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  1. Article ; Online: Associations Between Measures of Disability and Quality of Life at Three Months After Stroke.

    Chang, Victoria A / Tirschwell, David L / Becker, Kyra J / Schubert, Glenn B / Longstreth, Will T / Creutzfeldt, Claire J

    Journal of palliative medicine

    2023  Volume 27, Issue 1, Page(s) 18–23

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Male ; Cohort Studies ; Outcome Assessment, Health Care ; Quality of Life ; Stroke ; Washington
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1427361-5
    ISSN 1557-7740 ; 1096-6218
    ISSN (online) 1557-7740
    ISSN 1096-6218
    DOI 10.1089/jpm.2023.0061
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  2. Article ; Online: Inflammation and the Silent Sequelae of Stroke.

    Becker, Kyra J

    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    2016  Volume 13, Issue 4, Page(s) 801–810

    Abstract: Depression and fatigue are common after stroke and negatively impact the quality of life of stroke survivors. The biological bases of these symptoms are unknown, but an abundance of data point to a role for inflammation. This review highlights evidence ... ...

    Abstract Depression and fatigue are common after stroke and negatively impact the quality of life of stroke survivors. The biological bases of these symptoms are unknown, but an abundance of data point to a role for inflammation. This review highlights evidence supporting the contribution of inflammation to poststroke depression and poststroke fatigue. Potential treatments for poststroke depression and poststroke fatigue are explored, with a special emphasis on those that modulate the immune response.
    MeSH term(s) Animals ; Depression/etiology ; Disease Progression ; Fatigue/etiology ; Humans ; Inflammation/etiology ; Stroke/complications ; Stroke/psychology
    Language English
    Publishing date 2016-06-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2316693-9
    ISSN 1878-7479 ; 1933-7213
    ISSN (online) 1878-7479
    ISSN 1933-7213
    DOI 10.1007/s13311-016-0451-5
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  3. Article ; Online: Strain-Related Differences in the Immune Response: Relevance to Human Stroke.

    Becker, Kyra J

    Translational stroke research

    2016  Volume 7, Issue 4, Page(s) 303–312

    Abstract: There are significant differences in the immune response and in the susceptibility to autoimmune diseases among rodent strains. It would thus be expected that the contribution of the immune response to cerebral ischemic injury would also differ among ... ...

    Abstract There are significant differences in the immune response and in the susceptibility to autoimmune diseases among rodent strains. It would thus be expected that the contribution of the immune response to cerebral ischemic injury would also differ among rodent strains. More importantly, there are significant differences between the immune responses of rodents and humans. All of these factors are likely to impact the successful translation of immunomodulatory therapies from experimental rodent models to patients with stroke.
    MeSH term(s) Age Factors ; Animals ; Cytokines/metabolism ; Disease Models, Animal ; Humans/immunology ; Rodentia/immunology ; Sex Factors ; Species Specificity ; Stroke/immunology ; Stroke/therapy
    Chemical Substances Cytokines
    Language English
    Publishing date 2016-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2541897-X
    ISSN 1868-601X ; 1868-4483
    ISSN (online) 1868-601X
    ISSN 1868-4483
    DOI 10.1007/s12975-016-0455-9
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  4. Article ; Online: Fatigue, Toll-Like Receptor 4, and Pro-Inflammatory Cytokines in Adults With Subarachnoid Hemorrhage: A 6-Month Longitudinal Study.

    Byun, Eeeseung / McCurry, Susan M / Kwon, Suyoung / Tsai, Chi-Shan / Jun, Jeehye / Bammler, Theo K / Becker, Kyra J / Thompson, Hilaire J

    Biological research for nursing

    2023  Volume 26, Issue 2, Page(s) 192–201

    Abstract: Background: Fatigue is prevalent in subarachnoid hemorrhage (SAH) survivors. Biological mechanisms underlying fatigue post-SAH are not clear. Inflammation may contribute to the development of fatigue. This study aimed to examine the associations between ...

