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Article ; Online: Modulation of dendritic cell responses by parasites: a common strategy to survive.

Terrazas, César A / Terrazas, Luis I / Gómez-García, Lorena

2010 Volume 2010, Page(s) 357106

Abstract: Parasitic infections are one of the most important causes of morbidity and mortality in our planet and the immune responses triggered by these organisms are critical to determine their outcome. Dendritic cells are key elements for the development of ... ...

Abstract	Parasitic infections are one of the most important causes of morbidity and mortality in our planet and the immune responses triggered by these organisms are critical to determine their outcome. Dendritic cells are key elements for the development of immunity against parasites; they control the responses required to eliminate these pathogens while maintaining host homeostasis. However, there is evidence showing that parasites can influence and regulate dendritic cell function in order to promote a more permissive environment for their survival. In this review we will focus on the strategies protozoan and helminth parasites have developed to interfere with dendritic cell activities as well as in the possible mechanisms involved.
MeSH term(s)	Animals ; Dendritic Cells/immunology ; Host-Parasite Interactions/immunology ; Humans ; Parasites/immunology
Language	English
Publishing date	2010
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2052552-7
ISSN	1110-7251 ; 1110-7243
ISSN (online)	1110-7251
ISSN	1110-7243
DOI	10.1155/2010/357106
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Article ; Online: Impaired pro-inflammatory cytokine production and increased Th2-biasing ability of dendritic cells exposed to Taenia excreted/secreted antigens: A critical role for carbohydrates but not for STAT6 signaling.

Terrazas, César A / Gómez-García, Lorena / Terrazas, Luis I

International journal for parasitology

2010 Volume 40, Issue 9, Page(s) 1051–1062

Abstract: In cysticercosis, a parasitic disease caused by cestodes, the details of early interactions between parasite antigens and innate cells from the host are not well understood. In this study, the role of cestode-conditioned dendritic cells (DCs) in priming ... ...

Abstract	In cysticercosis, a parasitic disease caused by cestodes, the details of early interactions between parasite antigens and innate cells from the host are not well understood. In this study, the role of cestode-conditioned dendritic cells (DCs) in priming Th1 versus Th2 responses to bystander antigen was examined by using CD11c(+) DCs as antigen-presenting cells and naive CD4(+) DO11.10 lymphocytes specific to ovalbumin (OVA) as responding cells. No conventional maturation was induced in DCs exposed to Taenia crassiceps excreted/secreted antigens (TcES). The ability of TcES to affect Toll-like receptor (TLR)-mediated maturation and the pro-inflammatory response was analyzed by co-pulsing DCs with TcES and TLR ligands. DCs exposed to TcES blocked TLR4, TLR9 and Toxoplasma soluble antigen-induced phenotypic maturation. TcES-exposed DCs also blocked secretion of pro-inflammatory cytokines and alloreactive T cell proliferation, while preserving IL-10 production. DCs pulsed with TcES+OVA suppressed IFN-gamma, whereas they induced greater IL-4 production by CD4(+) DO11.10 cells. TcES with chemically-altered glycans failed to modulate TLR-mediated activation of DCs and their Th1-inhibitng ability, which was STAT6-independent. Our results reflect the capacity of TcES glyco-antigens to modulate Th1-type and inflammatory responses mediated through DC activation.
MeSH term(s)	Animals ; Antigens, Helminth/chemistry ; Antigens, Helminth/immunology ; Carbohydrates/immunology ; Cell Proliferation ; Cells, Cultured ; Cytokines/biosynthesis ; Dendritic Cells/immunology ; Female ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; STAT6 Transcription Factor/immunology ; Signal Transduction ; Taenia/immunology ; Th2 Cells/immunology ; Toll-Like Receptor 4/antagonists & inhibitors ; Toll-Like Receptor 9/antagonists & inhibitors
Chemical Substances	Antigens, Helminth ; Carbohydrates ; Cytokines ; STAT6 Transcription Factor ; Stat6 protein, mouse ; Toll-Like Receptor 4 ; Toll-Like Receptor 9
Language	English
Publishing date	2010-08-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120518-3
ISSN	1879-0135 ; 0020-7519
ISSN (online)	1879-0135
ISSN	0020-7519
DOI	10.1016/j.ijpara.2010.02.016
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Article ; Online: Cutting Edge: CXCR3 Escapes X Chromosome Inactivation in T Cells during Infection: Potential Implications for Sex Differences in Immune Responses.

