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Article ; Online: Controlled Release of Drugs from Extracellular Matrix-Derived Peptide-Based Nanovesicles through Tailored Noncovalent Interactions.

Huang, Haofu / Hwang, Jeongmin / Anilkumar, Sudha / Kiick, Kristi L

Biomacromolecules

2024 Volume 25, Issue 4, Page(s) 2408–2422

Abstract: Elastin-collagen nanovesicles (ECnV) have emerged as a promising platform for drug delivery due to their tunable physicochemical properties and biocompatibility. The potential of nine distinct ECnVs to serve as drug-delivery vehicles was investigated in ... ...

Abstract	Elastin-collagen nanovesicles (ECnV) have emerged as a promising platform for drug delivery due to their tunable physicochemical properties and biocompatibility. The potential of nine distinct ECnVs to serve as drug-delivery vehicles was investigated in this study, and it was demonstrated that various small-molecule cargo (e.g., dexamethasone, methotrexate, doxorubicin) can be encapsulated in and released from a set of ECnVs, with extents of loading and rates of release dictated by the composition of the elastin domain of the ECnV and the type of cargo. Elastin-like peptides (ELPs) and collagen-like peptides (CLPs) of various compositions were produced; the secondary structure of the corresponding peptides was determined using CD, and the morphology and average hydrodynamic diameter (∼100 nm) of the ECnVs were determined using TEM and DLS. It was observed that hydrophobic drugs exhibited slower release kinetics than hydrophilic drugs, but higher drug loading was achieved for the more hydrophilic Dox. The collagen-binding ability of the ECnVs was demonstrated through a 2D collagen-binding assay, suggesting the potential for longer retention times in collagen-enriched tissues or matrices. Sustained release of drugs for up to 7 days was observed and, taken together with the collagen-binding data, demonstrates the potential of this set of ECnVs as a versatile drug delivery vehicle for longer-term drug release of a variety of cargo. This study provides important insights into the drug delivery potential of ECnVs and offers useful information for future development of ECnV-based drug delivery systems for the treatment of various diseases.
MeSH term(s)	Delayed-Action Preparations ; Peptides/chemistry ; Drug Delivery Systems ; Doxorubicin/chemistry ; Collagen/chemistry ; Extracellular Matrix ; Elastin/chemistry
Chemical Substances	Delayed-Action Preparations ; Peptides ; Doxorubicin (80168379AG) ; Collagen (9007-34-5) ; Elastin (9007-58-3)
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ISSN	1526-4602
ISSN (online)	1526-4602
DOI	10.1021/acs.biomac.3c01361
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: VEGF-Encoding, Gene-Activated Collagen-Based Matrices Promote Blood Vessel Formation and Improved Wound Repair.

Hwang, Jeongmin / Kiick, Kristi L / Sullivan, Millicent O

ACS applied materials & interfaces

2023 Volume 15, Issue 13, Page(s) 16434–16447

Abstract: Disruption in vascularization during wound repair can severely impair healing. Proangiogenic growth factor therapies have shown great healing potential; however, controlling growth factor activity and cellular behavior over desired healing time scales ... ...

