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  1. Article ; Online: Structure–function relationship of resistant starch formation: Enhancement technologies and need for more viable alternatives for whole rice grains

    Sahoo, Bijendra / Rāẏa, Anupama

    Journal of Food Process Engineering. 2023 Feb., v. 46, no. 2 p.e14214-

    2023  

    Abstract: The aim of this review is to gather information on key controlling parameters affecting resistant starch (RS) formation, different strategies for its enhancement and to direct future prospect of viable RS enhancement technologies in whole rice. To ... ...

    Abstract The aim of this review is to gather information on key controlling parameters affecting resistant starch (RS) formation, different strategies for its enhancement and to direct future prospect of viable RS enhancement technologies in whole rice. To achieve this, a thorough literature review is done, and the possible ways are suggested. People in developing countries rely on starch‐based whole rice. Excessive rice consumption may promote several potential health diseases, such as obesity, type II diabetes, and the risk of colorectal cancer. RS, functionally similar to dietary fiber, could effectively minimize and control such health diseases. Therefore, successive progress in the enhancement of RS content in starch‐based powder or flour has been achieved through the improvement of functional attributes of starch with the adoption of different methodologies (genetic, physical, chemical, and enzymatic treatments). However, as people primarily consume starch‐rich whole rice grains in their regular diet than diets with rice flour, the functional attributes of whole rice grains without destroying its native structure and wholesomeness should be developed. Physical treatment could be more inexpensive and effective than chemical and enzymatic methods while applying on whole rice grains. But it does not improve as much RS level in whole rice as compared to other methods. Hence, one or more physical treatments could be combined with each other or may be conjugated with chemical or enzymatic treatment for significant improvement of rice RS. PRACTICAL APPLICATIONS: Recently, people are much concerned about functional diets which are capable to provide nutritive value as well as to minimize potential health diseases. Such awareness enhances the consumption of resistant starch, like dietary fiber. Cereals like rice contain meager amount of resistant starch. Hence, the demand for resistant starch in our body cannot be fulfilled through rice consumption. The only way to resolve this problem is to enhance resistant starch content in whole rice grains through developing different process modification (physical, chemical, and enzymatic). To develop such modified process technologies, a detailed knowledge on the key controlling parameters affecting starch RS formation and different strategies for enhancement of RS content is required. This review explores the current status of RS enhancement strategies and tried to explore the possible future directions of viable RS enhancement technologies for whole grain.
    Keywords colorectal neoplasms ; diabetes ; dietary fiber ; enzymatic treatment ; nutritive value ; obesity ; people ; resistant starch ; rice ; rice flour ; risk ; structure-activity relationships ; whole grain foods
    Language English
    Dates of publication 2023-02
    Publishing place John Wiley & Sons, Inc.
    Document type Article ; Online
    Note REVIEW
    ZDB-ID 752358-0
    ISSN 0145-8876
    ISSN 0145-8876
    DOI 10.1111/jfpe.14214
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: CAR-T cells and CAR-Tregs targeting conventional type-1 dendritic cell suppress experimental autoimmune encephalomyelitis.

    Moorman, Cody D / Yu, Sherman / Briseno, Carlos G / Phee, Hyewon / Sahoo, Anupama / Ramrakhiani, Ambika / Chaudhry, Ashutosh

    Frontiers in immunology

    2023  Volume 14, Page(s) 1235222

    Abstract: Conventional type 1 dendritic cells (DC1) contribute to the development of pathogenic T helper type 1 (Th1) cells in ... ...

    Abstract Conventional type 1 dendritic cells (DC1) contribute to the development of pathogenic T helper type 1 (Th1) cells in part
    MeSH term(s) Mice ; Animals ; Encephalomyelitis, Autoimmune, Experimental ; CD8-Positive T-Lymphocytes/pathology ; Cytokines/metabolism ; Th1 Cells ; Dendritic Cells
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-10-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1235222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A tuning fork-shaped bisbenzothiazole derivative as a pH-responsive digital fluorescent probe and its

    Sahoo, Priya Ranjan / Kumar, Nikhil / Sairam, Keloth / Gulati, L K / Gulati, G K / Datta, Anupama / Kumar, Satish

    Analytical methods : advancing methods and applications

    2023  Volume 15, Issue 48, Page(s) 6722–6726

    Abstract: A new highly emissive pH-responsive near-IR active digital probe was designed and synthesized. The probe is based on a bisbenzothiazole motif with a highly vulnerable hydrogen unit attached in an intramolecular fashion. The probe produced a large Stokes ... ...

