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Article ; Online: Guideline directed medical therapy induced nephrotoxicity in HFrEF patients; an insight to its mechanism.

Philip, Anu / Dwivedi, Prarambh S R / Shastry, C S / Utagi, Basavaraj

Journal of biomolecular structure & dynamics

2024 , Page(s) 1–15

Abstract: Guideline Directed Medical Therapy (GDMT) has been the standard pharmacotherapy for the treatment of Heart Failure patients with reduced Ejection Fraction (HFrEF) recommended by the European Society of Cardiology (ESC). However, patients on GDMT are ... ...

Abstract	Guideline Directed Medical Therapy (GDMT) has been the standard pharmacotherapy for the treatment of Heart Failure patients with reduced Ejection Fraction (HFrEF) recommended by the European Society of Cardiology (ESC). However, patients on GDMT are likely to possess nephrotoxicity as an adverse effect. We utilized multiple system biology tools like ADVER-Pred, gene enrichment analysis, molecular docking, molecular dynamic simulations, and MMPBSA analysis to predict a possible molecular mechanism of how selected combinations of GDMT may cause nephrotoxicity. As per the ACC/AHA/ESC guidelines, we categorized the drugs as category 1 including β-blockers (BB), angiotensin receptor blockers (ARB), and sodium-glucose cotransporter-2 inhibitors (SGLT2I), category 2 includes BB's, SGLT2I, and angiotensin receptor-neprilysin inhibitors (ARNI), and category 3 includes BB's, SGLT2I, and angiotensin-converting enzyme (ACE) inhibitors. Enrichment analysis predicted category 2 drugs to possess the highest number of proteins to be involved in the development of nephrotoxicity i.e. 79.41%. The targets
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2024.2326193
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Zs.A 2093: Show issues

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Article ; Online: Long standing untreated multifocal cutaneous tuberculosis with development of breast carcinoma.

Srihari, S / S Ranugha, P S / Shastry, V / Betkerur, J B

Journal of postgraduate medicine

2022 Volume 68, Issue 2, Page(s) 115–116

MeSH term(s)	Antitubercular Agents/therapeutic use ; Breast Neoplasms/drug therapy ; Female ; Humans ; Tuberculosis, Cutaneous/diagnosis ; Tuberculosis, Cutaneous/drug therapy
Chemical Substances	Antitubercular Agents
Language	English
Publishing date	2022-04-14
Publishing country	India
Document type	Case Reports
ZDB-ID	410691-x
ISSN	0972-2823 ; 0022-3859
ISSN (online)	0972-2823
ISSN	0022-3859
DOI	10.4103/jpgm.JPGM_144_21
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Zs.A 443: Show issues

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Article: Prevalence of blood group antigens among regular blood donors: A single center study from South India with a review of national literature.

Chenna, Deepika / Polavarapu, Isha / Shastry, Shamee

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

2023 Volume 62, Issue 5, Page(s) 103747

Abstract: ... Lu(a-b+) ( 99.61%), M+N+ (48.17%), S-s+ (45.29%) respectively. The prevalence of D and E antigens was ... P1, M, N, S, s, using commercially available monoclonal antisera by column agglutination technology ... Lutheran and MNSs were CcDee (34.93%), Le(a-b+) (61.80%), K-k+(98.27%), Fy(a+b-) 43.19%, Jk(a+b+) 42.61 ...

Abstract	Background and objectives: The antigen frequencies vary across different regions and ethnic groups. Hence, we aimed to study the prevalence of blood group antigens in our population and to systemize the zone-wise prevalence of the same across India. Materials and methods: Regular voluntary O group blood donors were screened for 21 blood group antigens; C, c, E, e, K, k, Kpa, Kpb, Jka, Jkb, Fya, Fyb, Lea, Leb, Lua, Lub, P1, M, N, S, s, using commercially available monoclonal antisera by column agglutination technology. A literature search was performed to identify all the studies that reported blood group antigens prevalence to estimate the zone-wise prevalence of these antigens in the country. Results: A total of 521 participants of 9248 O group donors meeting all the inclusion criteria were included. Among the study group, the male-to-female ratio was 9:1 with a mean age of 32.6 years (±10.01) ranging from 18-60 years. The majority of the donors 446 (85.6%) were D positive. The most common phenotypes among Rh, Lewis, Kell, Duffy, Kidd, Lutheran and MNSs were CcDee (34.93%), Le(a-b+) (61.80%), K-k+(98.27%), Fy(a+b-) 43.19%, Jk(a+b+) 42.61%, Lu(a-b+) ( 99.61%), M+N+ (48.17%), S-s+ (45.29%) respectively. The prevalence of D and E antigens was significantly lower in the South zone compared to other zones of India. Conclusion: Significant difference in the prevalence of blood group antigens is observed between the South and other zones of India. Zone-wise prevalence of blood group phenotypes is essential in the timely management of alloimmunized patients.
MeSH term(s)	Adult ; Female ; Humans ; Male ; ABO Blood-Group System/genetics ; Blood Donors ; Blood Group Antigens/genetics ; India ; Phenotype ; Prevalence ; Adolescent ; Young Adult ; Middle Aged
Chemical Substances	ABO Blood-Group System ; Blood Group Antigens ; N,N-dimethylglycylbenzocaine (78448-04-1)
Language	English
Publishing date	2023-06-03
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2046795-3
ISSN	1878-1683 ; 1473-0502
ISSN (online)	1878-1683
ISSN	1473-0502
DOI	10.1016/j.transci.2023.103747
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Zs.A 1739: Show issues

