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Article ; Online: Integrated cellular pathology-systems biology of human diseases.

Gaigneaux, Anthoula / Chateauvieux, Sébastien / Diederich, Marc

Omics : a journal of integrative biology

2012 Volume 16, Issue 1-2, Page(s) 1–2

MeSH term(s)	Congresses as Topic ; Disease ; High-Throughput Screening Assays/methods ; Humans ; Pathology ; Systems Biology
Language	English
Publishing date	2012-01
Publishing country	United States
Document type	Editorial
ZDB-ID	2030312-9
ISSN	1557-8100 ; 1536-2310
ISSN (online)	1557-8100
ISSN	1536-2310
DOI	10.1089/omi.2012.ed01
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Article ; Online: Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells.

Orsini, Marion / Chateauvieux, Sébastien / Rhim, Jiyun / Gaigneaux, Anthoula / Cheillan, David / Christov, Christo / Dicato, Mario / Morceau, Franck / Diederich, Marc

Cell death and differentiation

2018 Volume 26, Issue 9, Page(s) 1796–1812

Abstract: Elevated levels of the pro-inflammatory cytokine tumor necrosis factor-α (TNFα) inhibit erythropoiesis and cause anemia in patients with cancer and chronic inflammatory diseases. TNFα is also a potent activator of the sphingomyelinase (SMase)/ceramide ... ...

Abstract	Elevated levels of the pro-inflammatory cytokine tumor necrosis factor-α (TNFα) inhibit erythropoiesis and cause anemia in patients with cancer and chronic inflammatory diseases. TNFα is also a potent activator of the sphingomyelinase (SMase)/ceramide pathway leading to ceramide synthesis and regulating cell differentiation, proliferation, apoptosis, senescence, and autophagy. Here we evaluated the implication of the TNFα/SMase/ceramide pathway on inhibition of erythropoiesis in human CD34
MeSH term(s)	Anemia/genetics ; Anemia/pathology ; Autophagy/genetics ; Autophagy-Related Protein 5/genetics ; Autophagy-Related Protein-1 Homolog/genetics ; Cell Differentiation/drug effects ; Ceramides/genetics ; Ceramides/metabolism ; Erythropoiesis/genetics ; Gene Expression Regulation, Developmental/genetics ; Hematopoietic Stem Cells/metabolism ; Humans ; Inflammation/genetics ; Inflammation/pathology ; Myelopoiesis/genetics ; Neoplasms/genetics ; Neoplasms/pathology ; Phosphorylation/drug effects ; Signal Transduction/genetics ; Sphingolipids/genetics ; Sphingolipids/metabolism ; Sphingomyelin Phosphodiesterase/genetics ; TOR Serine-Threonine Kinases/genetics ; Tumor Necrosis Factor-alpha/genetics
Chemical Substances	Autophagy-Related Protein 5 ; Ceramides ; Sphingolipids ; Tumor Necrosis Factor-alpha ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Autophagy-Related Protein-1 Homolog (EC 2.7.11.1) ; Sphingomyelin Phosphodiesterase (EC 3.1.4.12)
Language	English
Publishing date	2018-12-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1225672-9
ISSN	1476-5403 ; 1350-9047
ISSN (online)	1476-5403
ISSN	1350-9047
DOI	10.1038/s41418-018-0245-x
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Article: Long and short non-coding RNAs as regulators of hematopoietic differentiation.

Morceau, Franck / Chateauvieux, Sébastien / Gaigneaux, Anthoula / Dicato, Mario / Diederich, Marc

International journal of molecular sciences

2013 Volume 14, Issue 7, Page(s) 14744–14770

Abstract: Genomic analyses estimated that the proportion of the genome encoding proteins corresponds to approximately 1.5%, while at least 66% are transcribed, suggesting that many non-coding DNA-regions generate non-coding RNAs (ncRNAs). The relevance of these ... ...