    Abstract A new highly emissive pH-responsive near-IR active digital probe was designed and synthesized. The probe is based on a bisbenzothiazole motif with a highly vulnerable hydrogen unit attached in an intramolecular fashion. The probe produced a large Stokes shift which was observed to be highly pH dependent. The optical pH dependence can be used for sensing pH over a wide range.
    MeSH term(s) Fluorescent Dyes/chemistry ; Hydrogen-Ion Concentration
    Chemical Substances Fluorescent Dyes
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d3ay01702h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Magnetorheological fluids containing rod-shaped lithium-zinc ferrite particles: the steady-state shear response.

    Anupama, A V / Kumaran, V / Sahoo, B

    Soft matter

    2018  Volume 14, Issue 26, Page(s) 5407–5419

    Abstract: We report the magnetic field and particle-concentration dependent steady-state shear-responses of rod shaped Li-Zn ferrite particle based magnetorheological fluids (MRFs). Rod-shaped soft ferrimagnetic Li-Zn ferrite (Li0.4Zn0.2Fe2.4O4) particles were ... ...

    Abstract We report the magnetic field and particle-concentration dependent steady-state shear-responses of rod shaped Li-Zn ferrite particle based magnetorheological fluids (MRFs). Rod-shaped soft ferrimagnetic Li-Zn ferrite (Li0.4Zn0.2Fe2.4O4) particles were synthesized using the combustion synthesis method. MRFs of three different particle-concentrations (φ = 0.1, 0.2 and 0.4, in weight fraction) were prepared using silicone oil. Their yield strength and dynamic viscosity were studied at different applied magnetic fields (B). With an increase in B and φ, the yield strength (τY) of the MRFs increases. This behaviour is assigned to the formation of stronger columnar structures of the magnetically interacting particles which resist the flow (shear) of the MRF. For the MRF with φ = 0.4 and B = 1.2 T, we observed a maximum τY value of ∼1.25 kPa. Furthermore, we observed that, based on the on-state to off-state viscosity ratio (ηon/ηoff) at a particular operating B value, the optimum particle concentration required for energy- and cost-efficient operation of the MRFs can be chosen. The absence of a stabilizing-agent or de-agglomerating-coating, the low density, and the excellent oxidation- and corrosion-resistance of the soft ferrimagnetic rod-shaped Li-Zn ferrite particles make this MRF-system highly versatile and economical for many magneto-mechanical applications.
    Language English
    Publishing date 2018-07-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2191476-X
    ISSN 1744-6848 ; 1744-683X
    ISSN (online) 1744-6848
    ISSN 1744-683X
    DOI 10.1039/c8sm00807h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Human umbilical cord blood-mesenchymal stem cell derived exosomes as an efficient nanocarrier for Docetaxel and miR-125a: Formulation optimization and anti-metastatic behaviour.

    Basak, Moumita / Sahoo, Biswajit / Chaudhary, Dharmendra Kumar / Narisepalli, SaiBhargav / Tiwari, Swasti / Chitkara, Deepak / Mittal, Anupama

    Life sciences

    2023  Volume 322, Page(s) 121621

    Abstract: Aim: Exosomes, as a nanocarrier for the co-delivery of biologicals and small anticancer molecules is yet in its infancy. Herein, we investigated hUCBMSC derived exosomes as a biogenic nanocarrier for the co-delivery of tumor suppressor miR-125a and ... ...

