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  1. Book: Gangliosides

    Sonnino, Sandro / Prinetti, Alessandro

    methods and protocols

    (Methods in molecular biology ; 1804 ; Springer protocols)

    2018  

    Author's details edited by Sandro Sonnino and Alessandro Prinetti
    Series title Methods in molecular biology ; 1804
    Springer protocols
    Collection
    Language English
    Size xv, 456 Seiten, Illustrationen, Diagramme
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT019748749
    ISBN 978-1-4939-8551-7 ; 9781493985524 ; 1-4939-8551-5 ; 1493985523
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1804- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Afterword (Editorial).

    Iwabuchi, Kazuhisa / Prinetti, Alessandro

    Glycoconjugate journal

    2022  Volume 40, Issue 1, Page(s) 119–122

    MeSH term(s) Cell Membrane ; Cell Adhesion ; G(M3) Ganglioside
    Chemical Substances G(M3) Ganglioside
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 283770-5
    ISSN 1573-4986 ; 0282-0080
    ISSN (online) 1573-4986
    ISSN 0282-0080
    DOI 10.1007/s10719-022-10090-8
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  3. Article ; Online: Introduction: the Glycobiology of nervous system.

    Sonnino, Sandro / Prinetti, Alessandro

    Glycoconjugate journal

    2018  Volume 35, Issue 4, Page(s) 343–344

    MeSH term(s) Animals ; Congresses as Topic ; Glycomics ; Humans ; Nervous System/metabolism ; Polysaccharides/metabolism ; Republic of Korea ; Societies, Scientific
    Chemical Substances Polysaccharides
    Language English
    Publishing date 2018-09-04
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 283770-5
    ISSN 1573-4986 ; 0282-0080
    ISSN (online) 1573-4986
    ISSN 0282-0080
    DOI 10.1007/s10719-018-9840-9
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  4. Article ; Online: The Role of Sphingolipids in Cancer Immunotherapy.

    Giussani, Paola / Prinetti, Alessandro / Tringali, Cristina

    International journal of molecular sciences

    2021  Volume 22, Issue 12

    Abstract: Immunotherapy is now considered an innovative and strong strategy to beat metastatic, drug-resistant, or relapsing tumours. It is based on the manipulation of several mechanisms involved in the complex interplay between cancer cells and immune system ... ...

    Abstract Immunotherapy is now considered an innovative and strong strategy to beat metastatic, drug-resistant, or relapsing tumours. It is based on the manipulation of several mechanisms involved in the complex interplay between cancer cells and immune system that culminates in a form of immune-tolerance of tumour cells, favouring their expansion. Current immunotherapies are devoted enforcing the immune response against cancer cells and are represented by approaches employing vaccines, monoclonal antibodies, interleukins, checkpoint inhibitors, and chimeric antigen receptor (CAR)-T cells. Despite the undoubted potency of these treatments in some malignancies, many issues are being investigated to amplify the potential of application and to avoid side effects. In this review, we discuss how sphingolipids are involved in interactions between cancer cells and the immune system and how knowledge in this topic could be employed to enhance the efficacy of different immunotherapy approaches. In particular, we explore the following aspects: how sphingolipids are pivotal components of plasma membranes and could modulate the functionality of surface receptors expressed also by immune cells and thus their functionality; how sphingolipids are related to the release of bioactive mediators, sphingosine 1-phosphate, and ceramide that could significantly affect lymphocyte egress and migration toward the tumour milieu, in addition regulating key pathways needed to activate immune cells; given the renowned capability of altering sphingolipid expression and metabolism shown by cancer cells, how it is possible to employ sphingolipids as antigen targets.
    MeSH term(s) Animals ; Antigens, Neoplasm/immunology ; Cell Communication ; Disease Management ; Disease Susceptibility ; Humans ; Immune System/immunology ; Immune System/metabolism ; Immunomodulation ; Immunotherapy/adverse effects ; Immunotherapy/methods ; Immunotherapy, Adoptive/adverse effects ; Immunotherapy, Adoptive/methods ; Lysophospholipids/metabolism ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/therapy ; Signal Transduction ; Sphingolipids/chemistry ; Sphingolipids/immunology ; Sphingolipids/metabolism ; Sphingosine/analogs & derivatives ; Sphingosine/metabolism ; Treatment Outcome
    Chemical Substances Antigens, Neoplasm ; Lysophospholipids ; Sphingolipids ; sphingosine 1-phosphate (26993-30-6) ; Sphingosine (NGZ37HRE42)
    Language English
    Publishing date 2021-06-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22126492
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The role of Sphingolipids in myelination and myelin stability and their involvement in childhood and adult demyelinating disorders.

