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  1. Article ; Online: “Quando a Massa Erra, o Estado Avança”

    Fabio Candotti

    Tomo, Iss

    2022  Volume 40

    Abstract: Em 2017 e 2019 ocorreram dois ‘massacres’ em prisões de Manaus, capital do estado brasileiro do Amazonas. O discurso dominante reduz esses acontecimentos a uma ‘guerra’ entre facções criminosas pelo controle de rotas internacionais de tráfico de drogas. ... ...

    Abstract Em 2017 e 2019 ocorreram dois ‘massacres’ em prisões de Manaus, capital do estado brasileiro do Amazonas. O discurso dominante reduz esses acontecimentos a uma ‘guerra’ entre facções criminosas pelo controle de rotas internacionais de tráfico de drogas. O artigo parte de uma problematização desse discurso (de sua natureza colonial e de seus efeitos de verdade) e esboça uma outra análise que atenta para as correlações entre transformações carcerárias e criminais. O artigo defende a ideia de que uma nova gestão do sofrimento e um novo regime de tortura, experimentados por presos e suas familiares, foram determinantes para a desestabilização e reconfiguração das alianças no crime após os massacres. O texto é fruto de uma experiência de conhecimento imersa na luta anticarcerária, incluindo convivência intensa com familiares de pessoas presas e sobreviventes, comunicações com órgãos de fiscalização e participação em inspeções dentro de unidades prisionais.
    Keywords Social Sciences ; H ; Social sciences (General) ; H1-99
    Language Spanish
    Publishing date 2022-01-01T00:00:00Z
    Publisher Universidade Federal de Sergipe
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: "Inborn errors of immunity: An expanding horizon through a multitude of biological pathways".

    Candotti, Fabio / Eigenmann, Philippe

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2023  Volume 34, Issue 1, Page(s) e13908

    Language English
    Publishing date 2023-01-27
    Publishing country England
    Document type Editorial
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13908
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    Zs.A 3096: Show issues Location:
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  3. Article ; Online: Gene therapy for Wiskott-Aldrich syndrome: here to stay.

    Candotti, Fabio

    The Lancet. Haematology

    2019  Volume 6, Issue 5, Page(s) e230–e231

    MeSH term(s) Gene Transfer Techniques ; Genetic Therapy/methods ; Humans ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Wiskott-Aldrich Syndrome/genetics ; Wiskott-Aldrich Syndrome/immunology ; Wiskott-Aldrich Syndrome/therapy
    Language English
    Publishing date 2019-04-10
    Publishing country England
    Document type Letter
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(19)30066-3
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  4. Article ; Online: Gene Therapy for Inborn Errors of Immunity.

    Arlabosse, Tiphaine / Booth, Claire / Candotti, Fabio

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 6, Page(s) 1592–1601

    Abstract: In the early 1990s, gene therapy (GT) entered the clinical arena as an alternative to hematopoietic stem cell transplantation for forms of inborn errors of immunity (IEIs) that are not medically manageable because of their severity. In principle, the use ...

    Abstract In the early 1990s, gene therapy (GT) entered the clinical arena as an alternative to hematopoietic stem cell transplantation for forms of inborn errors of immunity (IEIs) that are not medically manageable because of their severity. In principle, the use of gene-corrected autologous hematopoietic stem cells presents several advantages over hematopoietic stem cell transplantation, including making donor searches unnecessary and avoiding the risks for graft-versus-host disease. In the past 30 years or more of clinical experience, the field has witnessed multiple examples of successful applications of GT to a number of IEIs, as well as some serious drawbacks, which have highlighted the potential genotoxicity of integrating viral vectors and stimulated important progress in the development of safer gene transfer tools. The advent of gene editing technologies promises to expand the spectrum of IEIs amenable to GT to conditions caused by mutated genes that require the precise regulation of expression or by dominant-negative variants. Here, we review the main concepts of GT as it applies to IEIs and the clinical results obtained to date. We also describe the challenges faced by this branch of medicine, which operates in the unprofitable sector of human rare diseases.
    MeSH term(s) Humans ; Genetic Therapy/methods ; Hematopoietic Stem Cell Transplantation/methods ; Graft vs Host Disease
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.04.001
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  5. Article ; Online: Clinical Manifestations and Pathophysiological Mechanisms of the Wiskott-Aldrich Syndrome.

    Candotti, Fabio

    Journal of clinical immunology

    2017  Volume 38, Issue 1, Page(s) 13–27

    Abstract: The Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder originally described by Dr. Alfred Wiskott in 1937 and Dr. Robert Aldrich in 1954 as a familial disease characterized by infections, bleeding tendency, and eczema. Today, it is well ... ...

