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Article ; Online: Painful Chronic Ulcers on the Neck and Back.

Erstine, Emily M / Collie, Angela M B / Piliang, Melissa P

2016 Volume 152, Issue 12, Page(s) 1375–1376

MeSH term(s)	Back ; Biopsy ; Chronic Disease ; Diagnosis, Differential ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/diagnosis ; Humans ; Male ; Middle Aged ; Neck ; Pain/diagnosis ; Pain/etiology ; Positron-Emission Tomography ; Skin/diagnostic imaging ; Tomography, X-Ray Computed ; Ulcer/complications ; Ulcer/diagnosis
Language	English
Publishing date	2016-09-13
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2701761-8
ISSN	2168-6084 ; 2168-6068
ISSN (online)	2168-6084
ISSN	2168-6068
DOI	10.1001/jamadermatol.2016.3270
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Ui VI Zs.32: Show issues

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Article ; Online: Testicular myeloid sarcoma: a rare manifestation of acute myeloid leukemia in an infant.

Tran, Christine N / Collie, Angela M B / Flagg, Aron / Rhee, Audrey

Urology

2014 Volume 84, Issue 4, Page(s) 925–927

Abstract: Myeloid sarcoma manifesting in the testis is rare and may occur concomitantly with bone marrow disease or as a separate entity. We describe our experience with a 6-month-old boy who presented with painless scrotal swelling and was found to have bilateral ...

Abstract	Myeloid sarcoma manifesting in the testis is rare and may occur concomitantly with bone marrow disease or as a separate entity. We describe our experience with a 6-month-old boy who presented with painless scrotal swelling and was found to have bilateral testicular masses on ultrasonography. The patient underwent unilateral radical inguinal orchiectomy. Surgical pathology revealed myeloid sarcoma of the testicle. He developed peripheral blood involvement 1 week postoperatively. Bone marrow biopsy showed acute myeloid leukemia. He is in remission after 2 cycles of induction chemotherapy, local radiation therapy, and allogeneic bone marrow transplantation.
MeSH term(s)	Humans ; Infant ; Leukemia, Myeloid, Acute/complications ; Leukemia, Myeloid, Acute/diagnosis ; Male ; Sarcoma, Myeloid/etiology ; Testicular Neoplasms/etiology
Language	English
Publishing date	2014-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2014.07.005
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 275: Show issues

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Article ; Online: Cutaneous intravascular extramedullary hematopoiesis in a patient with post-polycythemia vera myelofibrosis.

Collie, Angela M B / Uchin, Jeffrey M / Bergfeld, Wilma F / Billings, Steven D

Journal of cutaneous pathology

2013 Volume 40, Issue 7, Page(s) 615–620

MeSH term(s)	Aged ; Female ; Hematopoiesis, Extramedullary ; Humans ; Polycythemia Vera/complications ; Polycythemia Vera/pathology ; Primary Myelofibrosis/etiology ; Primary Myelofibrosis/pathology ; Skin/blood supply ; Skin/pathology
Language	English
Publishing date	2013-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	187078-6
ISSN	1600-0560 ; 0303-6987
ISSN (online)	1600-0560
ISSN	0303-6987
DOI	10.1111/cup.12178
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Zs.A 1043: Show issues

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Article ; Online: Lobular neoplasia diagnosed on breast Core biopsy: frequency of carcinoma on excision and implications for management.

Calhoun, Benjamin C / Collie, Angela M B / Lott-Limbach, Abberly A / Udoji, Esther N / Sieck, Leah R / Booth, Christine N / Downs-Kelly, Erinn

Annals of diagnostic pathology

2016 Volume 25, Page(s) 20–25

Abstract: The appropriate follow-up and treatment for patients with a core biopsy diagnosis of lobular neoplasia (atypical lobular hyperplasia or lobular carcinoma in situ) remains controversial. Several studies have attempted to address this issue, with ... ...

