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  1. Article ; Online: Touting Traditional Knowledge and Herbal Medicine to Combat and Prevent COVID-19.

    Arokiaraj, Selvaraj / Vincent, Savariar / Vannam, Dinesh K

    Current pharmaceutical biotechnology

    2020  Volume 21, Issue 13, Page(s) 1280–1281

    Language English
    Publishing date 2020-12-01
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/138920102113201007102655
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  2. Article: Molecular Docking Studies on the Anti-viral Effects of Compounds From Kabasura Kudineer on SARS-CoV-2 3CL

    Vincent, Savariar / Arokiyaraj, Selvaraj / Saravanan, Muthupandian / Dhanraj, Manoj

    Frontiers in molecular biosciences

    2020  Volume 7, Page(s) 613401

    Abstract: The COVID-19 has now been declared a global pandemic by the World Health Organization. No approved drug is currently available; therefore, an urgent need has been developed for any antiviral therapy for COVID-19. Main protease ... ...

    Abstract The COVID-19 has now been declared a global pandemic by the World Health Organization. No approved drug is currently available; therefore, an urgent need has been developed for any antiviral therapy for COVID-19. Main protease 3CL
    Language English
    Publishing date 2020-12-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2020.613401
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  3. Article ; Online: Molecular Docking Studies on the Anti-viral Effects of Compounds From Kabasura Kudineer on SARS-CoV-2 3CLpro

    Savariar Vincent / Selvaraj Arokiyaraj / Muthupandian Saravanan / Manoj Dhanraj

    Frontiers in Molecular Biosciences, Vol

    2020  Volume 7

    Abstract: The COVID-19 has now been declared a global pandemic by the World Health Organization. No approved drug is currently available; therefore, an urgent need has been developed for any antiviral therapy for COVID-19. Main protease 3CLpro of this novel ... ...

    Abstract The COVID-19 has now been declared a global pandemic by the World Health Organization. No approved drug is currently available; therefore, an urgent need has been developed for any antiviral therapy for COVID-19. Main protease 3CLpro of this novel Coronavirus (SARS-CoV-2) play a critical role in the disease propagation, and hence represent a crucial target for the drug discovery. Herein, we have applied a bioinformatics approach for drug repurposing to identify the possible potent inhibitors of SARS-CoV-2 main proteases 3CLpro (6LU7). In search of the anti-COVID-19 compound, we selected 145 phyto-compounds from Kabasura kudineer (KK), a poly-herbal formulation recommended by AYUSH for COVID-19 which are effective against fever, cough, sore throat, shortness of breath (similar to SARS-CoV2-like symptoms). The present study aims to identify molecules from natural products which may inhibit COVID-19 by acting on the main protease (3CLpro). Obtained results by molecular docking showed that Acetoside (−153.06), Luteolin 7 -rutinoside (−134.6) rutin (−133.06), Chebulagic acid (−124.3), Syrigaresinol (−120.03), Acanthoside (−122.21), Violanthin (−114.9), Andrographidine C (−101.8), myricetin (−99.96), Gingerenone -A (−93.9), Tinosporinone (−83.42), Geraniol (−62.87), Nootkatone (−62.4), Asarianin (−79.94), and Gamma sitosterol (−81.94) are main compounds from KK plants which may inhibit COVID-19 giving the better energy score compared to synthetic drugs. Based on the binding energy score, we suggest that these compounds can be tested against Coronavirus and used to develop effective antiviral drugs.
    Keywords COVID-19 ; molecular docking ; Kabasura kudineer ; iGemdock ; anti-viral effects ; Biology (General) ; QH301-705.5
    Subject code 540
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
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  4. Article ; Online: Nanotechnology-based approaches for emerging and re-emerging viruses: Special emphasis on COVID-19.

    Saravanan, Muthupandian / Mostafavi, Ebrahim / Vincent, Savariar / Negash, Hadush / Andavar, Rajapriya / Perumal, Venkatesan / Chandra, Namas / Narayanasamy, Selvaraju / Kalimuthu, Kalishwaralal / Barabadi, Hamed

    Microbial pathogenesis

    2021  Volume 156, Page(s) 104908

    Abstract: In recent decades, the major concern of emerging and re-emerging viral diseases has become an increasingly important area of public health concern, and it is of significance to anticipate future pandemic that would inevitably threaten human lives. The ... ...

