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  1. Article ; Online: Stress and Type 2 diabetes.

    Kaneto, Hideaki

    Expert review of endocrinology & metabolism

    2019  Volume 1, Issue 6, Page(s) 701–703

    Language English
    Publishing date 2019-02-12
    Publishing country England
    Document type Journal Article
    ISSN 1744-8417
    ISSN (online) 1744-8417
    DOI 10.1586/17446651.1.6.701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pancreatic β-cell failure in type 2 diabetes mellitus.

    Kaneto, Hideaki

    Expert review of endocrinology & metabolism

    2016  Volume 11, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2016-01
    Publishing country England
    Document type Journal Article
    ISSN 1744-8417
    ISSN (online) 1744-8417
    DOI 10.1586/17446651.2016.1123090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Metformin induces insulin secretion by preserving pancreatic aquaporin 7 expression in type 2 diabetes mellitus.

    Kimura, Tomohiko / Kaneto, Hideaki

    Journal of diabetes investigation

    2021  Volume 13, Issue 2, Page(s) 227–229

    Abstract: In the presence of metformin, the c-Jun-NH2-terminal kinase and p38 pathways in β-cells are inhibited, resulting in preserved aquaporin 7 expression and improved glycerol influx, thus maintaining insulin secretion. ...

    Abstract In the presence of metformin, the c-Jun-NH2-terminal kinase and p38 pathways in β-cells are inhibited, resulting in preserved aquaporin 7 expression and improved glycerol influx, thus maintaining insulin secretion.
    MeSH term(s) Aquaporins/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Insulin/metabolism ; Insulin Secretion/drug effects ; Insulin-Secreting Cells/metabolism ; Metformin/pharmacology ; Metformin/therapeutic use
    Chemical Substances AQP7 protein, human ; Aquaporins ; Hypoglycemic Agents ; Insulin ; Metformin (9100L32L2N)
    Language English
    Publishing date 2021-12-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.13709
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  4. Article ; Online: Pathology of Ketoacidosis in Emergency of Diabetic Ketoacidosis and Alcoholic Ketoacidosis: A Retrospective Study.

    Koyama, Katsumasa / Anno, Takatoshi / Kimura, Yukiko / Kawasaki, Fumiko / Kaku, Kohei / Tomoda, Koichi / Kaneto, Hideaki

    Journal of diabetes research

    2024  Volume 2024, Page(s) 8889415

    Abstract: This study is aimed at examining which factors are useful for the diagnosis and distinction of ketoacidosis. We recruited 21 diabetic ketoacidosis (DKA) and alcoholic ketoacidosis (AKA) patients hospitalized in Kawasaki Medical School General Medical ... ...

    Abstract This study is aimed at examining which factors are useful for the diagnosis and distinction of ketoacidosis. We recruited 21 diabetic ketoacidosis (DKA) and alcoholic ketoacidosis (AKA) patients hospitalized in Kawasaki Medical School General Medical Center from April 2015 to March 2021. Almost all patients in this study were brought to the emergency room in a coma and hospitalized. All patients underwent blood gas aspiration and laboratory tests. We evaluated the difference in diagnosis markers in emergencies between DKA and alcoholic ketoacidosis AKA. Compared to AKA patients, DKA patients had statistically higher values of serum acetoacetic acid and lower values of serum lactate, arterial blood pH, and base excess. In contrast, total ketone bodies,
    MeSH term(s) Humans ; Diabetic Ketoacidosis/complications ; Diabetic Ketoacidosis/diagnosis ; Diabetic Ketoacidosis/therapy ; Retrospective Studies ; 3-Hydroxybutyric Acid ; Dehydration/complications ; Ketosis/diagnosis ; Ketosis/etiology ; Ketosis/metabolism ; Diabetes Mellitus ; Acetoacetates
    Chemical Substances acetoacetic acid (4ZI204Y1MC) ; 3-Hydroxybutyric Acid (TZP1275679) ; Acetoacetates
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2711897-6
    ISSN 2314-6753 ; 2314-6753
    ISSN (online) 2314-6753
    ISSN 2314-6753
    DOI 10.1155/2024/8889415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Simultaneous Versus Sequential Initiation of Lixisenatide and Basal Insulin for Type 2 Diabetes: Subgroup Analysis of a Japanese Post-Marketing Surveillance Study of Lixisenatide (PRANDIAL).

    Kaneto, Hideaki / Baxter, Mike / Takahashi, Yoko / Terauchi, Yasuo

    Advances in therapy

    2022  Volume 39, Issue 12, Page(s) 5453–5473

    Abstract: Introduction: We aimed to assess the efficacy and safety of lixisenatide and basal insulin (BI) according to timing of treatment initiation, treatment compliance, and number of concomitant daily injections in Japanese individuals with type 2 diabetes ( ... ...

