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Article: Electronic informed consent information for residual newborn specimen research: findings from focus groups with diverse populations.

Frost, Caren J / Johnson, Erin P / Witte, Brieanne / Stark, Louisa / Botkin, Jeff / Rothwell, Erin

2021 Volume 12, Issue 1, Page(s) 199–203

Abstract: We developed a video and an app for obtaining consent about allowing newborn blood spots (NBS) to be used as biospecimen resources for biobanking. Newborn screening programs test for treatable diseases and leave residual biospecimens that can be used in ... ...

Abstract	We developed a video and an app for obtaining consent about allowing newborn blood spots (NBS) to be used as biospecimen resources for biobanking. Newborn screening programs test for treatable diseases and leave residual biospecimens that can be used in future research activities. We conducted focus groups and interviews with three diverse communities to determine (a) how well the consent tools worked and (b) participant familiarity with NBS. Participants preferred the video and noted that they were unaware that NBS could be used for future research. Providing information about how biospecimens could be used was a key issue.
Language	English
Publishing date	2021-01-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2543127-4
ISSN	1868-6001 ; 1868-310X
ISSN (online)	1868-6001
ISSN	1868-310X
DOI	10.1007/s12687-020-00496-y
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Article ; Online: A scoping review of fall hazards in the homes of older adults and development of a framework for assessment and intervention.

Keglovits, Marian / Clemson, Lindy / Hu, Yi-Ling / Nguyen, An / Neff, Anna J / Mandelbaum, Caren / Hudson, Margaret / Williams, Rebecca / Silianoff, Tara / Stark, Susan

Australian occupational therapy journal

2020 Volume 67, Issue 5, Page(s) 470–478

Abstract: Introduction: Comprehensive evaluation and intervention provided by occupational therapists is effective in reducing the presence of fall hazards in the homes of older adults. The purpose of this study was to document known environmental hazards and to ... ...

Abstract	Introduction: Comprehensive evaluation and intervention provided by occupational therapists is effective in reducing the presence of fall hazards in the homes of older adults. The purpose of this study was to document known environmental hazards and to update a previous content analysis. A secondary goal reviewed a framework for evaluation and practice. Methods: A comprehensive scoping review of published academic articles was performed from 1996 to 2019 to answer: What environmental hazards have been associated with falls in the homes of community-dwelling older adults? Data was extracted in a standardised critical appraisal worksheet and content analysis was conducted. A review of a conceptual framework for assessment and intervention was conducted by international experts (n = 6) in face-to-face interviews. Results: Fourteen studies met the inclusion criteria for the scoping study. The studies reported 17 in-home environmental hazards: throw rugs/carpets, clutter, cords/wires, poorly placed light switches, items placed too low, items placed too high, no grab bars, toilet seats too low, uneven floor surfaces, slippery/wet surfaces, snowy/icy surfaces, backless/unsupportive shoes, unsteady stairs, inadequate lighting, inadequate heating/cooling, step stools without railings, and pets. Conclusion: A comprehensive list of specific fall hazards in and around the homes of older adults and a guiding framework offers occupational therapists an evidence-based foundation for fall prevention efforts.
MeSH term(s)	Accidental Falls/prevention & control ; Aged ; Humans ; Independent Living ; Occupational Therapy/organization & administration ; Risk Factors
Language	English
Publishing date	2020-07-09
Publishing country	Australia
Document type	Journal Article ; Systematic Review
ZDB-ID	604554-6
ISSN	1440-1630 ; 0045-0766
ISSN (online)	1440-1630
ISSN	0045-0766
DOI	10.1111/1440-1630.12682
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Article: Sensomics-Assisted Aroma Decoding of Pea Protein Isolates (

Utz, Florian / Spaccasassi, Andrea / Kreissl, Johanna / Stark, Timo D / Tanger, Caren / Kulozik, Ulrich / Hofmann, Thomas / Dawid, Corinna

Foods (Basel, Switzerland)

2022 Volume 11, Issue 3

Abstract: The aroma of pea protein ( ...

Abstract	The aroma of pea protein (
Language	English
Publishing date	2022-01-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods11030412
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Article ; Online: Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies.

