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  1. Article: Interview mit Priv.-Doz. Dr. med. Carsten Tschöpe, Berlin: - Das "gute" Cholesterin als Therapeutikum?

    Tschöpe, Carsten

    Cardiovasc

    2005  Volume 5, Issue 3, Page(s) 32

    Language German
    Document type Article
    ZDB-ID 2061994-7
    ISSN 1617-4933
    Database Current Contents Medicine

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  2. Article ; Online: A Potential New HFpEF Phenotype Caused by Psychological Stress.

    Anker, Markus S / Tschöpe, Carsten

    Journal of cardiac failure

    2022  Volume 28, Issue 9, Page(s) 1411–1413

    MeSH term(s) Heart Failure/diagnosis ; Heart Failure/etiology ; Humans ; Phenotype ; Stress, Psychological/complications ; Stroke Volume
    Language English
    Publishing date 2022-09-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2022.07.045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Treatment of Transthyretin Amyloid Cardiomyopathy: The Current Options, the Future, and the Challenges.

    Tschöpe, Carsten / Elsanhoury, Ahmed

    Journal of clinical medicine

    2022  Volume 11, Issue 8

    Abstract: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressively debilitating, rare disease associated with high mortality. ATTR-CM occurs when TTR amyloid protein builds up in the myocardium along with different organs, most commonly the peripheral and ...

    Abstract Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressively debilitating, rare disease associated with high mortality. ATTR-CM occurs when TTR amyloid protein builds up in the myocardium along with different organs, most commonly the peripheral and the autonomic nervous systems. Managing the cardiac complications with standard heart failure medications is difficult due to the challenge to maintain a balance between the high filling pressure associated with restricted ventricular volume and the low cardiac output. To date, tafamidis is the only agent approved for ATTR-CM treatment. Besides, several agents, including green tea, tolcapone, and diflunisal, are used off-label in ATTR-CM patients. Novel therapies using RNA interference also offer clinical promise. Patisiran and inotersen are currently approved for ATTR-polyneuropathy of hereditary origin and are under investigation for ATTR-CM. Monoclonal antibodies in the early development phases carry hope for amyloid deposit clearance. Despite several drug candidates in the clinical development pipeline, the small ATTR-CM patient population raises several challenges. This review describes current and future therapies for ATTR-CM and sheds light on the clinical development hurdles facing them.
    Language English
    Publishing date 2022-04-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11082148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reply to 'Heart failure with preserved ejection fraction and COVID-19: which comes first, the chicken or the egg?'

    Anker, Markus S / Tschöpe, Carsten

    European journal of heart failure

    2021  Volume 23, Issue 12, Page(s) 2092–2093

    MeSH term(s) COVID-19 ; Heart Failure ; Humans ; SARS-CoV-2 ; Stroke Volume ; Ventricular Function, Left
    Language English
    Publishing date 2021-07-28
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: [No title information]

    Paul, Thomas / Klingel, Karin / Tschöpe, Carsten / Bertram, Harald / Seidel, Franziska

    Klinische Padiatrie

    2023  Volume 235, Issue 3, Page(s) e1–e15

    Abstract: This consensus statement presents updated recommendations on diagnosis and treatment of myocarditis in childhood. ...

    Title translation Leitlinie Myokarditis der Deutschen Gesellschaft für Pädiatrische Kardiologie.
    Abstract This consensus statement presents updated recommendations on diagnosis and treatment of myocarditis in childhood.
    MeSH term(s) Child ; Humans ; Myocarditis/diagnosis ; Myocarditis/therapy ; Cardiology ; Consensus
    Language German
    Publishing date 2023-04-24
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 120650-3
    ISSN 1439-3824 ; 0300-8630
    ISSN (online) 1439-3824
    ISSN 0300-8630
    DOI 10.1055/a-2039-2604
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dilated cardiomyopathy: causes, mechanisms, and current and future treatment approaches.

    Heymans, Stephane / Lakdawala, Neal K / Tschöpe, Carsten / Klingel, Karin

    Lancet (London, England)

    2023  Volume 402, Issue 10406, Page(s) 998–1011

    Abstract: Dilated cardiomyopathy is conventionally defined as the presence of left ventricular or biventricular dilatation or systolic dysfunction in the absence of abnormal loading conditions (eg, primary valve disease) or significant coronary artery disease ... ...

    Abstract Dilated cardiomyopathy is conventionally defined as the presence of left ventricular or biventricular dilatation or systolic dysfunction in the absence of abnormal loading conditions (eg, primary valve disease) or significant coronary artery disease sufficient to cause ventricular remodelling. This definition has been recognised as overly restrictive, as left ventricular hypokinesis without dilation could be the initial presentation of dilated cardiomyopathy. The causes of dilated cardiomyopathy comprise genetic (primary dilated cardiomyopathy) or acquired factors (secondary dilated cardiomyopathy). Acquired factors include infections, toxins, cancer treatment, endocrinopathies, pregnancy, tachyarrhythmias, and immune-mediated diseases. 5-15% of patients with acquired dilated cardiomyopathy harbour a likely pathogenic or pathogenic gene variant (ie, gene mutation). Therefore, the diagnostic tests and therapeutic approach should always consider both genetic and acquired factors. This Seminar will focus on the current multidimensional diagnostic and therapeutic approach and discuss the underlying pathophysiology that could drive future treatments aiming to repair or replace the existing gene mutation, or target the specific inflammatory, metabolic, or pro-fibrotic drivers of genetic or acquired dilated cardiomyopathy.
    MeSH term(s) Female ; Pregnancy ; Humans ; Cardiomyopathy, Dilated/diagnosis ; Cardiomyopathy, Dilated/etiology ; Cardiomyopathy, Dilated/therapy ; Causality ; Catheters ; Coronary Artery Disease ; Mutation
    Language English
    Publishing date 2023-09-16
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)01241-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Hypertrophe Kardiomyopathien und die kardiale ATTR-Amyloidose – eine aktuelle Übersicht für den klinischen Alltag.