    Abstract Background: Fatigue is prevalent in subarachnoid hemorrhage (SAH) survivors. Biological mechanisms underlying fatigue post-SAH are not clear. Inflammation may contribute to the development of fatigue. This study aimed to examine the associations between inflammatory markers and fatigue during the first 6 months post-SAH. Specific biomarkers examined included both early and concurrent expression of Toll-Like Receptor 4 (TLR4) messenger RNA (mRNA) and plasma concentrations of pro-inflammatory cytokines, Tumor Necrosis Factor-alpha (TNF-α), Interleukin (IL)1β, and IL6.
    Methods: We conducted a 6-month longitudinal study with a convenience sample of 43 SAH survivors. We collected blood samples on days 2, 3, and 7 and 2, 3, and 6 months post-SAH to assess biomarkers. Fatigue was assessed by the PROMIS Fatigue Scale at 2, 3, and 6 months. Linear mixed models were used to test the associations between early (days 2, 3, and 7) and concurrent (2, 3, and 6 months) TLR4 mRNA expression (TagMan gene expression assays) and TNF-α, IL1β, and IL6 plasma concentrations (multiplex assays) and concurrent fatigue.
    Results: 28% of SAH survivors experienced fatigue during the first 6 months post-SAH. Fatigue levels in SAH survivors were higher than those of the U.S. population and consistent during the 6 months. Experience of fatigue during the 6 months post-SAH was associated with higher IL1β plasma concentrations on day 7 and IL1β, IL6, and TNF-α plasma concentrations during the 6 months post-SAH.
    Conclusion: Inflammation appears to underlie the development of fatigue in SAH survivors.
    MeSH term(s) Adult ; Humans ; Cytokines/genetics ; Subarachnoid Hemorrhage/complications ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Longitudinal Studies ; Inflammation/metabolism ; Fatigue/complications ; RNA, Messenger ; Biomarkers
    Chemical Substances Cytokines ; Toll-Like Receptor 4 ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; RNA, Messenger ; Biomarkers
    Language English
    Publishing date 2023-10-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2145107-2
    ISSN 1552-4175 ; 1099-8004
    ISSN (online) 1552-4175
    ISSN 1099-8004
    DOI 10.1177/10998004231203257
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  5. Article ; Online: Stroke, Inflammation and the Immune Response: Dawn of a New Era.

    Becker, Kyra J / Buckwalter, Marion

    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    2016  Volume 13, Issue 4, Page(s) 659–660

    MeSH term(s) Humans ; Immunity, Mucosal/immunology ; Inflammation/immunology ; Stroke/immunology
    Language English
    Publishing date 2016-09-27
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2316693-9
    ISSN 1878-7479 ; 1933-7213
    ISSN (online) 1878-7479
    ISSN 1933-7213
    DOI 10.1007/s13311-016-0478-7
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  6. Article ; Online: Impact of Age on Plasma Inflammatory Biomarkers in the 6 Months Following Mild Traumatic Brain Injury.

    Thompson, Hilaire J / Martha, Sarah R / Wang, Jin / Becker, Kyra J

    The Journal of head trauma rehabilitation

    2020  Volume 35, Issue 5, Page(s) 324–331

    Abstract: Objective: To compare plasma inflammatory biomarker concentrations to 6 months in young and older adults with and without mild traumatic brain injury (TBI).: Setting: Level 1 trauma center.: Participants: Younger (21-54 years) and older (55+) ... ...

    Abstract Objective: To compare plasma inflammatory biomarker concentrations to 6 months in young and older adults with and without mild traumatic brain injury (TBI).
    Setting: Level 1 trauma center.
    Participants: Younger (21-54 years) and older (55+) adults diagnosed with mild TBI along with age-/sex-matched noninjured controls (n = 313).
    Design: Prospective cohort study.
    Main measures: Multiplex assays were used to quantify concentrations of selected plasma inflammatory markers at day 0, months 1 and 6.
    Results: Persistent aging-related differences were found between control groups in concentrations of 4 cytokines up to 6 months. At day 0, interleukin-6 (IL-6), IL-8, and fractalkine were higher in the older TBI compared with older control as well as the younger TBI groups, while IL-10 was higher in older TBI compared with controls. At month 1, significantly higher concentrations of IL-8, fractalkine, and tumor necrosis factor-α (TNF-α) were seen. At 6 months postinjury, significantly higher concentrations of IL-6 and IL-8 were seen, while a lower concentration of IL-7 was found in older versus younger TBI groups.
    Conclusion: The neuroinflammatory signature that accompanies mild TBI in older adults differs from that of younger adults. The differences seen are notable for their roles in neutrophil attraction (IL-8), neuronal-microglial-immune cell interactions (fractalkine), and chronic inflammation (IL-6).
    MeSH term(s) Adult ; Age Factors ; Aged ; Biomarkers/blood ; Brain Concussion/diagnosis ; Cytokines/blood ; Female ; Humans ; Inflammation/blood ; Male ; Middle Aged ; Prospective Studies
    Chemical Substances Biomarkers ; Cytokines
    Language English
    Publishing date 2020-09-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639221-0
    ISSN 1550-509X ; 0885-9701
    ISSN (online) 1550-509X
    ISSN 0885-9701
    DOI 10.1097/HTR.0000000000000606
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  7. Article ; Online: Activation of immune responses to brain antigens after stroke.

    Becker, Kyra J

    Journal of neurochemistry

    2012  Volume 123 Suppl 2, Page(s) 148–155

    Abstract: Infection is common after stroke and is independently associated with a worse outcome. The predisposition to infection following stroke is in part related to a sympathetically mediated suppression of the peripheral immune response. The teleological ... ...

