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Article ; Online: Immune interference in effectiveness of influenza and COVID-19 vaccination.

Xie, Yiwen / Tian, Xuebin / Zhang, Xiaodi / Yao, Hangping / Wu, Nanping

2023 Volume 14, Page(s) 1167214

Abstract: Vaccines are known to function as the most effective interventional therapeutics for controlling infectious diseases, including polio, smallpox, rabies, tuberculosis, influenza and SARS-CoV-2. Smallpox has been eliminated completely and polio is almost ... ...

Abstract	Vaccines are known to function as the most effective interventional therapeutics for controlling infectious diseases, including polio, smallpox, rabies, tuberculosis, influenza and SARS-CoV-2. Smallpox has been eliminated completely and polio is almost extinct because of vaccines. Rabies vaccines and Bacille Calmette-Guérin (BCG) vaccines could effectively protect humans against respective infections. However, both influenza vaccines and COVID-19 vaccines are unable to eliminate these two infectious diseases of their highly variable antigenic sites in viral proteins. Vaccine effectiveness (VE) could be negatively influenced (i.e., interfered with) by immune imprinting of previous infections or vaccinations, and repeated vaccinations could interfere with VE against infections due to mismatch between vaccine strains and endemic viral strains. Moreover, VE could also be interfered with when more than one kind of vaccine is administrated concomitantly (i.e., co-administrated), suggesting that the VE could be modulated by the vaccine-induced immunity. In this review, we revisit the evidence that support the interfered VE result from immune imprinting or repeated vaccinations in influenza and COVID-19 vaccine, and the interference in co-administration of these two types of vaccines is also discussed. Regarding the development of next-generation COVID-19 vaccines, the researchers should focus on the induction of cross-reactive T-cell responses and naive B-cell responses to overcome negative effects from the immune system itself. The strategy of co-administrating influenza and COVID-19 vaccine needs to be considered more carefully and more clinical data is needed to verify this strategy to be safe and immunogenic.
MeSH term(s)	Humans ; Influenza, Human/prevention & control ; Influenza Vaccines ; COVID-19 Vaccines ; SARS-CoV-2 ; COVID-19/prevention & control ; Smallpox ; Vaccination ; BCG Vaccine ; Rabies Vaccines
Chemical Substances	Influenza Vaccines ; COVID-19 Vaccines ; BCG Vaccine ; Rabies Vaccines
Language	English
Publishing date	2023-04-19
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1167214
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A new deep eutectic solvent-agarose gel with hydroxylated fullerene as electrical "switch" system for drug release.

Guo, Yingying / Wang, Yan / Chen, Hangping / Jiang, Wanhang / Zhu, Chanrong / Toufouki, Sara / Yao, Shun

Carbohydrate polymers

2022 Volume 296, Page(s) 119939

Abstract: A novel portable conductive system of hydroxylated fullerene (TEGs- ... ...

Abstract	A novel portable conductive system of hydroxylated fullerene (TEGs-C
MeSH term(s)	Animals ; Deep Eutectic Solvents ; Drug Liberation ; Escherichia coli ; Fullerenes ; Rabbits ; Sepharose ; Solvents ; Staphylococcus aureus
Chemical Substances	Deep Eutectic Solvents ; Fullerenes ; Solvents ; Sepharose (9012-36-6)
Language	English
Publishing date	2022-08-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2022.119939
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Article ; Online: Simple Preparation of a Unique Ionic Liquid/Deep Eutectic Solvent and β-Cyclodextrin Composite Discs and Its Use to Capture Hazardous Substances from Water

Yingying Guo / Na Liu / Hangping Chen / Ahmad Ali / Sara Toufouki / Shun Yao

Separations, Vol 10, Iss 357, p

2023 Volume 357

Abstract: With the development of health service, animal husbandry, aquaculture and the chemical industry, more and more pollutants are discharged into the water environment, including antibiotics and heavy-metal ions. These hazardous substances pose a great ... ...

