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  1. Article: Prevalence and Characteristics of Plasmid-Encoded Serine Protease EspP in Clinical Shiga Toxin-Producing

    Wang, Lei / Hua, Ying / Bai, Xiangning / Zhang, Ji / Mernelius, Sara / Chromek, Milan / Frykman, Anne / Hansson, Sverker / Matussek, Andreas

    Microorganisms

    2024  Volume 12, Issue 3

    Abstract: Shiga toxin- ... ...

    Abstract Shiga toxin-producing
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12030589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Genomic Characterization of

    Yang, Xi / Liu, Qian / Sun, Hui / Xiong, Yanwen / Matussek, Andreas / Bai, Xiangning

    Microorganisms

    2022  Volume 10, Issue 6

    Abstract: Shiga toxin- ... ...

    Abstract Shiga toxin-producing
    Language English
    Publishing date 2022-06-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10061245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Genetic Diversity and Expression of Intimin in

    Liu, Qian / Yang, Xi / Sun, Hui / Wang, Hua / Sui, Xinxia / Zhang, Peihua / Bai, Xiangning / Xiong, Yanwen

    Microorganisms

    2023  Volume 11, Issue 12

    Abstract: Escherichia ... ...

    Abstract Escherichia albertii
    Language English
    Publishing date 2023-11-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11122843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Genetic Characterization of Intimin Gene (

    Wang, Lei / Bai, Xiangning / Ylinen, Elisa / Zhang, Ji / Saxén, Harri / Matussek, Andreas

    Toxins

    2023  Volume 15, Issue 12

    Abstract: Shiga toxin (Stx)- ... ...

    Abstract Shiga toxin (Stx)-producing
    MeSH term(s) Adolescent ; Child ; Humans ; Adhesins, Bacterial/genetics ; Escherichia coli Infections/epidemiology ; Escherichia coli O157/genetics ; Escherichia coli Proteins/genetics ; Finland/epidemiology ; Hemolytic-Uremic Syndrome/epidemiology ; Hemolytic-Uremic Syndrome/genetics ; Serotyping ; Shiga-Toxigenic Escherichia coli/genetics ; Scandinavians and Nordic People
    Chemical Substances Adhesins, Bacterial ; eaeA protein, E coli (147094-99-3) ; Escherichia coli Proteins
    Language English
    Publishing date 2023-11-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins15120669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Characterization of the novel temperate Escherichia coli phage phiStx2k.

    Yang, Xi / Sui, Xinxia / Liu, Qian / Wang, Hua / Sun, Hui / Bai, Xiangning / Xiong, Yanwen

    Archives of virology

    2023  Volume 169, Issue 1, Page(s) 5

    Abstract: A novel temperate phage, phiStx2k, was induced from a clinical Escherichia coli isolate producing Shiga toxin (Stx) 2k. The phage particles have an icosahedral head (50 nm in diameter) and a long non-contractile tail (149 nm long). The phage genome ... ...

    Abstract A novel temperate phage, phiStx2k, was induced from a clinical Escherichia coli isolate producing Shiga toxin (Stx) 2k. The phage particles have an icosahedral head (50 nm in diameter) and a long non-contractile tail (149 nm long). The phage genome consists of 46,647 bp of double-stranded DNA with an average G + C content of 51%. Genome sequence comparisons suggested that phiStx2k represents a new genus in the class Caudoviricetes. phiStx2k was capable of converting non-Stx-producing E. coli strains to Stx producers. These results expand our knowledge on the characteristics of Stx phages and highlight the potential risks of the emergence of Stx-producing strains or novel pathogens via horizontal gene transfer.
    MeSH term(s) Escherichia coli/genetics ; Coliphages/genetics ; Bacteriophages/genetics
    Language English
    Publishing date 2023-12-11
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-023-05941-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.110: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Genetic Characterization of Intimin Gene ( eae ) in Clinical Shiga Toxin-Producing Escherichia coli Strains from Pediatric Patients in Finland

    Lei Wang / Xiangning Bai / Elisa Ylinen / Ji Zhang / Harri Saxén / Andreas Matussek

    Toxins, Vol 15, Iss 12, p

    2023  Volume 669

    Abstract: Shiga toxin (Stx)-producing Escherichia coli (STEC) infections cause outbreaks of severe disease in children ranging from bloody diarrhea to hemolytic uremic syndrome (HUS). The adherent factor intimin, encoded by eae , can facilitate the colonization ... ...