    Abstract Infection is common after stroke and is independently associated with a worse outcome. The predisposition to infection following stroke is in part related to a sympathetically mediated suppression of the peripheral immune response. The teleological explanation for this immune dysfunction is that it serves to prevent autoimmune responses to brain antigens. We believe that the systemic immune response in patients who develop infection, however, thwarts this seemingly protective response and predisposes to central nervous system autoimmunity. These autoimmune responses may mediate, at least in part, the worse outcome associated with post-stroke infection.
    MeSH term(s) Animals ; Antigens/immunology ; Autoimmunity ; Brain/immunology ; Humans ; Infections/etiology ; Models, Biological ; Monocytes/pathology ; Stroke/complications ; Stroke/immunology ; Stroke/pathology
    Chemical Substances Antigens
    Language English
    Publishing date 2012-10-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/j.1471-4159.2012.07953.x
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  8. Article ; Online: Brief Psychosocial Intervention to Address Poststroke Depression May Also Benefit Fatigue and Sleep-Wake Disturbance.

    Byun, Eeeseung / Becker, Kyra J / Kohen, Ruth / Kirkness, Catherine J / Mitchell, Pamela H

    Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses

    2021  Volume 46, Issue 4, Page(s) 222–231

    Abstract: Purpose: This study aimed to determine if brief psychosocial/behavioral therapy directed to reduce poststroke depression would decrease fatigue and improve sleep-wake disturbance.: Design: A preplanned secondary data analysis from a completed ... ...

    Abstract Purpose: This study aimed to determine if brief psychosocial/behavioral therapy directed to reduce poststroke depression would decrease fatigue and improve sleep-wake disturbance.
    Design: A preplanned secondary data analysis from a completed clinical trial was conducted.
    Methods: One hundred participants received usual care, in-person intervention, or telephone intervention. Depression, fatigue, and sleep-wake disturbance were measured at entry, 8 weeks, 21 weeks, and 12 months following the intervention.
    Findings: Fatigue (within: p = .042, between: p = .394), sleep disturbance (within: p = .024, between: p = .102), and wake disturbance (within: p = .004, between: p = .508) decreased over the 12 months in the intervention groups, but not in the control group. This difference was clinically meaningful for wake disturbance and approached the clinically important difference for fatigue.
    Conclusions/clinical relevance: Reduction in wake disturbance was consistent with clinically meaningful difference standards for patient-reported outcomes, warranting further research in larger samples.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Depression/etiology ; Depression/psychology ; Fatigue/etiology ; Fatigue/psychology ; Female ; Humans ; Male ; Mass Screening/methods ; Middle Aged ; Psychotherapy, Brief/methods ; Psychotherapy, Brief/standards ; Psychotherapy, Brief/statistics & numerical data ; Sleep Wake Disorders/etiology ; Sleep Wake Disorders/psychology ; Stroke/complications ; Stroke/psychology ; Washington
    Language English
    Publishing date 2021-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604872-9
    ISSN 2048-7940 ; 0278-4807 ; 0248-7940
    ISSN (online) 2048-7940
    ISSN 0278-4807 ; 0248-7940
    DOI 10.1097/RNJ.0000000000000304
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  9. Article ; Online: Advances in critical care/emergency medicine 2013.

    Keller, Emanuela / Becker, Kyra J

    Stroke

    2014  Volume 45, Issue 2, Page(s) 359–360

    MeSH term(s) Brain Ischemia/therapy ; Cerebral Hemorrhage/therapy ; Critical Care/trends ; Emergency Medical Services/trends ; Emergency Medicine/trends ; Heart Arrest/therapy ; Humans ; Stroke/therapy ; Thrombolytic Therapy ; United States
    Language English
    Publishing date 2014-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.113.004223
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    Zs.A 448: Show issues Location:
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  10. Article ; Online: Modulation of the postischemic immune response to improve stroke outcome.

    Becker, Kyra J

    Stroke

    2010  Volume 41, Issue 10 Suppl, Page(s) S75–8

    Abstract: Recent advances in understanding how the poststroke immune response may contribute to ischemic brain injury are discussed in this article. In particular, the potential of modulating the postischemic immune response to improve stroke outcome is explored. ...

    Abstract Recent advances in understanding how the poststroke immune response may contribute to ischemic brain injury are discussed in this article. In particular, the potential of modulating the postischemic immune response to improve stroke outcome is explored.
    MeSH term(s) Brain/immunology ; Brain Ischemia/immunology ; Humans ; Inflammation/immunology ; Interleukins/immunology ; Stroke/immunology ; Treatment Outcome
    Chemical Substances Interleukins
    Language English
    Publishing date 2010-09-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.110.592881
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