Oghumu, Steve / Varikuti, Sanjay / Stock, James C / Volpedo, Greta / Saljoughian, Noushin / Terrazas, Cesar A / Satoskar, Abhay R

Journal of immunology (Baltimore, Md. : 1950)

2019 Volume 203, Issue 4, Page(s) 789–794

Abstract: CXCR3, an X-linked gene, is subject to X chromosome inactivation (XCI), but it is unclear whether CXCR3 escapes XCI in immune cells. We determined whether CXCR3 escapes XCI in vivo, evaluated the contribution of allelic CXCR3 expression to the phenotypic ...

Abstract	CXCR3, an X-linked gene, is subject to X chromosome inactivation (XCI), but it is unclear whether CXCR3 escapes XCI in immune cells. We determined whether CXCR3 escapes XCI in vivo, evaluated the contribution of allelic CXCR3 expression to the phenotypic properties of T cells during experimental infection with
MeSH term(s)	Animals ; Female ; Infections/immunology ; Male ; Mice ; Mice, Mutant Strains ; Receptors, CXCR3/genetics ; Receptors, CXCR3/immunology ; Sex Characteristics ; T-Lymphocyte Subsets/immunology ; Th1 Cells/immunology ; X Chromosome Inactivation/immunology
Chemical Substances	Cxcr3 protein, mouse ; Receptors, CXCR3
Language	English
Publishing date	2019-06-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1800931
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Article ; Online: Helminth-excreted/secreted products are recognized by multiple receptors on DCs to block the TLR response and bias Th2 polarization in a cRAF dependent pathway.

Terrazas, César A / Alcántara-Hernández, Marcela / Bonifaz, Laura / Terrazas, Luis I / Satoskar, Abhay R

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2013 Volume 27, Issue 11, Page(s) 4547–4560

Abstract: Dendritic cells (DCs) recognize pathogens and initiate the T-cell response. The DC-helminth interaction induces an immature phenotype in DCs; as a result, these DCs display impaired responses to TLR stimulation and prime Th2-type responses. However, the ... ...

Abstract	Dendritic cells (DCs) recognize pathogens and initiate the T-cell response. The DC-helminth interaction induces an immature phenotype in DCs; as a result, these DCs display impaired responses to TLR stimulation and prime Th2-type responses. However, the DC receptors and intracellular pathways targeted by helminth molecules and their importance in the initiation of the Th2 response are poorly understood. In this report, we found that products excreted/secreted by Taenia crassiceps (TcES) triggered cRAF phosphorylation through MGL, MR, and TLR2. TcES interfered with the LPS-induced NFκB p65 and p38 MAPK signaling pathways. In addition, TcES-induced cRAF signaling pathway was critical for down-regulation of the TLR-mediated DC maturation and secretion of IL-12 and TNF-α. Finally, we show for the first time that blocking cRAF in DCs abolishes their ability to induce Th2 polarization in vitro after TcES exposure. Our data demonstrate a new mechanism by which helminths target intracellular pathways to block DC maturation and efficiently program Th2 polarization.
MeSH term(s)	Animals ; Asialoglycoproteins/genetics ; Asialoglycoproteins/metabolism ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Down-Regulation ; Immunomodulation ; Interleukin-12/metabolism ; Lectins, C-Type/genetics ; Lectins, C-Type/metabolism ; MAP Kinase Signaling System ; Mannose-Binding Lectins/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Phosphorylation ; Proto-Oncogene Proteins c-raf/metabolism ; Receptors, Cell Surface/metabolism ; Taenia/immunology ; Th2 Cells/immunology ; Th2 Cells/metabolism ; Toll-Like Receptor 2/metabolism ; Transcription Factor RelA/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	Asialoglycoproteins ; Clec10a protein, mouse ; Lectins, C-Type ; Mannose-Binding Lectins ; Membrane Proteins ; Receptors, Cell Surface ; Toll-Like Receptor 2 ; Transcription Factor RelA ; Tumor Necrosis Factor-alpha ; mannose receptor ; Interleukin-12 (187348-17-0) ; Proto-Oncogene Proteins c-raf (EC 2.7.11.1) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2013-08-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.13-228932
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Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Modulation of Dendritic Cell Responses by Parasites