    Abstract In recent decades, the major concern of emerging and re-emerging viral diseases has become an increasingly important area of public health concern, and it is of significance to anticipate future pandemic that would inevitably threaten human lives. The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged virus that causes mild to severe pneumonia. Coronavirus disease (COVID-19) became a very much concerned issue worldwide after its super-spread across the globe and emerging viral diseases have not got specific and reliable diagnostic and treatments. As the COVID-19 pandemic brings about a massive life-loss across the globe, there is an unmet need to discover a promising and typically effective diagnosis and treatment to prevent super-spreading and mortality from being decreased or even eliminated. This study was carried out to overview nanotechnology-based diagnostic and treatment approaches for emerging and re-emerging viruses with the current treatment of the disease and shed light on nanotechnology's remarkable potential to provide more effective treatment and prevention to a special focus on recently emerged coronavirus.
    MeSH term(s) COVID-19 ; Humans ; Nanotechnology ; Pandemics/prevention & control ; Public Health ; SARS-CoV-2
    Language English
    Publishing date 2021-04-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2021.104908
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  5. Article ; Online: Enhanced performance of Aloe vera incorporated chitosan-polyethylene oxide electrospun wound scaffold produced using novel Spirograph based collector assembly.

    Pathalamuthu, P / Siddharthan, A / Giridev, V R / Victoria, Victor / Thangam, Ramar / Sivasubramanian, Srinivasan / Savariar, Vincent / Hemamalini, T

    International journal of biological macromolecules

    2019  Volume 140, Page(s) 808–824

    Abstract: Spirograph is a geometric drawing that produces mathematical roulette curves of the variety technically known as hypotrochoids and epitrochoids. This paper presents a research on a novel Spirograph Based Mechanical System (SBMS) meant for the production ... ...

    Abstract Spirograph is a geometric drawing that produces mathematical roulette curves of the variety technically known as hypotrochoids and epitrochoids. This paper presents a research on a novel Spirograph Based Mechanical System (SBMS) meant for the production of electrospun mat with near uniform characteristics for wound dressing applications. A combination of natural (Chitosan) and artificial (Polyethylene oxide) polymer, along with Aloe vera plant extract has been evaluated as a material for wound dressing application. The improvement in the mechanical property, in vitro and in vivo studies indicate developed SBMS compared to the typical collectors has been found suitable for producing electrospun mat for wound dressing applications.
    MeSH term(s) Aloe/chemistry ; Animals ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Biocompatible Materials/chemistry ; Cell Line ; Chitosan/chemistry ; Collagen ; Female ; Mice ; Microbial Sensitivity Tests ; Polyethylene Glycols/chemistry ; Spectrum Analysis ; Tensile Strength ; Wound Healing
    Chemical Substances Anti-Infective Agents ; Biocompatible Materials ; Polyethylene Glycols (3WJQ0SDW1A) ; Collagen (9007-34-5) ; Chitosan (9012-76-4)
    Language English
    Publishing date 2019-08-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2019.08.158
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  6. Article ; Online: Enquêter sur les savoirs juridiques

    Vincent Réveillère

    Cahiers Jean Moulin, Vol

    controverses juridiques et traductions conceptuelles

    2023  Volume 8

    Abstract: This contribution develops a methodological reflection on the way in which it is possible to investigate legal knowledge. Firstly, an inquiry into the surface of EU law is proposed: taking seriously the controversy before the judge and surrounding its ... ...

    Abstract This contribution develops a methodological reflection on the way in which it is possible to investigate legal knowledge. Firstly, an inquiry into the surface of EU law is proposed: taking seriously the controversy before the judge and surrounding its rulings allow us to see its institutive dimension. Legal concepts are not mere tools, totally under control, used to achieve certain ends defined in other terms, outside the law. They are far more than that : they participate to the constitution of legal and social realities that they pretend to regulate. They enable and limit what participants of a language-game can do, and they can even influence what they may want to do. Secondly, this approach is used to study a conceptual translation that occurs in three rulings of the Court of justice of the European Union dealing with family name.
    Keywords legal knowledge ; legal controversy ; family name ; conceptual translation ; EU citizenship ; CJEU ; Social Sciences ; H
    Subject code 340
    Language French
    Publishing date 2023-01-01T00:00:00Z
    Publisher Université Jean Moulin - Lyon 3
    Document type Article ; Online
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  7. Article: Nanotechnology-based approaches for emerging and re-emerging viruses: Special emphasis on COVID-19

    Saravanan, Muthupandian / Mostafavi, Ebrahim / Vincent, Savariar / Negash, Hadush / Andavar, Rajapriya / Perumal, Venkatesan / Chandra, Namas / Narayanasamy, Selvaraju / Kalimuthu, Kalishwaralal / Barabadi, Hamed

    Elsevier Ltd Microbial pathogenesis. 2021 July, v. 156

    2021  

    Abstract: In recent decades, the major concern of emerging and re-emerging viral diseases has become an increasingly important area of public health concern, and it is of significance to anticipate future pandemic that would inevitably threaten human lives. The ... ...

