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  1. Book: Artificial Intelligence Platform for Molecular Targeted Therapy

    Ariel Fernández

    A Translational Science Approach

    2021  

    Keywords Deep learning ; drug discovery
    Language English
    Size 470 p.
    Publisher WSPC
    Document type Book
    Note PDA Manuell_13
    Format 157 x 235 x 30
    ISBN 9789811232305 ; 981123230X
    Database PDA

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  2. Book ; Online ; E-Book: Physics at the biomolecular interface

    Fernández, Ariel

    fundamentals for molecular targeted therapy

    (Soft and biological matter)

    2016  

    Author's details Ariel Fernández
    Series title Soft and biological matter
    Keywords Physics ; Molecular biology ; Pharmaceutical technology ; Physical chemistry ; Proteins ; Biophysics ; Biological physics ; Statistical physics ; Dynamical systems
    Subject code 571.4
    Language English
    Size 1 Online-Ressource (XV, 483 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019061912
    ISBN 978-3-319-30852-4 ; 9783319308517 ; 3-319-30852-1 ; 3319308513
    DOI 10.1007/978-3-319-30852-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  3. Book: Biomolecular interfaces

    Fernández Stigliano, Ariel

    interactions, functions and drug design

    2015  

    Author's details Ariel Fernández Stigliano
    Keywords Biomolecular interface ; Hydrogen bond ; Protein interactions ; Biological water ; Drug design ; Membrane biophysics
    Language English
    Size XIX, 372 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Cham u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018648904
    ISBN 978-3-319-16849-4 ; 3-319-16849-5 ; 9783319168500 ; 3319168509
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 1857 available for loan (reading room) Lesesaal EG

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  4. Article ; Online: Artificial Intelligence Set to Reverse Engineer Drug Targeting in the Cell.

    Fernández, Ariel

    ACS pharmacology & translational science

    2021  Volume 4, Issue 3, Page(s) 1256–1259

    Abstract: Therapeutic drugs are required to target proteins in the cell, ... ...

    Abstract Therapeutic drugs are required to target proteins in the cell, not
    Language English
    Publishing date 2021-04-28
    Publishing country United States
    Document type Journal Article
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.1c00107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Artificial Intelligence Deconstructs Drug Targeting

    Fernández, Ariel

    ACS medicinal chemistry letters

    2021  Volume 12, Issue 7, Page(s) 1052–1055

    Abstract: Lead optimization in structure-based drug design ultimately requires that the therapeutic agent be evaluated in the cellular context. However, ... ...

    Abstract Lead optimization in structure-based drug design ultimately requires that the therapeutic agent be evaluated in the cellular context. However, the
    Language English
    Publishing date 2021-06-07
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.1c00237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Molecular Biology Clues Portray SARS-CoV-2 as a Gain-of-Function Laboratory Manipulation of Bat CoV RaTG13.

    Fernández, Ariel

    ACS medicinal chemistry letters

    2021  Volume 12, Issue 6, Page(s) 941–942

    Language English
    Publishing date 2021-05-27
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.1c00274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Glycosylation of SARS-CoV-2 Steers Evolutionary Outcomes in the Postvaccination Phase.

    Fernández, Ariel

    ACS pharmacology & translational science

    2021  Volume 4, Issue 1, Page(s) 410–412

    Abstract: There is a need to assess evolutionary outcomes for SARS-CoV-2 in the postvaccination phase. The role of virus glycosylation in deterring the development of vaccine resistance is weighed against the epitopes of extant vaccines and the modulation of ... ...

    Abstract There is a need to assess evolutionary outcomes for SARS-CoV-2 in the postvaccination phase. The role of virus glycosylation in deterring the development of vaccine resistance is weighed against the epitopes of extant vaccines and the modulation of induced immune surveillance on antigens containing glycosylation sites.
    Language English
    Publishing date 2021-01-21
    Publishing country United States
    Document type Journal Article
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.1c00015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: SARS-CoV-2 Glycosylation Suggests That Vaccines Should Have Adopted the S1 Subunit as Antigen.

    Fernández, Ariel

    ACS pharmacology & translational science

    2021  Volume 4, Issue 2, Page(s) 1016–1017

    Abstract: Extant SARS-CoV-2 vaccines use the trimeric spike (S) protein as antigen. In the virus, the spike region is extensively glycosylated, modulating immune surveillance. Because they have been defused, many epitopes in the vaccine sidetrack the immune ... ...

    Abstract Extant SARS-CoV-2 vaccines use the trimeric spike (S) protein as antigen. In the virus, the spike region is extensively glycosylated, modulating immune surveillance. Because they have been defused, many epitopes in the vaccine sidetrack the immune response. Only the receptor binding domain within the S1 subunit is well-exposed to antibody recognition. After proteolytic virus activation, the S1 subunit offers additional epitopes with antibody exposure. Thus, vaccines adopting the S1 subunit as antigen would have been more efficacious than the existing ones.
    Language English
    Publishing date 2021-02-05
    Publishing country United States
    Document type Journal Article
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.1c00036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Toward the Next-Generation COVID-19 Vaccines That Circumvent Antigenic Drift while Defusing Viral Infection.

    Fernández, Ariel

    ACS pharmacology & translational science

    2021  Volume 4, Issue 2, Page(s) 1018–1020

    Abstract: The emergence of vaccine-resistant variants suggests a complicated endemic scenario in the vaccination aftermath for COVID-19. The situation prompts us to enquire whether the antigen adopted by extant vaccines, the trimeric spike (S) protein, is the ... ...

    Abstract The emergence of vaccine-resistant variants suggests a complicated endemic scenario in the vaccination aftermath for COVID-19. The situation prompts us to enquire whether the antigen adopted by extant vaccines, the trimeric spike (S) protein, is the optimal in the sense of inducing an immunity that leaves the virus with no evolutionary route of evasion. The patterns of glycosylation camouflage suggest that the answer is negative while also suggesting an alternative antigen that appears to be better optimized, eliciting an additional immune attack as the virus gets primed for cell penetration. This type of vaccine is expected to induce antibodies capable of defusing the virus during the priming phase while also circumventing antigenic drift.
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Journal Article
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.1c00054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Targeted Disassembling of SARS-CoV-2 as It Gets Ready for Cell Penetration.

    Fernández, Ariel

    ACS medicinal chemistry letters

    2020  Volume 11, Issue 11, Page(s) 2055–2057

    Keywords covid19
    Language English
    Publishing date 2020-11-12
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.0c00548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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