Abstract	The appropriate follow-up and treatment for patients with a core biopsy diagnosis of lobular neoplasia (atypical lobular hyperplasia or lobular carcinoma in situ) remains controversial. Several studies have attempted to address this issue, with recommendations ranging from close clinical follow-up or surveillance to mandatory surgical excision in all cases. We report the findings at our institution, where virtually every core needle biopsy diagnosis of lobular neoplasia results in follow-up excision. The goal of the study was to identify potential predictors of upgrade to a more significant lesion. We identified 76 patients over a 15-year period with a core biopsy diagnosis of pure lobular neoplasia and no other high-risk lesions. Subsequent surgical excision identified 10 cases (13%) that were upgraded to carcinoma. Upgrade diagnoses included invasive ductal carcinoma (n=1), invasive lobular carcinoma (n=4), ductal carcinoma in situ (n=3), and pleomorphic lobular carcinoma in situ (n=2). All 10 upgraded cases had imaging findings suspicious for malignancy including irregular masses, asymmetric densities, or pleomorphic calcifications. Of the 10 upgraded cases, 7 were diagnosed as lobular carcinoma in situ on core biopsy. The data support a role for radiologic-pathologic correlation in the evaluation of suspicious breast lesions and suggest that the extent of lobular neoplasia in core biopsy specimens may be an indicator of the likelihood of upgrade to carcinoma.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biopsy, Large-Core Needle/methods ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Carcinoma in Situ/pathology ; Carcinoma in Situ/therapy ; Carcinoma, Lobular/diagnosis ; Carcinoma, Lobular/pathology ; Female ; Humans ; Hyperplasia/diagnosis ; Hyperplasia/pathology ; Mammography ; Middle Aged ; Precancerous Conditions/pathology
Language	English
Publishing date	2016-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1440011-x
ISSN	1532-8198 ; 1092-9134
ISSN (online)	1532-8198
ISSN	1092-9134
DOI	10.1016/j.anndiagpath.2016.07.009
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Zs.A 5463: Show issues

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Article ; Online: Differential monocyte/macrophage interleukin-1β production due to biomaterial topography requires the β2 integrin signaling pathway.

Collie, Angela M B / Bota, Paige C S / Johns, Rachel E / Maier, Ronald V / Stayton, Patrick S

Journal of biomedical materials research. Part A

2011 Volume 96, Issue 1, Page(s) 162–169

Abstract: ... factor kappa-B, another component of the β2 integrin signaling pathway, although it may not be ...

Abstract	Monocytes/macrophages are crucial mediators of the host response to biomaterials, and their level of activation can be directly affected by material characteristics. Previous work has demonstrated that primary human monocytes cultured on polytetrafluoroethylene materials of varying topography but identical surface chemistry are differentially affected. Monocytes/macrophages on biaxially-expanded polytetrafluoroethylene with an average intranodal distance of 4.4 μm (4.4-ePTFE) produced higher levels of the inflammatory cytokine interleukin-1 beta (IL-1β) compared with monocytes/macrophages on nonporous polytetrafluoroethylene (np-PTFE). The current study provides a mechanistic understanding of this response. Scanning electron microscopy revealed that monocytes/macrophages cultured on np-PTFE were more spread than those on 4.4-ePTFE. In addition, the actin cytoskeleton and intact β2 integrin receptors were necessary for IL-1β production by monocytes/macrophages on 4.4-ePTFE. This IL-1β production also required the transcription factor nuclear factor kappa-B, another component of the β2 integrin signaling pathway, although it may not be the primary transcription factor involved. These studies demonstrate the importance of several β2 integrin signaling components to the monocyte/macrophage response to biomaterial topography.
MeSH term(s)	CD18 Antigens/immunology ; Cell Shape ; Cells, Cultured ; Coated Materials, Biocompatible/chemistry ; Cytoskeleton/metabolism ; Humans ; I-kappa B Kinase/metabolism ; Interleukin-1beta/immunology ; Macrophages/cytology ; Macrophages/immunology ; Materials Testing ; Mitogen-Activated Protein Kinases/metabolism ; Monocytes/cytology ; Monocytes/immunology ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/metabolism ; Signal Transduction/immunology ; Surface Properties
Chemical Substances	CD18 Antigens ; Coated Materials, Biocompatible ; IKBKG protein, human ; Interleukin-1beta ; NF-kappa B ; I-kappa B Kinase (EC 2.7.11.10) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2011-01
Publishing country	United States
Document type	Evaluation Studies ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2099989-6
ISSN	1552-4965 ; 1549-3296 ; 0021-9304
ISSN (online)	1552-4965
ISSN	1549-3296 ; 0021-9304
DOI	10.1002/jbm.a.32963
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Zs.A 6195: Show issues

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Article ; Online: Flow cytometric analysis of cerebrospinal fluid has low diagnostic yield in samples without atypical morphology or prior history of hematologic malignancy.

