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Article ; Online: Utilization and Impact of Symptomatic and Exposure SARS-CoV-2 Testing in K-12 Schools.

2023 Volume 152, Issue Suppl 1

Abstract: Objectives: The Centers for Disease Control and Prevention recommend that schools can offer severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic (on-demand) testing for students and staff with coronavirus disease 2019 symptoms or ... ...

Abstract	Objectives: The Centers for Disease Control and Prevention recommend that schools can offer severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic (on-demand) testing for students and staff with coronavirus disease 2019 symptoms or exposures. Data related to the uptake, implementation, and effect of school-associated on-demand diagnostic testing have not been described. Methods: The Rapid Acceleration of Diagnostics Underserved Populations Return to School program provided resources to researchers to implement on-demand SARS-CoV-2 testing in schools. This study describes the strategies used and uptake among the different testing programs. Risk of positivity was compared for symptomatic and exposure testing during the δ and ο variant periods. We estimated the number of school absence days saved with school-based diagnostic testing. Results: Of the 16 eligible programs, 7 provided school-based on-demand testing. The number of persons that participated in these testing programs is 8281, with 4134 (49.9%) receiving >1 test during the school year. Risk of positivity was higher for symptomatic testing compared with exposure testing and higher during the ο variant predominant period compared with the δ variant predominant period. Overall, access to testing saved an estimated 13 806 absent school days. Conclusions: School-based on-demand SARS-CoV-2 testing was used throughout the school year, and nearly half the participants accessed testing on more than 1 occasion. Future studies should work to understand participant preferences around school-based testing and how these strategies can be used both during and outside of pandemics.
MeSH term(s)	United States/epidemiology ; Humans ; SARS-CoV-2 ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Testing ; Acceleration
Language	English
Publishing date	2023-06-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	207677-9
ISSN	1098-4275 ; 0031-4005
ISSN (online)	1098-4275
ISSN	0031-4005
DOI	10.1542/peds.2022-060352I
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Article ; Online: VU0810464, a non-urea G protein-gated inwardly rectifying K

Vo, Baovi N / Abney, Kristopher K / Anderson, Allison / Marron Fernandez de Velasco, Ezequiel / Benneyworth, Michael A / Daniels, John Scott / Morrison, Ryan D / Hopkins, Corey R / Weaver, Charles David / Wickman, Kevin

British journal of pharmacology

2019 Volume 176, Issue 13, Page(s) 2238–2249

Abstract: Background and purpose: G protein-gated inwardly rectifying K: Experimental approach: We used ... the selectivity of VU0810464 for neuronal and cardiac K: Key results: VU0810464 and ML297 exhibited comparable ... efficacy and potency as neuronal K: Conclusion and implications: VU0810464 represents a new class of K ...

Abstract	Background and purpose: G protein-gated inwardly rectifying K Experimental approach: We used whole-cell electrophysiology to measure the efficacy and potency of VU0810464 in neurons and the selectivity of VU0810464 for neuronal and cardiac K Key results: VU0810464 and ML297 exhibited comparable efficacy and potency as neuronal K Conclusion and implications: VU0810464 represents a new class of K
MeSH term(s)	Animals ; Anxiety/physiopathology ; Behavior, Animal/drug effects ; Brain/cytology ; Brain/metabolism ; Cells, Cultured ; Female ; Fever/etiology ; Fever/physiopathology ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/physiology ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurons/drug effects ; Neurons/physiology ; Sinoatrial Node/cytology ; Stress, Psychological/complications ; Stress, Psychological/physiopathology
Chemical Substances	G Protein-Coupled Inwardly-Rectifying Potassium Channels
Language	English
Publishing date	2019-05-30
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.14671
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Article ; Online: Supramolecular Organization and Functional Implications of K

Visscher, Koen M / Medeiros-Silva, João / Mance, Deni / Rodrigues, João P G L M / Daniëls, Mark / Bonvin, Alexandre M J J / Baldus, Marc / Weingarth, Markus

Angewandte Chemie (International ed. in English)

2017 Volume 56, Issue 43, Page(s) 13222–13227

Abstract: ... of signaling across membranes. We herein report on the supramolecular organization of clusters of the K ...