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Article ; Online: Effect of exercise-based rehabilitation on functional capacity and renal function in type 2 diabetes mellitus with nephropathy: a randomized controlled trial.

Nataraj, Megha / Maiya, G Arun / Nagaraju, Shankar Prasad / Shastry, B A / Shivashankara, K N / Shetty, Sahana / Mayya, Shreemathi S

International urology and nephrology

2024

Abstract: Introduction: Diabetic nephropathy is a growing public health challenge with implications on health. Renal function decline impacts the functional ability and overall health and well-being of individuals with diabetic nephropathy due to development of ... ...

Abstract	Introduction: Diabetic nephropathy is a growing public health challenge with implications on health. Renal function decline impacts the functional ability and overall health and well-being of individuals with diabetic nephropathy due to development of several renal manifestations. The objective of the study was to determine the effect of an exercise-based rehabilitation program on functional capacity and renal function among individuals with type 2 diabetic nephropathy. Methods: A total of 283 individuals were screened and 60 eligible participants aged 45-70 years with diabetic nephropathy were randomly allocated (n = 30 each) to the intervention group (IG) and control group (CG), respectively. The study outcome measures comprised of functional capacity (6-min walk test) and renal function assessed at baseline, 12th week and 24th week. Participants allocated to IG received 12 weeks of exercise based rehabilitation (comprising of supervised + home-based exercises) along with standard care and followed-up till 24th week. Results: The repeated measures ANOVA with Greenhouse-Geisser correction indicated significant timepointgroup interaction effect for 6-min walk distance F Conclusion:* The study found that exercise based rehabilitation improved both functional capacity and renal function among individuals with type 2 diabetic nephropathy.
Language	English
Publishing date	2024-03-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	204048-7
ISSN	1573-2584 ; 0301-1623 ; 0042-1162
ISSN (online)	1573-2584
ISSN	0301-1623 ; 0042-1162
DOI	10.1007/s11255-024-03987-w
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Zs.A 733: Show issues

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Article: Illustration: Thromboelastography - A useful tool to monitor COVID-19-associated coagulopathy.

Vaidya, Ashwinkumar / Paonam, Bemma / Mohan, Ganesh / Shastry, Shamee

Asian journal of transfusion science

2022 Volume 16, Issue 1, Page(s) 148–149

Abstract: COVID 19 is caused by Severe Acute Respiratory Syndrome Corona Virus-2 which results in wide range of manifestations. Systemic hypercoagulation is a typical feature of COVID-19. We present a case of COVID-19 in whom TEG was performed on admission and ... ...

Abstract	COVID 19 is caused by Severe Acute Respiratory Syndrome Corona Virus-2 which results in wide range of manifestations. Systemic hypercoagulation is a typical feature of COVID-19. We present a case of COVID-19 in whom TEG was performed on admission and hypercoagulability was diagnosed and hence patient was started on Enoxaparin sodium 6000 IU twice daily. TEG was repeated after 5 days which showed normal coagulation status and the patient was discharged without any thrombotic complications.
Language	English
Publishing date	2022-07-30
Publishing country	India
Document type	Journal Article
ZDB-ID	2267310-6
ISSN	1998-3565 ; 0973-6247
ISSN (online)	1998-3565
ISSN	0973-6247
DOI	10.4103/ajts.ajts_73_21
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Article ; Online: CURTAIN-A unique web-based tool for exploration and sharing of MS-based proteomics data.

Phung, Toan K / Berndsen, Kerryn / Shastry, Rosamund / Phan, Tran L C H B / Muqit, Miratul M K / Alessi, Dario R / Nirujogi, Raja S

Proceedings of the National Academy of Sciences of the United States of America

2024 Volume 121, Issue 7, Page(s) e2312676121

Abstract: ... analysis of all identified PTM sites on protein(s) of interest with selected databases. CURTAIN-PTM also ...