Collie, Angela M B / Hill, Brian T / Stevens, Glen H J / Fenner, Kathleen / Gazdick, Elizabeth / Hsi, Eric D

American journal of clinical pathology

2014 Volume 141, Issue 4, Page(s) 515–521

Abstract: Objectives: To identify pretest characteristics of cerebrospinal fluid (CSF) specimens that will allow the rational use of flow cytometric analysis (FCA) in the diagnosis of hematologic malignancy.: Methods: Retrospective data were collected on 501 ... ...

Abstract	Objectives: To identify pretest characteristics of cerebrospinal fluid (CSF) specimens that will allow the rational use of flow cytometric analysis (FCA) in the diagnosis of hematologic malignancy. Methods: Retrospective data were collected on 501 consecutive CSF samples submitted for FCA. Results: A positive diagnosis of hematologic malignancy was made in 41 specimens (8.2%). Blasts or atypical lymphocytes were noted on Wright-stained slides in 98% of FCA-positive specimens (40/41), and a history of a hematologic malignancy was present in 89% of specimens (34/38). All FCA-positive specimens had atypical morphology or history of hematologic malignancy. Four hundred six specimens (81%) were FCA negative. Of FCA-negative specimens, 7% (30/406) had atypical morphology, and 3% (12/404) had future central nervous system involvement seen within 30 days. Conclusions: These data support a policy in which FCA of CSF is actively discouraged unless atypical lymphocytes or blasts are seen or a history of hematologic malignancy is present.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Female ; Flow Cytometry ; Hematologic Neoplasms/cerebrospinal fluid ; Hematologic Neoplasms/pathology ; Humans ; Infant ; Leukemia/cerebrospinal fluid ; Leukemia/pathology ; Lymphoma/cerebrospinal fluid ; Lymphoma/pathology ; Male ; Middle Aged ; Retrospective Studies
Language	English
Publishing date	2014-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2944-0
ISSN	1943-7722 ; 0002-9173
ISSN (online)	1943-7722
ISSN	0002-9173
DOI	10.1309/AJCP8IB8FRQDVPXL
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Ud II Zs.91: Show issues

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Article ; Online: Dual expression of MYC and BCL2 proteins predicts worse outcomes in diffuse large B-cell lymphoma.

Clark Schneider, Kelli M / Banks, Peter M / Collie, Angela M B / Lanigan, Christopher P / Manilich, Elena / Durkin, Lisa M / Hill, Brian T / Hsi, Eric D

Leukemia & lymphoma

2015 Volume 57, Issue 7, Page(s) 1640–1648

Abstract: ... of poor prognosis in diffuse large B-cell lymphoma. However, the immunohistochemistry protocols for dual ... expression staining and the scoring cut-offs vary by study. Sixty-nine cases of diffuse large B-cell lymphoma ... information in patients with de novo diffuse large B-cell lymphoma. This study has practical implications ...

Abstract	Recent studies suggested that MYC and BCL2 protein co-expression is an independent indicator of poor prognosis in diffuse large B-cell lymphoma. However, the immunohistochemistry protocols for dual-expression staining and the scoring cut-offs vary by study. Sixty-nine cases of diffuse large B-cell lymphoma were evaluated for MYC and BCL2 protein expression using various cut-offs that have been recommended in prior studies. Independent of the International Prognostic Index risk group, cases with dual protein expression of BCL2 and MYC using ≥50%/40% cut-offs and ≥70%/40% had significantly shorter overall survival than cases without. It was verified in this patient population that the use of BCL2 and MYC immunohistochemistry, performed with available in vitro diagnostic-cleared antibodies, provides rapid prognostic information in patients with de novo diffuse large B-cell lymphoma. This study has practical implications for diagnostic laboratories and serves as a guide for implementation in the setting of future clinical trials.
MeSH term(s)	Adult ; Aged ; Antibodies, Monoclonal, Murine-Derived/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Case-Control Studies ; Cyclophosphamide/therapeutic use ; Doxorubicin/therapeutic use ; Female ; Gene Expression ; Humans ; Immunohistochemistry ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/mortality ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prednisone/therapeutic use ; Proportional Hazards Models ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Treatment Outcome ; Vincristine/therapeutic use
Chemical Substances	Antibodies, Monoclonal, Murine-Derived ; Proto-Oncogene Proteins c-bcl-2 ; Proto-Oncogene Proteins c-myc ; R-CHOP protocol ; Vincristine (5J49Q6B70F) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
Language	English
Publishing date	2015-12-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.3109/10428194.2015.1101099
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Zs.A 2997: Show issues