Abstract	The segregation of cellular surfaces in heterogeneous patches is considered to be a common motif in bacteria and eukaryotes that is underpinned by the observation of clustering and cooperative gating of signaling membrane proteins such as receptors or channels. Such processes could represent an important cellular strategy to shape signaling activity. Hence, structural knowledge of the arrangement of channels or receptors in supramolecular assemblies represents a crucial step towards a better understanding of signaling across membranes. We herein report on the supramolecular organization of clusters of the K
Language	English
Publishing date	2017-08-09
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.201705723
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Book ; Online ; E-Book: Achieving sustainable workplace wellbeing

Daniels, Kevin

(Aligning perspectives on health, safety and well-being)

2022

Author's details	Kevin Daniels [and three others]
Series title	Aligning perspectives on health, safety and well-being
MeSH term(s)	Working Conditions. ; Work Engagement. ; Organizational Culture. ; Organization and Administration.
Keywords	Employee health promotion ; Industrial hygiene ; Well-being ; Condicions de treball ; Malalties professionals ; Satisfacció en el treball
Subject code	658.382
Language	English
Size	1 online resource (172 pages)
Publisher	Springer
Publishing place	Cham, Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	3-031-00665-8 ; 9783031006647 ; 978-3-031-00665-4 ; 303100664X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: An innovative program to provide methodological mentoring and to foster the development of robust research teams for K awardees: RAMP Mentors.

Rasmussen-Torvik, Laura J / Daniels, Lauren A / Herzog, Keith A / Traw, Emily J / Fleming, Michael F / Pope, Richard M / Lloyd-Jones, Donald M / Welty, Leah J

Journal of clinical and translational science

2020 Volume 5, Issue 1, Page(s) e43

Abstract: ... Compared with other Northwestern University K awardees, KL2 scholars reported higher confidence ... in obtaining research funding, including subsequent K or R awards, and selecting appropriate, up-to-date ...

Abstract	Within the Biostatistics, Epidemiology, and Research Design (BERD) component of the Northwestern University Clinical and Translational Sciences Institute, we created a mentoring program to complement training provided by the associated Multidisciplinary Career Development Program (KL2). Called Research design Analysis Methods Program (RAMP) Mentors, the program provides each KL2 scholar with individualized, hands-on mentoring in biostatistics, epidemiology, informatics, and related fields, with the goal of building multidisciplinary research teams. From 2015 to 2019, RAMP Mentors paired 8 KL2 scholars with 16 individually selected mentors. Mentors had funded/protected time to meet at least monthly with their scholar to provide advice and instruction on methods for ongoing research, including incorporating novel techniques. RAMP Mentors has been evaluated through focus groups and surveys. KL2 scholars reported high satisfaction with RAMP Mentors and confidence in their ability to establish and maintain methodologic collaborations. Compared with other Northwestern University K awardees, KL2 scholars reported higher confidence in obtaining research funding, including subsequent K or R awards, and selecting appropriate, up-to-date research methods. RAMP Mentors is a promising partnership between a BERD group and KL2 program, promoting methodologic education and building multidisciplinary research teams for junior investigators pursuing clinical and translational research.
Language	English
Publishing date	2020-09-04
Publishing country	England
Document type	Journal Article
ISSN	2059-8661
ISSN (online)	2059-8661
DOI	10.1017/cts.2020.536
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Article: Erratum: Mwiiri, F.K.; et al. Electrospun Bioactive Wound Dressing Containing Colloidal Dispersions of Birch Bark Dry Extract.

Mwiiri, Francis Kamau / Brandner, Johanna M / Daniels, Rolf

Pharmaceutics

2020 Volume 12, Issue 10

Abstract: The authors wish to make the following correction to this paper [ ... ]. ...

Abstract	The authors wish to make the following correction to this paper [...].
Language	English
Publishing date	2020-10-19
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics12100991
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Article ; Online: Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe.