Abstract	Genomic analyses estimated that the proportion of the genome encoding proteins corresponds to approximately 1.5%, while at least 66% are transcribed, suggesting that many non-coding DNA-regions generate non-coding RNAs (ncRNAs). The relevance of these ncRNAs in biological, physiological as well as in pathological processes increased over the last two decades with the understanding of their implication in complex regulatory networks. This review particularly focuses on the involvement of two large families of ncRNAs, namely microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the regulation of hematopoiesis. To date, miRNAs have been widely studied, leading to a wealth of data about processing, regulation and mechanisms of action and more specifically, their involvement in hematopoietic differentiation. Notably, the interaction of miRNAs with the regulatory network of transcription factors is well documented whereas roles, regulation and mechanisms of lncRNAs remain largely unexplored in hematopoiesis; this review gathers current data about lncRNAs as well as both potential and confirmed roles in normal and pathological hematopoiesis.
MeSH term(s)	Animals ; Gene Regulatory Networks ; Hematopoiesis/genetics ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Humans ; MicroRNAs/metabolism ; RNA Interference ; RNA, Untranslated/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	MicroRNAs ; RNA, Untranslated ; Transcription Factors
Language	English
Publishing date	2013-07-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1661-6596
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms140714744
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Article ; Online: Natural compounds and pharmaceuticals reprogram leukemia cell differentiation pathways.

Morceau, Franck / Chateauvieux, Sébastien / Orsini, Marion / Trécul, Anne / Dicato, Mario / Diederich, Marc

Biotechnology advances

2015 Volume 33, Issue 6 Pt 1, Page(s) 785–797

Abstract: In addition to apoptosis resistance and cell proliferation capacities, the undifferentiated state also characterizes most cancer cells, especially leukemia cells. Cell differentiation is a multifaceted process that depends on complex regulatory networks ... ...

Abstract	In addition to apoptosis resistance and cell proliferation capacities, the undifferentiated state also characterizes most cancer cells, especially leukemia cells. Cell differentiation is a multifaceted process that depends on complex regulatory networks that involve transcriptional, post-transcriptional and epigenetic regulation of gene expression. The time- and spatially-dependent expression of lineage-specific genes and genes that control cell growth and cell death is implicated in the process of maturation. The induction of cancer cell differentiation is considered an alternative approach to elicit cell death and proliferation arrest. Differentiation therapy has mainly been developed to treat acute myeloid leukemia, notably with all-trans retinoic acid (ATRA). Numerous molecules from diverse natural or synthetic origins are effective alone or in association with ATRA in both in vitro and in vivo experiments. During the last two decades, pharmaceuticals and natural compounds with various chemical structures, including alkaloids, flavonoids and polyphenols, were identified as potential differentiating agents of hematopoietic pathways and osteogenesis.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Biological Products/pharmacology ; Cell Differentiation/drug effects ; Humans ; Leukemia/physiopathology ; Mice ; Neoplastic Processes ; Signal Transduction/drug effects
Chemical Substances	Antineoplastic Agents ; Biological Products
Language	English
Publishing date	2015-11-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	47165-3
ISSN	1873-1899 ; 0734-9750
ISSN (online)	1873-1899
ISSN	0734-9750
DOI	10.1016/j.biotechadv.2015.03.013
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Article ; Online: Molecular and therapeutic potential and toxicity of valproic acid.

Chateauvieux, Sébastien / Morceau, Franck / Dicato, Mario / Diederich, Marc

Journal of biomedicine & biotechnology

2010 Volume 2010

Abstract: Valproic acid (VPA), a branched short-chain fatty acid, is widely used as an antiepileptic drug and a mood stabilizer. Antiepileptic properties have been attributed to inhibition of Gamma Amino Butyrate (GABA) transaminobutyrate and of ion channels. VPA ... ...

