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Article: The contribution of cooking appliances and residential traffic proximity to aerosol personal exposure.

Shehab, M / Pope, F D / Delgado-Saborit, J M

Journal of environmental health science & engineering

2021 Volume 19, Issue 1, Page(s) 307–318

Abstract: ... μg/m: Supplementary information: The online version contains supplementary material available ...

Abstract	Purpose: Indoor and outdoor factors affect personal exposure to air pollutants. Type of cooking appliance (i.e. gas, electricity), and residential location related to traffic are such factors. This research aims to investigate the effect of cooking with gas and electric appliances, as an indoor source of aerosols, and residential traffic as outdoor sources, on personal exposures to particulate matter with an aerodynamic diameter lower than 2.5 μm (PM Methods: Forty subjects were sampled for four consecutive days measuring personal exposures to three aerosol pollutants, namely PM Results/conclusion: Cooking was identified as an indoor activity affecting exposure to aerosols, with mean concentrations during cooking ranging 24.7-50.0 μg/m Supplementary information: The online version contains supplementary material available at 10.1007/s40201-020-00604-7.
Language	English
Publishing date	2021-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2756287-6
ISSN	2052-336X
ISSN	2052-336X
DOI	10.1007/s40201-020-00604-7
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Article ; Online: Systematic Review of Health-Related Quality of Life Impact in Juvenile Localized Scleroderma.

Sanchez-Espino, Luis F / Luca, Nadia / Pope, Elena / Laxer, Ronald M / Knight, Andrea M / Sibbald, Cathryn

Arthritis care & research

2024 Volume 76, Issue 3, Page(s) 340–349

Abstract: Objective: The prevalence and types of psychosocial complications of juvenile localized scleroderma (JLS), also known as morphea, an inflammatory and sclerosing disease involving the skin, fascia, muscle, and bone, are poorly understood.: Methods: We ...

Abstract	Objective: The prevalence and types of psychosocial complications of juvenile localized scleroderma (JLS), also known as morphea, an inflammatory and sclerosing disease involving the skin, fascia, muscle, and bone, are poorly understood. Methods: We performed a systematic review of literature published between 2000 and 2020 in PubMed, EMBASE, the Cochrane Skin Group Specialized Register, the Cochrane Central Register of Controlled Trials, and the Cumulative Index to Nursing and Allied Health Literature using the search terms "scleroderma, localized," "Morphea," "anxiety," "depression," "resilience," "social stigma," "quality of life," "mood," or "stress" and limited the search to pediatric patients and English language. Patient demographics, characteristics of JLS, and comorbidities were extracted. The outcomes included measures of health-related quality of life (HRQoL), psychosocial functioning, evaluation of self-perception, and the treatment burden of the study population. The protocol was registered with PROSPERO (CRD42021257124). Thematic synthesis generated descriptive analysis. Results: Thirteen studies fulfilled the inclusion criteria: three retrospective cohort studies, two prospective cohort studies, and eight cross-sectional studies. A total of 690 pediatric patients with JLS were included (n = 484 with linear scleroderma). Six studies used the Children's Dermatology Life Quality Index, reporting little to no effect on HRQoL. One study used the Health-Related Quality of Life in Children and Adolescents Questionnaire and did not find differences between children with JLS or atopic dermatitis and healthy controls. One study used a self-perception questionnaire that showed normal self-worth of patients with JLS. Two studies used focus groups, both reporting elevated levels of stress, decreased self-worth, "feeling different," and bullying/teasing in patients with JLS. These emotions were associated with skin symptoms (pain, itch, and tightness), physical limitations, and treatment burden. Conclusion: Overall, quantitative studies did not report a statistically significant impairment in HRQoL in JLS. However, qualitative studies (focus groups) reported significant psychosocial impacts related to JLS. There is a need to develop a JLS-specific tool for the HRQoL evaluation of this population.
MeSH term(s)	Adolescent ; Humans ; Child ; Quality of Life ; Scleroderma, Localized/diagnosis ; Retrospective Studies ; Cross-Sectional Studies ; Prospective Studies
Language	English
Publishing date	2024-01-07
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	645059-3
ISSN	2151-4658 ; 0893-7524 ; 2151-464X
ISSN (online)	2151-4658
ISSN	0893-7524 ; 2151-464X
DOI	10.1002/acr.25243
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Zs.A 2446: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Multivariate information theory uncovers synergistic subsystems of the human cerebral cortex.

Varley, Thomas F / Pope, Maria / Faskowitz, Joshua / Sporns, Olaf

Communications biology

2023 Volume 6, Issue 1, Page(s) 451

Abstract: One of the most well-established tools for modeling the brain is the functional connectivity network, which is constructed from pairs of interacting brain regions. While powerful, the network model is limited by the restriction that only pairwise ... ...