Abstract	Disruption in vascularization during wound repair can severely impair healing. Proangiogenic growth factor therapies have shown great healing potential; however, controlling growth factor activity and cellular behavior over desired healing time scales remains challenging. In this study, we evaluated collagen-mimetic peptide (CMP) tethers for their capacity to control growth factor gene transfer and growth factor activity using our recently developed gene-activated hyaluronic acid-collagen matrix (GAHCM). GAHCM was comprised of DNA/polyethyleneimine (PEI) polyplexes that were retained on hyaluronic acid (HA)-collagen hydrogels using CMPs. We hypothesized that using CMP-collagen tethers to control vascular endothelial growth factor-A (VEGF-A) gene delivery in fibroblasts would provide a powerful strategy to modulate the proangiogenic behaviors of endothelial cells (ECs) for blood vessel formation, resulting in enhanced wound repair. In co-culture experiments, we observed that CMP-modified GAHCM induced tunable gene delivery in fibroblasts as predicted, and correspondingly, VEGF-A produced by the fibroblasts led to increased growth and persistent migration of ECs for at least 7 days, as compared to non-CMP-modified GAHCM. Moreover, when ECs were exposed to fibroblast-containing VEGF-GAHCM with higher levels of CMP modification (50% CMP-PEI, or 50 CP), high CD31 expression was stimulated, resulting in the formation of an interconnected EC network with a significantly higher network volume and a larger diameter network structure than controls. Application of VEGF-GAHCM with 50 CP in murine splinted excisional wounds facilitated prolonged prohealing and proangiogenic responses resulting in increased blood vessel formation, improved granulation tissue formation, faster re-epithelialization, and overall enhanced repair. These findings suggest the benefits of CMP-collagen tethers as useful tools to control gene transfer and growth factor activity for improved treatment of wounds.
MeSH term(s)	Mice ; Animals ; Wound Healing ; Vascular Endothelial Growth Factor A/metabolism ; Hyaluronic Acid/chemistry ; Endothelial Cells/metabolism ; Collagen/chemistry
Chemical Substances	Vascular Endothelial Growth Factor A ; Hyaluronic Acid (9004-61-9) ; Collagen (9007-34-5)
Language	English
Publishing date	2023-03-24
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c23022
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Article ; Online: Controlled Delivery of Vancomycin from Collagen-tethered Peptide Vehicles for the Treatment of Wound Infections.

Hwang, Jeongmin / Huang, Haofu / Sullivan, Millicent O / Kiick, Kristi L

Molecular pharmaceutics

2023 Volume 20, Issue 3, Page(s) 1696–1708

Abstract: Despite the great promise of antibiotic therapy in wound infections, antibiotic resistance stemming from frequent dosing diminishes drug efficacy and contributes to recurrent infection. To identify improvements in antibiotic therapies, new antibiotic ... ...

Abstract	Despite the great promise of antibiotic therapy in wound infections, antibiotic resistance stemming from frequent dosing diminishes drug efficacy and contributes to recurrent infection. To identify improvements in antibiotic therapies, new antibiotic delivery systems that maximize pharmacological activity and minimize side effects are needed. In this study, we developed elastin-like peptide and collagen-like peptide nanovesicles (ECnVs) tethered to collagen-containing matrices to control vancomycin delivery and provide extended antibacterial effects against methicillin-resistant
MeSH term(s)	Humans ; Vancomycin ; Methicillin-Resistant Staphylococcus aureus ; Anti-Bacterial Agents/pharmacology ; Liposomes/pharmacology ; Microbial Sensitivity Tests ; Collagen/pharmacology ; Wound Infection
Chemical Substances	Vancomycin (6Q205EH1VU) ; Anti-Bacterial Agents ; Liposomes ; Collagen (9007-34-5)
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.2c00898
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Article ; Online: Modified hyaluronic acid-collagen matrices trigger efficient gene transfer and prohealing behavior in fibroblasts for improved wound repair.

Hwang, Jeongmin / Kiick, Kristi L / Sullivan, Millicent O

Acta biomaterialia

2022 Volume 150, Page(s) 138–153

Abstract: Growth factor therapy has demonstrated great promise for chronic wound repair, but controlling growth factor activity and cell phenotype over desired time frames remains a critical challenge. In this study, we developed a gene-activated hyaluronic acid- ... ...

