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Article ; Online: Cathepsin W restrains peripheral regulatory T cells for mucosal immune quiescence.

Li, Jian / Chen, Zuojia / Kim, Girak / Luo, Jialie / Hori, Shohei / Wu, Chuan

2023 Volume 9, Issue 28, Page(s) eadf3924

Abstract: Peripheral regulatory T ( ... ...

Abstract	Peripheral regulatory T (pT
MeSH term(s)	Animals ; T-Lymphocytes, Regulatory ; Cathepsin W ; Cell Differentiation ; Cell Division ; Cell Lineage
Chemical Substances	Cathepsin W (EC 3.4.22.-)
Language	English
Publishing date	2023-07-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adf3924
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Article ; Online: Lipids regulate peripheral serotonin release via gut CD1d.

Luo, Jialie / Chen, Zuojia / Castellano, David / Bao, Bin / Han, Wenyan / Li, Jian / Kim, Girak / An, Dingding / Lu, Wei / Wu, Chuan

Immunity

2023 Volume 56, Issue 7, Page(s) 1533–1547.e7

Abstract: The crosstalk between the immune and neuroendocrine systems is critical for intestinal homeostasis and gut-brain communications. However, it remains unclear how immune cells participate in gut sensation of hormones and neurotransmitters release in ... ...

Abstract	The crosstalk between the immune and neuroendocrine systems is critical for intestinal homeostasis and gut-brain communications. However, it remains unclear how immune cells participate in gut sensation of hormones and neurotransmitters release in response to environmental cues, such as self-lipids and microbial lipids. We show here that lipid-mediated engagement of invariant natural killer T (iNKT) cells with enterochromaffin (EC) cells, a subset of intestinal epithelial cells, promoted peripheral serotonin (5-HT) release via a CD1d-dependent manner, regulating gut motility and hemostasis. We also demonstrated that inhibitory sphingolipids from symbiotic microbe Bacteroides fragilis represses 5-HT release. Mechanistically, CD1d ligation on EC cells transduced a signal and restrained potassium conductance through activation of protein tyrosine kinase Pyk2, leading to calcium influx and 5-HT secretion. Together, our data reveal that by engaging with iNKT cells, gut chemosensory cells selectively perceive lipid antigens via CD1d to control 5-HT release, modulating intestinal and systemic homeostasis.
MeSH term(s)	Serotonin/metabolism ; Lipids ; Antigens, CD1d/metabolism ; Natural Killer T-Cells
Chemical Substances	Serotonin (333DO1RDJY) ; Lipids ; Antigens, CD1d
Language	English
Publishing date	2023-06-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2023.06.001
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

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Article: Modification of Neurogenic Colonic Motor Behaviours by Chemogenetic Ablation of Calretinin Neurons.

Feng, Jing / Hibberd, Tim J / Luo, Jialie / Yang, Pu / Xie, Zili / Travis, Lee / Spencer, Nick J / Hu, Hongzhen

Frontiers in cellular neuroscience

2022 Volume 16, Page(s) 799717

Abstract: How the enteric nervous system determines the pacing and propagation direction of neurogenic contractions along the colon remains largely unknown. We used a chemogenetic strategy to ablate enteric neurons expressing calretinin (CAL). Mice expressing ... ...

Abstract	How the enteric nervous system determines the pacing and propagation direction of neurogenic contractions along the colon remains largely unknown. We used a chemogenetic strategy to ablate enteric neurons expressing calretinin (CAL). Mice expressing human diphtheria toxin receptor (DTR) in CAL neurons were generated by crossing
Language	English
Publishing date	2022-03-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2022.799717
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Article ; Online: Gut-liver axis calibrates intestinal stem cell fitness.

Kim, Girak / Chen, Zuojia / Li, Jian / Luo, Jialie / Castro-Martinez, Felipe / Wisniewski, Jan / Cui, Kairong / Wang, Yan / Sun, Jialei / Ren, Xiaobai / Crawford, Susan E / Becerra, S Patricia / Zhu, Jimin / Liu, Taotao / Wang, Sui / Zhao, Keji / Wu, Chuan

Cell

2024 Volume 187, Issue 4, Page(s) 914–930.e20

Abstract: The gut and liver are recognized to mutually communicate through the biliary tract, portal vein, and systemic circulation. However, it remains unclear how this gut-liver axis regulates intestinal physiology. Through hepatectomy and transcriptomic and ... ...