Abstract	To facilitate analysis and sharing of mass spectrometry (MS)-based proteomics data, we created online tools called CURTAIN (https://curtain.proteo.info) and CURTAIN-PTM (https://curtainptm.proteo.info) with an accompanying series of video tutorials (https://www.youtube.com/@CURTAIN-me6hl). These are designed to enable non-MS experts to interactively peruse volcano plots and deconvolute primary experimental data so that replicates can be visualized in bar charts or violin plots and exported in publication-ready format. They also allow assessment of overall experimental quality by correlation matrix and profile plot analysis. After making a selection of protein "hits", the user can analyze known domain structure, AlphaFold predicted structure, reported interactors, relative expression as well as disease links. CURTAIN-PTM permits analysis of all identified PTM sites on protein(s) of interest with selected databases. CURTAIN-PTM also links with the Kinase Library to predict upstream kinases that may phosphorylate sites of interest. We provide examples of the utility of CURTAIN and CURTAIN-PTM in analyzing how targeted degradation of the PPM1H Rab phosphatase that counteracts the Parkinson's LRRK2 kinase impacts cellular protein levels and phosphorylation sites. We also reanalyzed a ubiquitylation dataset, characterizing the PINK1-Parkin pathway activation in primary neurons, revealing data of interest not highlighted previously. CURTAIN and CURTAIN-PTM are free to use and open source, enabling researchers to share and maximize the impact of their proteomics data. We advocate that MS data published in volcano plot format be reported containing a shareable CURTAIN weblink, thereby allowing readers to better analyze and exploit the data.
MeSH term(s)	Internet ; Mass Spectrometry ; Phosphorylation ; Protein Processing, Post-Translational ; Proteins/analysis ; Proteomics/methods ; Software
Chemical Substances	Proteins
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2312676121
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Zs.A 1148: Show issues

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Article ; Online: Variable reactivity of Rh D antigen and its serological characterization.

S, Sreelekshmi / Shastry, Shamee / B, Poornima Baliga

Acta clinica Belgica

2020 Volume 76, Issue 5, Page(s) 346–350

Abstract: ... ...

Abstract	Background
MeSH term(s)	Blood Grouping and Crossmatching ; Humans ; Male ; Prospective Studies ; Rh-Hr Blood-Group System/genetics
Chemical Substances	Rh-Hr Blood-Group System
Language	English
Publishing date	2020-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	390201-8
ISSN	2295-3337 ; 0001-5512 ; 1784-3286
ISSN (online)	2295-3337
ISSN	0001-5512 ; 1784-3286
DOI	10.1080/17843286.2020.1735115
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Article ; Online: Vanillin derivative inhibits quorum sensing and biofilm formation in Pseudomonas aeruginosa: a study in a Caenorhabditis elegans infection model

Shastry, Rajesh P. / Ghate, Sudeep D. / Sukesh Kumar, B. / Srinath, B. S. / Kumar, Vasanth

Natural Product Research. 2022 Mar. 19, v. 36, no. 6 p.1610-1615

2022

Abstract: Vanillin and its derivative, (4-((E)-(4-hydroxy-2-methylphenylimino) methyl)-2-methoxyphenol (MMP) were showed clear inhibition of violacein and pyocyanin at sub-MICs indicating a possible quorum quenching effect of both the compounds. MMP was able to ... ...

Abstract	Vanillin and its derivative, (4-((E)-(4-hydroxy-2-methylphenylimino) methyl)-2-methoxyphenol (MMP) were showed clear inhibition of violacein and pyocyanin at sub-MICs indicating a possible quorum quenching effect of both the compounds. MMP was able to inhibit the biofilm formation in Pseudomonas aeruginosa PAO1 at 125 μg/mL (p < 0.05), while vanillin at 250 μg/mL (p < 0.05) indicating that they act against quorum sensing regulated biofilm formation. The inhibition of biofilm was confirmed by visualization through fluorescence microscopy followed by docking analysis of molecules against quorum sensing activator proteins. Caenorhabditis elegans survival assay revealed that vanillin and MMP were able to increase survival of C. elegans from P. aeruginosa PAO1 infection. The study showed that the potent features of the MMP and vanillin in inhibiting the quorum sensing regulated virulence and biofilm, which was proved in C. elegans infection model as well as molecular docking studies.
Keywords	Caenorhabditis elegans ; Pseudomonas aeruginosa ; biofilm ; fluorescence microscopy ; models ; pyocyanin ; research ; vanillin ; violacein ; virulence ; Anti-quorum sensing
Language	English
Dates of publication	2022-0319
Size	p. 1610-1615.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2021.1887866
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A critical evaluation of pictogram based patient information leaflet on hypothyroidism patients with metabolic syndrome: a visual approach to enhance health literacy.