    Abstract Introduction: We aimed to assess the efficacy and safety of lixisenatide and basal insulin (BI) according to timing of treatment initiation, treatment compliance, and number of concomitant daily injections in Japanese individuals with type 2 diabetes (T2D).
    Methods: Each substudy analyzed subgroup data from the 3-year post-marketing surveillance PRANDIAL study. Endpoints included glycated hemoglobin (HbA1c), postprandial glucose, treatment response (HbA1c < 7.0% at week 24 and 156), and safety. Changes in HbA1c levels were analyzed using paired t tests; between-group comparisons were made using analysis of variance (ANOVA).
    Results: Of 2679 participants, 46.5% initiated BI before lixisenatide, 12.0% the same day, 2.7% between 1 and 90 days, and 2.8% at 91 or more days after lixisenatide; 36.0% did not receive BI. Overall, 85.4% of patients were compliant with lixisenatide treatment. The majority of patients (52.4%) received two injections/day (one was lixisenatide). Compared with other subgroups taking BI and lixisenatide, the subgroup starting them simultaneously had a mean change in HbA1c of - 0.69% [8 mmol/mol] (vs + 0.07% [0.8 mmol/mol] to - 0.79% [9 mmol/mol]) and numerically higher treatment response (21.0% vs 8.3-18.7%), but more hypoglycemia (8.1% vs 2.3-2.8%).
    Conclusions: Japanese people with T2D achieved better glycemic control by simultaneous as opposed to sequential initiation of lixisenatide and BI.
    MeSH term(s) Humans ; Blood Glucose ; Diabetes Mellitus, Type 2/drug therapy ; Glycated Hemoglobin/analysis ; Hypoglycemic Agents ; Insulins/therapeutic use ; Japan ; Product Surveillance, Postmarketing
    Chemical Substances Blood Glucose ; Glycated Hemoglobin A ; Hypoglycemic Agents ; Insulins ; lixisenatide (74O62BB01U)
    Language English
    Publishing date 2022-10-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-022-02311-1
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  6. Article: [Pathophysiology of type 2 diabetes mellitus].

    Kaneto, Hideaki

    Nihon rinsho. Japanese journal of clinical medicine

    2015  Volume 73, Issue 12, Page(s) 2003–2007

    Abstract: The development of type 2 diabetes is usually associated with a combination of pancreatic β-cell dysfunction and insulin resistance in various insulin target tissues such as the liver, muscle and adipocytes. Normal β-cells can compensate for insulin ... ...

    Abstract The development of type 2 diabetes is usually associated with a combination of pancreatic β-cell dysfunction and insulin resistance in various insulin target tissues such as the liver, muscle and adipocytes. Normal β-cells can compensate for insulin resistance by increasing insulin secretion or β-cell mass, but insufficient compensation leads to the onset of glucose intolerance. Once hyperglycemia becomes apparent, β-cell function gradually deteriorates and insulin resistance aggravates. This process is called "glucose toxicity".
    MeSH term(s) Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/physiopathology ; Glucose Intolerance/complications ; Humans ; Lipid Metabolism
    Language Japanese
    Publishing date 2015-12
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
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  7. Article: Case Report: Repeated esophageal obstruction in a patient with type 3C diabetes mellitus.

    Koyama, Katsumasa / Anno, Takatoshi / Takenouchi, Haruka / Kimura, Tomohiko / Kaku, Kohei / Kaneto, Hideaki

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1225385

    Abstract: Although diabetic neuropathy is a well-known cause of gastrointestinal motility disorders, it is rare that diabetic neuropathy brings about esophageal obstruction. Here, we report a case with Type 3C diabetes mellitus (DM) lasting over 15 years and ... ...

    Abstract Although diabetic neuropathy is a well-known cause of gastrointestinal motility disorders, it is rare that diabetic neuropathy brings about esophageal obstruction. Here, we report a case with Type 3C diabetes mellitus (DM) lasting over 15 years and repeated esophageal obstruction resulting in chicken-meat-induced esophageal obstruction and candidiasis. This case highlights the importance of management of DM to prevent the development of complications such as diabetic neuropathy and associated symptoms.
    MeSH term(s) Humans ; Diabetic Neuropathies/diagnosis ; Gastrointestinal Diseases ; Candidiasis ; Diabetes Mellitus
    Language English
    Publishing date 2023-07-28
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1225385
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  8. Article: Obstructive pneumonia with bronchial foreign body: A case report.

    Tanaka, Hitomi / Anno, Takatoshi / Takenouchi, Haruka / Koyama, Katsumasa / Kaneto, Hideaki / Okimoto, Niro / Tomoda, Koichi

    Heliyon

    2023  Volume 9, Issue 11, Page(s) e21362

    Abstract: The age of predilection for foreign body aspiration into the lower airway shows a bimodal distribution, with the majority of cases occurring in children or infants and in the elderly. Although several pediatric airway foreign bodies have been summarized, ...