    Giussani, Paola / Prinetti, Alessandro / Tringali, Cristina

    Journal of neurochemistry

    2020  Volume 156, Issue 4, Page(s) 403–414

    Abstract: Multiple sclerosis (MS) represents the most common demyelinating disease affecting the central nervous system (CNS) in adults as well as in children. Furthermore, in children, in addition to acquired diseases such as MS, genetically inherited diseases ... ...

    Abstract Multiple sclerosis (MS) represents the most common demyelinating disease affecting the central nervous system (CNS) in adults as well as in children. Furthermore, in children, in addition to acquired diseases such as MS, genetically inherited diseases significantly contribute to the incidence of demyelinating disorders. Some genetic defects lead to sphingolipid alterations that are able to elicit neurological symptoms. Sphingolipids are essential for brain development, and their aberrant functionality may thus contribute to demyelinating diseases such as MS. In particular, sphingolipidoses caused by deficits of sphingolipid-metabolizing enzymes, are often associated with demyelination. Sphingolipids are not only structural molecules but also bioactive molecules involved in the regulation of cellular events such as development of the nervous system, myelination and maintenance of myelin stability. Changes in the sphingolipid metabolism deeply affect plasma membrane organization. Thus, changes in myelin sphingolipid composition might crucially contribute to the phenotype of diseases characterized by demyelinalization. Here, we review key features of several sphingolipids such as ceramide/dihydroceramide, sphingosine/dihydrosphingosine, glucosylceramide and, galactosylceramide which act in myelin formation during rat brain development and in human brain demyelination during the pathogenesis of MS, suggesting that this knowledge could be useful in identifying targets for possible therapies.
    MeSH term(s) Adult ; Animals ; Child ; Demyelinating Diseases/metabolism ; Demyelinating Diseases/pathology ; Humans ; Myelin Sheath/metabolism ; Myelin Sheath/pathology ; Nerve Fibers, Myelinated/metabolism ; Nerve Fibers, Myelinated/pathology ; Sphingolipids/metabolism
    Chemical Substances Sphingolipids
    Language English
    Publishing date 2020-08-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/jnc.15133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.170: Show issues Location:
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  6. Article ; Online: The Role of Sphingolipids in Cancer Immunotherapy

    Paola Giussani / Alessandro Prinetti / Cristina Tringali

    International Journal of Molecular Sciences, Vol 22, Iss 6492, p

    2021  Volume 6492

    Abstract: Immunotherapy is now considered an innovative and strong strategy to beat metastatic, drug-resistant, or relapsing tumours. It is based on the manipulation of several mechanisms involved in the complex interplay between cancer cells and immune system ... ...