    Abstract In recent decades, the major concern of emerging and re-emerging viral diseases has become an increasingly important area of public health concern, and it is of significance to anticipate future pandemic that would inevitably threaten human lives. The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged virus that causes mild to severe pneumonia. Coronavirus disease (COVID-19) became a very much concerned issue worldwide after its super-spread across the globe and emerging viral diseases have not got specific and reliable diagnostic and treatments. As the COVID-19 pandemic brings about a massive life-loss across the globe, there is an unmet need to discover a promising and typically effective diagnosis and treatment to prevent super-spreading and mortality from being decreased or even eliminated. This study was carried out to overview nanotechnology-based diagnostic and treatment approaches for emerging and re-emerging viruses with the current treatment of the disease and shed light on nanotechnology's remarkable potential to provide more effective treatment and prevention to a special focus on recently emerged coronavirus.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; humans ; mortality ; pandemic ; pathogenesis ; pneumonia ; public health ; viruses
    Language English
    Dates of publication 2021-07
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2021.104908
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  8. Article ; Online: TBDRUGS - Database of drugs for tuberculosis.

    Sundaramurthi, Jagadish Chandrabose / Hanna, Luke Elizabeth / Selvaraju, Sriram / Brindha, Sridharan / Joel Gnanadoss, J / Vincent, Savariar / Singh, Harpreet / Swaminathan, Soumya

    Tuberculosis (Edinburgh, Scotland)

    2016  Volume 100, Page(s) 69–71

    Language English
    Publishing date 2016-09
    Publishing country Scotland
    Document type Letter
    ZDB-ID 2046804-0
    ISSN 1873-281X ; 1472-9792
    ISSN (online) 1873-281X
    ISSN 1472-9792
    DOI 10.1016/j.tube.2016.06.006
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  9. Article: Enhanced performance of Aloe vera incorporated chitosan-polyethylene oxide electrospun wound scaffold produced using novel Spirograph based collector assembly

    Pathalamuthu, P / Siddharthan, A / Giridev, V.R / Victoria, Victor / Thangam, Ramar / Sivasubramanian, Srinivasan / Savariar, Vincent / Hemamalini, T

    International journal of biological macromolecules. 2019 Nov. 01, v. 140

    2019  

    Abstract: Spirograph is a geometric drawing that produces mathematical roulette curves of the variety technically known as hypotrochoids and epitrochoids. This paper presents a research on a novel Spirograph Based Mechanical System (SBMS) meant for the production ... ...

    Abstract Spirograph is a geometric drawing that produces mathematical roulette curves of the variety technically known as hypotrochoids and epitrochoids. This paper presents a research on a novel Spirograph Based Mechanical System (SBMS) meant for the production of electrospun mat with near uniform characteristics for wound dressing applications. A combination of natural (Chitosan) and artificial (Polyethylene oxide) polymer, along with Aloe vera plant extract has been evaluated as a material for wound dressing application. The improvement in the mechanical property, in vitro and in vivo studies indicate developed SBMS compared to the typical collectors has been found suitable for producing electrospun mat for wound dressing applications.
    Keywords Aloe vera ; chitosan ; collectors ; geometry ; in vivo studies ; mechanical properties ; plant extracts ; polyethylene glycol
    Language English
    Dates of publication 2019-1101
    Size p. 808-824.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2019.08.158
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  10. Article ; Online: Green synthesis of silver nanoparticles using Rheum palmatum root extract and their antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa.

    Arokiyaraj, Selvaraj / Vincent, Savariar / Saravanan, Muthupandian / Lee, Yoonseok / Oh, Young Kyoon / Kim, Kyoung Hoon

    Artificial cells, nanomedicine, and biotechnology

    2017  Volume 45, Issue 2, Page(s) 372–379

    Abstract: In the present study, silver nanoparticles (AgNPs) were synthesized by using aqueous root extracts of Rheum palmatum and characterized by various spectroscopic methods. The nanoparticles were found to be in hexagonal and spherical shapes. The average ... ...

    Abstract In the present study, silver nanoparticles (AgNPs) were synthesized by using aqueous root extracts of Rheum palmatum and characterized by various spectroscopic methods. The nanoparticles were found to be in hexagonal and spherical shapes. The average particle size was found to be 121 ± 2 nm with zeta potential values of -21.6 mv by dynamic light scattering (DLS) method. Gas chromatography-mass spectrometry (GC-MS) analysis of R. palmatum revealed 35 compounds. The synthesized AgNPs showed significant activity against Staphylococcus aureus and Pseudomonas aeruginosa with IC
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Metal Nanoparticles/chemistry ; Plant Extracts/chemistry ; Plant Roots/chemistry ; Pseudomonas aeruginosa/growth & development ; Rheum/chemistry ; Silver/chemistry ; Silver/pharmacology ; Staphylococcus aureus/growth & development
    Chemical Substances Anti-Bacterial Agents ; Plant Extracts ; Silver (3M4G523W1G)
    Language English
    Publishing date 2017-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2723095-8
    ISSN 2169-141X ; 2169-1401
    ISSN (online) 2169-141X
    ISSN 2169-1401
    DOI 10.3109/21691401.2016.1160403
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