    Tschöpe, Carsten / Elsanhoury, Ahmed / Diekmann, Sonja / Kühl, Uwe

    Deutsche medizinische Wochenschrift (1946)

    2022  Volume 147, Issue 17, Page(s) 1127–1134

    Abstract: Cardiomyopathies include dilated and restrictive cardiomyopathies as well as the various forms of hypertrophic cardiomyopathies (HCM). By definition, HCM is considered to occur when left ventricular wall thickness is ≥ 15 mm. This may be masked by ... ...

    Title translation Hypertrophic cardiomyopathies and ATTR amyloidosis - a current review for clinical practice.
    Abstract Cardiomyopathies include dilated and restrictive cardiomyopathies as well as the various forms of hypertrophic cardiomyopathies (HCM). By definition, HCM is considered to occur when left ventricular wall thickness is ≥ 15 mm. This may be masked by genetic sarcomeric diseases, storage diseases, or syndromes. In clinical practice, sarcomere mutations and the cardiac amyloidoses are of particular interest because they are not always easy to distinguish from each other and early diagnosis of the disease is important for prognosis.
    MeSH term(s) Amyloidosis ; Cardiomyopathies ; Cardiomyopathy, Hypertrophic ; Heart Ventricles ; Humans ; Mutation
    Language German
    Publishing date 2022-08-28
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1744-3126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Aktuelle und zukünftige Therapieansätze.

    Tschöpe, Carsten

    MMW Fortschritte der Medizin

    2015  Volume 157, Issue 5, Page(s) 45–48

    Title translation Heart failure with preserved ejection fraction (HFpEF).
    MeSH term(s) Aged ; Cardiovascular Agents/therapeutic use ; Combined Modality Therapy ; Diagnosis, Differential ; Drug Therapy, Combination ; Heart Failure, Diastolic/diagnosis ; Heart Failure, Diastolic/physiopathology ; Heart Failure, Diastolic/therapy ; Humans ; Stroke Volume/drug effects ; Stroke Volume/physiology
    Chemical Substances Cardiovascular Agents
    Language German
    Publishing date 2015-03-19
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1478211-x
    ISSN 1438-3276
    ISSN 1438-3276
    DOI 10.1007/s15006-015-2824-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Medikamentöse Therapie bei Herzinsuffizienz mit erhaltener Pumpfunktion.

    Trippel, Tobias Daniel / Tschöpe, Carsten

    Deutsche medizinische Wochenschrift (1946)

    2020  Volume 145, Issue 19, Page(s) 1377–1383

    Abstract: Heart Failure causes an enormous individual and societal burden of disease with severe symptoms, a reduction in activities of daily life, frequent hospitalizations and poor prognosis. The field of heart failure with reduced ejection fraction has seen ... ...

    Title translation Pharmaceutical Treatment Options in Heart Failure with Preserved Ejection Fraction.
    Abstract Heart Failure causes an enormous individual and societal burden of disease with severe symptoms, a reduction in activities of daily life, frequent hospitalizations and poor prognosis. The field of heart failure with reduced ejection fraction has seen substantial innovation in the past years. Novel and successful treatment regimens were established, the pharmaceutical treatment options for heart failure with preserved ejection fraction remains limited to date. Yet, promising concepts are emerging. Today we have only symptoms and risk factors-based therapeutic options, and include basically diuretics, RAAsi, and antidiabetics, respectively. A causal therapy is still missing.
    MeSH term(s) Angiotensin Receptor Antagonists/therapeutic use ; Calcium Channel Blockers/therapeutic use ; Cardiovascular Agents/therapeutic use ; Diagnosis, Differential ; Diuretics/therapeutic use ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Heart Failure/physiopathology ; Humans ; Hypoglycemic Agents/therapeutic use ; Stroke Volume/physiology
    Chemical Substances Angiotensin Receptor Antagonists ; Calcium Channel Blockers ; Cardiovascular Agents ; Diuretics ; Hypoglycemic Agents
    Language German
    Publishing date 2020-09-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1038-7678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Diagnostic recommendations and phenotyping for heart failure with preserved ejection fraction: knowing more and understanding less?

    Fraser, Alan G / Tschöpe, Carsten / de Boer, Rudolf A

    European journal of heart failure

    2021  Volume 23, Issue 6, Page(s) 964–972

    MeSH term(s) Heart Failure/diagnosis ; Humans ; Stroke Volume
    Language English
    Publishing date 2021-05-18
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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