Abstract	One of the most well-established tools for modeling the brain is the functional connectivity network, which is constructed from pairs of interacting brain regions. While powerful, the network model is limited by the restriction that only pairwise dependencies are considered and potentially higher-order structures are missed. Here, we explore how multivariate information theory reveals higher-order dependencies in the human brain. We begin with a mathematical analysis of the O-information, showing analytically and numerically how it is related to previously established information theoretic measures of complexity. We then apply the O-information to brain data, showing that synergistic subsystems are widespread in the human brain. Highly synergistic subsystems typically sit between canonical functional networks, and may serve an integrative role. We then use simulated annealing to find maximally synergistic subsystems, finding that such systems typically comprise ≈10 brain regions, recruited from multiple canonical brain systems. Though ubiquitous, highly synergistic subsystems are invisible when considering pairwise functional connectivity, suggesting that higher-order dependencies form a kind of shadow structure that has been unrecognized by established network-based analyses. We assert that higher-order interactions in the brain represent an under-explored space that, accessible with tools of multivariate information theory, may offer novel scientific insights.
MeSH term(s)	Humans ; Brain Mapping ; Information Theory ; Brain ; Cerebral Cortex ; Models, Neurological
Language	English
Publishing date	2023-04-24
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-04843-w
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Article ; Online: Author Correction: Multivariate information theory uncovers synergistic subsystems of the human cerebral cortex.

Varley, Thomas F / Pope, Maria / Faskowitz, Joshua / Sporns, Olaf

Communications biology

2023 Volume 6, Issue 1, Page(s) 615

Language	English
Publishing date	2023-06-07
Publishing country	England
Document type	Published Erratum
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-04984-y
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Article ; Online: Limited impact of diesel particle filters on road traffic emissions of ultrafine particles.

Damayanti, Seny / Harrison, Roy M / Pope, Francis / Beddows, David C S

Environment international

2023 Volume 174, Page(s) 107888

Abstract: Diesel engines are a major contributor to emissions of both Black Carbon (BC) and ultrafine particles. Analysis of data from the only roadside monitoring site in Europe with a continuous dataset for size-segregated particle number count (Marylebone Road, ...

Abstract	Diesel engines are a major contributor to emissions of both Black Carbon (BC) and ultrafine particles. Analysis of data from the only roadside monitoring site in Europe with a continuous dataset for size-segregated particle number count (Marylebone Road, London) from 2010 to 2021 reveals that the growing number of vehicles fitted with a Diesel Oxidation Catalyst (DOC) and Diesel Particle Filter (DPF) has been very effective in controlling the emissions of solid particles and hence BC, but that there has been little change in the liquid mode (<30 nm) particles, and that concentrations of ultrafine particles (<100 nm) still well exceed the threshold for "high" concentrations (>10
MeSH term(s)	Particulate Matter/analysis ; Air Pollutants/analysis ; Vehicle Emissions/analysis ; Environmental Monitoring ; London ; Particle Size
Chemical Substances	Particulate Matter ; Air Pollutants ; Vehicle Emissions
Language	English
Publishing date	2023-03-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2023.107888
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Article ; Online: Effects of short-term exposure to particulate matter air pollution on cognitive performance.

Shehab, M A / Pope, F D

Scientific reports

2019 Volume 9, Issue 1, Page(s) 8237

Abstract: This paper assesses the effect of short-term exposure to particulate matter (PM) air pollution on human cognitive performance via a double cross over experimental design. Two distinct experiments were performed, both of which exposed subjects to low and ... ...

Abstract	This paper assesses the effect of short-term exposure to particulate matter (PM) air pollution on human cognitive performance via a double cross over experimental design. Two distinct experiments were performed, both of which exposed subjects to low and high concentrations of PM. Firstly, subjects completed a series of cognitive tests after being exposed to low ambient indoor PM concentrations and elevated PM concentrations generated via candle burning, which is a well-known source of PM. Secondly, a different cohort underwent cognitive tests after being exposed to low ambient indoor PM concentrations and elevated ambient outdoor PM concentrations via commuting on or next to roads. Three tests were used to assess cognitive performance: Mini-Mental State Examination (MMSE), the Stroop Color and Word test, and Ruff 2 & 7 test. The results from the MMSE test showed a statistically robust decline in cognitive function after exposure to both the candle burning and outdoor commuting compared to ambient indoor conditions. The similarity in the results between the two experiments suggests that PM exposure is the cause of the short-term cognitive decline observed in both. The outdoor commuting experiment also showed a statistically significant short-term cognitive decline in automatic detection speed from the Ruff 2 and 7 selective attention test. The other cognitive tests, for both the candle and commuting experiments, showed no statistically significant difference between the high and low PM exposure conditions. The findings from this study are potentially far reaching; they suggest that elevated PM pollution levels significantly affect short term cognition. This implies average human cognitive ability will vary from city to city and country to country as a function of PM air pollution exposure.
MeSH term(s)	Adult ; Air Pollution/analysis ; Cognition/physiology ; Female ; Humans ; Male ; Mental Status and Dementia Tests ; Middle Aged ; Particle Size ; Particulate Matter/adverse effects ; Stroop Test ; Time Factors ; Young Adult
Chemical Substances	Particulate Matter
Language	English
Publishing date	2019-06-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-44561-0
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Article: Extracutaneous features and complications of the Ehlers-Danlos syndromes: A systematic review.