César A. Terrazas / Luis I. Terrazas / Lorena Gómez-García

Journal of Biomedicine and Biotechnology, Vol

A Common Strategy to Survive

2010 Volume 2010

Abstract	Parasitic infections are one of the most important causes of morbidity and mortality in our planet and the immune responses triggered by these organisms are critical to determine their outcome. Dendritic cells are key elements for the development of immunity against parasites; they control the responses required to eliminate these pathogens while maintaining host homeostasis. However, there is evidence showing that parasites can influence and regulate dendritic cell function in order to promote a more permissive environment for their survival. In this review we will focus on the strategies protozoan and helminth parasites have developed to interfere with dendritic cell activities as well as in the possible mechanisms involved.
Keywords	Biotechnology ; TP248.13-248.65 ; Chemical technology ; TP1-1185 ; Technology ; T ; DOAJ:Biotechnology ; DOAJ:Life Sciences ; DOAJ:Biology and Life Sciences
Language	English
Publishing date	2010-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
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Article: Reflexed flowers in Aeschynomene amorphoides (Fabaceae: Faboideae): a mechanism promoting pollination specialization?

Carleial, Samuel / Delgado‐Salinas, Alfonso / Domínguez, César A / Terrazas, Teresa

Botanical journal of the Linnean Society. 2015 Apr., v. 177, no. 4

2015

Abstract: This study aims to understand the role of floral traits in determining the reproductive biology of the leguminous shrub Aeschynomene amorphoides, endemic to western Mexico, which has unusually orientated flowers. We investigated the floral biology, ... ...

Abstract	This study aims to understand the role of floral traits in determining the reproductive biology of the leguminous shrub Aeschynomene amorphoides, endemic to western Mexico, which has unusually orientated flowers. We investigated the floral biology, pollination and breeding system based on a combination of morphological studies and field experiments, using controlled pollinations in a natural environment. The architecture and reflexed position of A. amorphoides flowers facilitate precise placement of pollen on the body of the pollinator, but this has a cost to A. amorphoides in terms of available flower resources. These costs to reproduction success are set against the attraction of a specialized pollinator, Tetraloniella jaliscoensis, which is capable of manipulating this unique pollination system in papilionoid (or flag) flowers. © 2015 The Linnean Society of London, Botanical Journal of the Linnean Society, 2015, 177, 657–666.
Keywords	Aeschynomene ; breeding ; field experimentation ; flowers ; pollen ; pollination ; shrubs ; Mexico
Language	English
Dates of publication	2015-04
Size	p. 657-666.
Publishing place	Academic Press.
Document type	Article
ZDB-ID	2975-0
ISSN	0024-4074 ; 0373-5044
ISSN	0024-4074 ; 0373-5044
DOI	10.1111/boj.12264
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Taenia crassiceps

Martínez-Saucedo, Diana / Ruíz-Rosado, Juan de Dios / Terrazas, César / Callejas, Blanca E / Satoskar, Abhay R / Partida-Sánchez, Santiago / Terrazas, Luis I

Journal of immunology research

2019 Volume 2019, Page(s) 2946713

Abstract: Helminth parasites modulate immune responses in their host to prevent their elimination and to establish chronic infections. Our previous studies indicate ... ...

Abstract	Helminth parasites modulate immune responses in their host to prevent their elimination and to establish chronic infections. Our previous studies indicate that
MeSH term(s)	Animals ; Biomarkers ; Cytokines/metabolism ; Female ; Host-Parasite Interactions/genetics ; Host-Parasite Interactions/immunology ; Immunomodulation ; Inflammation Mediators/metabolism ; Lipopolysaccharides/immunology ; Macrophages/immunology ; Macrophages/metabolism ; Mice ; MicroRNAs/genetics ; Taenia/physiology ; Taeniasis/genetics ; Taeniasis/immunology ; Taeniasis/metabolism ; Taeniasis/parasitology
Chemical Substances	Biomarkers ; Cytokines ; Inflammation Mediators ; Lipopolysaccharides ; MicroRNAs
Language	English
Publishing date	2019-05-14
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2817541-4
ISSN	2314-7156 ; 2314-8861
ISSN (online)	2314-7156
ISSN	2314-8861
DOI	10.1155/2019/2946713
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Article: Impaired pro-inflammatory cytokine production and increased Th2-biasing ability of dendritic cells exposed to Taenia excreted/secreted antigens: A critical role for carbohydrates but not for STAT6 signaling