Abstract	The gut and liver are recognized to mutually communicate through the biliary tract, portal vein, and systemic circulation. However, it remains unclear how this gut-liver axis regulates intestinal physiology. Through hepatectomy and transcriptomic and proteomic profiling, we identified pigment epithelium-derived factor (PEDF), a liver-derived soluble Wnt inhibitor, which restrains intestinal stem cell (ISC) hyperproliferation to maintain gut homeostasis by suppressing the Wnt/β-catenin signaling pathway. Furthermore, we found that microbial danger signals resulting from intestinal inflammation can be sensed by the liver, leading to the repression of PEDF production through peroxisome proliferator-activated receptor-α (PPARα). This repression liberates ISC proliferation to accelerate tissue repair in the gut. Additionally, treating mice with fenofibrate, a clinical PPARα agonist used for hypolipidemia, enhances colitis susceptibility due to PEDF activity. Therefore, we have identified a distinct role for PEDF in calibrating ISC expansion for intestinal homeostasis through reciprocal interactions between the gut and liver.
MeSH term(s)	Animals ; Mice ; Cell Proliferation ; Liver/metabolism ; PPAR alpha/metabolism ; Proteomics ; Stem Cells/metabolism ; Wnt Signaling Pathway ; Intestines/cytology ; Intestines/metabolism
Chemical Substances	PPAR alpha
Language	English
Publishing date	2024-01-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2024.01.001
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Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 58: Show issues

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Article ; Online: Intestinal IL-33 promotes platelet activity for neutrophil recruitment during acute inflammation.

Chen, Zuojia / Luo, Jialie / Li, Jian / Kim, Girak / Stewart, Andy / Huang, Yuefeng / Wu, Chuan

Blood

2021 Volume 139, Issue 12, Page(s) 1878–1891

Abstract: Peripheral serotonin (5-HT) is mainly generated from the gastrointestinal tract and taken up and stored by platelets in the circulation. Although the gut is recognized as a major immune organ, how intestinal local immune responses control whole-body ... ...

Abstract	Peripheral serotonin (5-HT) is mainly generated from the gastrointestinal tract and taken up and stored by platelets in the circulation. Although the gut is recognized as a major immune organ, how intestinal local immune responses control whole-body physiology via 5-HT remains unclear. Here, we show that intestinal inflammation enhances systemic platelet activation and blood coagulation. Intestinal epithelium damage induces elevated levels of the alarm cytokine interleukin-33 (IL-33), leading to platelet activation via promotion of gut-derived 5-HT release. More importantly, we found that loss of intestinal epithelial-derived IL-33 lowers peripheral 5-HT levels, resulting in compromised platelet activation and hemostasis. Functionally, intestinal IL-33 contributes to the recruitment of neutrophils to sites of acute inflammation by enhancing platelet activities. Genetic deletion of intestinal IL-33 or neutralization of peripheral IL-33 protects animals from lipopolysaccharide endotoxic shock through attenuated neutrophil extravasation. Therefore, our data establish a distinct role of intestinal IL-33 in activating platelets by promoting 5-HT release for systemic physiology and inflammation.
MeSH term(s)	Animals ; Inflammation ; Interleukin-33 ; Neutrophil Infiltration ; Neutrophils ; Serotonin
Chemical Substances	Interleukin-33 ; Serotonin (333DO1RDJY)
Language	English
Publishing date	2021-12-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2021013474
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Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 364: Show issues

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Article ; Online: Enhancing Sketch-Based Image Retrieval by CNN Semantic Re-ranking.

Wang, Luo / Qian, Xueming / Zhang, Yuting / Shen, Jialie / Cao, Xiaochun

IEEE transactions on cybernetics

2019 Volume 50, Issue 7, Page(s) 3330–3342

Abstract: This paper introduces a convolutional neural network (CNN) semantic re-ranking system to enhance the performance of sketch-based image retrieval (SBIR). Distinguished from the existing approaches, the proposed system can leverage category information ... ...

