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Article: Mogamulizumab-kpkc: A Novel Therapy for the Treatment of Cutaneous T-Cell Lymphoma.

Watson, Sutton / Marx, Justin Bradley

Journal of the advanced practitioner in oncology

2019 Volume 10, Issue 8, Page(s) 883–888

Abstract: Mogamulizumab-kpkc provides a novel mechanism of action for the treatment of mycosis fungoides and Sézary syndrome. The efficacy and safety of mogamulizumab-kpkc for the treatment of relapsed or refractory mycosis fungoides and Sézary syndrome were ... ...

Abstract	Mogamulizumab-kpkc provides a novel mechanism of action for the treatment of mycosis fungoides and Sézary syndrome. The efficacy and safety of mogamulizumab-kpkc for the treatment of relapsed or refractory mycosis fungoides and Sézary syndrome were demonstrated in a multicenter, open-label, randomized phase III trial comparing mogamulizumab-kpkc with vorinostat. Patients treated with mogamulizumab-kpkc showed a statistically significant increased progression-free survival (PFS; 7.7 months) compared with vorinostat (3.1 months). Overall response rates were higher with mogamulizumab-kpkc compared with vorinostat (28% vs. 5%;
Language	English
Publishing date	2019-11-01
Publishing country	United States
Document type	Journal Article
ISSN	2150-0878
ISSN	2150-0878
DOI	10.6004/jadpro.2019.10.8.10
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Article ; Online: Reply to Mathew.

Fowler, Hayley / Clifford, Rachael E / Sutton, Paul / Watson, Angus J M / Fearnhead, Nicola / Rose, Azmina / Bach, Simon / Jackson, Richard / Moran, Brendan / Vimalachandran, Dale

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2021 Volume 23, Issue 3, Page(s) 752–753

Language	English
Publishing date	2021-01-09
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.15490
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Zs.A 5799: Show issues

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Article ; Online: N-Alkyl-α-amino acids in Nature and their biocatalytic preparation.

Hyslop, Julia F / Lovelock, Sarah L / Watson, Allan J B / Sutton, Peter W / Roiban, Gheorghe-Doru

Journal of biotechnology

2019 Volume 293, Page(s) 56–65

Abstract: N-Alkylated-α-amino acids are useful building blocks for the pharmaceutical and fine chemical industries. Enantioselective methods of N-alkylated-α-amino acid synthesis are therefore highly valuable and widely investigated. While there are a variety of ... ...

Abstract	N-Alkylated-α-amino acids are useful building blocks for the pharmaceutical and fine chemical industries. Enantioselective methods of N-alkylated-α-amino acid synthesis are therefore highly valuable and widely investigated. While there are a variety of chemical methods for their synthesis, they often employ stoichiometric quantities of hazardous reagents such as pyrophoric metal hydrides or genotoxic alkylating agents, whereas biocatalytic routes can provide a greener and cleaner alternative to existing methods. This review highlights the occurrence of the N-alkyl-α-amino acid motif and its role in nature, important applications towards human health and biocatalytic methods of preparation. Several enzyme classes that can be used to access chiral N-alkylated-α-amino acids and their substrate selectivities are detailed.
MeSH term(s)	Amino Acids/biosynthesis ; Amino Acids/chemistry ; Animals ; Biocatalysis ; Humans ; Nature
Chemical Substances	Amino Acids
Language	English
Publishing date	2019-01-26
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	843647-2
ISSN	1873-4863 ; 0168-1656 ; 1389-0352
ISSN (online)	1873-4863
ISSN	0168-1656 ; 1389-0352
DOI	10.1016/j.jbiotec.2019.01.006
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Zs.A 2299: Show issues

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Article: Can competencies at selection predict performance and development needs?

Sutton, Anna / Watson, Sara

The journal of management development Vol. 32, No. 9 , p. 1023-1035

2013 Volume 32, Issue 9, Page(s) 1023–1035

Author's details	Anna Sutton and Sara Watson
Keywords	Development ; Selection ; Competencies ; Manager
Language	English
Publisher	Emerald
Publishing place	Bradford
Document type	Article
ZDB-ID	83190-6 ; 2020272-6
ISSN	0262-1711
ISSN	0262-1711
Database	ECONomics Information System

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Article ; Online: Hartmann's procedure versus intersphincteric abdominoperineal excision (HiP Study): a multicentre prospective cohort study.