    Abstract The Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder originally described by Dr. Alfred Wiskott in 1937 and Dr. Robert Aldrich in 1954 as a familial disease characterized by infections, bleeding tendency, and eczema. Today, it is well recognized that the syndrome has a wide clinical spectrum ranging from mild, isolated thrombocytopenia to full-blown presentation that can be complicated by life-threatening hemorrhages, immunodeficiency, atopy, autoimmunity, and cancer. The pathophysiology of classic and emerging features is being elucidated by clinical studies, but remains incompletely defined, which hinders the application of targeted therapies. At the same time, progress of hematopoietic stem cell transplantation and gene therapy offer optimistic prospects for treatment options aimed at the replacement of the defective lymphohematopoietic system that have the potential to provide a cure for this rare and polymorphic disease.
    MeSH term(s) Autoimmunity ; Eczema ; Genes, X-Linked/genetics ; Genetic Therapy ; Hematopoietic Stem Cell Transplantation ; Humans ; Infections ; Mutation/genetics ; Neoplasms ; Thrombocytopenia ; Wiskott-Aldrich Syndrome/genetics ; Wiskott-Aldrich Syndrome/physiopathology ; Wiskott-Aldrich Syndrome/therapy ; Wiskott-Aldrich Syndrome Protein/genetics
    Chemical Substances Wiskott-Aldrich Syndrome Protein
    Language English
    Publishing date 2017-10-30
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-017-0453-z
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  6. Article ; Online: Editorial comment on "Inborn errors of immunity associated with defects of thymic development".

    Beken, Burcin / Castagnoli, Riccardo / Candotti, Fabio

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2022  Volume 33, Issue 9, Page(s) e13847

    Language English
    Publishing date 2022-09-26
    Publishing country England
    Document type Editorial
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13847
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  7. Article: Advances of gene therapy for primary immunodeficiencies.

    Candotti, Fabio

    F1000Research

    2016  Volume 5

    Abstract: In the recent past, the gene therapy field has witnessed a remarkable series of successes, many of which have involved primary immunodeficiency diseases, such as X-linked severe combined immunodeficiency, adenosine deaminase deficiency, chronic ... ...

    Abstract In the recent past, the gene therapy field has witnessed a remarkable series of successes, many of which have involved primary immunodeficiency diseases, such as X-linked severe combined immunodeficiency, adenosine deaminase deficiency, chronic granulomatous disease, and Wiskott-Aldrich syndrome. While such progress has widened the choice of therapeutic options in some specific cases of primary immunodeficiency, much remains to be done to extend the geographical availability of such an advanced approach and to increase the number of diseases that can be targeted. At the same time, emerging technologies are stimulating intensive investigations that may lead to the application of precise genetic editing as the next form of gene therapy for these and other human genetic diseases.
    Language English
    Publishing date 2016-03-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.7512.1
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  8. Article ; Online: Access to gene therapy for rare diseases when commercialization is not fit for purpose.

    Fox, Thomas / Bueren, Juan / Candotti, Fabio / Fischer, Alain / Aiuti, Alessandro / Lankester, Arjan / Booth, Claire

    Nature medicine

    2023  Volume 29, Issue 3, Page(s) 518–519

    MeSH term(s) Humans ; Rare Diseases/genetics ; Rare Diseases/therapy ; Genetic Therapy
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Letter
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-023-02208-8
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  9. Article ; Online: Apresentação do Dossiê

    Fernando Rodrigues / Fabio Magalhães Candotti / Karina Biondi / Luiz Fábio S. Paiva

    Tomo, Iss

    2022  Volume 40

    Abstract: Apresentação do ... ...

    Abstract Apresentação do Dossiê
    Keywords Social Sciences ; H ; Social sciences (General) ; H1-99
    Language Spanish
    Publishing date 2022-01-01T00:00:00Z
    Publisher Universidade Federal de Sergipe
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Advances of gene therapy for primary immunodeficiencies [version 1; referees

    Fabio Candotti

    F1000Research, Vol

    2 approved]

    2016  Volume 5

    Abstract: In the recent past, the gene therapy field has witnessed a remarkable series of successes, many of which have involved primary immunodeficiency diseases, such as X-linked severe combined immunodeficiency, adenosine deaminase deficiency, chronic ... ...

    Abstract In the recent past, the gene therapy field has witnessed a remarkable series of successes, many of which have involved primary immunodeficiency diseases, such as X-linked severe combined immunodeficiency, adenosine deaminase deficiency, chronic granulomatous disease, and Wiskott-Aldrich syndrome. While such progress has widened the choice of therapeutic options in some specific cases of primary immunodeficiency, much remains to be done to extend the geographical availability of such an advanced approach and to increase the number of diseases that can be targeted. At the same time, emerging technologies are stimulating intensive investigations that may lead to the application of precise genetic editing as the next form of gene therapy for these and other human genetic diseases.
    Keywords Genetics of the Immune System ; Hematopoietic Stem Cells ; Immunomodulation ; Immunopharmacology & Hematologic Pharmacology ; Medical Genetics ; Medical Microbiology ; Non-hematopoietic Stem Cells ; Pediatric Hematology ; Pediatric Infectious Diseases ; Pharmacokinetics & Drug Delivery ; Stem Cells & Regeneration ; Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2016-03-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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