Abstract	With the development of health service, animal husbandry, aquaculture and the chemical industry, more and more pollutants are discharged into the water environment, including antibiotics and heavy-metal ions. These hazardous substances pose a great threat to environmental safety and human health. Two new kinds of green solvents, ionic liquids (ILs) and deep eutectic solvents (DESs), are widely utilized in various fields, including separation and environmental engineering, and are attracting much attention from academia and industry. In this study, an optimal ionic liquid and a deep eutectic solvent were selected, and their complex with β-cyclodextrin (β-CD) was first prepared by a process of simple and effective inclusion. After necessary characterization and analysis, two kinds of complexes were applied to prepare a special two-sided sorbent disc by adding a diluent (excipient) and pressing the substance under 5~15 MPa. As a result, the IL and DES were stably immobilized on the disc to play a key role in the selective adsorption of targets. Moreover, the experiments with different hazardous substances achieved the expected results. This study demonstrates that the complex disc, with its easy preparation, good stability, and simple operation, exhibited many merits in its separation performance. We believe it to be a useful tool for water purification and detection of noxious substances.
Keywords	ionic liquid ; deep eutectic solvent ; cyclodextrin ; sorbent disc ; water environment ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	660
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A new deep eutectic solvent-agarose gel with hydroxylated fullerene as electrical “switch” system for drug release

Guo, Yingying / Wang, Yan / Chen, Hangping / Jiang, Wanhang / Zhu, Chanrong / Toufouki, Sara / Yao, Shun

Carbohydrate polymers. 2022 Nov. 15, v. 296

2022

Abstract: A novel portable conductive system of hydroxylated fullerene (TEGs-C₆₀) embedded on the deep eutectic solvent (DES, choline chloride/malic acid)-agarose gel was developed for on-demand curation with skin contact. It has been found with better elasticity, ...

Abstract	A novel portable conductive system of hydroxylated fullerene (TEGs-C₆₀) embedded on the deep eutectic solvent (DES, choline chloride/malic acid)-agarose gel was developed for on-demand curation with skin contact. It has been found with better elasticity, conductivity and thermal stability than agarose hydrogel. Especially, the electro-responsive drug releasing amount on the skin of mice and live rabbits through small batteries was proved to be 4–5 times of those without electrical stimulation, which reached the level of clinic daily dosage. Meanwhile, it also showed good biocompatibility and much higher antibacterial rate against S. aureus (78.67 ± 0.80 %) together with E. coli (92.08 ± 1.50 %) than those of commercial chitosan gel. The new electrical “switch” gel system provided an effective and useful development strategy for advanced drug delivery.
Keywords	Escherichia coli ; agarose ; biocompatibility ; chitosan ; choline chloride ; drugs ; electrical treatment ; fullerene ; hydrogels ; hydroxylation ; malic acid ; solvents ; thermal stability
Language	English
Dates of publication	2022-1115
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2022.119939
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Article ; Online: Rapid emergence of a PB2 D701N substitution during adaptation of an H9N2 avian influenza virus in mice.

Yang, Fan / Zhang, Xiaodi / Liu, Fumin / Yao, Hangping / Wu, Nanping / Wu, Haibo

Archives of virology

2022 Volume 167, Issue 11, Page(s) 2299–2303

Abstract: H9N2 avian influenza viruses (AIVs) have been isolated frequently from multiple avian species and, occasionally, from humans. To explore the potential molecular basis of cross-species transmission of H9N2 AIVs, an H9N2 AIV (A/chicken/Zhejiang/221/2016) ... ...

Abstract	H9N2 avian influenza viruses (AIVs) have been isolated frequently from multiple avian species and, occasionally, from humans. To explore the potential molecular basis of cross-species transmission of H9N2 AIVs, an H9N2 AIV (A/chicken/Zhejiang/221/2016) was serially passaged in mouse lung. The results showed that the mouse-adapted H9N2 virus exhibited higher virulence and replicated more efficiently in mouse lung and liver. Whole-genome sequencing showed an amino acid substitution, D701N, in the PB2 protein, which is likely associated with the increased replicative ability of H9N2 virus in mice. The rapid emergence of adaptive substitutions indicates the necessity of continuous monitoring of H9N2 virus in poultry.
MeSH term(s)	Amino Acid Substitution ; Animals ; Chickens ; Humans ; Influenza A Virus, H9N2 Subtype/genetics ; Influenza in Birds ; Mice ; Orthomyxoviridae Infections
Language	English
Publishing date	2022-08-03
Publishing country	Austria
Document type	Journal Article
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-022-05536-1
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Article ; Online: A multiplex TaqMan real-time RT-PCR assay for the simultaneous detection of H4, H6, and H10 avian influenza viruses

Fan Yang / Sijing Yan / Linwei Zhu / Hangping Yao / Dalu Dong / Danna Wu / Nanping Wu / Chunsheng Ye / Haibo Wu

Heliyon, Vol 9, Iss 5, Pp e15647- (2023)

2023

Abstract: Avian influenza viruses (AIVs) have caused a large number of epidemics in domestic and wild birds, and even posed a health challenge to humans. Highly pathogenic AIVs have attracted the most public attention. However, low pathogenic AIVs, including H4, ... ...