Fowler, H / Clifford, R / Sutton, P / Watson, A / Fearnhead, N / Bach, S / Moran, B / Rose, A / Jackson, R / Vimalachandran, D

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2020 Volume 22, Issue 12, Page(s) 2114–2122

Abstract: Aim: In patients with low rectal cancer it is occasionally necessary to avoid a low coloanal anastomosis due to patient frailty or poor function. In such situations there are two alternative approaches: Hartmann's procedure (HP) or intersphincteric ... ...

Abstract	Aim: In patients with low rectal cancer it is occasionally necessary to avoid a low coloanal anastomosis due to patient frailty or poor function. In such situations there are two alternative approaches: Hartmann's procedure (HP) or intersphincteric abdominoperineal excision (IAPE). There are few data to guide surgeons as to which of these two procedures is the safest. The aim of this study was to determine the surgical complication rates associated with each procedure. Method: This was a multicentre, nonrandomized prospective cohort study of patients undergoing either HP or IAPE. The primary objective was to determine surgical complication rates. Secondary objectives included length of stay, time to adjuvant therapy and quality of life at 90 days. Results: One hundred and seventy nine patients were recruited between April 2016 and June 2019; approximately two thirds of patients underwent HP and one third IAPE. The overall complication rate was high in both groups (54% for the HP group and 52% for the IAPE group). Surgery-specific complication rates were also high, but not significantly different: 43% for HP and 48% for IAPE. The pelvic abscess rate in HP was 11% and was significantly higher in patients with a palpable staple line (15% vs 2%). There was a higher incidence of serious medical complications following IAPE (16% vs 5%), along with a reduction in 90-day quality of life scores. Conclusion: This is the largest prospective study to compare HP and IAPE in patients undergoing rectal cancer surgery where primary anastomosis is not deemed appropriate. With similar complication rates, these data support the ongoing use of either HP or IAPE in this patient group.
MeSH term(s)	Anastomosis, Surgical/adverse effects ; Colostomy ; Humans ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Proctectomy/adverse effects ; Proctocolectomy, Restorative ; Prospective Studies ; Quality of Life ; Rectal Neoplasms/surgery ; Treatment Outcome
Language	English
Publishing date	2020-10-02
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.15366
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Article ; Online: Risk categorization for oversight of laboratory-developed tests for inherited conditions: an updated position statement of the American College of Medical Genetics and Genomics (ACMG).

South, Sarah T / McClure, Michelle / Astbury, Caroline / Bashford, Michael T / Benkendorf, Judith / Esplin, Edward D / Monaghan, Kristin G / Oglesbee, Devin / Sutton, V Reid / Watson, Michael S

Genetics in medicine : official journal of the American College of Medical Genetics

2020 Volume 22, Issue 6, Page(s) 983–985

MeSH term(s)	Genetic Testing ; Genetics, Medical ; Genomics ; Humans ; Laboratories ; United States
Language	English
Publishing date	2020-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1455352-1
ISSN	1530-0366 ; 1098-3600
ISSN (online)	1530-0366
ISSN	1098-3600
DOI	10.1038/s41436-020-0765-x
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Zs.A 5059: Show issues

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Article ; Online: Diet alters age-related remodeling of aortic collagen in mice susceptible to atherosclerosis.

Watson, Shana R / Cooper, Kara M / Liu, Piaomu / Gharraee, Nazli / Du, Liya / Han, Savannah M / Peña, Edsel A / Sutton, Michael A / Eberth, John F / Lessner, Susan M

American journal of physiology. Heart and circulatory physiology

2021 Volume 320, Issue 1, Page(s) H52–H65

Abstract: Vascular cells restructure extracellular matrix in response to aging or changes in mechanical loading. Here, we characterized collagen architecture during age-related aortic remodeling in atherosclerosis-prone mice. We hypothesized that changes in ... ...