Abstract	Valproic acid (VPA), a branched short-chain fatty acid, is widely used as an antiepileptic drug and a mood stabilizer. Antiepileptic properties have been attributed to inhibition of Gamma Amino Butyrate (GABA) transaminobutyrate and of ion channels. VPA was recently classified among the Histone Deacetylase Inhibitors, acting directly at the level of gene transcription by inhibiting histone deacetylation and making transcription sites more accessible. VPA is a widely used drug, particularly for children suffering from epilepsy. Due to the increasing number of clinical trials involving VPA, and interesting results obtained, this molecule will be implicated in an increasing number of therapies. However side effects of VPA are substantially described in the literature whereas they are poorly discussed in articles focusing on its therapeutic use. This paper aims to give an overview of the different clinical-trials involving VPA and its side effects encountered during treatment as well as its molecular properties.
MeSH term(s)	Anticonvulsants/pharmacology ; Clinical Trials as Topic ; Epilepsy/drug therapy ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Valproic Acid/pharmacology ; gamma-Aminobutyric Acid
Chemical Substances	Anticonvulsants ; Histone Deacetylase Inhibitors ; gamma-Aminobutyric Acid (56-12-2) ; Valproic Acid (614OI1Z5WI)
Language	English
Publishing date	2010-07-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2052552-7
ISSN	1110-7251 ; 1110-7243
ISSN (online)	1110-7251
ISSN	1110-7243
DOI	10.1155/2010/479364
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Article ; Online: Inflammation regulates long non-coding RNA-PTTG1-1:1 in myeloid leukemia.

Chateauvieux, Sébastien / Gaigneaux, Anthoula / Gérard, Déborah / Orsini, Marion / Morceau, Franck / Orlikova-Boyer, Barbora / Farge, Thomas / Récher, Christian / Sarry, Jean-Emmanuel / Dicato, Mario / Diederich, Marc

Haematologica

2019 Volume 105, Issue 6, Page(s) e280–e284

MeSH term(s)	Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; Inflammation/genetics ; Leukemia, Myeloid ; RNA, Long Noncoding/genetics
Chemical Substances	RNA, Long Noncoding
Language	English
Publishing date	2019-10-03
Publishing country	Italy
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2019.217281
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Article ; Online: Long and Short Non-Coding RNAs as Regulators of Hematopoietic Differentiation

Mario Dicato / Marc Diederich / Anthoula Gaigneaux / Sébastien Chateauvieux / Franck Morceau

International Journal of Molecular Sciences, Vol 14, Iss 7, Pp 14744-

2013 Volume 14770

Abstract	Genomic analyses estimated that the proportion of the genome encoding proteins corresponds to approximately 1.5%, while at least 66% are transcribed, suggesting that many non-coding DNA-regions generate non-coding RNAs (ncRNAs). The relevance of these ncRNAs in biological, physiological as well as in pathological processes increased over the last two decades with the understanding of their implication in complex regulatory networks. This review particularly focuses on the involvement of two large families of ncRNAs, namely microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the regulation of hematopoiesis. To date, miRNAs have been widely studied, leading to a wealth of data about processing, regulation and mechanisms of action and more specifically, their involvement in hematopoietic differentiation. Notably, the interaction of miRNAs with the regulatory network of transcription factors is well documented whereas roles, regulation and mechanisms of lncRNAs remain largely unexplored in hematopoiesis; this review gathers current data about lncRNAs as well as both potential and confirmed roles in normal and pathological hematopoiesis.
Keywords	ncRNA ; miRNA ; lncRNA ; transcription factors ; regulatory network ; erythropoiesis ; leukemia ; lymphoma ; differentiation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2013-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Tumor necrosis factor α-mediated inhibition of erythropoiesis involves GATA-1/GATA-2 balance impairment and PU.1 over-expression.

Grigorakaki, Christine / Morceau, Franck / Chateauvieux, Sébastien / Dicato, Mario / Diederich, Marc

Biochemical pharmacology

2011 Volume 82, Issue 2, Page(s) 156–166

Abstract: Many physiological perturbations can cause anemia. In cancer patients, activation of the immune system leads to the production of proinflammatory cytokines including tumor necrosis factor alpha (TNFα), that have been shown to inhibit red-cell production ... ...