Shaji, Bipin / Joel, Juno Jerold / Sharma, Raghava / Shetty, Shraddha / Shastry, C S / Mateti, Uday Venkat

Endocrine

2023 Volume 84, Issue 1, Page(s) 185–192

Abstract: Introduction: Hypothyroidism is a condition with an underactive thyroid gland. Since thyroid hormones play a significant role in metabolism, hypothyroidism is often associated with metabolic syndrome. Thus, the patient's awareness regarding metabolic ... ...

Abstract	Introduction: Hypothyroidism is a condition with an underactive thyroid gland. Since thyroid hormones play a significant role in metabolism, hypothyroidism is often associated with metabolic syndrome. Thus, the patient's awareness regarding metabolic syndrome is crucial. Objectives: To develop and evaluate a Pictogram-based Patient Information Leaflet (P-PIL) for hypothyroidism with metabolic syndrome. Materials and methods: This is a quasi-experimental study without a control group. The P-PIL was developed and validated using the Lawshe Method, translated, and evaluated with 72 patients (24 patients each for English and regional languages, Kannada and Malayalam). Results: The leaflet's Flesch Reading Ease (FRE) and Flesch-Kincaid Grade Level (FKGL) scores were 62.0 and 7.1, respectively. The Baker Able Leaflet Design (BALD) index of English, Kannada, and Malayalam versions of the P-PIL were 28, 27, and 27, respectively. The user testing of the P-PIL was assessed in 72 patients. The overall mean knowledge assessment scores significantly improved from 52.92 ± 6.90 to 77.92 ± 9.31. The majority of patients, precisely 84.72%, expressed a positive opinion regarding the design and layout of the P-PIL. Conclusion: The evaluation results strongly suggest that this P-PIL can be an effective educational tool for hypothyroidism patients with metabolic syndrome.
MeSH term(s)	Humans ; Health Literacy ; Metabolic Syndrome/complications ; Pamphlets ; Comprehension ; Hypothyroidism/complications
Language	English
Publishing date	2023-12-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-023-03622-1
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Zs.A 3884: Show issues

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Article ; Online: Transfusion requirement prediction score for patients undergoing cardiac surgery: An experience from a tertiary care set-up from South India.

Doshi, Karishma Ashwin / Shastry, Shamee / Pai, Vasudev B

Transfusion medicine (Oxford, England)

2021 Volume 31, Issue 4, Page(s) 243–249

Abstract: Background: Prediction of transfusion requirement is part of preoperative management in a surgical case. We aimed to develop one such tool for patients undergoing cardiac surgery.: Methods: A retrospective study for a period of 3 years was done to ... ...

Abstract	Background: Prediction of transfusion requirement is part of preoperative management in a surgical case. We aimed to develop one such tool for patients undergoing cardiac surgery. Methods: A retrospective study for a period of 3 years was done to develop the scoring tool, Transfusion Requirement Prediction Score for Cardiac Surgery (TRPS), and internal validation was done prospectively. The primary outcome was administration of allogenic red cell units to the patients during perioperative period. The outcome is dichotomized as controls and cases based on the number of Red Blood Cell units received. Independent variables were chosen based on statistical significance and clinical judgement. Receiver operating characteristic curve was used to obtain the cut-off for each independent variable, odds ratio, and regression coefficients were used to assign the score. All patients with a cumulative score below the cut-off value were categorised as 'low risk' and above the cut off as 'high risk' group. Results: During the study period, out of 602 patients, 345 met the inclusion criteria (controls: 175; cases: 170). Six variables such as age (more than 58 years), gender (female), bypass time (more than 148 min), haemoglobin (less than 12.5 g/dL), ejection fraction (less than 57%), and history of warfarin prophylaxis were chosen to develop the score. The total score value of 5 was chosen as the cut-off for the two risk groups. It predicted blood utilisation with a strength of 68% sensitivity and 79% specificity. On internal validation, the score was observed to have an accuracy of 70%. Conclusion: The TRPS is a simple reliable and handy tool with high accuracy.
MeSH term(s)	Blood Transfusion ; Cardiac Surgical Procedures ; Female ; Humans ; Middle Aged ; ROC Curve ; Retrospective Studies ; Risk Factors ; Tertiary Healthcare
Language	English
Publishing date	2021-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1067989-3
ISSN	1365-3148 ; 0958-7578
ISSN (online)	1365-3148
ISSN	0958-7578
DOI	10.1111/tme.12774
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