    Abstract Aim: Exosomes, as a nanocarrier for the co-delivery of biologicals and small anticancer molecules is yet in its infancy. Herein, we investigated hUCBMSC derived exosomes as a biogenic nanocarrier for the co-delivery of tumor suppressor miR-125a and microtubule destabilizing Docetaxel (DTX) to target the proliferative and migratory aggressiveness of the murine TNBC 4T1 cells.
    Main methods: In this study, hUCBMSCs from the human umbilical cord blood cells (hUCB) were successfully transfected with miR-125a. Thereafter, DTX was encapsulated into both non-transfected and transfected exosomes by optimized mild sonication-incubation technique. The anticancer efficiency of hUCBMSC Exo-DTX and miR-125a Exo-DTX was compared by MTT and morphometric assay. The prominent anti-metastatic behaviour of the latter was confirmed by in-vitro wound healing and transwell invasion assay. Further, the synergistic effect of miR-125a and DTX was confirmed by F-actin and nuclear degradation by confocal and FESEM assay.
    Key findings: hUCBMSC exosomes exhibited DTX payload of 8.86 ± 1.97 ng DTX/ μg exosomes and miRNA retention capacity equivalent to 12.31 ± 5.73 %. The co-loaded formulation (miR-125a Exo-DTX) exhibited IC
    Significance: The synergistic anticancer and anti-metastatic effect of miR-125a Exo-DTX was observed due to presence of both DTX and miR-125a as the cargo of hUCBMSC derived exosomes.
    MeSH term(s) Humans ; Animals ; Mice ; Docetaxel/pharmacology ; Exosomes/metabolism ; Fetal Blood/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Mesenchymal Stem Cells/metabolism ; Umbilical Cord/metabolism
    Chemical Substances Docetaxel (15H5577CQD) ; MicroRNAs
    Language English
    Publishing date 2023-03-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2023.121621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Comparison of Opioid-Based Versus Opioid-Sparing Anesthesia in Patients Undergoing Glioma Surgery.

    A S, Anupama / Kaushal, Ashutosh / Waindeskar, Vaishali / Saigal, Saurabh / Jain, Anuj / Kumar, Harish / Mandal, Pranita / Kumar, Sandeep / Kumari, Sweta / Sahoo, Anjan K

    Cureus

    2024  Volume 16, Issue 2, Page(s) e54153

    Abstract: Background In the neurosurgical population, opioids may cause respiratory depression, leading to hypercapnia, increased cerebral blood flow (CBF), and ultimately increased intracranial pressure (ICP), which can mask early signs of intracranial ... ...

    Abstract Background In the neurosurgical population, opioids may cause respiratory depression, leading to hypercapnia, increased cerebral blood flow (CBF), and ultimately increased intracranial pressure (ICP), which can mask early signs of intracranial complications and delayed emergence. This study was designed to compare perioperative hemodynamic stability, analgesia, and recovery parameters in opioid-based (fentanyl) general anesthesia versus opioid-sparing (dexmedetomidine) general anesthesia in patients undergoing glioma surgeries. Methodology This prospective observational comparative study compared 52 patients in two groups. Twenty-six (50%) patients in group F received Inj. fentanyl IV (intravenous; bolus 2 mcg/kg 10 minutes before induction and then infusion 1 mcg/kg/hour till 30 minutes before skin closure), whereas 26 (50%) patients in group D received Inj. dexmedetomidine IV (0.5 mcg/kg infusion 10 minutes before induction and then maintenance with a 0.5 mcg/kg/hour infusion till 30 minutes before skin closure). Perioperative heart rate (HR), mean arterial pressure (MAP), Numerical Rating Scale for Pain (NRS) assessment and postoperative emergence time, modified Aldrete score, patient satisfaction, and surgeon satisfaction score were estimated and compared in both groups. Results The mean HR was less in group D compared to group F at following time points - 10 minutes after infusion (
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.54153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Human umbilical cord blood-mesenchymal stem cell derived exosomes as an efficient nanocarrier for Docetaxel and miR-125a: Formulation optimization and anti-metastatic behaviour

    Basak, Moumita / Sahoo, Biswajit / Chaudhary, Dharmendra Kumar / Narisepalli, SaiBhargav / Tiwari, Swasti / Chitkara, Deepak / Mittal, Anupama

    Life Sciences. 2023 June, v. 322 p.121621-

    2023  

    Abstract: Exosomes, as a nanocarrier for the co-delivery of biologicals and small anticancer molecules is yet in its infancy. Herein, we investigated hUCBMSC derived exosomes as a biogenic nanocarrier for the co-delivery of tumor suppressor miR-125a and ... ...