    Abstract The age of predilection for foreign body aspiration into the lower airway shows a bimodal distribution, with the majority of cases occurring in children or infants and in the elderly. Although several pediatric airway foreign bodies have been summarized, in adults, bronchial foreign bodies are relatively uncommon. There are a variety of symptoms induced by airway foreign bodies, although the typical symptoms of some bronchial foreign bodies are cough. Bronchial foreign bodies, especially in the elderly, may have few symptoms and it is necessary for careful identification. Therefore, it is very important to carefully perform medical consultations about current and past medical history. Herein, we report a case of an elderly Japanese with obstructive pneumonia with a bronchial foreign body of fish bone with a long history of cough. It is known that people in some countries such as Japan have a habit of eating fish. Therefore, it is necessary to more carefully explore the possibility of some bronchial foreign body such as a fish bone, when we observe symptoms of persistent cough in such countries.
    Language English
    Publishing date 2023-10-21
    Publishing country England
    Document type Case Reports
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e21362
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  9. Article ; Online: Diabetic ketoacidosis and sinus arrest conditions in a patient with an inserted cardiac pacemaker.

    Anno, Takatoshi / Tsujimoto, Kotone / Shigemoto, Ryo / Kojima, Sunao / Kaneto, Hideaki

    Acta diabetologica

    2021  Volume 58, Issue 5, Page(s) 657–660

    Language English
    Publishing date 2021-01-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1097676-0
    ISSN 1432-5233 ; 0940-5429
    ISSN (online) 1432-5233
    ISSN 0940-5429
    DOI 10.1007/s00592-020-01615-4
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  10. Article ; Online: A case of Empty Sella syndrome with adrenal insufficiency masked by prednisolone after administration of immune checkpoint inhibitors.

    Iwamoto, Yuichiro / Tatsumi, Fuminori / Ohnishi, Mana / Katakura, Yukino / Kimura, Tomohiko / Shimoda, Masashi / Nakanishi, Shuhei / Mune, Tomoatsu / Kaneto, Hideaki

    Medicine

    2024  Volume 103, Issue 10, Page(s) e37204

    Abstract: Introduction: The use of immune checkpoint inhibitors (ICIs) is gradually increasing; ICIs produce a variety of immune-related adverse events (irAEs), especially ICI-induced hypoadrenocorticism, which can be a lethal complication if treatment is delayed. ...

    Abstract Introduction: The use of immune checkpoint inhibitors (ICIs) is gradually increasing; ICIs produce a variety of immune-related adverse events (irAEs), especially ICI-induced hypoadrenocorticism, which can be a lethal complication if treatment is delayed.
    Patient concerns: A 63-year-old man received chemotherapy with pembrolizumab for nonsmall cell lung cancer. He developed drug-induced interstitial pneumonia 366 days after receiving pembrolizumab and was treated with prednisolone. Five hundred thirty-seven days later, he developed drug-induced eosinophilic enteritis, and pembrolizumab was discontinued and prednisolone was continued. After discontinuation of prednisolone, general malaise and edema of the lower extremities appeared, and adrenal insufficiency was suspected.
    Diagnosis: In blood tests on admission adrenocorticotropic hormone (ACTH) was 2.2 pg/mL and cortisol was 15 μg/dL, with no apparent cortisol deficiency. However, the cortisol circadian rhythm disappeared and remained low throughout the day; a corticotropin-releasing hormone stimulation test showed decreased reactive secretion of ACTH. Pituitary magnetic resonance imaging showed pituitary emptying, suggesting Empty Sella syndrome.
    Interventions and outcomes: We started hydrocortisone and his symptoms were improved.
    Conclusions: The administration of high-dose steroids after ICI administration may mask the symptoms of hypoadrenocorticism as irAEs. Therefore, we should bear in mind the possibility of hypoadrenocorticism when we stop steroid therapy in patients who are treated with steroids after ICI administration.
    MeSH term(s) Male ; Humans ; Middle Aged ; Prednisolone/therapeutic use ; Hydrocortisone ; Immune Checkpoint Inhibitors/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Empty Sella Syndrome/chemically induced ; Lung Neoplasms/drug therapy ; Adrenal Insufficiency/chemically induced ; Adrenal Insufficiency/drug therapy ; Adrenocorticotropic Hormone
    Chemical Substances Prednisolone (9PHQ9Y1OLM) ; Hydrocortisone (WI4X0X7BPJ) ; Immune Checkpoint Inhibitors ; Adrenocorticotropic Hormone (9002-60-2)
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000037204
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