Abstract	Many physiological perturbations can cause anemia. In cancer patients, activation of the immune system leads to the production of proinflammatory cytokines including tumor necrosis factor alpha (TNFα), that have been shown to inhibit red-cell production via poorly understood mechanisms. Treatment of anemia by human recombinant erythropoietin (EPO) is strongly suspected to induce tumor growth. This study focuses on the mechanisms involved in TNFα-mediated inhibition of erythropoiesis. CD34(+) hematopoietic stem/progenitor cells (HSPCs) were isolated from human cord blood. Erythropoiesis was achieved in vitro by stimulating cells with EPO. We show that TNFα clearly affected erythroid development, as assessed by May-Grünwald/Giemsa staining, flow cytometry analysis and fluorescent microscopy. The amount of hemoglobin-producing cells as well as the expression of GATA-1 target erythro-specific genes (EPO receptor, glycophorin A and globins) was found decreased after TNFα treatment of HSPC. In correlation, TNFα induced the expression of the transcription factors GATA-2 and PU.1, described as inhibitors of erythropoiesis. In this regard, TNFα promoted the formation of the GATA-1/PU.1 complex that has been reported to block the transcriptional activity of GATA-1. Our results clearly demonstrate that TNFα prevents EPO-mediated erythropoiesis of HSPC as an early event, by directly affecting erythroid cell development.
MeSH term(s)	Cells, Cultured ; Erythroid Cells/drug effects ; Erythropoiesis/drug effects ; Erythropoietin/pharmacology ; GATA1 Transcription Factor/metabolism ; GATA2 Transcription Factor/metabolism ; Gene Expression Regulation/drug effects ; Humans ; Proto-Oncogene Proteins/metabolism ; Trans-Activators/metabolism ; Tumor Necrosis Factor-alpha/pharmacology
Chemical Substances	GATA1 Transcription Factor ; GATA1 protein, human ; GATA2 Transcription Factor ; GATA2 protein, human ; Proto-Oncogene Proteins ; Trans-Activators ; Tumor Necrosis Factor-alpha ; proto-oncogene protein Spi-1 ; Erythropoietin (11096-26-7)
Language	English
Publishing date	2011-07-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2011.03.030
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Article ; Online: Molecular and Therapeutic Potential and Toxicity of Valproic Acid

Sébastien Chateauvieux / Franck Morceau / Mario Dicato / Marc Diederich

Journal of Biomedicine and Biotechnology, Vol

2010 Volume 2010

Keywords	Biotechnology ; TP248.13-248.65 ; Medicine ; R
Language	English
Publishing date	2010-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article ; Online: Molecular and Therapeutic Potential and Toxicity of Valproic Acid

Sébastien Chateauvieux / Franck Morceau / Mario Dicato / Marc Diederich

Journal of Biomedicine and Biotechnology, Vol

2010 Volume 2010

Abstract	Valproic acid (VPA), a branched short-chain fatty acid, is widely used as an antiepileptic drug and a mood stabilizer. Antiepileptic properties have been attributed to inhibition of Gamma Amino Butyrate (GABA) transaminobutyrate and of ion channels. VPA was recently classified among the Histone Deacetylase Inhibitors, acting directly at the level of gene transcription by inhibiting histone deacetylation and making transcription sites more accessible. VPA is a widely used drug, particularly for children suffering from epilepsy. Due to the increasing number of clinical trials involving VPA, and interesting results obtained, this molecule will be implicated in an increasing number of therapies. However side effects of VPA are substantially described in the literature whereas they are poorly discussed in articles focusing on its therapeutic use. This paper aims to give an overview of the different clinical-trials involving VPA and its side effects encountered during treatment as well as its molecular properties.
Keywords	Biotechnology ; TP248.13-248.65 ; Chemical technology ; TP1-1185 ; Technology ; T ; DOAJ:Biotechnology ; DOAJ:Life Sciences ; DOAJ:Biology and Life Sciences
Language	English
Publishing date	2010-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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