Abstract	This paper introduces a convolutional neural network (CNN) semantic re-ranking system to enhance the performance of sketch-based image retrieval (SBIR). Distinguished from the existing approaches, the proposed system can leverage category information brought by CNNs to support effective similarity measurement between the images. To achieve effective classification of query sketches and high-quality initial retrieval results, one CNN model is trained for classification of sketches, another for that of natural images. Through training dual CNN models, the semantic information of both the sketches and natural images is captured by deep learning. In order to measure the category similarity between images, a category similarity measurement method is proposed. Category information is then used for re-ranking. Re-ranking operation first infers the retrieval category of the query sketch and then uses the category similarity measurement to measure the category similarity between the query sketch and each initial retrieval result. Finally, the initial retrieval results are re-ranked. The experiments on different types of SBIR datasets demonstrate the effectiveness of the proposed re-ranking method. Comparisons with other re-ranking algorithms are also given to show the proposed method's superiority. Further, compared to the baseline systems, the proposed re-ranking approach achieves significantly higher precision in the top ten different SBIR methods and datasets.
Language	English
Publishing date	2019-03-15
Publishing country	United States
Document type	Journal Article
ISSN	2168-2275
ISSN (online)	2168-2275
DOI	10.1109/TCYB.2019.2894498
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Article ; Online: Inhalation anaesthetic isoflurane inhibits the muscarinic cation current and carbachol-induced gastrointestinal smooth muscle contractions.

Dryn, Dariia / Luo, Jialie / Melnyk, Mariia / Zholos, Alexander / Hu, Hongzhen

European journal of pharmacology

2018 Volume 820, Page(s) 39–44

Abstract: Gastrointestinal tract motility may be demoted significantly after surgery operations at least in part due to anaesthetic agents, but there is no comprehensive explanation of the molecular mechanism(s) of such adverse effects. Anesthetics are known to ... ...

Abstract	Gastrointestinal tract motility may be demoted significantly after surgery operations at least in part due to anaesthetic agents, but there is no comprehensive explanation of the molecular mechanism(s) of such adverse effects. Anesthetics are known to interact with various receptors and ion channels including several subtypes of transient receptor potential (TRP) channels. Two members of the canonical subfamily of TRP channels (TRPC), TRPC4 and TRPC6 are Ca
MeSH term(s)	Anesthetics, Inhalation/pharmacology ; Animals ; Calcium/metabolism ; Carbachol/antagonists & inhibitors ; Carbachol/pharmacology ; Electrophysiological Phenomena/drug effects ; Intestines/drug effects ; Intestines/physiology ; Intracellular Space/drug effects ; Intracellular Space/metabolism ; Isoflurane/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Muscle Contraction/drug effects ; Muscle, Smooth/cytology ; Muscle, Smooth/drug effects ; Muscle, Smooth/physiology ; TRPC Cation Channels/metabolism ; TRPC6 Cation Channel/metabolism
Chemical Substances	Anesthetics, Inhalation ; TRPC Cation Channels ; TRPC4 ion channel ; TRPC6 Cation Channel ; Carbachol (8Y164V895Y) ; Isoflurane (CYS9AKD70P) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2018-02-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2017.11.044
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Zs.A 522: Show issues

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Article: Thermally activated TRPV3 channels.

Luo, Jialie / Hu, Hongzhen

Current topics in membranes

2014 Volume 74, Page(s) 325–364

Abstract: TRPV3 is a temperature-sensitive transient receptor potential (TRP) ion channel. The TRPV3 protein functions as a Ca(2+)-permeable nonselective cation channel with six transmembrane domains forming a tetrameric complex. TRPV3 is known to be activated by ... ...

Abstract	TRPV3 is a temperature-sensitive transient receptor potential (TRP) ion channel. The TRPV3 protein functions as a Ca(2+)-permeable nonselective cation channel with six transmembrane domains forming a tetrameric complex. TRPV3 is known to be activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. Its function is regulated by a variety of physiological factors including extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. TRPV3 shows a broad expression pattern in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice exhibit abnormal hair morphogenesis and compromised skin barrier function. Recent advances suggest that TRPV3 may play critical roles in inflammatory skin disorders, itch, and pain sensation. Thus, identification of selective TRPV3 activators and inhibitors could potentially lead to beneficial pharmacological interventions in several diseases. The intent of this review is to summarize our current knowledge of the tissue expression, structure, function, and mechanisms of activation of TRPV3.
MeSH term(s)	Animals ; Gene Expression Regulation ; Humans ; TRPV Cation Channels/chemistry ; TRPV Cation Channels/metabolism ; Temperature ; Thermosensing
Chemical Substances	TRPV Cation Channels
Language	English
Publishing date	2014-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ISSN	1063-5823
ISSN	1063-5823
DOI	10.1016/B978-0-12-800181-3.00012-9
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Article ; Online: Transient stimulation of TRPV4-expressing keratinocytes promotes hair follicle regeneration in mice.