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Article ; Online: Next generation sequencing of Cytokeratin 20-negative Merkel cell carcinoma reveals ultraviolet-signature mutations and recurrent TP53 and RB1 inactivation.

Harms, Paul W / Collie, Angela M B / Hovelson, Daniel H / Cani, Andi K / Verhaegen, Monique E / Patel, Rajiv M / Fullen, Douglas R / Omata, Kei / Dlugosz, Andrzej A / Tomlins, Scott A / Billings, Steven D

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

2016 Volume 29, Issue 3, Page(s) 240–248

Abstract: Merkel cell carcinoma is a rare but highly aggressive cutaneous neuroendocrine carcinoma. Cytokeratin 20 (CK20) is expressed in ~95% of Merkel cell carcinomas and is useful for distinction from morphologically similar entities including metastatic small- ... ...

Abstract	Merkel cell carcinoma is a rare but highly aggressive cutaneous neuroendocrine carcinoma. Cytokeratin 20 (CK20) is expressed in ~95% of Merkel cell carcinomas and is useful for distinction from morphologically similar entities including metastatic small-cell lung carcinoma. Lack of CK20 expression may make diagnosis of Merkel cell carcinoma more challenging, and has unknown biological significance. Approximately 80% of CK20-positive Merkel cell carcinomas are associated with the oncogenic Merkel cell polyomavirus. Merkel cell carcinomas lacking Merkel cell polyomavirus display distinct genetic changes from Merkel cell polyomavirus-positive Merkel cell carcinoma, including RB1 inactivating mutations. Unlike CK20-positive Merkel cell carcinoma, the majority of CK20-negative Merkel cell carcinomas are Merkel cell polyomavirus-negative, suggesting CK20-negative Merkel cell carcinomas predominantly arise through virus-independent pathway(s) and may harbor additional genetic differences from conventional Merkel cell carcinoma. Hence, we analyzed 15 CK20-negative Merkel cell carcinoma tumors (10 Merkel cell polyomavirus-negative, four Merkel cell polyomavirus-positive, and one undetermined) using the Ion Ampliseq Comprehensive Cancer Panel, which assesses copy number alterations and mutations in 409 cancer-relevant genes. Twelve tumors displayed prioritized high-level chromosomal gains or losses (average 1.9 per tumor). Non-synonymous high-confidence somatic mutations were detected in 14 tumors (average 11.9 per tumor). Assessing all somatic coding mutations, an ultraviolet-signature mutational profile was present, and more prevalent in Merkel cell polyomavirus-negative tumors. Recurrent deleterious tumor suppressor mutations affected TP53 (9/15, 60%), RB1 (3/15, 20%), and BAP1 (2/15, 13%). Oncogenic activating mutations included PIK3CA (3/15, 20%), AKT1 (1/15, 7%) and EZH2 (1/15, 7%). In conclusion, CK20-negative Merkel cell carcinoma display overlapping genetic changes with CK20-positive Merkel cell carcinoma, including RB1 mutations restricted to Merkel cell polyomavirus-negative tumors. However, some CK20-negative Merkel cell carcinomas harbor mutations not previously described in Merkel cell carcinoma. Hence, CK20-negative Merkel cell carcinomas harbor diverse oncogenic drivers which may represent therapeutic targets in individual tumors.
MeSH term(s)	Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Carcinoma, Merkel Cell/genetics ; DNA Mutational Analysis/methods ; Female ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Keratin-20/genetics ; Male ; Middle Aged ; Mutation ; Retinoblastoma Binding Proteins/genetics ; Skin Neoplasms/genetics ; Tumor Suppressor Protein p53/genetics ; Ubiquitin-Protein Ligases/genetics
Chemical Substances	Biomarkers, Tumor ; KRT20 protein, human ; Keratin-20 ; RB1 protein, human ; Retinoblastoma Binding Proteins ; TP53 protein, human ; Tumor Suppressor Protein p53 ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2016-01-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	645073-8
ISSN	1530-0285 ; 0893-3952
ISSN (online)	1530-0285
ISSN	0893-3952
DOI	10.1038/modpathol.2015.154
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Zs.A 2450: Show issues