Abstract	Vascular cells restructure extracellular matrix in response to aging or changes in mechanical loading. Here, we characterized collagen architecture during age-related aortic remodeling in atherosclerosis-prone mice. We hypothesized that changes in collagen fiber orientation reflect an altered balance between passive and active forces acting on the arterial wall. We examined two factors that can alter this balance, endothelial dysfunction and reduced smooth muscle cell (SMC) contractility. Collagen fiber organization was visualized by second-harmonic generation microscopy in aortic adventitia of apolipoprotein E (apoE) knockout (KO) mice at 6 wk and 6 mo of age on a chow diet and at 7.5 mo of age on a Western diet (WD), using image analysis to yield mean fiber orientation. Adventitial collagen fibers became significantly more longitudinally oriented with aging in apoE knockout mice on chow diet. Conversely, fibers became more circumferentially oriented with aging in mice on WD. Total collagen content increased significantly with age in mice fed WD. We compared expression of endothelial nitric oxide synthase and acetylcholine-mediated nitric oxide release but found no evidence of endothelial dysfunction in older mice. Time-averaged volumetric blood flow in all groups showed no significant changes. Wire myography of aortic rings revealed decreases in active stress generation with age that were significantly exacerbated in WD mice. We conclude that the aorta displays a distinct remodeling response to atherogenic stimuli, indicated by altered collagen organization. Collagen reorganization can occur in the absence of altered hemodynamics and may represent an adaptive response to reduced active stress generation by vascular SMCs.
MeSH term(s)	Age Factors ; Animals ; Aorta, Abdominal/metabolism ; Aorta, Abdominal/pathology ; Aorta, Abdominal/physiopathology ; Aorta, Thoracic/metabolism ; Aorta, Thoracic/pathology ; Aorta, Thoracic/physiopathology ; Aortic Diseases/genetics ; Aortic Diseases/metabolism ; Aortic Diseases/pathology ; Aortic Diseases/physiopathology ; Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Atherosclerosis/physiopathology ; Diet, Western ; Disease Models, Animal ; Female ; Fibrillar Collagens/metabolism ; Male ; Mice, Knockout, ApoE ; Vascular Remodeling ; Vasoconstriction ; Mice
Chemical Substances	Fibrillar Collagens
Language	English
Publishing date	2021-02-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00420.2020
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Article ; Online: Effectiveness of offering tailored text message, self-help smoking cessation support to pregnant women who want information on stopping smoking: MiQuit3 randomised controlled trial and meta-analysis.

Coleman, Tim / Clark, Miranda / Welch, Charlie / Whitemore, Rachel / Leonardi-Bee, Jo / Cooper, Sue / Hewitt, Catherine / Jones, Matthew / Sutton, Stephen / Watson, Judith / Daykin, Karen / Ussher, Michael / Parrott, Steve / Naughton, Felix

Addiction (Abingdon, England)

2021 Volume 117, Issue 4, Page(s) 1079–1094

Abstract: Aims: To test the efficacy of 'MiQuit', a tailored, self-help, text message stop smoking programme for pregnancy, as an adjunct to usual care (UC) for smoking cessation in pregnancy.: Design: Multicentre, open, two-arm, parallel-group, superiority ... ...

Abstract	Aims: To test the efficacy of 'MiQuit', a tailored, self-help, text message stop smoking programme for pregnancy, as an adjunct to usual care (UC) for smoking cessation in pregnancy. Design: Multicentre, open, two-arm, parallel-group, superiority randomised controlled trial (RCT) and a trial sequential analysis (TSA) meta-analysis combining trial findings with two previous ones. Setting: Twenty-four English hospital antenatal clinics. Participants: A total of 1002 pregnant women who were ≥16 years old, were ≤25 weeks gestation and smoked ≥1 daily cigarette and accepted information on cessation with no requirement to set quit dates. Interventions: UC or UC plus 'MiQuit': 12 weeks of tailored, smoking cessation text messages focussed on inducing and aiding cessation. Measurements: Primary outcome: biochemically validated cessation between 4 weeks after randomisation and late pregnancy. Secondary outcomes: shorter and non-validated abstinence periods, pregnancy outcomes and incremental cost-effectiveness ratios. Findings: RCT: cessation was 5.19% (26/501) and 4.59% (23/501) in MiQuit and UC groups (adjusted odds ratio [adj OR] for quitting with MiQuit versus UC, 95% CI = 1.15 [0.65-2.04]); other abstinence findings were similar, with higher point estimates. Primary outcome ascertainment was 61.7% (309) and 67.3% (337) in MiQuit and UC groups with 71.1% (54/76) and 69.5% (41/59) abstinence validation rates, respectively. Pregnancy outcomes were similar and the incremental cost per quality-adjusted life year was -£1118 (95% CI = -£4806-£1911). More MiQuit group women reported making at least one quit attempt (adj OR [95% CI]) for making an attempt, 1.50 (1.07-2.09). TSA meta-analysis: this found no significant difference in prolonged abstinence between MiQuit and UC (pooled OR = 1.49, adjusted 95% CI = 0.62-3.60). Conclusions: Irrespective of whether they want to try quitting, when offered a tailored, self-help, text message stop smoking programme for pregnancy (MiQuit) as an adjunct to usual care, pregnant women are not more likely to stop smoking until childbirth but they report more attempts at stopping smoking.
MeSH term(s)	Adolescent ; Female ; Health Behavior ; Humans ; Multicenter Studies as Topic ; Pregnancy ; Pregnant Women ; Randomized Controlled Trials as Topic ; Smoking ; Smoking Cessation ; Text Messaging
Language	English
Publishing date	2021-11-05
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	1141051-6
ISSN	1360-0443 ; 0965-2140
ISSN (online)	1360-0443
ISSN	0965-2140
DOI	10.1111/add.15715
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Article ; Online: Biocatalytic Synthesis of Chiral N-Functionalized Amino Acids.