Yang, Pu / Lu, Ping / Luo, Jialie / Du, Lixia / Feng, Jing / Cai, Tao / Yuan, Yi / Cheng, Hunter / Hu, Hongzhen

British journal of pharmacology

2020 Volume 177, Issue 18, Page(s) 4181–4192

Abstract: Background and purpose: Hair follicle telogen to anagen transition results in a break in cellular quiescence of the hair follicle stem cells, which subsequently promotes hair follicle regeneration. Many critical molecules and signalling pathways are ... ...

Abstract	Background and purpose: Hair follicle telogen to anagen transition results in a break in cellular quiescence of the hair follicle stem cells, which subsequently promotes hair follicle regeneration. Many critical molecules and signalling pathways are involved in hair follicle cycle progression. Transient receptor potential vanilloid 4 (TRPV4) is a polymodal sensory transducer that regulates various cutaneous functions under both normal and disease conditions. However, the role of TRPV4 in hair follicle regeneration in vivo remains incompletely understood. Experimental approach: Using adult C57BL/6J mice, keratinocyte (K14 Key results: Here, we show that a single intradermal injection of GSK1016790A is sufficient to induce telogen to anagen transition and hair follicle regeneration in mice by increasing the expression of the anagen-promoting growth factors and down-regulating the expression of growth factors that inhibit anagen. The action of GSK1016790A relies largely on the function of TRPV4 in skin and involves activation of downstream ERK signalling. Conclusion and implications: Our results suggest that transient chemical activation of TRPV4 in the skin induces hair follicle regeneration in mice, which might provide an effective therapeutic strategy for the treatment of hair loss and alopecia.
MeSH term(s)	Alopecia/drug therapy ; Animals ; Female ; Hair Follicle ; Keratinocytes ; Male ; Mice ; Mice, Inbred C57BL ; Regeneration ; TRPV Cation Channels/genetics
Chemical Substances	TRPV Cation Channels ; Trpv4 protein, mouse
Language	English
Publishing date	2020-07-17
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.15161
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Uf I Zs.146: Show issues

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Article ; Online: Piezo2 channel-Merkel cell signaling modulates the conversion of touch to itch.

Feng, Jing / Luo, Jialie / Yang, Pu / Du, Junhui / Kim, Brian S / Hu, Hongzhen

Science (New York, N.Y.)

2018 Volume 360, Issue 6388, Page(s) 530–533

Abstract: The somatosensory system relays many signals ranging from light touch to pain and itch. Touch is critical to spatial awareness and communication. However, in disease states, innocuous mechanical stimuli can provoke pathologic sensations such as ... ...

Abstract	The somatosensory system relays many signals ranging from light touch to pain and itch. Touch is critical to spatial awareness and communication. However, in disease states, innocuous mechanical stimuli can provoke pathologic sensations such as mechanical itch (alloknesis). The molecular and cellular mechanisms that govern this conversion remain unknown. We found that in mice, alloknesis in aging and dry skin is associated with a loss of Merkel cells, the touch receptors in the skin. Targeted genetic deletion of Merkel cells and associated mechanosensitive Piezo2 channels in the skin was sufficient to produce alloknesis. Chemogenetic activation of Merkel cells protected against alloknesis in dry skin. This study reveals a previously unknown function of the cutaneous touch receptors and may provide insight into the development of alloknesis.
MeSH term(s)	Animals ; Gene Deletion ; Ion Channels/genetics ; Ion Channels/physiology ; Mechanotransduction, Cellular/genetics ; Mechanotransduction, Cellular/physiology ; Merkel Cells/drug effects ; Merkel Cells/physiology ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Pruritus/genetics ; Pruritus/physiopathology ; Skin/innervation ; Touch
Chemical Substances	Ion Channels ; Piezo2 protein, mouse
Language	English
Publishing date	2018-05-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.aar5703
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Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 77: Show issues

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