Stark, Caren J / Atreya, C D

Virology journal

2005 Volume 2, Page(s) 35

Abstract: In the aftermath of the SARS epidemic, there has been significant progress in understanding the molecular and cell biology of SARS-CoV. Some of the milestones are the availability of viral genome sequence, identification of the viral receptor, ... ...

Abstract	In the aftermath of the SARS epidemic, there has been significant progress in understanding the molecular and cell biology of SARS-CoV. Some of the milestones are the availability of viral genome sequence, identification of the viral receptor, development of an infectious cDNA clone, and the identification of viral antigens that elicit neutralizing antibodies. However, there is still a large gap in our understanding of how SARS-CoV interacts with the host cell and the rapidly changing viral genome adds another variable to this equation. Now the SARS-CoV story has entered a new phase, a search for preventive strategies and a cure for the disease. This review highlights the progress made in identifying molecular aspects of SARS-CoV biology that is relevant in developing disease prevention strategies. Authors conclude that development of successful SARS-CoV vaccines and antivirals depends on the progress we make in these areas in the immediate future.
MeSH term(s)	Antiviral Agents/therapeutic use ; SARS Virus/genetics ; SARS Virus/physiology ; Severe Acute Respiratory Syndrome/drug therapy ; Severe Acute Respiratory Syndrome/prevention & control ; Severe Acute Respiratory Syndrome/virology ; Viral Vaccines/immunology
Chemical Substances	Antiviral Agents ; Viral Vaccines
Keywords	covid19
Language	English
Publishing date	2005-04-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ISSN	1743-422X
ISSN (online)	1743-422X
DOI	10.1186/1743-422X-2-35
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Article ; Online: Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies

Atreya CD / Stark Caren J

Virology Journal, Vol 2, Iss 1, p

2005 Volume 35

Abstract: Abstract In the aftermath of the SARS epidemic, there has been significant progress in understanding the molecular and cell biology of SARS-CoV. Some of the milestones are the availability of viral genome sequence, identification of the viral receptor, ... ...

Abstract	Abstract In the aftermath of the SARS epidemic, there has been significant progress in understanding the molecular and cell biology of SARS-CoV. Some of the milestones are the availability of viral genome sequence, identification of the viral receptor, development of an infectious cDNA clone, and the identification of viral antigens that elicit neutralizing antibodies. However, there is still a large gap in our understanding of how SARS-CoV interacts with the host cell and the rapidly changing viral genome adds another variable to this equation. Now the SARS-CoV story has entered a new phase, a search for preventive strategies and a cure for the disease. This review highlights the progress made in identifying molecular aspects of SARS-CoV biology that is relevant in developing disease prevention strategies. Authors conclude that development of successful SARS-CoV vaccines and antivirals depends on the progress we make in these areas in the immediate future.
Keywords	Antivirals ; Cell biology ; Molecular virology ; SARS-CoV ; Vaccines ; Infectious and parasitic diseases ; RC109-216
Language	English
Publishing date	2005-04-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Discovery of Small-Molecule Antibiotics against a Unique tRNA-Mediated Regulation of Transcription in Gram-Positive Bacteria.

Frohlich, Kyla M / Weintraub, Spencer F / Bell, Janeen T / Todd, Gabrielle C / Väre, Ville Y P / Schneider, Ryan / Kloos, Zachary A / Tabe, Ebot S / Cantara, William A / Stark, Caren J / Onwuanaibe, Urenna J / Duffy, Bryan C / Basanta-Sanchez, Maria / Kitchen, Douglas B / McDonough, Kathleen A / Agris, Paul F

ChemMedChem

2019 Volume 14, Issue 7, Page(s) 758–769

Abstract: The emergence of multidrug-resistant bacteria necessitates the identification of unique targets of intervention and compounds that inhibit their function. Gram-positive bacteria use a well-conserved tRNA-responsive transcriptional regulatory element in ... ...