    Abstract Shiga toxin (Stx)-producing Escherichia coli (STEC) infections cause outbreaks of severe disease in children ranging from bloody diarrhea to hemolytic uremic syndrome (HUS). The adherent factor intimin, encoded by eae , can facilitate the colonization process of strains and is frequently associated with severe disease. The purpose of this study was to examine and analyze the prevalence and polymorphisms of eae in clinical STEC strains from pediatric patients under 17 years old with and without HUS, and to assess the pathogenic risk of different eae subtypes. We studied 240 STEC strains isolated from pediatric patients in Finland with whole genome sequencing. The gene eae was present in 209 (87.1%) strains, among which 49 (23.4%) were from patients with HUS, and 160 (76.6%) were from patients without HUS. O157:H7 (126, 60.3%) was the most predominant serotype among eae -positive STEC strains. Twenty-three different eae genotypes were identified, which were categorized into five eae subtypes, i.e., γ1, β3, ε1, θ and ζ3. The subtype eae -γ1 was significantly overrepresented in strains from patients aged 5–17 years, while β3 and ε1 were more commonly found in strains from patients under 5 years. All O157:H7 strains carried eae -γ1; among non-O157 strains, strains of each serotype harbored one eae subtype. No association was observed between the presence of eae /its subtypes and HUS. However, the combination of eae -γ1+ stx2a was significantly associated with HUS. In conclusion, this study demonstrated a high occurrence and genetic variety of eae in clinical STEC from pediatric patients under 17 years old in Finland, and that eae is not essential for STEC-associated HUS. However, the combination of certain eae subtypes with stx subtypes, i.e., eae -γ1+ stx2a , may be used as risk predictors for the development of severe disease in children.
    Keywords Shiga toxin (Stx)-producing Escherichia coli ; intimin ; eae subtype ; hemolytic uremic syndrome ; pediatric patients ; Medicine ; R
    Subject code 610 ; 570
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: Characteristics of Shiga Toxin-Producing

    Sui, Xinxia / Yang, Xi / Luo, Ming / Wang, Hua / Liu, Qian / Sun, Hui / Jin, Yujuan / Wu, Yannong / Bai, Xiangning / Xiong, Yanwen

    Toxins

    2023  Volume 15, Issue 11

    Abstract: Shiga toxin- ... ...

    Abstract Shiga toxin-producing
    MeSH term(s) Humans ; Shiga-Toxigenic Escherichia coli ; Escherichia coli Infections ; Diarrhea ; Serogroup ; Food ; Escherichia coli Proteins/genetics
    Chemical Substances Escherichia coli Proteins
    Language English
    Publishing date 2023-11-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins15110640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Characterization of Clinical

    Bai, Xiangning / Scheutz, Flemming / Dahlgren, Henrik Mellström / Hedenström, Ingela / Jernberg, Cecilia

    Microorganisms

    2021  Volume 9, Issue 11

    Abstract: Shiga toxin (Stx) is the key virulence factor in the Shiga Toxin- ... ...

    Abstract Shiga toxin (Stx) is the key virulence factor in the Shiga Toxin-Producing
    Language English
    Publishing date 2021-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9112374
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  9. Article: Safety and efficacy of magnesium-rich artificial cerebrospinal fluid for subarachnoid hemorrhage.

    Cheng, Yawen / Han, Xiangning / Xie, Wanfu / Xu, Gaofeng / Bai, Xiaobin / Qi, Lei / Zhang, Linjuan / Liu, Rui / Dong, Weihua / Feng, Weiyi / Pang, Chengsen / Zhang, Wei / Liu, Fude / Cao, Xiangqi / Xu, Yue / Luo, Guogang

    Frontiers in neurology

    2024  Volume 15, Page(s) 1376216

    Abstract: Objectives: This study aimed to investigate the efficacy of using a newly formulated magnesium-rich artificial cerebrospinal fluid (MACSF) as an alternative to normal saline (NS) for intraoperative irrigation during aneurysm clipping in improving the ... ...

    Abstract Objectives: This study aimed to investigate the efficacy of using a newly formulated magnesium-rich artificial cerebrospinal fluid (MACSF) as an alternative to normal saline (NS) for intraoperative irrigation during aneurysm clipping in improving the prognosis of patients with Aneurysmal subarachnoid hemorrhage (aSAH).
    Methods: Patients with aSAH who underwent intraoperative irrigation with MACSF or NS during the clipping in the First Affiliated Hospital of Xi 'an Jiaotong University from March 2019 to March 2022 were selected as MACSF group and NS group, respectively. The primary prognostic indicators were the incidence of favorable outcomes (mRS 0-2). The secondary outcome measures included cerebral vasospasm (CVS), mortality, total hospital stay, and intensive care unit (ICU) stay. Safety was evaluated based on the occurrence rates of hypermagnesemia, meningitis, and hydrocephalus.
    Results: Overall, 34 and 37 patients were enrolled in the MACSF and NS groups, respectively. At 90 days after aSAH onset, the proportion of favorable prognosis in the MACSF group was significantly higher than that in the NS group (
    Conclusion: Using MACSF as an irrigation fluid for aneurysm clipping can significantly improve the 90-day prognosis of patients with aSAH, which may be related to the reduced incidence of CVS.
    Clinical trial registration: https://www.clinicaltrials.gov, identifier NCT04358445.
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2024.1376216
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  10. Article: Escherichia albertii

    Liu, Qian / Wang, Hong / Zhang, Suchuan / Yan, Guodong / Yang, Xi / Bai, Xiangning / Deng, Jianping / Chen, Xi / Zhang, Ling / Zhang, Jie / Wang, Bin / Zou, Nianli / Xiong, Yanwen / Zhang, Zhengdong

    Heliyon

    2023  Volume 9, Issue 11, Page(s) e22298

    Abstract: A rare case of bacteremia caused ... ...

    Abstract A rare case of bacteremia caused by
    Language English
    Publishing date 2023-11-11
    Publishing country England
    Document type Case Reports
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e22298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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