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  1. Book: TRP channels

    Ferrer-Montiel, Antonio / Hucho, Tim

    methods and protocols

    (Methods in molecular biology ; 1987 ; Springer protocols)

    2019  

    Author's details edited by Antonio Ferrer-Montiel, Tim Hucho
    Series title Methods in molecular biology ; 1987
    Springer protocols
    Collection
    Language English
    Size x, 238 Seiten, Illustrationen
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT020057102
    ISBN 978-1-4939-9445-8 ; 9781493994465 ; 1-4939-9445-X ; 1493994468
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1987- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Membrane Channels in Health and Diseases.

    Felipe, Antonio / Ferrer-Montiel, Antonio

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: The goal of this Special Issue, entitled "Membrane Channels in Health and Diseases (https://www [ ... ]. ...

    Abstract The goal of this Special Issue, entitled "Membrane Channels in Health and Diseases (https://www [...].
    MeSH term(s) Ion Channels
    Chemical Substances Ion Channels
    Language English
    Publishing date 2023-04-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Membrane Channels in Health and Diseases

    Antonio Felipe / Antonio Ferrer-Montiel

    International Journal of Molecular Sciences, Vol 24, Iss 6719, p

    2023  Volume 6719

    Abstract: The goal of this Special Issue, entitled “Membrane Channels in Health and Diseases (https://www [.] ...

    Abstract The goal of this Special Issue, entitled “Membrane Channels in Health and Diseases (https://www [.]
    Keywords n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: TRPV1 in chronic pruritus and pain: Soft modulation as a therapeutic strategy.

    Fernández-Carvajal, Asia / Fernández-Ballester, Gregorio / Ferrer-Montiel, Antonio

    Frontiers in molecular neuroscience

    2022  Volume 15, Page(s) 930964

    Abstract: Chronic pain and pruritus are highly disabling pathologies that still lack appropriate therapeutic intervention. At cellular level the transduction and transmission of pain and pruritogenic signals are closely intertwined, negatively modulating each ... ...

    Abstract Chronic pain and pruritus are highly disabling pathologies that still lack appropriate therapeutic intervention. At cellular level the transduction and transmission of pain and pruritogenic signals are closely intertwined, negatively modulating each other. The molecular and cellular pathways involved are multifactorial and complex, including peripheral and central components. Peripherally, pain and itch are produced by subpopulations of specialized nociceptors that recognize and transduce algesic and pruritogenic signals. Although still under intense investigation, cumulative evidence is pointing to the thermosensory channel TRPV1 as a hub for a large number of pro-algesic and itchy agents. TRPV1 appears metabolically coupled to most neural receptors that recognize algesic and pruritic molecules. Thus, targeting TRPV1 function appears as a valuable and reasonable therapeutic strategy. In support of this tenet, capsaicin, a desensitizing TRPV1 agonist, has been shown to exhibit clinically relevant analgesic, anti-inflammatory, and anti-pruritic activities. However, potent TRPV1 antagonists have been questioned due to an hyperthermic secondary effect that prevented their clinical development. Thus, softer strategies directed to modulate peripheral TRPV1 function appear warranted to alleviate chronic pain and itch. In this regard, soft, deactivatable TRPV1 antagonists for topical or local application appear as an innovative approach for improving the distressing painful and itchy symptoms of patients suffering chronic pain or pruritus. Here, we review the data on these compounds and propose that this strategy could be used to target other peripheral therapeutic targets.
    Language English
    Publishing date 2022-09-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2022.930964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Spanish Ion Channel Initiative (SICI) Consortium: Ten Years (2008⁻2018) of a Network of Excellence on Ion Channel Research.

    Felipe, Antonio / Ferrer-Montiel, Antonio

    International journal of molecular sciences

    2018  Volume 19, Issue 11

    Abstract: The Spanish Ion Channel Initiative consortium (SICI, http://sici. [ ... ]. ...

    Abstract The Spanish Ion Channel Initiative consortium (SICI, http://sici. [...].
    MeSH term(s) Evoked Potentials, Motor/genetics ; Humans ; Ion Channels/genetics ; Research ; Spain
    Chemical Substances Ion Channels
    Language English
    Publishing date 2018-11-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19113514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Progress in the Structural Basis of thermoTRP Channel Polymodal Gating

    Gregorio Fernández-Ballester / Asia Fernández-Carvajal / Antonio Ferrer-Montiel

    International Journal of Molecular Sciences, Vol 24, Iss 1, p

    2023  Volume 743

    Abstract: The thermosensory transient receptor potential (thermoTRP) family of ion channels is constituted by several nonselective cation channels that are activated by physical and chemical stimuli functioning as paradigmatic polymodal receptors. Gating of these ... ...