    Abstract Exosomes, as a nanocarrier for the co-delivery of biologicals and small anticancer molecules is yet in its infancy. Herein, we investigated hUCBMSC derived exosomes as a biogenic nanocarrier for the co-delivery of tumor suppressor miR-125a and microtubule destabilizing Docetaxel (DTX) to target the proliferative and migratory aggressiveness of the murine TNBC 4T1 cells. In this study, hUCBMSCs from the human umbilical cord blood cells (hUCB) were successfully transfected with miR-125a. Thereafter, DTX was encapsulated into both non-transfected and transfected exosomes by optimized mild sonication-incubation technique. The anticancer efficiency of hUCBMSC Exo-DTX and miR-125a Exo-DTX was compared by MTT and morphometric assay. The prominent anti-metastatic behaviour of the latter was confirmed by in-vitro wound healing and transwell invasion assay. Further, the synergistic effect of miR-125a and DTX was confirmed by F-actin and nuclear degradation by confocal and FESEM assay. hUCBMSC exosomes exhibited DTX payload of 8.86 ± 1.97 ng DTX/ μg exosomes and miRNA retention capacity equivalent to 12.31 ± 5.73 %. The co-loaded formulation (miR-125a Exo-DTX) exhibited IC₅₀ at 192.8 ng/ml in 4T1 cells, which is almost 2.36 folds' lower than the free DTX IC₅₀ (472.8 ng/ml). Additionally, miR-125a Exo-DTX treatment caused wound broadening upto 6.14±0.38 % while treatment with free DTX and miR-125a exosomes alone caused 18.71±4.5 % and 77.36±10.4 % of wound closure respectively in 36 h. miR-125a Exo-DTX treatment further exhibited significantly reduced invasiveness of 4T1 cells (by 3.5 ± 1.8 %) along with prominent cytoskeletal degradation and nuclear deformation as compared to the miR-125a exosomes treated group. The miR-125a expressing DTX loaded exosomal formulation clearly demonstrated the synergistic apoptotic and anti-migratory efficiency of the miR-125a Exo-DTX. The synergistic anticancer and anti-metastatic effect of miR-125a Exo-DTX was observed due to presence of both DTX and miR-125a as the cargo of hUCBMSC derived exosomes.
    Keywords actin ; aggression ; apoptosis ; blood ; deformation ; exosomes ; humans ; mice ; microRNA ; microtubules ; migratory behavior ; morphometry ; nanocarriers ; neoplasms ; stem cells ; synergism ; umbilical cord ; MSC ; Docetaxel ; miR-125a ; Metastasis ; Multi-nucleation
    Language English
    Dates of publication 2023-06
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2023.121621
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Application of Ni-Zn ferrite powders with polydisperse spherical particles in magnetorheological fluids

    Anupama, A.V / B. Sahoo / V. Kumaran

    Powder technology. 2018 Oct., v. 338

    2018  

    Abstract: We report the steady-state shear response of polydisperse Ni-Zn ferrite-submicrospheres-based magnetorheological fluids (MRFs). The Ni-Zn ferrite spherical particles were prepared by solvothermal method. MRFs of three different concentrations (10, 20 and ...

