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  1. Book: Neuropathologic evaluation

    Gokden, Murat

    from pathologic features to diagnosis

    2013  

    Author's details Murat Gokden
    Keywords Nervous System Diseases / diagnosis ; Nervous System Diseases / pathology
    Language English
    Size XII, 542 S. : zahlr. Ill., graph. Darst.
    Publisher Wolters Kluwer Lippincott Williams & Wilkins
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index ; Gross features -- Microscopic features -- Intraoperative consultations -- Radiologic features -- Cerebrospinal fluid -- Histochemistry -- Immunohistochemical features -- Non-neoplastic diseases of skeletal muscle -- Non-neoplastic diseases of peripheral nerve
    Accompanying material Zugang zur Internetausgabe über Code
    HBZ-ID HT017510702
    ISBN 978-1-4511-1655-7 ; 1-4511-1655-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 4762 order for loan Magazin
    Zugang zur Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Article ; Online: Commentary: Neuropathology of Pituitary Adenomas and Sellar Lesions.

    Gokden, Murat

    Neurosurgery

    2021  Volume 88, Issue 5, Page(s) E374–E376

    MeSH term(s) Adenoma ; Humans ; Nervous System Diseases ; Pituitary Neoplasms ; Sella Turcica
    Language English
    Publishing date 2021-01-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyaa569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1424: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 539: Show issues

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  3. Article ; Online: Brain Autopsy Findings in a Patient Who Received Lipid Emulsion Therapy for Suspected Drug Intoxication.

    Cutshall, Hannah / Gokden, Murat

    The American journal of forensic medicine and pathology

    2024  

    Abstract: Abstract: Lipid emulsion therapy (LET) is the intravenous administration of lipid solution for parenteral alimentation, especially in preterm infants and adults with debilitating illnesses. It has also been used in attempts of detoxification in ... ...

    Abstract Abstract: Lipid emulsion therapy (LET) is the intravenous administration of lipid solution for parenteral alimentation, especially in preterm infants and adults with debilitating illnesses. It has also been used in attempts of detoxification in suspected cases of drug overdose. Whether this interferes with circulation and/or perfusion is debatable, and it is suggested that it may interfere with coagulation process. The emulsifying agent has been identified microscopically mainly in the lungs of these patients, with rare reports in adults and even more rare ones in the brain; however, although it is rarely reported in other organs, to our knowledge, no reports of gross autopsy findings in the brain are available in the English literature, nor are there reports of pathologic findings after lipid emulsion therapy administration for drug toxicity. Although it is also debated in the literature whether this material forms as an artifact or represents the actual agent, here we report the gross and microscopic autopsy findings in the brain of a patient who received LET for suspected beta-blocker intoxication. It will be beneficial for pathologists who perform autopsies in the forensic or medical settings to be aware of these findings, along with the uses and potential complications of LET.
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604537-6
    ISSN 1533-404X ; 0195-7910
    ISSN (online) 1533-404X
    ISSN 0195-7910
    DOI 10.1097/PAF.0000000000000933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Amyloid Deposition in the Brain.

    Gokden, Murat

    Archives of pathology & laboratory medicine

    2020  Volume 144, Issue 10, Page(s) 1162–1163

    MeSH term(s) Amyloid ; Amyloidosis ; Brain ; Diagnosis, Differential ; Humans ; Pathology, Surgical
    Chemical Substances Amyloid
    Language English
    Publishing date 2020-10-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2020-0136-LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Brain Banking in Dementia Studies.

    Isik, Ahmet Turan / Kaya, Derya / Gokden, Murat

    Methods in molecular biology (Clifton, N.J.)

    2024  Volume 2785, Page(s) 287–295

    Abstract: It is now well-established practice in dementia that one clinical entity may be caused by various neurodegenerative disorders, each with different histopathological findings, whereas neuropathologically confirmed patients may have different, unusual, and ...