Abstract	Avian influenza viruses (AIVs) have caused a large number of epidemics in domestic and wild birds, and even posed a health challenge to humans. Highly pathogenic AIVs have attracted the most public attention. However, low pathogenic AIVs, including H4, H6, and H10 subtype AIVs, have spread covertly in domestic poultry, without obvious clinical signs. The emergence of human infections with H6 and H10 AIVs and the evidence of seropositivity of H4 AIV in poultry-exposed individuals indicated that these AIVs sporadically infect humans and could cause a potential pandemic. Therefore, a rapid and sensitive diagnostic method to simultaneously detect Eurasian lineage H4, H6, and H10 subtype AIVs is urgently required. Four singleplex real-time RT-PCR (RRT-PCR) assays were established based on carefully designed primers and probes of the conserved regions of the matrix, H4, H6, and H10 genes and combined into a multiplex RRT-PCR method to simultaneously detect H4, H6, and H10 AIVs in one reaction. The detection limit of the multiplex RRT-PCR method was 1–10 copies per reaction when detecting standard plasmids, and showed no cross-reaction against other subtype AIVs and other common avian viruses. Additionally, this method was suitable to detect the AIVs in samples from different sources, the results of which showed high consistency with virus isolation and a commercial influenza detection kit. In summary, this rapid, convenient, and practical multiplex RRT-PCR method could be applied in laboratory testing and clinical screening to detect AIVs.
Keywords	Avian influenza virus ; Multiplex real-time RT-PCR ; Subtyping ; Virus diagnosis ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	616
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A multiplex real-time RT-PCR assay for the detection of H1, H2 and H3 subtype avian influenza viruses

Yan, Sijing / Yang, Fan / Yao, Hangping / Dong, Dalu / Wu, Danna / Wu, Nanping / Ye, Chunsheng / Wu, Haibo

Virus Genes. 2023 Apr., v. 59, no. 2 p.333-337

2023

Abstract: Avian influenza viruses (AIVs) are influenza A viruses, of which subtypes H1, H2 and H3 are highly transmissible in poultry and have the risk of transmission to human as well. It is important to establish an accurate, sensitive and convenient means of ... ...

Abstract	Avian influenza viruses (AIVs) are influenza A viruses, of which subtypes H1, H2 and H3 are highly transmissible in poultry and have the risk of transmission to human as well. It is important to establish an accurate, sensitive and convenient means of virus detection. In this study, we developed a multiplex real-time RT-PCR assay based on conserved sequences of the virus hemagglutinin and matrix, and designed primers and probes for the simultaneous and rapid detection of AIV subtypes H1, H2 and H3. We used different subtypes of AIVs and other avian respiratory viruses for evaluation of the specificity of this method. The results showed good sensitivity, specificity and reproducibility. The detection limit was 10–100 copies per reaction. The method also achieved good concordance with the virus isolation method when compared to 81 poultry samples evaluated. It provides a new method for detecting mixed infections of AIVs.
Keywords	avian influenza ; birds ; detection limit ; hemagglutinins ; humans ; isolation techniques ; poultry ; rapid methods ; risk ; viruses
Language	English
Dates of publication	2023-04
Size	p. 333-337.
Publishing place	Springer US
Document type	Article ; Online
ZDB-ID	639496-6
ISSN	1572-994X ; 0920-8569
ISSN (online)	1572-994X
ISSN	0920-8569
DOI	10.1007/s11262-022-01963-z
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Rapid emergence of a PB2 D701N substitution during adaptation of an H9N2 avian influenza virus in mice

Yang, Fan / Zhang, Xiaodi / Liu, Fumin / Yao, Hangping / Wu, Nanping / Wu, Haibo

Arch Virol. 2022 Nov., v. 167, no. 11 p.2299-2303

2022

Abstract	H9N2 avian influenza viruses (AIVs) have been isolated frequently from multiple avian species and, occasionally, from humans. To explore the potential molecular basis of cross-species transmission of H9N2 AIVs, an H9N2 AIV (A/chicken/Zhejiang/221/2016) was serially passaged in mouse lung. The results showed that the mouse-adapted H9N2 virus exhibited higher virulence and replicated more efficiently in mouse lung and liver. Whole-genome sequencing showed an amino acid substitution, D701N, in the PB2 protein, which is likely associated with the increased replicative ability of H9N2 virus in mice. The rapid emergence of adaptive substitutions indicates the necessity of continuous monitoring of H9N2 virus in poultry.
Keywords	Influenza A virus ; amino acid substitution ; avian influenza ; chickens ; liver ; lungs ; mice ; virulence
Language	English
Dates of publication	2022-11
Size	p. 2299-2303.
Publishing place	Springer Vienna
Document type	Article ; Online
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-022-05536-1
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Increased virulence of a novel reassortant H1N3 avian influenza virus in mice as a result of adaptive amino acid substitutions.