    Abstract The thermosensory transient receptor potential (thermoTRP) family of ion channels is constituted by several nonselective cation channels that are activated by physical and chemical stimuli functioning as paradigmatic polymodal receptors. Gating of these ion channels is achieved through changes in temperature, osmolarity, voltage, pH, pressure, and by natural or synthetic chemical compounds that directly bind to these proteins to regulate their activity. Given that thermoTRP channels integrate diverse physical and chemical stimuli, a thorough understanding of the molecular mechanisms underlying polymodal gating has been pursued, including the interplay between stimuli and differences between family members. Despite its complexity, recent advances in cryo-electron microscopy techniques are facilitating this endeavor by providing high-resolution structures of these channels in different conformational states induced by ligand binding or temperature that, along with structure-function and molecular dynamics, are starting to shed light on the underlying allosteric gating mechanisms. Because dysfunctional thermoTRP channels play a pivotal role in human diseases such as chronic pain, unveiling the intricacies of allosteric channel gating should facilitate the development of novel drug-based resolving therapies for these disorders.
    Keywords TRP channels ; thermoreceptors ; polymodality ; channel opening ; TRPV1 ; TRPM8 ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 572
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Paclitaxel in vitro reversibly sensitizes the excitability of IB4(-) and IB4(+) sensory neurons from male and female rats.

    Villalba-Riquelme, Eva / de la Torre-Martínez, Roberto / Fernández-Carvajal, Asia / Ferrer-Montiel, Antonio

    British journal of pharmacology

    2022  Volume 179, Issue 14, Page(s) 3693–3710

    Abstract: Background and purpose: Paclitaxel produces a chemotherapy-induced peripheral neuropathy that persists in 50-60% of cancer patients upon treatment. Evidence from animal models suggests an axonopathy of peripheral A- and C-type fibres that affects their ... ...

    Abstract Background and purpose: Paclitaxel produces a chemotherapy-induced peripheral neuropathy that persists in 50-60% of cancer patients upon treatment. Evidence from animal models suggests an axonopathy of peripheral A- and C-type fibres that affects their excitability. However, direct effects of paclitaxel on sensory neuron excitability and sexual dimorphism remain poorly understood.
    Experimental approach: We used a long-lasting (10 days in vitro) primary culture of rat dorsal root ganglion (DRG) neurons to investigate the time course effect of paclitaxel on the electrical activity of IB4(-) and IB4(+) sensory neurons of female and male adult Wistar rats.
    Key results: Paclitaxel strongly and reversibly stimulated spontaneous activity and augmented action potential tonic firing in IB4(-) and IB4(+) neurons in both sexes, peaking at 48 h post-treatment and virtually disappearing at 96 h. Paclitaxel decreased the current rheobase for action potential firing by reducing and accelerating the after-hyperpolarization phase. Molecularly, paclitaxel modulated Na
    Conclusions and implications: Our data indicate that paclitaxel similarly potentiated IB4(-) and IB4(+) electrogenicity and uncover a potential sex dimorphism in paclitaxel-induced chemotherapy-induced peripheral neuropathy. Our in vitro, pre-clinical, chemotherapy-induced peripheral neuropathy paradigm provides a tool for studying the dynamics and underlying molecular mechanisms contributing to nociceptor sensitization in peripheral neuropathies and for testing desensitizing compounds.
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Female ; Ganglia, Spinal ; Humans ; Male ; Paclitaxel/pharmacology ; Peripheral Nervous System Diseases ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar ; Sensory Receptor Cells
    Chemical Substances Antineoplastic Agents ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2022-03-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.15809
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uf I Zs.146: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: ThermoTRP channels in pain sexual dimorphism: new insights for drug intervention.

    Cabañero, David / Villalba-Riquelme, Eva / Fernández-Ballester, Gregorio / Fernández-Carvajal, Asia / Ferrer-Montiel, Antonio

    Pharmacology & therapeutics

    2022  Volume 240, Page(s) 108297

    Abstract: Chronic pain is a major burden for the society and remains more prevalent and severe in females. The presence of chronic pain is linked to persistent alterations in the peripheral and the central nervous system. One of the main types of peripheral pain ... ...