Terrazas, César A / Gómez-García, Lorena / Terrazas, Luis I

International journal for parasitology. 2010 Aug. 1, v. 40, no. 9

2010

Abstract	In cysticercosis, a parasitic disease caused by cestodes, the details of early interactions between parasite antigens and innate cells from the host are not well understood. In this study, the role of cestode-conditioned dendritic cells (DCs) in priming Th1 versus Th2 responses to bystander antigen was examined by using CD11c⁺ DCs as antigen-presenting cells and naive CD4⁺ DO11.10 lymphocytes specific to ovalbumin (OVA) as responding cells. No conventional maturation was induced in DCs exposed to Taenia crassiceps excreted/secreted antigens (TcES). The ability of TcES to affect Toll-like receptor (TLR)-mediated maturation and the pro-inflammatory response was analyzed by co-pulsing DCs with TcES and TLR ligands. DCs exposed to TcES blocked TLR4, TLR9 and Toxoplasma soluble antigen-induced phenotypic maturation. TcES-exposed DCs also blocked secretion of pro-inflammatory cytokines and alloreactive T cell proliferation, while preserving IL-10 production. DCs pulsed with TcES+OVA suppressed IFN-γ, whereas they induced greater IL-4 production by CD4⁺ DO11.10 cells. TcES with chemically-altered glycans failed to modulate TLR-mediated activation of DCs and their Th1-inhibitng ability, which was STAT6-independent. Our results reflect the capacity of TcES glyco-antigens to modulate Th1-type and inflammatory responses mediated through DC activation.
Keywords	T-lymphocytes ; Taenia crassiceps ; Toll-like receptor 4 ; Toll-like receptor 9 ; Toxoplasma ; antigens ; cell proliferation ; cysticercosis ; dendritic cells ; inflammation ; interferon-gamma ; interleukin-10 ; interleukin-4 ; ovalbumin ; parasites ; polysaccharides ; secretion
Language	English
Dates of publication	2010-0801
Size	p. 1051-1062.
Publishing place	[Oxford; New York]: Elsevier Science
Document type	Article
ZDB-ID	120518-3
ISSN	1879-0135 ; 0020-7519
ISSN (online)	1879-0135
ISSN	0020-7519
DOI	10.1016/j.ijpara.2010.02.016
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Zs.A 789: Show issues

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Article ; Online: Differential response of antigen presenting cells from susceptible and resistant strains of mice to Taenia crassiceps infection.

Reyes, José L / Terrazas, César A / Vera-Arias, Laura / Terrazas, Luis I

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

2009 Volume 9, Issue 6, Page(s) 1115–1127

Abstract: Antigen presenting cells (APCs) are critically involved in the interaction between pathogens and the host immune system. Here, we examined two different populations of APCs in mice that are susceptible (BALB/c) or resistant (C57BL/6) to Taenia crassiceps ...