Hyslop, Julia F / Lovelock, Sarah L / Sutton, Peter W / Brown, Kristin K / Watson, Allan J B / Roiban, Gheorghe-Doru

Angewandte Chemie (International ed. in English)

2018 Volume 57, Issue 42, Page(s) 13821–13824

Abstract: N-Functionalized amino acids are important building blocks for the preparation of diverse bioactive molecules, including peptides. The development of sustainable manufacturing routes to chiral N-alkylated amino acids remains a significant challenge in ... ...

Abstract	N-Functionalized amino acids are important building blocks for the preparation of diverse bioactive molecules, including peptides. The development of sustainable manufacturing routes to chiral N-alkylated amino acids remains a significant challenge in the pharmaceutical and fine-chemical industries. Herein we report the discovery of a structurally diverse panel of biocatalysts which catalyze the asymmetric synthesis of N-alkyl amino acids through the reductive coupling of ketones and amines. Reactions have been performed on a gram scale to yield optically pure N-alkyl-functionalized products in high yields.
MeSH term(s)	Alkylation ; Amino Acids/chemistry ; Amino Acids/metabolism ; Animals ; Biocatalysis ; Chromatography, High Pressure Liquid ; Humans ; Ketones/chemistry ; Pseudomonas/enzymology ; Stereoisomerism
Chemical Substances	Amino Acids ; Ketones
Language	English
Publishing date	2018-09-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.201806893
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Article ; Online: Structural and Functional MRI Evidence for Distinct Medial Temporal and Prefrontal Roles in Context-dependent Relational Memory.

Schwarb, Hillary / Johnson, Curtis L / Dulas, Michael R / McGarry, Matthew D J / Holtrop, Joseph L / Watson, Patrick D / Wang, Jane X / Voss, Joel L / Sutton, Bradley P / Cohen, Neal J

Journal of cognitive neuroscience

2019 Volume 31, Issue 12, Page(s) 1857–1872

Abstract: Declarative memory is supported by distributed brain networks in which the medial-temporal lobes (MTLs) and pFC serve as important hubs. Identifying the unique and shared contributions of these regions to successful memory performance is an active area ... ...

Abstract	Declarative memory is supported by distributed brain networks in which the medial-temporal lobes (MTLs) and pFC serve as important hubs. Identifying the unique and shared contributions of these regions to successful memory performance is an active area of research, and a growing literature suggests that these structures often work together to support declarative memory. Here, we present data from a context-dependent relational memory task in which participants learned that individuals belonged in a single room in each of two buildings. Room assignment was consistent with an underlying contextual rule structure in which male and female participants were assigned to opposite sides of a building and the side assignment switched between buildings. In two experiments, neural correlates of performance on this task were evaluated using multiple neuroimaging tools: diffusion tensor imaging (Experiment 1), magnetic resonance elastography (Experiment 1), and functional MRI (Experiment 2). Structural and functional data from each individual modality provided complementary and consistent evidence that the hippocampus and the adjacent white matter tract (i.e., fornix) supported relational memory, whereas the ventromedial pFC/OFC (vmPFC/OFC) and the white matter tract connecting vmPFC/OFC to MTL (i.e., uncinate fasciculus) supported memory-guided rule use. Together, these data suggest that MTL and pFC structures differentially contribute to and support contextually guided relational memory.
MeSH term(s)	Adolescent ; Adult ; Brain Mapping ; Color ; Diffusion Tensor Imaging ; Elasticity Imaging Techniques ; Face ; Female ; Fornix, Brain/physiology ; Hippocampus/physiology ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Memory/physiology ; Mental Recall ; Neural Pathways ; Prefrontal Cortex/physiology ; Psychomotor Performance ; Spatial Memory/physiology ; Temporal Lobe/physiology ; White Matter/physiology ; Young Adult
Language	English
Publishing date	2019-08-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1007410-7
ISSN	1530-8898 ; 0898-929X ; 1096-8857
ISSN (online)	1530-8898
ISSN	0898-929X ; 1096-8857
DOI	10.1162/jocn_a_01454
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