    Abstract Chronic pain is a major burden for the society and remains more prevalent and severe in females. The presence of chronic pain is linked to persistent alterations in the peripheral and the central nervous system. One of the main types of peripheral pain transducers are the transient receptor potential channels (TRP), also known as thermoTRP channels, which intervene in the perception of hot and cold external stimuli. These channels, and especially TRPV1, TRPA1 and TRPM8, have been subjected to profound investigation because of their role as thermosensors and also because of their implication in acute and chronic pain. Surprisingly, their sensitivity to endogenous signaling has been far less studied. Cumulative evidence suggests that the function of these channels may be differently modulated in males and females, in part through sexual hormones, and this could constitute a significant contributor to the sex differences in chronic pain. Here, we review the exciting advances in thermoTRP pharmacology for males and females in two paradigmatic types of chronic pain with a strong peripheral component: chronic migraine and chemotherapy-induced peripheral neuropathy (CIPN). The possibilities of peripheral druggability offered by these channels and the differential exploitation for men and women represent a development opportunity that will lead to a significant increment of the armamentarium of analgesic medicines for personalized chronic pain treatment.
    MeSH term(s) Female ; Humans ; Male ; Analgesics/therapeutic use ; Chronic Pain/drug therapy ; Migraine Disorders/drug therapy ; Sex Characteristics ; Transient Receptor Potential Channels/metabolism ; Peripheral Nervous System Diseases ; Antineoplastic Agents/adverse effects ; Thermoreceptors/metabolism
    Chemical Substances Analgesics ; Transient Receptor Potential Channels ; Antineoplastic Agents
    Language English
    Publishing date 2022-10-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2022.108297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1183: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Benzydamine plays a role in limiting inflammatory pain induced by neuronal sensitization.

    Nikolaeva-Koleva, Magdalena / Espinosa, Ana / Vergassola, Matteo / Polenzani, Lorenzo / Mangano, Giorgina / Ragni, Lorella / Zucchi, Sara / Ferrer-Montiel, Antonio / Devesa, Isabel

    Molecular pain

    2023  Volume 19, Page(s) 17448069231204191

    Abstract: Benzydamine is an active pharmaceutical compound used in the oral care pharmaceutical preparation as NSAID. Beside from its anti-inflammatory action, benzydamine local application effectively reliefs pain showing analgesic and anaesthetic properties. ... ...

    Abstract Benzydamine is an active pharmaceutical compound used in the oral care pharmaceutical preparation as NSAID. Beside from its anti-inflammatory action, benzydamine local application effectively reliefs pain showing analgesic and anaesthetic properties. Benzydamine mechanism of action has been characterized on inflammatory cell types and mediators highlighting its capacity to inhibit pro-inflammatory mediators' synthesis and release. On the other hand, the role of benzydamine as neuronal excitability modulator has not yet fully explored. Thus, we studied benzydamine's effect over primary cultured DRG nociceptors excitability and after acute and chronic inflammatory sensitization, as a model to evaluate relative nociceptive response. Benzydamine demonstrated to effectively inhibit neuronal basal excitability reducing its firing frequency and increasing rheobase and afterhyperpolarization amplitude. Its effect was time and dose-dependent. At higher doses, benzydamine induced changes in action potential wavelength, decreasing its height and slightly increasing its duration. Moreover, the compound reduced neuronal acute and chronic inflammatory sensitization. It inhibited neuronal excitability mediated either by an inflammatory cocktail, acidic pH or high external KCl. Notably, higher potency was evidenced under inflammatory sensitized conditions. This effect could be explained either by modulation of inflammatory and/or neuronal sensitizing signalling cascades or by direct modulation of proalgesic and action potential firing initiating ion channels. Apparently, the compound inhibited Na
    MeSH term(s) Humans ; Benzydamine/metabolism ; Benzydamine/pharmacology ; Benzydamine/therapeutic use ; Pain/drug therapy ; Pain/metabolism ; Nociceptors/metabolism ; Inflammation/drug therapy ; Inflammation/metabolism ; Anti-Inflammatory Agents/therapeutic use ; Analgesics/pharmacology ; Analgesics/therapeutic use ; Analgesics/metabolism
    Chemical Substances Benzydamine (4O21U048EF) ; Anti-Inflammatory Agents ; Analgesics
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2174252-2
    ISSN 1744-8069 ; 1744-8069
    ISSN (online) 1744-8069
    ISSN 1744-8069
    DOI 10.1177/17448069231204191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Spanish Ion Channel Initiative (SICI) Consortium

    Antonio Felipe / Antonio Ferrer-Montiel

    International Journal of Molecular Sciences, Vol 19, Iss 11, p

    Ten Years (2008–2018) of a Network of Excellence on Ion Channel Research

    2018  Volume 3514

    Abstract: The Spanish Ion Channel Initiative consortium (SICI, http://sici. [.] ...

    Abstract The Spanish Ion Channel Initiative consortium (SICI, http://sici. [.]
    Keywords n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2018-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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