Abstract	The emergence of multidrug-resistant bacteria necessitates the identification of unique targets of intervention and compounds that inhibit their function. Gram-positive bacteria use a well-conserved tRNA-responsive transcriptional regulatory element in mRNAs, known as the T-box, to regulate the transcription of multiple operons that control amino acid metabolism. T-box regulatory elements are found only in the 5'-untranslated region (UTR) of mRNAs of Gram-positive bacteria, not Gram-negative bacteria or the human host. Using the structure of the 5'UTR sequence of the Bacillus subtilis tyrosyl-tRNA synthetase mRNA T-box as a model, in silico docking of 305 000 small compounds initially yielded 700 as potential binders that could inhibit the binding of the tRNA ligand. A single family of compounds inhibited the growth of Gram-positive bacteria, but not Gram-negative bacteria, including drug-resistant clinical isolates at minimum inhibitory concentrations (MIC 16-64 μg mL
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Drug Discovery ; Gene Expression Regulation, Bacterial/drug effects ; Gram-Positive Bacteria/drug effects ; Gram-Positive Bacteria/genetics ; Magnetic Resonance Spectroscopy ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; RNA, Messenger/genetics ; RNA, Transfer/metabolism ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Structure-Activity Relationship ; Transcription, Genetic/drug effects
Chemical Substances	Anti-Bacterial Agents ; RNA, Messenger ; Small Molecule Libraries ; RNA, Transfer (9014-25-9)
Language	English
Publishing date	2019-03-01
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2218496-X
ISSN	1860-7187 ; 1860-7179
ISSN (online)	1860-7187
ISSN	1860-7179
DOI	10.1002/cmdc.201800744
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Article ; Online: Sensomics-Assisted Flavor Decoding of Dairy Model Systems and Flavor Reconstitution Experiments.

Utz, Florian / Kreissl, Johanna / Stark, Timo D / Schmid, Christian / Tanger, Caren / Kulozik, Ulrich / Hofmann, Thomas / Dawid, Corinna

Journal of agricultural and food chemistry

2021 Volume 69, Issue 23, Page(s) 6588–6600

Abstract: The whole sensometabolome of a typical dairy milk dessert was decoded to potentially serve as a blueprint for further flavor optimization steps of functional fat-reduced food. By applying the sensomics approach, a wide range of different dairy volatiles, ...

Abstract	The whole sensometabolome of a typical dairy milk dessert was decoded to potentially serve as a blueprint for further flavor optimization steps of functional fat-reduced food. By applying the sensomics approach, a wide range of different dairy volatiles, semi and nonvolatiles, were analyzed by ultrahigh-performance liquid chromatography tandem mass spectrometry with or without derivatization presteps. While for volatile sulfur compounds with low odor thresholds, headspace solid-phase microextraction gas chromatography was established, abundant carbohydrates and organic acids were quantified by quantitative
MeSH term(s)	Flavoring Agents ; Gas Chromatography-Mass Spectrometry ; Odorants/analysis ; Solid Phase Microextraction ; Taste ; Volatile Organic Compounds/analysis
Chemical Substances	Flavoring Agents ; Volatile Organic Compounds
Language	English
Publishing date	2021-06-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.1c02165
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Article ; Online: Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies

Stark, Caren J. / Atreya, CD

Virology journal, 2(1):35

2005

Abstract	In the aftermath of the SARS epidemic, there has been significant progress in understanding the molecular and cell biology of SARS-CoV. Some of the milestones are the availability of viral genome sequence, identification of the viral receptor, development of an infectious cDNA clone, and the identification of viral antigens that elicit neutralizing antibodies. However, there is still a large gap in our understanding of how SARS-CoV interacts with the host cell and the rapidly changing viral genome adds another variable to this equation. Now the SARS-CoV story has entered a new phase, a search for preventive strategies and a cure for the disease. This review highlights the progress made in identifying molecular aspects of SARS-CoV biology that is relevant in developing disease prevention strategies. Authors conclude that development of successful SARS-CoV vaccines and antivirals depends on the progress we make in these areas in the immediate future.
Keywords	COVID-19 ; Antivirals ; Molecular virology ; SARS-CoV ; Vaccines ; Cell biology ; covid19
Language	English
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Transplant-Free Survival and Interventions at 6 Years in the SVR Trial.