    Abstract It is now well-established practice in dementia that one clinical entity may be caused by various neurodegenerative disorders, each with different histopathological findings, whereas neuropathologically confirmed patients may have different, unusual, and atypical clinical manifestations.This inconsistency in dementia patients leads to neuropathological examination of cases, and neuropathological examination seems to be an inevitable part of dementia practice, at least until all clinical entities are properly identified for humans.Additionally, the development of disease-modifying therapies and confirmation of the actual accurate diagnosis of the neurodegenerative disease that the drug is thought to modify or act upon are of great importance for neuropathological evaluation in brain banks.Neuropathological processes coexisting among patients diagnosed with established clinical criteria or international guidelines have provided a new perspective in the context of drug development.Here, we review our routinely used methodology in the context of the brain banking process.
    MeSH term(s) Humans ; Alzheimer Disease/pathology ; Brain/pathology ; Neurodegenerative Diseases/pathology ; Tissue Banks
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3774-6_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: If it is Not a Glioblastoma, Then What is it? A Differential Diagnostic Review.

    Gokden, Murat

    Advances in anatomic pathology

    2017  Volume 24, Issue 6, Page(s) 379–391

    Abstract: As its historical name glioblastoma multiforme implies, glioblastoma is a histologically diverse, World Health Organization grade IV astrocytic neoplasm. In spite of its simple definition of presence of vascular proliferation and/or necrosis in a diffuse ...

    Abstract As its historical name glioblastoma multiforme implies, glioblastoma is a histologically diverse, World Health Organization grade IV astrocytic neoplasm. In spite of its simple definition of presence of vascular proliferation and/or necrosis in a diffuse astrocytoma, the wide variety of cytohistomorphologic appearances overlap with many other neoplastic or non-neoplastic lesions. Here, after a brief review of glioblastoma is provided, the differential diagnostic possibilities with an emphasis on mimics and pitfalls are discussed. To provide an approach applicable to diagnostic practice, these discussions are grouped arbitrarily according to general malignant appearance such as pleomorphic xanthoastrocytoma and ganglioglioma, especially their anaplastic versions, and cellular features such as small cell and epithelioid glioblastoma. Some non-neoplastic lesions that can potentially be mistaken for glioblastoma under certain circumstances are also briefly mentioned. Additional studies, including immunohistochemistry and molecular markers, are included where applicable. Otherwise, exhaustive review of these individual entities, including their epidemiology and molecular biology, is outside the scope of this discussion.
    Language English
    Publishing date 2017-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1212493-x
    ISSN 1533-4031 ; 1072-4109
    ISSN (online) 1533-4031
    ISSN 1072-4109
    DOI 10.1097/PAP.0000000000000170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4118: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Glioblastoma, IDH-Wildtype, CNS WHO Grade 4, Associated with Deep Brain Stimulation in a Patient with Essential Tremor: Report of a Case with Molecular Characterization, and Review of the Literature.

    Burns, Jennie / Guley, Natalie / Gokden, Murat / Petersen, Erika / Virmani, Tuhin

    Movement disorders clinical practice

    2023  Volume 10, Issue 3, Page(s) 526–528

    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A rare case of atypical intradural extramedullary glioblastoma diagnosed utilizing next-generation sequencing and methylation profiling: illustrative case.

    Shelton, William J / Mathews, Andrew P / Aljiboori, Karrar / Nix, J Stephen / Gokden, Murat / Rodriguez, Analiz

    Journal of neurosurgery. Case lessons

    2024  Volume 7, Issue 16

    Abstract: Background: Primary spinal cord tumors, especially primary spinal cord glioblastoma multiforme (PSC-GBM), are exceptionally rare, accounting for less than 1.5% of all spinal tumors. Their infrequency and aggressive yet atypical presentation make ... ...

