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  1. Article ; Online: ERK signaling waves via body-wall muscles guide planarian whole-body regeneration across long distances

    Chenglu Xiao / Jing-Wei Xiong

    Cell Regeneration, Vol 12, Iss 1, Pp 1-

    2023  Volume 4

    Abstract: Abstract Whole-body regeneration is a multifaceted process that reinstates a body to its initial three-dimension size and structure after resection injury. It is well-known that signaling waves such as calcium and extracellular signal-related kinase (ERK) ...

    Abstract Abstract Whole-body regeneration is a multifaceted process that reinstates a body to its initial three-dimension size and structure after resection injury. It is well-known that signaling waves such as calcium and extracellular signal-related kinase (ERK) signaling waves can efficiently transmit information between tissues or cells. However, the mechanisms responsible for coordinating wound responses over long distances are largely unexplored. A recent study has reported that the propagation of ERK signaling waves via longitudinal body-wall muscles play an essential role in wound response and whole-body regeneration in planarians, underscoring the significance of feedback interactions between spatially distinct tissues during whole-body regeneration over long distances. These findings not only address the central questions of regenerative biology but also have potential implications for regenerative medicine.
    Keywords Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: ERK signaling waves via body-wall muscles guide planarian whole-body regeneration across long distances.

    Xiao, Chenglu / Xiong, Jing-Wei

    Cell regeneration (London, England)

    2023  Volume 12, Issue 1, Page(s) 36

    Abstract: Whole-body regeneration is a multifaceted process that reinstates a body to its initial three-dimension size and structure after resection injury. It is well-known that signaling waves such as calcium and extracellular signal-related kinase (ERK) ... ...

    Abstract Whole-body regeneration is a multifaceted process that reinstates a body to its initial three-dimension size and structure after resection injury. It is well-known that signaling waves such as calcium and extracellular signal-related kinase (ERK) signaling waves can efficiently transmit information between tissues or cells. However, the mechanisms responsible for coordinating wound responses over long distances are largely unexplored. A recent study has reported that the propagation of ERK signaling waves via longitudinal body-wall muscles play an essential role in wound response and whole-body regeneration in planarians, underscoring the significance of feedback interactions between spatially distinct tissues during whole-body regeneration over long distances. These findings not only address the central questions of regenerative biology but also have potential implications for regenerative medicine.
    Language English
    Publishing date 2023-11-08
    Publishing country China
    Document type Journal Article
    ZDB-ID 2682438-3
    ISSN 2045-9769
    ISSN 2045-9769
    DOI 10.1186/s13619-023-00180-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Unveiling new horizons in heart research: the promise of multi-chamber cardiac organoids.

    Hou, Junjie / Chen, Ye-Guang / Xiong, Jing-Wei

    Cell regeneration (London, England)

    2024  Volume 13, Issue 1, Page(s) 10

    Abstract: Human cardiac and other organoids have recently emerged as a groundbreaking tool for advancing our understanding the developmental biology of human organs. A recent paper from Sasha Mendjan's laboratory published in the journal Cell on December 7, 2023, ... ...

    Abstract Human cardiac and other organoids have recently emerged as a groundbreaking tool for advancing our understanding the developmental biology of human organs. A recent paper from Sasha Mendjan's laboratory published in the journal Cell on December 7, 2023, reported the generation of multi-chamber cardioids from human pluripotent stem cells, a transformative technology in the field of cardiology. In this short highlight paper, we summarize their findings. Their cardioids remarkably recapitulate the complexity of the human embryonic heart, including tissue architecture, cellular diversity, and functionality providing an excellent in vitro model for investigation of human heart development, disease modeling, precision medicine, and regenerative medicine. Thus, generating cardioids is an important step forward for understanding human heart development and developing potential therapies for heart diseases.
    Language English
    Publishing date 2024-04-23
    Publishing country China
    Document type Journal Article
    ZDB-ID 2682438-3
    ISSN 2045-9769
    ISSN 2045-9769
    DOI 10.1186/s13619-024-00193-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Evolutionary insights into heart regeneration.

    Xiong, Jing-Wei

    Cell regeneration (London, England)

    2020  Volume 9, Issue 1, Page(s) 23

    Abstract: Some lower vertebrates such as zebrafish and axolotl have incredible cardiac regenerative potential while mammals have very limited ones. Comparative studies among species have revealed that cardiomyocyte polyploidy, endothermy, and injury-induced ... ...

    Abstract Some lower vertebrates such as zebrafish and axolotl have incredible cardiac regenerative potential while mammals have very limited ones. Comparative studies among species have revealed that cardiomyocyte polyploidy, endothermy, and injury-induced activation of certain transcriptional factors including AP1 complexes are critical for cardiomyocyte proliferation and heart regeneration during animal evolution. Gaining insights into these evolutionarily conserved mechanisms will likely lead to achieving heart regeneration in non-regenerative mammals including humans.
    Language English
    Publishing date 2020-12-01
    Publishing country China
    Document type Letter
    ZDB-ID 2682438-3
    ISSN 2045-9769
    ISSN 2045-9769
    DOI 10.1186/s13619-020-00069-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Evolutionary insights into heart regeneration

    Jing-Wei Xiong

    Cell Regeneration, Vol 9, Iss 1, Pp 1-

    2020  Volume 2

    Abstract: Abstract Some lower vertebrates such as zebrafish and axolotl have incredible cardiac regenerative potential while mammals have very limited ones. Comparative studies among species have revealed that cardiomyocyte polyploidy, endothermy, and injury- ... ...