Doolan, Brent J / Lavallee, Mark E / Hausser, Ingrid / Schubart, Jane R / Michael Pope, F / Seneviratne, Suranjith L / Winship, Ingrid M / Burrows, Nigel P

Frontiers in medicine

2023 Volume 10, Page(s) 1053466

Abstract: Introduction: The Ehlers-Danlos syndromes (EDS) comprise a group of inherited connective tissue disorders presenting with variable fragility to skin, soft tissue, and certain internal organs, which can cause significant complications, particularly ... ...

Abstract	Introduction: The Ehlers-Danlos syndromes (EDS) comprise a group of inherited connective tissue disorders presenting with variable fragility to skin, soft tissue, and certain internal organs, which can cause significant complications, particularly arterial rupture, bowel perforation and joint difficulties. Currently, there are 14 proposed subtypes of EDS, with all except one subtype (hypermobile EDS) having an identified genetic etiology. An understanding of the extracutaneous features and complications within each subtype is key to maximizing clinical care and reducing the risk of further complications. Methods: A systematic review of EDS-related extracutaneous features and complications was undertaken. Results: We identified 839 EDS cases that met the inclusion criteria. We noted a high prevalence of joint hypermobility amongst kyphoscoliotic (39/39, 100%), spondylodysplastic (24/25, 96.0%), and hypermobile (153/160, 95.6%) EDS subtypes. The most common musculoskeletal complications were decreased bone density (39/43, 90.7%), joint pain (217/270, 80.4%), and hypotonia/weakness (79/140, 56.4%). Vascular EDS presented with cerebrovascular events (25/153, 16.3%), aneurysm (77/245, 31.4%), arterial dissection/rupture (89/250, 35.5%), and pneumothorax/hemothorax. Chronic pain was the most common miscellaneous complication, disproportionately affecting hypermobile EDS patients (139/157, 88.5%). Hypermobile EDS cases also presented with chronic fatigue (61/63, 96.8%) and gastrointestinal complications (57/63, 90.5%). Neuropsychiatric complications were noted in almost all subtypes. Discussion: Understanding the extracutaneous features and complications of each EDS subtype may help diagnose and treat EDS prior to the development of substantial comorbidities and/or additional complications. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022308151, identifier CRD42022308151.
Language	English
Publishing date	2023-01-23
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1053466
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Article ; Online: Quantification of T2-FLAIR Mismatch in Nonenhancing Diffuse Gliomas Using Digital Subtraction.

Cho, Nicholas S / Sanvito, Francesco / Le, Viên Lam / Oshima, Sonoko / Teraishi, Ashley / Yao, Jingwen / Telesca, Donatello / Raymond, Catalina / Pope, Whitney B / Nghiemphu, Phioanh L / Lai, Albert / Cloughesy, Timothy F / Salamon, Noriko / Ellingson, Benjamin M

AJNR. American journal of neuroradiology

2024 Volume 45, Issue 2, Page(s) 188–197

Abstract: Background and purpose: The T2-FLAIR mismatch sign on MR imaging is a highly specific imaging biomarker of isocitrate dehydrogenase (: Materials and methods: Two cohorts of treatment-naïve, nonenhancing gliomas with known : Results: Thresholds of ≥ ...