Abstract	Growth factor therapy has demonstrated great promise for chronic wound repair, but controlling growth factor activity and cell phenotype over desired time frames remains a critical challenge. In this study, we developed a gene-activated hyaluronic acid-collagen matrix (GAHCM) comprising DNA/polyethylenimine (PEI) polyplexes retained on hyaluronic acid (HA)-collagen hydrogels using collagen mimetic peptides (CMPs). We hypothesized that manipulating both the number of CMP-collagen tethers and the ECM composition would provide a powerful strategy to control growth factor gene transfer kinetics while regulating cell behavior, resulting in enhanced growth factor activity for wound repair. We observed that polyplexes with 50% CMP-modified PEI (50 CP) showed enhanced retention of polyplexes in HCM hydrogels by 2.7-fold as compared to non-CMP modified polyplexes. Moreover, the incorporation of HA in the hydrogel promoted a significant increase in gene transfection efficiency based upon analysis of Gaussia luciferase (GLuc) reporter gene expression, and gene expression could be attenuated by blocking HA-CD44 signaling. Furthermore, when fibroblasts were exposed to vascular endothelial growth factor-A (VEGF-A)-GAHCM, the 50 CP matrix facilitated sustained VEGF-A production for up to 7 days, with maximal expression at day 5. Application of these VEGF-A-50 CP samples stimulated prolonged pro-healing responses, including the TGF-β1-induced myofibroblast-like phenotypes and enhanced closure of murine splinted wounds. Overall, these findings demonstrate the use of ECM-based materials to stimulate efficient gene transfer and regulate cellular phenotype, resulting in improved control of growth factor activity for wound repair. GAHCM has significant potential to overcome key challenges in growth factor therapy for regenerative medicine. STATEMENT OF SIGNIFICANCE: Despite great promise for growth factor therapies in wound treatment, controlling growth factor activity and providing a microenvironment for cells that maximizes growth factor signaling have continued to limit the success of existing formulations. Our GAHCM strategy, combining CMP gene delivery and a hyaluronic acid-collagen matrix, enabled enhanced wound healing efficacy via the combination of controlled and localized growth factor expression and matrix-mediated regulation of cell behavior. Incorporation of CMPs and HA in the same matrix synergistically enhanced VEGF activity as compared with simpler matrices. Accordingly, GAHCM will advance our ability to leverage growth factor signaling for wound healing, resulting in new long-term treatments for recalcitrant wounds.
MeSH term(s)	Animals ; Collagen/chemistry ; Fibroblasts/metabolism ; Hyaluronic Acid/chemistry ; Hyaluronic Acid/pharmacology ; Hydrogels/chemistry ; Hydrogels/pharmacology ; Mice ; Polyethyleneimine/chemistry ; Polyethyleneimine/pharmacology ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism ; Wound Healing
Chemical Substances	Hydrogels ; Vascular Endothelial Growth Factor A ; Polyethyleneimine (9002-98-6) ; Hyaluronic Acid (9004-61-9) ; Collagen (9007-34-5)
Language	English
Publishing date	2022-07-28
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2173841-5
ISSN	1878-7568 ; 1742-7061
ISSN (online)	1878-7568
ISSN	1742-7061
DOI	10.1016/j.actbio.2022.07.039
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Article ; Online: How to Better Treat Patients with Intermittent Exotropia: A Review of Surgical Treatment of Intermittent Exotropia.

Hwang, Jeong-Min

Korean journal of ophthalmology : KJO

2022 Volume 36, Issue 6, Page(s) 550–564

Abstract: Intermittent exotropia (X(T)) is the most common form of strabismus, especially in Asians. Treatment of X(T) includes occlusion, overminus lens, and surgery, of which, surgery is the mainstay of treatment. Commonly performed surgical procedures for X(T) ... ...

Abstract	Intermittent exotropia (X(T)) is the most common form of strabismus, especially in Asians. Treatment of X(T) includes occlusion, overminus lens, and surgery, of which, surgery is the mainstay of treatment. Commonly performed surgical procedures for X(T) are bilateral lateral rectus muscle recession or unilateral lateral rectus recession with medial rectus resection; however, it is unclear which of the two surgeries is more effective. The purpose of this review is to provide an insight on the surgical treatment of X(T). Randomized controlled trials, comparative observational studies, and case series with a large number of patients as well as a long follow-up period of over a year were included.
Language	English
Publishing date	2022-10-11
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	639346-9
ISSN	2092-9382 ; 1011-8942
ISSN (online)	2092-9382
ISSN	1011-8942
DOI	10.3341/kjo.2022.0043
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Article ; Online: Superoxide Dismutase-Mimetic Polyphenol-Based Carbon Dots for Multimodal Bioimaging and Treatment of Atopic Dermatitis.