    Abstract Background: Primary spinal cord tumors, especially primary spinal cord glioblastoma multiforme (PSC-GBM), are exceptionally rare, accounting for less than 1.5% of all spinal tumors. Their infrequency and aggressive yet atypical presentation make diagnosis challenging. In uncertain cases, a surgical approach for tissue diagnosis is often optimal.
    Observations: A 76-year-old male presented with a rapidly progressing clinical history marked by worsening extremity weakness, urinary retention, and periodic fecal incontinence alongside diffuse changes on neuraxis imaging. The patient, in whom subacute polyneuropathy was initially diagnosed, received multiple rounds of steroids and intravenous immunoglobulin without clinical improvement. Histopathological review of the biopsy tissue yielded an initial diagnosis of spindle cell neoplasm. Next-generation sequencing (NGS) is done routinely on all neuropathology specimens at the authors' institution, and methylation profiling is pursued in difficult cases. Ultimately, NGS and methylation profiling results were essential to an integrated final diagnosis of GBM.
    Lessons: PSC-GBM is a rare but highly aggressive occurrence of this tumor. Prolonged back pain, rapid neurological decline, and imaging changes warrant the consideration of lesional biopsy for precise disease characterization. In inconclusive cases, NGS has proved invaluable for clinical clarification and diagnosis, underscoring its importance for integrated diagnoses in guiding appropriate treatment strategies.
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ISSN 2694-1902
    ISSN (online) 2694-1902
    DOI 10.3171/CASE24103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: IgG4-Related Disease Presenting as Hypertrophic Pachymeningitis.

    Sapkota, Binita / Rampure, Ritesh / Gokden, Murat / Kanuru, Sruthi

    Cureus

    2022  Volume 14, Issue 2, Page(s) e21850

    Abstract: IgG4-related disease (IgG4-RD) is a multi-organ, immune-mediated inflammatory condition of unknown etiology characterized by infiltration of tissues by IgG4 producing plasma cells. IgG4-related disease (IgG4-RD) can ideally affect any organs, but the ... ...

    Abstract IgG4-related disease (IgG4-RD) is a multi-organ, immune-mediated inflammatory condition of unknown etiology characterized by infiltration of tissues by IgG4 producing plasma cells. IgG4-related disease (IgG4-RD) can ideally affect any organs, but the involvement of the central nervous system (CNS) is a rare entity. We present a case of a 67-year-old male who presented with diplopia with imaging showing hypertrophic pachymeningitis (HPM) and was diagnosed with IgG4-RD of the CNS based on histopathology report.
    Language English
    Publishing date 2022-02-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.21850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Diffuse Leptomeningeal Glioneuronal Tumor: First Description of Metastasis to the Lung and Bone Marrow.

    Battini, Sahithi / Gokden, Murat / Palys, Viktoras / Santos Horta, Erika

    Cureus

    2023  Volume 15, Issue 11, Page(s) e48185

    Abstract: Diffuse leptomeningeal glioneuronal tumor (DLGNT) is a rare neoplasm of the central nervous system (CNS) that primarily affects the leptomeninges. However, it can also involve the brain parenchyma and spinal cord. We report the first case of metastasis ... ...

    Abstract Diffuse leptomeningeal glioneuronal tumor (DLGNT) is a rare neoplasm of the central nervous system (CNS) that primarily affects the leptomeninges. However, it can also involve the brain parenchyma and spinal cord. We report the first case of metastasis of this primary CNS tumor to the lung and bone marrow. An 18-year-old male was diagnosed with DLGNT through meningeal biopsy after multiple events of transient neurologic signs and symptoms that included recurrent episodes of encephalopathy, seizures, cerebral vasospasms, cranial nerve palsy, and urinary dysfunction. Five months after diagnosis, the patient presented with pancytopenia and pulmonary effusion. At that time, he was being treated with temozolomide, after radiation treatment to the brain and spinal cord. Bone marrow biopsy and pleural cytology revealed systemic metastases from the primary CNS tumor. He was then treated with chemotherapy with carboplatin and vincristine which improved his condition for two and a half months. Unfortunately, the patient died of a high systemic metastatic burden. Primary CNS tumors rarely produce systemic metastases, and this is the first report of DLGNT with bone marrow and pulmonary metastases. Chemotherapy with carboplatin and vincristine should be considered as a treatment for patients with DLGNT, as the patient presented a systemic response with clinical and radiological improvement.
    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.48185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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