    Abstract Abstract Some lower vertebrates such as zebrafish and axolotl have incredible cardiac regenerative potential while mammals have very limited ones. Comparative studies among species have revealed that cardiomyocyte polyploidy, endothermy, and injury-induced activation of certain transcriptional factors including AP1 complexes are critical for cardiomyocyte proliferation and heart regeneration during animal evolution. Gaining insights into these evolutionarily conserved mechanisms will likely lead to achieving heart regeneration in non-regenerative mammals including humans.
    Keywords Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  6. Article ; Online: Effective therapy of the small-molecule cocktail 5SM on adult rat heart after ischemia-reperfusion injury.

    Zheng, Lixia / Chen, Yuanyuan / Wu, Zhengyuan / Zhu, Xiaojun / Xiong, Jing-Wei

    Journal of molecular cell biology

    2023  Volume 15, Issue 6

    MeSH term(s) Rats ; Animals ; Reperfusion Injury/drug therapy ; Myocardium
    Language English
    Publishing date 2023-06-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2500949-7
    ISSN 1759-4685 ; 1759-4685
    ISSN (online) 1759-4685
    ISSN 1759-4685
    DOI 10.1093/jmcb/mjad034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Correction to: AHA Life's Essential 8 and new‑onset CKD: a prospective cohort study from the UK Biobank.

    Ruan, Yong-Xiang / Wu, Mao-Xiong / Gao, Jing-Wei / Guo, Da-Chuan / Cai, Yang-Wei / Huang, Ze-Gui / He, Wan-Bing / Chen, Yang-Xin / Wang, Jing-Feng / Zhang, Hai-Feng

    Clinical and experimental nephrology

    2024  

    Language English
    Publishing date 2024-03-20
    Publishing country Japan
    Document type Published Erratum
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-024-02473-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4922: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: A DUSP6 inhibitor suppresses inflammatory cardiac remodeling and improves heart function after myocardial infarction

    Zongwang Zhang / Yang Chen / Lixia Zheng / Jianyong Du / Shicheng Wei / Xiaojun Zhu / Jing-Wei Xiong

    Disease Models & Mechanisms, Vol 16, Iss

    2023  Volume 5

    Keywords myocardial infarction ; dusp6 ; bci ; macrophages ; inflammation ; plga ; Medicine ; R ; Pathology ; RB1-214
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Chemical screening links disulfiram with cardiac protection after ischemic injury.

    Chen, Yuanyuan / Du, Jianyong / Zheng, Lixia / Wang, Zihao / Zhang, Zongwang / Wu, Zhengyuan / Zhu, Xiaojun / Xiong, Jing-Wei

    Cell regeneration (London, England)

    2023  Volume 12, Issue 1, Page(s) 25

    Abstract: Ischemia-reperfusion injury occurs after reperfusion treatment for patients suffering myocardial infarction, however the underlying mechanisms are incompletely understood and effective pharmacological interventions are limited. Here, we report the ... ...

    Abstract Ischemia-reperfusion injury occurs after reperfusion treatment for patients suffering myocardial infarction, however the underlying mechanisms are incompletely understood and effective pharmacological interventions are limited. Here, we report the identification and characterization of the FDA-approved drug disulfiram (DSF) as a cardioprotective compound. By applying high-throughput chemical screening, we found that DSF decreased H
    Language English
    Publishing date 2023-07-19
    Publishing country China
    Document type Journal Article
    ZDB-ID 2682438-3
    ISSN 2045-9769
    ISSN 2045-9769
    DOI 10.1186/s13619-023-00170-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cardiovascular health metrics defined by Life's Essential 8 scores and subsequent macrovascular and microvascular complications in individuals with type 2 diabetes: A prospective cohort study.

    Huang, Ze-Gui / Gao, Jing-Wei / Zhang, Hai-Feng / You, Si / Xiong, Zhuo-Chao / Wu, Yu-Biao / Guo, Da-Chuan / Wang, Jing-Feng / Chen, Yang-Xin / Zhang, Shao-Ling / Liu, Pin-Ming

    Diabetes, obesity & metabolism

    2024  

    Abstract: Aim: To investigate the association between cardiovascular health metrics defined by Life's Essential 8 (LE8) scores and vascular complications among individuals with type 2 diabetes (T2D).: Materials and methods: This prospective study included 11 ... ...

    Abstract Aim: To investigate the association between cardiovascular health metrics defined by Life's Essential 8 (LE8) scores and vascular complications among individuals with type 2 diabetes (T2D).
    Materials and methods: This prospective study included 11 033 participants with T2D, all devoid of macrovascular diseases (including cardiovascular and peripheral artery disease) and microvascular complications (e.g. diabetic retinopathy, neuropathy and nephropathy) at baseline from the UK Biobank. The LE8 score comprised eight metrics: smoking, body mass index, physical activity, non-high-density lipoprotein cholesterol, blood pressure, glycated haemoglobin, diet and sleep duration. Cox proportional hazards models were established to assess the associations of LE8 scores with incident macrovascular and microvascular complications.
    Results: During a median follow-up of 12.1 years, we identified 1975 cases of incident macrovascular diseases and 1797 cases of incident microvascular complications. After adjusting for potential confounders, each 10-point increase in the LE8 score was associated with an 18% lower risk of macrovascular diseases and a 15% lower risk of microvascular complications. Comparing individuals in the highest and lowest quartiles of LE8 scores revealed hazard ratios of 0.55 (95% confidence interval 0.47-0.62) for incident macrovascular diseases, and 0.61 (95% confidence interval 0.53-0.70) for incident microvascular complications. This association remained robust across a series of sensitivity analyses and nearly all subgroups.
    Conclusion: Higher LE8 scores were associated with a lower risk of incident macrovascular and microvascular complications among individuals with T2D. These findings underscore the significance of adopting fundamental strategies to maintain optimal cardiovascular health and curtail the risk of developing diabetic vascular complications.
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.15583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5442: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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