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Article ; Online: Molecular subtype classification of formalin-fixed, paraffin-embedded diffuse large B-cell lymphoma samples on the ICEPlex® system.

Collie, Angela M B / Nölling, Jörk / Divakar, Kiran M / Lin, Jeffrey J / Carver, Paula / Durkin, Lisa M / Hill, Brian T / Smith, Mitchell R / Radivoyevitch, Tomas / Kong, Lilly I / Daly, Thomas / Murugesan, Gurunathan / Guenther-Johnson, Jeanna / Dave, Sandeep S / Manilich, Elena A / Hsi, Eric D

British journal of haematology

2014 Volume 167, Issue 2, Page(s) 281–285

MeSH term(s)	Formaldehyde ; Gene Expression Profiling/methods ; Humans ; Lymphoma, Large B-Cell, Diffuse/classification ; Multiplex Polymerase Chain Reaction/methods ; Paraffin Embedding
Chemical Substances	Formaldehyde (1HG84L3525)
Language	English
Publishing date	2014-06-25
Publishing country	England
Document type	Letter ; Research Support, N.I.H., Extramural
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.12983
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Article ; Online: Acute seizure risk in patients with encephalitis: development and validation of clinical prediction models from two independent prospective multicentre cohorts.

BMJ neurology open

2022 Volume 4, Issue 2, Page(s) e000323

Abstract: Objective: In patients with encephalitis, the development of acute symptomatic seizures is highly variable, but when present is associated with a worse outcome. We aimed to determine the factors associated with seizures in encephalitis and develop a ... ...

Abstract	Objective: In patients with encephalitis, the development of acute symptomatic seizures is highly variable, but when present is associated with a worse outcome. We aimed to determine the factors associated with seizures in encephalitis and develop a clinical prediction model. Methods: We analysed 203 patients from 24 English hospitals (2005-2008) (Cohort 1). Outcome measures were seizures prior to and during admission, inpatient seizures and status epilepticus. A binary logistic regression risk model was converted to a clinical score and independently validated on an additional 233 patients from 31 UK hospitals (2013-2016) (Cohort 2). Results: In Cohort 1, 121 (60%) patients had a seizure including 103 (51%) with inpatient seizures. Admission Glasgow Coma Scale (GCS) ≤8/15 was predictive of subsequent inpatient seizures (OR (95% CI) 5.55 (2.10 to 14.64), p<0.001), including in those without a history of prior seizures at presentation (OR 6.57 (95% CI 1.37 to 31.5), p=0.025).A clinical model of overall seizure risk identified admission GCS along with aetiology (autoantibody-associated OR 11.99 (95% CI 2.09 to 68.86) and Herpes simplex virus 3.58 (95% CI 1.06 to 12.12)) (area under receiver operating characteristics curve (AUROC) =0.75 (95% CI 0.701 to 0.848), p<0.001). The same model was externally validated in Cohort 2 (AUROC=0.744 (95% CI 0.677 to 0.811), p<0.001). A clinical scoring system for stratifying inpatient seizure risk by decile demonstrated good discrimination using variables available on admission; age, GCS and fever (AUROC=0.716 (95% CI 0.634 to 0.798), p<0.001) and once probable aetiology established (AUROC=0.761 (95% CI 0.6840.839), p<0.001). Conclusion: Age, GCS, fever and aetiology can effectively stratify acute seizure risk in patients with encephalitis. These findings can support the development of targeted interventions and aid clinical trial design for antiseizure medication prophylaxis.
Language	English
Publishing date	2022-09-05
Publishing country	England
Document type	Journal Article
ISSN	2632-6140
ISSN (online)	2632-6140
DOI	10.1136/bmjno-2022-000323
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