Circulation

2018 Volume 137, Issue 21, Page(s) 2246–2253

Abstract: Background: In the SVR trial (Single Ventricle Reconstruction), 1-year transplant-free survival was better for the Norwood procedure with right ventricle-to-pulmonary artery shunt (RVPAS) compared with a modified Blalock-Taussig shunt in patients with ... ...

Abstract	Background: In the SVR trial (Single Ventricle Reconstruction), 1-year transplant-free survival was better for the Norwood procedure with right ventricle-to-pulmonary artery shunt (RVPAS) compared with a modified Blalock-Taussig shunt in patients with hypoplastic left heart and related syndromes. At 6 years, we compared transplant-free survival and other outcomes between the groups. Methods: Medical history was collected annually using medical record review, telephone interviews, and the death index. The cohort included 549 patients randomized and treated in the SVR trial. Results: Transplant-free survival for the RVPAS versus modified Blalock-Taussig shunt groups did not differ at 6 years (64% versus 59%, Conclusions: By 6 years, the hazards of death or transplant and catheter interventions were not different between the RVPAS versus modified Blalock-Taussig shunt groups. Children assigned to the RVPAS group had 5% higher transplant-free survival, but the difference did not reach statistical significance, and they required more catheter interventions. Both treatment groups have accrued important complications. Clinical trial registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT00115934.
MeSH term(s)	Blalock-Taussig Procedure/adverse effects ; Cardiac Catheterization/statistics & numerical data ; Child, Preschool ; Disease-Free Survival ; Follow-Up Studies ; Fontan Procedure ; Heart Transplantation ; Heart Ventricles/surgery ; Humans ; Hypoplastic Left Heart Syndrome/mortality ; Hypoplastic Left Heart Syndrome/surgery ; Infant ; Interviews as Topic ; Kaplan-Meier Estimate ; Norwood Procedures ; Proportional Hazards Models ; Pulmonary Artery/surgery ; Seizures/etiology ; Thrombosis/etiology
Language	English
Publishing date	2018-02-01
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.117.029375
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Article ; Online: Child development education in the Neonatal Unit: Understanding parent developmental literacy needs, priorities and preferences.

Bater, Megan L / Gould, Jacqueline F / Collins, Carmel T / Anderson, Peter J / Stark, Michael J

Patient education and counseling

2023 Volume 119, Page(s) 108058

Abstract: Objective: To describe child development knowledge needs, priorities, and preferences for education to enhance developmental literacy among parents with children admitted to the neonatal unit (NNU).: Methods: Two separate cohorts completed a survey; ... ...

Abstract	Objective: To describe child development knowledge needs, priorities, and preferences for education to enhance developmental literacy among parents with children admitted to the neonatal unit (NNU). Methods: Two separate cohorts completed a survey; 1) Parents with children graduated from Australian NNUs (n = 316); 2) Parents with infants' inpatient at two South Australian NNUs (n = 209). Results: Parents considered it extremely important to understand child development (Graduates: 80%; Inpatients: 71%). Inpatient parents reported lower child development knowledge. Almost half (42%) of graduate parents described the child development education provided by neonatal staff as poor or inadequate. There was consistency in preferences for developmental literacy education provision. Parents desired education to commence during NNU and continue post discharge. Priorities included content specific to preterm birth and how to support child development over the first two years of life. Individualised education by a Neonatal Nurse/Midwife was most preferred. Conclusion: Mothers and fathers value guidance to support their child's development during NNU admission and early childhood. Our study highlights the importance of improved early developmental literacy education for parents with children admitted to the neonatal unit. Practice implications: Our findings can be used to inform the creation of future educational resources targeting improved parent developmental literacy.
MeSH term(s)	Infant ; Female ; Child ; Infant, Newborn ; Humans ; Child, Preschool ; Child Development ; Literacy ; Aftercare ; Intensive Care Units, Neonatal ; Australia ; Patient Discharge ; Premature Birth ; Parents
Language	English
Publishing date	2023-11-10
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	605590-4
ISSN	1873-5134 ; 0738-3991
ISSN (online)	1873-5134
ISSN	0738-3991
DOI	10.1016/j.pec.2023.108058
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