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  1. Article ; Online: The 3D Revolution in Cancer Discovery.

    Wang, Linghua / Li, Mingyao / Hwang, Tae Hyun

    Cancer discovery

    2024  Volume 14, Issue 4, Page(s) 625–629

    Abstract: Summary: The transition from 2D to 3D spatial profiling marks a revolutionary era in cancer research, offering unprecedented potential to enhance cancer diagnosis and treatment. This commentary outlines the experimental and computational advancements ... ...

    Abstract Summary: The transition from 2D to 3D spatial profiling marks a revolutionary era in cancer research, offering unprecedented potential to enhance cancer diagnosis and treatment. This commentary outlines the experimental and computational advancements and challenges in 3D spatial molecular profiling, underscoring the innovation needed in imaging tools, software, artificial intelligence, and machine learning to overcome implementation hurdles and harness the full potential of 3D analysis in the field.
    MeSH term(s) Humans ; Artificial Intelligence ; Machine Learning ; Software ; Neoplasms/diagnosis ; Neoplasms/genetics
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-23-1499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6916: Show issues Location:
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  2. Article ; Online: Optimizing Shot Assignment in Variational Quantum Eigensolver Measurement.

    Zhu, Linghua / Liang, Senwei / Yang, Chao / Li, Xiaosong

    Journal of chemical theory and computation

    2024  Volume 20, Issue 6, Page(s) 2390–2403

    Abstract: Variational quantum eigensolvers (VQEs) show promise for tackling complex quantum chemistry challenges and realizing quantum advantages. However, in VQE, the measurement step encounters difficulties due to errors in objective function evaluation, e.g., ... ...

    Abstract Variational quantum eigensolvers (VQEs) show promise for tackling complex quantum chemistry challenges and realizing quantum advantages. However, in VQE, the measurement step encounters difficulties due to errors in objective function evaluation, e.g., the energy of a quantum state. While increasing the number of measurement shots can mitigate measurement errors, this approach leads to higher costs. Strategies for shot assignment have been investigated, allowing for the allocation of varying shot numbers to different Hamiltonian terms and reducing measurement variance through term-specific insights. In this paper, we introduce a dynamic approach, the Variance-Preserved Shot Reduction (VPSR) method. This technique strives to minimize the total number of measurement shots while preserving the variance of measurements throughout the VQE process. Our numerical experiments on H
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ISSN 1549-9626
    ISSN (online) 1549-9626
    DOI 10.1021/acs.jctc.3c01113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Machine learning-based prediction of composite risk of cardiovascular events in patients with stable angina pectoris combined with coronary heart disease: development and validation of a clinical prediction model for Chinese patients.

    Wang, Zihan / Sun, Ziyi / Yu, Linghua / Wang, Zhitian / Li, Lin / Lu, Xiaoyan

    Frontiers in pharmacology

    2024  Volume 14, Page(s) 1334439

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1334439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Genome-Wide Identification and Expression Analysis of the

    Yang, Linghua / Min, Xueyang / Wei, Zhenwu / Liu, Nana / Li, Jiaqing / Zhang, Youxin / Yang, Yuwei

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: ... ...

    Abstract The
    Language English
    Publishing date 2023-04-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12091831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Advances in diagnosis and treatment of talaromycosis in patients with AIDS

    Pengle Guo / Linghua Li / Xiaoping Tang / Yanjie Yin

    Chinese Medical Journal, Vol 135, Iss 22, Pp 2687-

    2022  Volume 2689

    Keywords Medicine ; R
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Advances in diagnosis and treatment of talaromycosis in patients with AIDS.

    Guo, Pengle / Li, Linghua / Tang, Xiaoping

    Chinese medical journal

    2022  Volume 135, Issue 22, Page(s) 2687–2689

    MeSH term(s) Humans ; Acquired Immunodeficiency Syndrome/diagnosis ; Acquired Immunodeficiency Syndrome/drug therapy ; Mycoses/diagnosis ; Mycoses/drug therapy ; Antifungal Agents/therapeutic use ; Talaromyces
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2022-11-20
    Publishing country China
    Document type Journal Article
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000002506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1207: Show issues Location:
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  7. Article ; Online: Enantioselective synthesis of cyclic α-aminoboronates

    Xu, Ming / Ouyang, Yizhao / Wang, Linghua / Zhang, Shuai / Li, Pengfei

    Chemical communications (Cambridge, England)

    2022  Volume 58, Issue 22, Page(s) 3677–3680

    Abstract: A highly enantioselective and regioselective dearomative borylation of 4-quinolinols was developed using a Cu(I)/( ...

    Abstract A highly enantioselective and regioselective dearomative borylation of 4-quinolinols was developed using a Cu(I)/(
    MeSH term(s) Catalysis ; Copper ; Hydroxyquinolines ; Stereoisomerism
    Chemical Substances Hydroxyquinolines ; Copper (789U1901C5)
    Language English
    Publishing date 2022-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc00027j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Simultaneous removal of urea nitrogen and inorganic nitrogen from high-salinity wastewater by Halomonas sp. H36

    Li, Yujing / Zhang, Linghua / Liu, Weifeng / Zhou, Zepeng

    Environ Sci Pollut Res. 2023 Jan., v. 30, no. 2 p.2544-2554

    2023  

    Abstract: To treat high-salt urea wastewater by microbial hydrolysis, it is necessary to overcome the dual problems of incomplete removal of nitrogen (N) from mixed strains and inhibition of microbial activity by high salt (NaCl) concentrations. In this paper, the ...