Abstract	Antigen presenting cells (APCs) are critically involved in the interaction between pathogens and the host immune system. Here, we examined two different populations of APCs in mice that are susceptible (BALB/c) or resistant (C57BL/6) to Taenia crassiceps cysticercosis. Bone marrow-derived dendritic cells (BMDCs) from both strains of mice were exposed to T. crassiceps excreted/secreted antigens (TcES) and, at the same time, to the Toll-like receptor (TLR) ligand LPS. BMDCs from BALB/c mice underwent a partial maturation when incubated with TcES and displayed decreased responses to TLR-dependent stimuli associated with low CD80, CD86, CD40 and CCR7 expression and impaired IL-15 production. These BMDCs-induced impaired allogenic responses. In contrast, BMDCs from C57BL/6 mice displayed normal maturation and induced strong allogenic responses. Moreover, the exposure to TcES resulted in a lower production of IL-12 and TNF-alpha by LPS-activated DCs from BALB/c mice compared to C57BL/6 DCs. Three parameters of macrophage activation were assessed during Taenia infection: LPS+IFN-gamma-induced production of IL-12, TNF-alpha and nitric oxide (NO) in vitro; infection-induced markers for alternatively activated macrophages (Arginase-1, RELM-alpha, Ym-1 and TREM-2 expression) and suppressive activity. The maximum response to LPS+IFN-gamma-induced TNF-alpha, IL-12 and NO production by macrophages from both strains of mice occurred 2 wk post-infection. However, as infection progressed, the production of these molecules by BALB/c macrophages declined. While the BALB/c macrophages displayed impaired pro-inflammatory responses, these macrophages showed strong Arginase-1, Ym-1, RELM-alpha and TREM-2 expression. By contrast, C57BL/6 macrophages maintained a pro-inflammatory profile and low transcripts for alternative activation markers. Macrophages from T. crassiceps-infected BALB/c mice showed stronger suppressive activity than those from C57BL/6 mice. These findings suggest that APC activation at both early and late time points during T. crassiceps infection is a possible mechanism that underlies the differential susceptibility to T. crassiceps infection displayed by these mouse strains.
MeSH term(s)	Animals ; Antigens, CD/biosynthesis ; Antigens, CD/blood ; Antigens, CD/immunology ; Antigens, Protozoan/immunology ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Female ; Gene Expression Regulation ; Genetic Predisposition to Disease ; Host-Parasite Interactions ; Interleukins/biosynthesis ; Interleukins/blood ; Interleukins/immunology ; Macrophage Activation ; Macrophages/immunology ; Macrophages/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Taenia/immunology ; Taeniasis/genetics ; Taeniasis/immunology ; Taeniasis/metabolism ; Time Factors
Chemical Substances	Antigens, CD ; Antigens, Protozoan ; Interleukins
Language	English
Publishing date	2009-12
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2037068-4
ISSN	1567-7257 ; 1567-1348
ISSN (online)	1567-7257
ISSN	1567-1348
DOI	10.1016/j.meegid.2009.05.011
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Article ; Online: Helminth-induced Ly6C

Terrazas, Cesar / de Dios Ruiz-Rosado, Juan / Amici, Stephanie A / Jablonski, Kyle A / Martinez-Saucedo, Diana / Webb, Lindsay M / Cortado, Hanna / Robledo-Avila, Frank / Oghumu, Steve / Satoskar, Abhay R / Rodriguez-Sosa, Miriam / Terrazas, Luis I / Guerau-de-Arellano, Mireia / Partida-Sánchez, Santiago

Scientific reports

2017 Volume 7, Page(s) 40814

Abstract: Helminths cause chronic infections and affect the immune response to unrelated inflammatory diseases. Although helminths have been used therapeutically to ameliorate inflammatory conditions, their anti-inflammatory properties are poorly understood. ... ...

Abstract	Helminths cause chronic infections and affect the immune response to unrelated inflammatory diseases. Although helminths have been used therapeutically to ameliorate inflammatory conditions, their anti-inflammatory properties are poorly understood. Alternatively activated macrophages (AAMϕs) have been suggested as the anti-inflammatory effector cells during helminth infections. Here, we define the origin of AAMϕs during infection with Taenia crassiceps, and their disease-modulating activity on the Experimental Autoimmune Encephalomyelitis (EAE). Our data show two distinct populations of AAMϕs, based on the expression of PD-L1 and PD-L2 molecules, resulting upon T. crassiceps infection. Adoptive transfer of Ly6C
MeSH term(s)	Adoptive Transfer/methods ; Animals ; Antigens, Ly/metabolism ; B7-H1 Antigen/genetics ; B7-H1 Antigen/metabolism ; Cells, Cultured ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/therapy ; Female ; Macrophage Activation ; Mice ; Mice, Inbred C57BL ; Monocyte-Macrophage Precursor Cells/immunology ; Programmed Cell Death 1 Ligand 2 Protein/genetics ; Programmed Cell Death 1 Ligand 2 Protein/metabolism ; Taenia/immunology
Chemical Substances	Antigens, Ly ; B7-H1 Antigen ; Cd274 protein, mouse ; Ly6 protein, mouse ; Pdcd1lg2 protein, mouse ; Programmed Cell Death 1 Ligand 2 Protein
Language	English
Publishing date	2017-01-17
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep40814
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