    Abstract Immunotherapy is now considered an innovative and strong strategy to beat metastatic, drug-resistant, or relapsing tumours. It is based on the manipulation of several mechanisms involved in the complex interplay between cancer cells and immune system that culminates in a form of immune-tolerance of tumour cells, favouring their expansion. Current immunotherapies are devoted enforcing the immune response against cancer cells and are represented by approaches employing vaccines, monoclonal antibodies, interleukins, checkpoint inhibitors, and chimeric antigen receptor (CAR)-T cells. Despite the undoubted potency of these treatments in some malignancies, many issues are being investigated to amplify the potential of application and to avoid side effects. In this review, we discuss how sphingolipids are involved in interactions between cancer cells and the immune system and how knowledge in this topic could be employed to enhance the efficacy of different immunotherapy approaches. In particular, we explore the following aspects: how sphingolipids are pivotal components of plasma membranes and could modulate the functionality of surface receptors expressed also by immune cells and thus their functionality; how sphingolipids are related to the release of bioactive mediators, sphingosine 1-phosphate, and ceramide that could significantly affect lymphocyte egress and migration toward the tumour milieu, in addition regulating key pathways needed to activate immune cells; given the renowned capability of altering sphingolipid expression and metabolism shown by cancer cells, how it is possible to employ sphingolipids as antigen targets.
    Keywords sphingolipids ; sphingosine 1-phosphate ; immunotherapy ; cancer ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Identification of the Lipid Antigens Recognized by rHIgM22, a Remyelination-Promoting Antibody.

    Grassi, Sara / Cabitta, Livia / Prioni, Simona / Mauri, Laura / Ciampa, Maria Grazia / Yokoyama, Noriko / Iwabuchi, Kazuhisa / Zorina, Yana / Prinetti, Alessandro

    Neurochemical research

    2023  Volume 48, Issue 6, Page(s) 1783–1797

    Abstract: Failure of the immune system to discriminate myelin components from foreign antigens plays a critical role in the pathophysiology of multiple sclerosis. In fact, the appearance of anti-myelin autoantibodies, targeting both proteins and glycolipids, is ... ...

    Abstract Failure of the immune system to discriminate myelin components from foreign antigens plays a critical role in the pathophysiology of multiple sclerosis. In fact, the appearance of anti-myelin autoantibodies, targeting both proteins and glycolipids, is often responsible for functional alterations in myelin-producing cells in this disease. Nevertheless, some of these antibodies were reported to be beneficial for remyelination. Recombinant human IgM22 (rHIgM22) binds to myelin and to the surface of O4-positive oligodendrocytes, and promotes remyelination in mouse models of chronic demyelination. Interestingly, the identity of the antigen recognized by this antibody remains to be elucidated. The preferential binding of rHIgM22 to sulfatide-positive cells or tissues suggests that sulfatide might be part of the antigen pattern recognized by the antibody, however, cell populations lacking sulfatide expression are also responsive to rHIgM22. Thus, we assessed the binding of rHIgM22 in vitro to purified lipids and lipid extracts from various sources to identify the antigen(s) recognized by this antibody. Our results show that rHIgM22 is indeed able to bind both sulfatide and its deacylated form, whereas no significant binding for other myelin sphingolipids has been detected. Remarkably, binding of rHIgM22 to sulfatide in lipid monolayers can be positively or negatively regulated by the presence of other lipids. Moreover, rHIgM22 also binds to phosphatidylinositol, phosphatidylserine and phosphatidic acid, suggesting that not only sulfatide, but also other membrane lipids might play a role in the binding of rHIgM22 to oligodendrocytes and to other cell types not expressing sulfatide.
    MeSH term(s) Animals ; Humans ; Mice ; Immunoglobulin M ; Myelin Sheath/metabolism ; Oligodendroglia/metabolism ; Remyelination ; Sulfoglycosphingolipids/metabolism ; Lipids/immunology
    Chemical Substances Immunoglobulin M ; Sulfoglycosphingolipids ; Lipids
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 199335-5
    ISSN 1573-6903 ; 0364-3190
    ISSN (online) 1573-6903
    ISSN 0364-3190
    DOI 10.1007/s11064-023-03859-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1368: Show issues Location:
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  8. Article ; Online: Fundamental neurochemistry review: Old brain stories - Influence of age and sex on the neurodegeneration-associated lipid changes.