Han, Jeongmin / Choi, Sumi / Hong, Jinwoo / Gang, Dayeong / Lee, Seunghoon / Shin, Kwangsoo / Ko, Junghyeon / Kim, Jeong-Uk / Hwang, Nathaniel S / An, Young-Hyeon / Gu, Minsu / Kim, Su-Hwan

ACS applied materials & interfaces

2024

Abstract: Polyphenols have been investigated for their potential to mitigate inflammation in the context of atopic dermatitis (AD). In this study, epigallocatechin-3-gallate (EGCG)-based carbon dots (EGCG@CDs) were developed to enhance transdermal penetration, ... ...

Abstract	Polyphenols have been investigated for their potential to mitigate inflammation in the context of atopic dermatitis (AD). In this study, epigallocatechin-3-gallate (EGCG)-based carbon dots (EGCG@CDs) were developed to enhance transdermal penetration, reduce inflammation, recapitulate superoxide dismutase (SOD) activity, and provide antimicrobial effects for AD treatment. The water-soluble EGCG@CDs in a few nanometers size exhibit a negative zeta potential, making them suitable for effective transdermal penetration. The fluorescence properties, including an upconversion effect, make EGCG@CDs suitable imaging probes for both
Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.4c02634
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Article ; Online: Recovering Nutrients from Waste Black Water Through Multi-Functional Mesoporous Silica.

Kim, Eun-Sik / Shim, Wang Geun / Cha, Jeongmin / Hwang, Min-Jin

Journal of nanoscience and nanotechnology

2021 Volume 21, Issue 9, Page(s) 4936–4940

Abstract: In order to prevent the harmful effects in water phase such as eutrophication, industrial and urban sewages must be treated before discharging into the aquatic environment. In this work, amine grafted magnetic nanoporous silica materials are synthesized ... ...

Abstract	In order to prevent the harmful effects in water phase such as eutrophication, industrial and urban sewages must be treated before discharging into the aquatic environment. In this work, amine grafted magnetic nanoporous silica materials are synthesized and applied as an adsorbent for the recovery of nutrients from waste black water. The magnetic force could separate the surface func-tionalized nanoporous silica materials from aqueous medium after treatment, and showed the higher adsorption capacity of nutrients than that of the original mesoporous silica. The multi-functional nanoporous silica adsorbents were effectively removed phosphate and nitrate at 20 °C with the maximum adsorption capacities of 42.5 and 34.9 mg/g, respectively. The overall results indicated that the synthesized multi-functional nanoporous silica sorbents can be a candidate material for the nutrient recovery in wastewater treatment system.
MeSH term(s)	Adsorption ; Nutrients ; Silicon Dioxide ; Waste Water ; Water
Chemical Substances	Waste Water ; Water (059QF0KO0R) ; Silicon Dioxide (7631-86-9)
Language	English
Publishing date	2021-03-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1533-4899
ISSN (online)	1533-4899
DOI	10.1166/jnn.2021.19270
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Article ; Online: Oxidation of iron by giant impact and its implication on the formation of reduced atmosphere in the early Earth.

Choi, Jinhyuk / Husband, Rachel J / Hwang, Huijeong / Kim, Taehyun / Bang, Yoonah / Yun, Seohee / Lee, Jeongmin / Sim, Heehyeon / Kim, Sangsoo / Nam, Daewoong / Chae, Boknam / Liermann, Hanns-Peter / Lee, Yongjae

Science advances

2023 Volume 9, Issue 50, Page(s) eadi6096

Abstract: Giant impact-driven redox processes in the atmosphere and magma ocean played crucial roles in the evolution of Earth. However, because of the absence of rock records from that time, understanding these processes has proven challenging. Here, we present ... ...

