimonas, Oscillibacter, and Christensenellaceae_R-7_group might be responsible for the regulatory effect of KSLP. Linking of obesity phenotypes with gut microbiota as well as fecal metabolites is therefore a powerful research strategy to reveal the mechanism of obesity and the ...
Keywords	Traditional Chinese medicine ; high-fat diet ; obesity ; gut microbiota ; fecal non-targeted metabolomics ; correlation analysis ; Therapeutics. Pharmacology ; RM1-950
Subject code	616
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Bu shen, Zhang yang, Kang shuai

Zhao, Jiaqi

xing gong neng zhang ai yu Zhong yi zi wo kang fu

1989

Title translation	Sex function disorders and self-rehabilitation in Chinese traditional medicine.
Author's details	zhu bian Zhao Jiaqi
MeSH term(s)	Medicine, Chinese Traditional ; Sexual Dysfunction, Physiological/rehabilitation ; Sexual Dysfunctions, Psychological
Language	Chinese
Size	2, 3, 262 p., [6] folded leaves :, ill.
Edition	Di 1 ban.
Publisher	Tianjin da hsëh chu ban she
Publishing place	Tianjin
Document type	Book
ISBN	9787561800874 ; 7561800878
Database	Catalogue of the US National Library of Medicine (NLM)

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Book ; Thesis: Hypoxia-inducible factors inhibit NLRP3 inflammasome by decreasing the activity of Inhibitory-κB Kinase in the THP-1 monocytic cell line

Zhao, Shuai / Bode, Christian

2021

Institution	Rheinische Friedrich-Wilhelms-Universität Bonn
Author's details	Shuai Zhao ; 1. Gutachter: PD Dr. med. Christian Bode
Language	English
Size	85 Seiten, Diagramme
Publishing place	Bonn
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2021
HBZ-ID	HT021079146
Database	Catalogue ZB MED Medicine, Health

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2022 D 315	order for loan	Magazin

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Article ; Online: Disorder-based T cell developmental order.

Liu, Shuai / Zhao, Keji

Nature immunology

2024 Volume 24, Issue 10, Page(s) 1602–1603

Language	English
Publishing date	2024-02-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-023-01623-w
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