Abstract	Background and purpose: The T2-FLAIR mismatch sign on MR imaging is a highly specific imaging biomarker of isocitrate dehydrogenase ( Materials and methods: Two cohorts of treatment-naïve, nonenhancing gliomas with known Results: Thresholds of ≥42% T2-FLAIR mismatch volume classified Conclusions: T2-FLAIR digital subtraction maps may be a useful, automated tool to obtain objective segmentations of tumor subregions based on quantitative thresholds for classifying
MeSH term(s)	Humans ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Retrospective Studies ; Glioma/diagnostic imaging ; Glioma/pathology ; Magnetic Resonance Imaging/methods ; Astrocytoma ; Isocitrate Dehydrogenase/genetics ; Mutation
Chemical Substances	Isocitrate Dehydrogenase (EC 1.1.1.41)
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	603808-6
ISSN	1936-959X ; 0195-6108
ISSN (online)	1936-959X
ISSN	0195-6108
DOI	10.3174/ajnr.A8094
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Article ; Online: Navigating the factor zoo around the world: an institutional investor perspective.

Bartram, Söhnke M / Lohre, Harald / Pope, Peter F / Ranganathan, Ananthalakshmi

Journal of business economics

2021 Volume 91, Issue 5, Page(s) 655–703

Abstract: The literature on cross-sectional stock return predictability has documented over 450 factors. We take the perspective of an institutional investor and navigate this zoo of factors by focusing on the evidence relevant to the practicalities of factor- ... ...

Abstract	The literature on cross-sectional stock return predictability has documented over 450 factors. We take the perspective of an institutional investor and navigate this zoo of factors by focusing on the evidence relevant to the practicalities of factor-based investment strategies. Establishing a sound theoretical rationale is key to identifying "true" factors, and we emphasize the need to recognize data-mining concerns that may cast doubt on the relevance of many factors. From a practical investment perspective, much of the factor evidence documented by academics may be more apparent than real. The performance of many factors is dependent on the inclusion of small- and micro-cap stocks in academic studies, although such stocks would likely be excluded from the real investment universe due to illiquidity and transaction costs. Nevertheless, a parsimonious set of factors emerges in equities and other asset classes, including currencies, fixed income, and commodities. These factors can serve as meaningful ingredients to factor-based portfolio construction.
Language	English
Publishing date	2021-04-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2059561-X
ISSN	1861-8928 ; 0044-2372
ISSN (online)	1861-8928
ISSN	0044-2372
DOI	10.1007/s11573-021-01035-y
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Article ; Online: Medial Gastrocnemius Muscle Properties of Children With Cerebral Palsy After Different Tone Treatments: A Pilot Study.

Raymond-Pope, Christiana J / Hoffman, Daniel B / Bloxsom, Rachael M / Greising, Sarah M / Novacheck, Tom F / Boyer, Elizabeth R

American journal of physical medicine & rehabilitation

2023 Volume 102, Issue 10, Page(s) 873–878

Abstract: Objective: Spasticity in children with cerebral palsy can be managed by a spectrum of approaches, from conservative therapy, to temporary botulinum toxin A injections, to permanent transection of sensory nerves with a selective dorsal rhizotomy. This ... ...

Abstract	Objective: Spasticity in children with cerebral palsy can be managed by a spectrum of approaches, from conservative therapy, to temporary botulinum toxin A injections, to permanent transection of sensory nerves with a selective dorsal rhizotomy. This pilot study investigated whether these three tone management approaches are associated with histological and biochemical properties of the medial gastrocnemius. Design: A convenience sample of children with cerebral palsy undergoing gastrocnemius lengthening surgery was enrolled. Intraoperative biopsies were obtained from three individuals (one each: minimal tone treatment; frequent gastrocnemius botulinum toxin A injections; previous selective dorsal rhizotomy). All individuals had plantarflexor contractures, weakness, and impaired motor control before the biopsy. Results: Differences between participants were observed for muscle fiber cross-sectional area, fiber type, lipid content, satellite cell density, and centrally located nuclei. The most pronounced difference was the abundance of centrally located nuclei in the botulinum toxin A participants (52%) compared with the others (3-5%). Capillary density, collagen area and content, and muscle protein content were similar across participants. Conclusions: Several muscle properties seemed to deviate from reported norms, although age- and muscle-specific references are sparse. Prospective studies are necessary to distinguish cause and effect and to refine the risks and benefits of these treatment options.
MeSH term(s)	Child ; Humans ; Botulinum Toxins, Type A/therapeutic use ; Pilot Projects ; Neuromuscular Agents/therapeutic use ; Prospective Studies ; Cerebral Palsy/pathology ; Treatment Outcome ; Muscle, Skeletal/pathology ; Muscle Spasticity/drug therapy ; Muscle Spasticity/etiology
Chemical Substances	Botulinum Toxins, Type A (EC 3.4.24.69) ; Neuromuscular Agents
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	219390-5
ISSN	1537-7385 ; 0002-9491 ; 0894-9115
ISSN (online)	1537-7385
ISSN	0002-9491 ; 0894-9115
DOI	10.1097/PHM.0000000000002235
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