    Abstract We report the steady-state shear response of polydisperse Ni-Zn ferrite-submicrospheres-based magnetorheological fluids (MRFs). The Ni-Zn ferrite spherical particles were prepared by solvothermal method. MRFs of three different concentrations (10, 20 and 40 wt%) were prepared by dispersing Ni-Zn ferrite submicrospheres in silicone oil. These MRFs were subjected to steady-state shear conditions, at different applied magnetic fields. Dynamic yield strength values corresponding to different applied field strengths showed increase in value with increase in magnetic field strength. Furthermore, the dynamic yield strength scaled up with the concentration of Ni-Zn ferrite spherical particles in the carrier fluid. Comparison of the dynamic yield strengths for the MRFs showed that the values depend strongly on the physical properties of the particles such as the particle size, size-distribution (polydispersity) and the saturation magnetization.
    Keywords ferrimagnetic materials ; magnetic fields ; oils ; particle size ; powders ; silicone
    Language English
    Dates of publication 2018-10
    Size p. 190-196.
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 0032-5910
    DOI 10.1016/j.powtec.2018.07.008
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Severe Oleander Poisoning Presenting with Hyperkalaemia and Unusual Electrocardiographic Changes.

    Guru, Satyabrata / Behera, Anupama / Barik, Sadananda / Hansdah, Upendra / Mohanty, Chitta R / Sahoo, Sangeeta

    European journal of case reports in internal medicine

    2021  Volume 8, Issue 12, Page(s) 3044

    Abstract: Background: Hyperkalaemia in oleander (Nerium oleander) poisoning has been associated with a poor prognosis. Different electrocardiographic (ECG) presentations are possible because of vagotonia and hyperkalaemia.: Methods/results: We report a series ... ...

    Abstract Background: Hyperkalaemia in oleander (Nerium oleander) poisoning has been associated with a poor prognosis. Different electrocardiographic (ECG) presentations are possible because of vagotonia and hyperkalaemia.
    Methods/results: We report a series of three cases of oleander poisoning in which ECG showed unusual hyperkalaemia features, such as bradyarrhythmia, sinoatrial block, atrioventricular block and junctional rhythm.
    Conclusions: If arterial blood gas analysis or laboratory values indicate hyperkalaemia in oleander poisoning, the hyperkalaemia should be treated immediately, even if the ECG does not show typical hyperkalaemia features.
    Learning points: Hyperkalaemia in oleander poisoning is associated with a poor prognosis.Hyperkalaemia should be treated aggressively in oleander poisoning even if the ECG does not show typical features, as mimics other conditions on ECG.
    Language English
    Publishing date 2021-12-14
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2021_003044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Magnetic field dependent steady-state shear response of Fe

    Anupama, A V / Khopkar, V B / Kumaran, V / Sahoo, B

    Physical chemistry chemical physics : PCCP

    2018  Volume 20, Issue 30, Page(s) 20247–20256

    Abstract: We report the synthesis of single crystalline octahedron-shaped magnetite microcrystals, the preparation of magnetorheological fluids (MRFs) and their magnetorheological properties under steady-state shear conditions. The magnetite microcrystals were ... ...

    Abstract We report the synthesis of single crystalline octahedron-shaped magnetite microcrystals, the preparation of magnetorheological fluids (MRFs) and their magnetorheological properties under steady-state shear conditions. The magnetite microcrystals were synthesized via the template-free hydrothermal route. MRFs with three different particle concentrations (10, 20 and 40 weight%) were prepared and were subjected to steady shear conditions at various externally applied magnetic fields of strength up to 1.2 T. The shear rates were chosen up to high enough values to observe the yield behaviour of the MRFs. The dynamic yield strengths of MRFs, estimated using the Bingham plastic model fit to the steady-state shear response curves, showed that they scale-up with the applied magnetic field strength and amount of magnetic particles in the fluid. The origin of the mechanical strength in the MRFs due to the inter-particle interaction is explained using a simple dipolar model. The observed high yield strengths of the MRFs were explained on the basis of the particle shape (octahedrons) and magnetic nature (saturation magnetization). By comparing the values of the yield strength with the on-state to off-state viscosity ratio for the MRFs (for each particle concentration), an optimum content of particles in the carrier fluid to obtain high efficiency is suggested. Because the particles are single crystalline, the off-state viscosity of the MRFs even at the highest studied (40 wt%) particle concentration was very low, which is ideal for their application as quickly responding MRFs.
    Language English
    Publishing date 2018-08-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/c8cp02335b
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