Delpire, Eric / Baranczak, Aleksandra / Waterson, Alex G / Kim, Kwangho / Kett, Nathan / Morrison, Ryan D / Daniels, J Scott / Weaver, C David / Lindsley, Craig W

Bioorganic & medicinal chemistry letters

2012 Volume 22, Issue 14, Page(s) 4532–4535

Abstract: ... 100-fold selectivity versus the closely related Na-K-2Cl cotransporter 1 (NKCC1) and no activity ...

Abstract	Further chemical optimization of the MLSCN/MLPCN probe ML077 (KCC2 IC(50)=537 nM) proved to be challenging as the effort was characterized by steep SAR. However, a multi-dimensional iterative parallel synthesis approach proved productive. Herein we report the discovery and SAR of an improved novel antagonist (VU0463271) of the neuronal-specific potassium-chloride cotransporter 2 (KCC2), with an IC(50) of 61 nM and >100-fold selectivity versus the closely related Na-K-2Cl cotransporter 1 (NKCC1) and no activity in a larger panel of GPCRs, ion channels and transporters.
MeSH term(s)	Molecular Structure ; Pyridazines/chemistry ; Pyridazines/pharmacology ; Structure-Activity Relationship ; Symporters/antagonists & inhibitors ; Thiazoles/chemistry ; Thiazoles/pharmacology ; K Cl- Cotransporters
Chemical Substances	Pyridazines ; Symporters ; Thiazoles ; VU0255011
Language	English
Publishing date	2012-06-07
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2012.05.126
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Article ; Online: Recounting the K-12 school experiences of adults who stutter: a qualitative analysis.

Daniels, Derek E / Gabel, Rodney M / Hughes, Stephanie

Journal of fluency disorders

2012 Volume 37, Issue 2, Page(s) 71–82

Abstract: Unlabelled: This study qualitatively explored the primary and secondary (K-12) school experiences ...

Abstract	Unlabelled: This study qualitatively explored the primary and secondary (K-12) school experiences of adults who stutter. The primary investigator conducted semi-structured interviews with 11 participants, a first focus group interview with 6 participants, and a second focus group interview with 4 participants. Participants discussed the various ways in which stuttering affected their personality; emotional and psychological experiences in the context of school; academic and learning experiences; classroom participation; teacher and peer relationships; speech therapy experiences; school activity involvement; and post-educational experiences. Results suggest that school is a complex cultural environment in which students must engage on academic and social levels. People who stutter may experience observable and unobservable challenges as they navigate the complexity of school. Educational objectives: After reading this article, the reader will be able to: (1) provide a rationale for the need to explore the school experiences of people who stutter; (2) describe the major themes associated with the school experiences of participants in the study; and (3) discuss how knowledge of school experiences can be useful to classroom teachers and speech-language pathologists.
MeSH term(s)	Adult ; Aged ; Female ; Focus Groups ; Humans ; Interviews as Topic ; Male ; Middle Aged ; Peer Group ; Personality ; Schools ; Social Participation/psychology ; Speech Therapy/psychology ; Students/psychology ; Stuttering/psychology ; Stuttering/therapy
Language	English
Publishing date	2012-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	434405-4
ISSN	1873-801X ; 0094-730X
ISSN (online)	1873-801X
ISSN	0094-730X
DOI	10.1016/j.jfludis.2011.12.001
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Article ; Online: High-k dielectric Al₂O₃ nanowire and nanoplate field effect sensors for improved pH sensing.

Reddy, Bobby / Dorvel, Brian R / Go, Jonghyun / Nair, Pradeep R / Elibol, Oguz H / Credo, Grace M / Daniels, Jonathan S / Chow, Edmond K C / Su, Xing / Varma, Madoo / Alam, Muhammad A / Bashir, Rashid

Biomedical microdevices

2011 Volume 13, Issue 2, Page(s) 335–344

Abstract: ... dielectrics and we compare these devices with FETs with SiO(2) gate dielectrics. The use of a high-k ...