Abstract	Giant impact-driven redox processes in the atmosphere and magma ocean played crucial roles in the evolution of Earth. However, because of the absence of rock records from that time, understanding these processes has proven challenging. Here, we present experimental results that simulate the giant impact-driven reactions between iron and volatiles (H
Language	English
Publishing date	2023-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adi6096
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Article ; Online: Disulfide polymer grafted polypropylene/polyethylene filter media for selective cadmium removal.

Hong, Jeongmin / Ko, Dongah / Hwang, Yuhoon

Journal of hazardous materials

2020 Volume 399, Page(s) 123060

Abstract: Heavy metal pollution caused by stormwater runoff has triggered a demand for effective heavy metal sorbents. Effective heavy metal removal using conventional stormwater runoff treatment processes that employ filtration mechanisms as primary removal ... ...

Abstract	Heavy metal pollution caused by stormwater runoff has triggered a demand for effective heavy metal sorbents. Effective heavy metal removal using conventional stormwater runoff treatment processes that employ filtration mechanisms as primary removal mechanisms is difficult. Therefore, we attempt to improve cadmium removal performance by attaching disulfide polymer (DiS-COP) containing soft bases, thiols, onto the surface of polypropylene/polyethylene (PP/PE) fiber media, which is widely used for stormwater runoff treatment. Material characterization demonstrated that DiS-COP was successfully grafted and grown on the surface of PP/PE (Dis-PP/PE). The batch and continuous flow adsorption capacities of Dis-PP/PE were 81.1 mg/g and 2.33 mg/g, respectively, which is 40 times higher than those of pristine PP/PE. Applicability of DiS-PP/PE at pH 6-8 was demonstrated, and effects of calcium and humic acid on cadmium adsorption were investigated. Calcium marginally affected cadmium adsorption, which can be explained using the Hard and soft (Lewis) acids and bases theory (HSAB), but cadmium removal efficiency decreased owing to humic acid (HA)-Cd complex formation and agglomeration in the presence of organic material. In a breakthrough test, the adsorption column exhibited complete cadmium uptake over 24 h until it reached the breakthrough point. Therefore, heavy metal adsorption performance of PP/PE was successfully enhanced by grafting DiS-COP on its surface.
Language	English
Publishing date	2020-05-28
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2020.123060
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Article: Targeted Drug Delivery via the Use of ECM-Mimetic Materials.

Hwang, Jeongmin / Sullivan, Millicent O / Kiick, Kristi L

Frontiers in bioengineering and biotechnology

2020 Volume 8, Page(s) 69

Abstract: The use of drug delivery vehicles to improve the efficacy of drugs and to target their action at effective concentrations over desired periods of time has been an active topic of research and clinical investigation for decades. Both synthetic and natural ...

Abstract	The use of drug delivery vehicles to improve the efficacy of drugs and to target their action at effective concentrations over desired periods of time has been an active topic of research and clinical investigation for decades. Both synthetic and natural drug delivery materials have facilitated locally controlled as well as targeted drug delivery. Extracellular matrix (ECM) molecules have generated widespread interest as drug delivery materials owing to the various biological functions of ECM. Hydrogels created using ECM molecules can provide not only biochemical and structural support to cells, but also spatial and temporal control over the release of therapeutic agents, including small molecules, biomacromolecules, and cells. In addition, the modification of drug delivery carriers with ECM fragments used as cell-binding ligands has facilitated cell-targeted delivery and improved the therapeutic efficiency of drugs through interaction with highly expressed cellular receptors for ECM. The combination of ECM-derived hydrogels and ECM-derived ligand approaches shows synergistic effects, leading to a great promise for the delivery of intracellular drugs, which require specific endocytic pathways for maximal effectiveness. In this review, we provide an overview of cellular receptors that interact with ECM molecules and discuss examples of selected ECM components that have been applied for drug delivery in both local and systemic platforms. Finally, we highlight the potential impacts of utilizing the interaction between ECM components and cellular receptors for intracellular delivery, particularly in tissue regeneration applications.
Language	English
Publishing date	2020-02-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2020.00069
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