    Abstract To treat high-salt urea wastewater by microbial hydrolysis, it is necessary to overcome the dual problems of incomplete removal of nitrogen (N) from mixed strains and inhibition of microbial activity by high salt (NaCl) concentrations. In this paper, the mechanism of NaCl tolerance of Halomonas sp. H36 was investigated. Using molecular biology and enzymatic methods, it was proven that the strain’s N-removal enzymes (urease; ammonia monooxygenase, AMO; nitrite reductase, NIR; nitrate reductase, NAR) played a key role in the removal of N, and the N-removal pathway was clarified. For the strain used to treat simulated ship domestic sewage, the urea nitrogen (CO(NH₂)₂-N)-removal rate was 88.52%, the ammonia nitrogen (NH₄⁺-N)-removal rate was 91.16%, the total nitrogen (TN)-removal rate was 90.25%, and nitrite nitrogen (NO₂⁻-N) and nitrate nitrogen (NO₃⁻-N) did not accumulate. It was proven for the first time that Halomonas sp. H36 has the function of simultaneous urea hydrolysis-nitrification–denitrification with urea as the initial substrate and can simultaneously remove urea nitrogen and inorganic nitrogen from high-salt urea wastewater.
    Keywords Halomonas ; ammonia monooxygenase ; ammonium nitrogen ; hydrolysis ; microbial activity ; molecular biology ; nitrate nitrogen ; nitrate reductase ; nitrite nitrogen ; nitrite reductase ; nitrogen ; salt tolerance ; sewage ; total nitrogen ; urea ; urea nitrogen ; urease ; wastewater
    Language English
    Dates of publication 2023-01
    Size p. 2544-2554.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-22018-8
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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  9. Article ; Online: Network structure of complex interactions of premenstrual syndrome and influencing factors in young adult women.

    Qin, Rui / Mao, Cui / Li, Guopeng / Zhao, Di / Kong, Linghua / Li, Ping

    Journal of affective disorders

    2024  Volume 354, Page(s) 199–205

    Abstract: Background: In the transition phase from adolescence to adulthood, premenstrual syndrome (PMS) occurs more commonly, with a variety of symptoms. The occurrence of PMS may be the result of a combination of demographic, physiological, psychological and ... ...

    Abstract Background: In the transition phase from adolescence to adulthood, premenstrual syndrome (PMS) occurs more commonly, with a variety of symptoms. The occurrence of PMS may be the result of a combination of demographic, physiological, psychological and sociological factors. This study aimed to identify the central symptoms of PMS, and explored the complex influencing factors especially the one-to-one inter-relationships factors with specific symptoms.
    Method: This is a cross-sectional study conducted in mainland China. 3458 young adult women were assessed. Using the Premenstrual Syndrome Scale (PSS) to assess the PMS, and PSS score was over 6 divided into PMS group, and vice versa. Influencing factors were assessed by a set of self-reported questionnaire. Network analysis was used to examined the interplay of PMS, whilst also considering the influencing factors of PMS.
    Results: In summary, 1479 participants were in PMS group. Anxiety had the highest strength centrality (1.12/1.09), shown higher centrality in the both network. Swelling of the hands or feet also shown higher strength centrality (0.89) in PMS group. PMS is associated with a higher history of dysmenorrhea, and neurotic personality. Neurotic personality - depressed mood/nervousness (0.27/0.23), history of dysmenorrhea - abdominal distension (0.21), had significantly higher weight than other edges in PMS group.
    Conclusion: Anxiety was the most central symptom in the network, and was closely associated with other symptoms like depressed mood, which provided additional evidence for the centrality of emotional features in PMS. Moreover, the influencing factors of PMS combined demographic, physiological, psychological, and sociological factors. According to the central symptoms and factors affecting the specific PMS symptoms in young adult women, targeted intervention is helpful to prevent and alleviate PMS.
    Limitation: Cross-sectional design cannot infer the directionality of the associations between variables. All data is self-reported with recall bias and the edge weights across the constructs of influencing factors and PMS were fairly small.
    MeSH term(s) Adolescent ; Female ; Humans ; Young Adult ; Cross-Sectional Studies ; Dysmenorrhea/epidemiology ; Premenstrual Syndrome/epidemiology ; Emotions ; Personality
    Language English
    Publishing date 2024-03-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2024.03.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1485: Show issues Location:
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  10. Article: Genome-Wide Identification and Expression Analysis of the

    Liu, Nana / Wei, Zhenwu / Min, Xueyang / Yang, Linghua / Zhang, Youxin / Li, Jiaqing / Yang, Yuwei

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 10

    Abstract: SWEET (Sugars will eventually be exported transporter) proteins are a group of sugar transporters that are involved in sugar efflux, phloem loading, reproductive development, plant senescence, and stress responses. In this study, 23 SWEET transporter ... ...

    Abstract SWEET (Sugars will eventually be exported transporter) proteins are a group of sugar transporters that are involved in sugar efflux, phloem loading, reproductive development, plant senescence, and stress responses. In this study, 23 SWEET transporter members were identified in the
    Language English
    Publishing date 2023-05-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12101948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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