Abstract	Over the last decade, field-effect transistors (FETs) with nanoscale dimensions have emerged as possible label-free biological and chemical sensors capable of highly sensitive detection of various entities and processes. While significant progress has been made towards improving their sensitivity, much is yet to be explored in the study of various critical parameters, such as the choice of a sensing dielectric, the choice of applied front and back gate biases, the design of the device dimensions, and many others. In this work, we present a process to fabricate nanowire and nanoplate FETs with Al(2)O(3) gate dielectrics and we compare these devices with FETs with SiO(2) gate dielectrics. The use of a high-k dielectric such as Al(2)O(3) allows for the physical thickness of the gate dielectric to be thicker without losing sensitivity to charge, which then reduces leakage currents and results in devices that are highly robust in fluid. This optimized process results in devices stable for up to 8 h in fluidic environments. Using pH sensing as a benchmark, we show the importance of optimizing the device bias, particularly the back gate bias which modulates the effective channel thickness. We also demonstrate that devices with Al(2)O(3) gate dielectrics exhibit superior sensitivity to pH when compared to devices with SiO(2) gate dielectrics. Finally, we show that when the effective electrical silicon channel thickness is on the order of the Debye length, device response to pH is virtually independent of device width. These silicon FET sensors could become integral components of future silicon based Lab on Chip systems.
MeSH term(s)	Aluminum Oxide/chemistry ; Electric Impedance ; Hydrogen-Ion Concentration ; Nanowires/chemistry ; Reproducibility of Results ; Silicon/chemistry ; Transistors, Electronic
Chemical Substances	Aluminum Oxide (LMI26O6933) ; Silicon (Z4152N8IUI)
Language	English
Publishing date	2011-01-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2004019-2
ISSN	1572-8781 ; 1387-2176
ISSN (online)	1572-8781
ISSN	1387-2176
DOI	10.1007/s10544-010-9497-z
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Article ; Online: Metastable (Bi, M)2(Fe, Mn, Bi)2O(6+x) (M = Na or K) pyrochlores from hydrothermal synthesis.

Daniels, Luke M / Playford, Helen Y / Grenèche, Jean-Marc / Hannon, Alex C / Walton, Richard I

Inorganic chemistry

2014 Volume 53, Issue 24, Page(s) 13197–13206

Abstract: The hydrothermal syntheses, structures, and magnetism of two new pyrochlore oxides of compositions (Na0.60Bi1.40)(Fe1.06Mn0.17Bi0.77)O6.87 and (K0.24Bi1.51)(Fe1.07Mn0.15Bi0.78)O6.86 are described. With preparation at 200 °C for 6 h in solutions of sodium ...

Abstract	The hydrothermal syntheses, structures, and magnetism of two new pyrochlore oxides of compositions (Na0.60Bi1.40)(Fe1.06Mn0.17Bi0.77)O6.87 and (K0.24Bi1.51)(Fe1.07Mn0.15Bi0.78)O6.86 are described. With preparation at 200 °C for 6 h in solutions of sodium or potassium hydroxide, the alkali metals introduced from these mineralizers are essential to the synthesis of the phases. The average long-range order of the pyrochlore structure, with space group Fd3̅m, was investigated and refined against X-ray and neutron diffraction data, and it was shown that disorder is present in both the metal and coordinating oxygen positions, along with metal-mixing across both the A and B sites of the structure. XANES analysis confirms the presence of Mn(4+), mixed valence Bi(3+) and Bi(5+), and Fe(3+), the last also verified by (57)Fe Mössbauer spectroscopy. Magnetic measurements show a lack of long-range magnetic ordering that is typical of geometrically frustrated pyrochlores. The observed glasslike interactions occur at low temperatures, with the onset temperature depending upon the magnitude of the applied external field. Variable temperature X-ray diffraction shows that these pyrochlores are metastable and collapse on heating at ca. 395 °C, which suggests that their formation by conventional solid-state synthesis would be impossible.
Language	English
Publishing date	2014-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/ic502411z
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