Yang, Fan / Zhang, Xiaodi / Liu, Fumin / Yao, Hangping / Wu, Nanping / Wu, Haibo

Virus genes

2022 Volume 58, Issue 5, Page(s) 473–477

Abstract: In this study, a novel multiple-gene reassortant H1N3 subtype avian influenza virus (AIV) (A/chicken/Zhejiang/81213/2017, CK81213) was isolated in Eastern China, whose genes were derived from H1 (H1N3), H7 (H7N3 and H7N9), and H10 (H10N3 and H10N8) AIVs. ...

Abstract	In this study, a novel multiple-gene reassortant H1N3 subtype avian influenza virus (AIV) (A/chicken/Zhejiang/81213/2017, CK81213) was isolated in Eastern China, whose genes were derived from H1 (H1N3), H7 (H7N3 and H7N9), and H10 (H10N3 and H10N8) AIVs. This AIV belongs to the avian Eurasian-lineage and exhibits low pathogenicity. Serial lung-to-lung passages of CK81213 in mice was performed to study the amino acid substitutions potentially related to the adaptation of H1 AIVs in mammals. And the mouse-adapted H1N3 virus showed greater virulence than wild-type H1N3 AIV in mice and the genomic analysis revealed a total of two amino acid substitutions in the PB2 (E627K) and HA (L67V) proteins. Additionally, the results of the animal study indicate that CK81213 could infect mice without prior adaption and become highly pathogenic to mice after continuous passage. Our findings show that routine surveillance of H1 AIVs is important for the prediction of influenza epidemics.
MeSH term(s)	Amino Acid Substitution/genetics ; Animals ; Chickens/genetics ; Influenza A Virus, H7N3 Subtype/genetics ; Influenza A Virus, H7N9 Subtype/genetics ; Influenza in Birds ; Mammals ; Mice ; Mice, Inbred BALB C ; Reassortant Viruses ; Virulence/genetics
Language	English
Publishing date	2022-05-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	639496-6
ISSN	1572-994X ; 0920-8569
ISSN (online)	1572-994X
ISSN	0920-8569
DOI	10.1007/s11262-022-01911-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A multiplex TaqMan real-time RT-PCR assay for the simultaneous detection of H4, H6, and H10 avian influenza viruses.

Yang, Fan / Yan, Sijing / Zhu, Linwei / Yao, Hangping / Dong, Dalu / Wu, Danna / Wu, Nanping / Ye, Chunsheng / Wu, Haibo

Heliyon

2023 Volume 9, Issue 5, Page(s) e15647

Abstract	Avian influenza viruses (AIVs) have caused a large number of epidemics in domestic and wild birds, and even posed a health challenge to humans. Highly pathogenic AIVs have attracted the most public attention. However, low pathogenic AIVs, including H4, H6, and H10 subtype AIVs, have spread covertly in domestic poultry, without obvious clinical signs. The emergence of human infections with H6 and H10 AIVs and the evidence of seropositivity of H4 AIV in poultry-exposed individuals indicated that these AIVs sporadically infect humans and could cause a potential pandemic. Therefore, a rapid and sensitive diagnostic method to simultaneously detect Eurasian lineage H4, H6, and H10 subtype AIVs is urgently required. Four singleplex real-time RT-PCR (RRT-PCR) assays were established based on carefully designed primers and probes of the conserved regions of the matrix, H4, H6, and H10 genes and combined into a multiplex RRT-PCR method to simultaneously detect H4, H6, and H10 AIVs in one reaction. The detection limit of the multiplex RRT-PCR method was 1-10 copies per reaction when detecting standard plasmids, and showed no cross-reaction against other subtype AIVs and other common avian viruses. Additionally, this method was suitable to detect the AIVs in samples from different sources, the results of which showed high consistency with virus isolation and a commercial influenza detection kit. In summary, this rapid, convenient, and practical multiplex RRT-PCR method could be applied in laboratory testing and clinical screening to detect AIVs.
Language	English
Publishing date	2023-04-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e15647
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