    Cuenca-Bermejo, Lorena / Prinetti, Alessandro / Kublickiene, Karolina / Raparelli, Valeria / Kautzky-Willer, Alexandra / Norris, Colleen M / Pilote, Louise / Herrero, María Trinidad

    Journal of neurochemistry

    2023  Volume 166, Issue 3, Page(s) 427–452

    Abstract: Brain aging is a naturally occurring process resulting in the decline of cognitive functions and increased vulnerability to develop age-associated disorders. Fluctuation in lipid species is crucial for normal brain development and function. However, ... ...

    Abstract Brain aging is a naturally occurring process resulting in the decline of cognitive functions and increased vulnerability to develop age-associated disorders. Fluctuation in lipid species is crucial for normal brain development and function. However, impaired lipid metabolism and changes in lipid composition in the brain have been increasingly recognized to play a crucial role in physiological aging, as well as in several neurodegenerative diseases. In the last decades, the role of sexual dimorphism in the vulnerability to develop age-related neurodegeneration has increased. However, further studies are warranted for detailed assessment of how age, sex, and additional non-biological factors may influence the lipid changes in brains. The aim of this work is to address the presence of sex differences in the brain lipid changes that occur along aging, and in the two most common age-related neurodegenerative disorders (Alzheimer's and Parkinson's diseases). We included the studies that assessed lipid-related alterations in the brain of both humans and experimental models. Additionally, we explored the influence of sex on lipid-lowering therapies. We conclude that sex exerts a notable effect on lipid modifications occurring with age and neurodegeneration, and in lipid-reducing interventions. Therefore, the application of sex as an experimental variable is strongly encouraged for future research in the field of precision medicine approach.
    MeSH term(s) Humans ; Female ; Male ; Alzheimer Disease/metabolism ; Neurochemistry ; Brain/metabolism ; Aging/metabolism ; Lipid Metabolism ; Lipids
    Chemical Substances Lipids
    Language English
    Publishing date 2023-06-20
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/jnc.15834
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  9. Article ; Online: The role of sphingolipids in neuronal plasticity of the brain.

    Sonnino, Sandro / Prinetti, Alessandro

    Journal of neurochemistry

    2016  Volume 137, Issue 4, Page(s) 485–488

    Abstract: This Editorial highlights a study by Müller et al. in which the authors suggest a new sphingolipid-dependent mechanism for behavioral extinction. Their study should be considered in the broad perspective of sphingolipid metabolic pathways and traffic ( ... ...

    Abstract This Editorial highlights a study by Müller et al. in which the authors suggest a new sphingolipid-dependent mechanism for behavioral extinction. Their study should be considered in the broad perspective of sphingolipid metabolic pathways and traffic (depicted in the graphic). Read the highlighted article 'A sphingolipid mechanism for behavioral extinction' on page 589.
    MeSH term(s) Animals ; Brain/metabolism ; Humans ; Metabolic Networks and Pathways/physiology ; Neuronal Plasticity/physiology ; Sphingolipids/physiology
    Chemical Substances Sphingolipids
    Language English
    Publishing date 2016
    Publishing country England
    Document type Editorial
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/jnc.13589
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  10. Article ; Online: Chemical and Physicochemical Properties of Gangliosides.

    Mauri, Laura / Sonnino, Sandro / Prinetti, Alessandro

    Methods in molecular biology (Clifton, N.J.)

    2018  Volume 1804, Page(s) 1–17

    Abstract: In this chapter, we briefly describe the structural features of gangliosides, and focus on the peculiar chemicophysical features of gangliosides, an important class of membrane amphipathic lipids that represent an important driving force determining the ... ...

    Abstract In this chapter, we briefly describe the structural features of gangliosides, and focus on the peculiar chemicophysical features of gangliosides, an important class of membrane amphipathic lipids that represent an important driving force determining the organization and properties of cellular membranes.
    MeSH term(s) Chemical Phenomena ; Gangliosides/chemistry ; Molecular Conformation
    Chemical Substances Gangliosides
    Language English
    Publishing date 2018-06-20
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-8552-4_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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